JP2017510641A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017510641A5 JP2017510641A5 JP2017502932A JP2017502932A JP2017510641A5 JP 2017510641 A5 JP2017510641 A5 JP 2017510641A5 JP 2017502932 A JP2017502932 A JP 2017502932A JP 2017502932 A JP2017502932 A JP 2017502932A JP 2017510641 A5 JP2017510641 A5 JP 2017510641A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- nitrogen
- independently selected
- oxygen
- sulfur
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461971023P | 2014-03-27 | 2014-03-27 | |
| US61/971,023 | 2014-03-27 | ||
| PCT/US2015/022841 WO2015148854A1 (en) | 2014-03-27 | 2015-03-26 | Substituted indole mcl-1 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017510641A JP2017510641A (ja) | 2017-04-13 |
| JP2017510641A5 true JP2017510641A5 (enExample) | 2018-05-17 |
| JP6757312B2 JP6757312B2 (ja) | 2020-09-16 |
Family
ID=54196421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017502932A Expired - Fee Related JP6757312B2 (ja) | 2014-03-27 | 2015-03-26 | 置換インドールｍｃｌ−１阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US10533010B2 (enExample) |
| EP (1) | EP3122353B1 (enExample) |
| JP (1) | JP6757312B2 (enExample) |
| CN (1) | CN106456602B (enExample) |
| AU (1) | AU2015235944B2 (enExample) |
| CA (1) | CA2943815C (enExample) |
| WO (1) | WO2015148854A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10533010B2 (en) | 2014-03-27 | 2020-01-14 | Vanderbilt University | Substituted indole Mcl-1 inhibitors |
| US9949965B2 (en) | 2014-10-17 | 2018-04-24 | Vanderbilt University | Tricyclic indole Mcl-1 inhibitors and uses thereof |
| US11306107B2 (en) | 2016-02-25 | 2022-04-19 | Amgen Inc. | Compounds that inhibit MCL-1 protein |
| JP7086395B2 (ja) * | 2016-03-04 | 2022-06-20 | ヴァンダービルト ユニバーシティー | 置換インドールＭｃｌ－１阻害剤 |
| CR20180499A (es) | 2016-04-22 | 2019-01-25 | Astrazeneca Ab | Inhibidores de mcl1 macrocicliclos para tratar el cancer |
| WO2017198341A1 (en) | 2016-05-19 | 2017-11-23 | Bayer Aktiengesellschaft | Macrocyclic indole derivatives |
| EP3458459B1 (en) * | 2016-05-19 | 2022-04-27 | Bayer Aktiengesellschaft | Macrocyclic indole derivatives |
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| JP6453507B2 (ja) * | 2017-03-30 | 2019-01-16 | アムジエン・インコーポレーテツド | Ｍｃｌ−１タンパク質を阻害する化合物 |
| CN111093659A (zh) * | 2017-04-30 | 2020-05-01 | 财团法人生物技术开发中心 | 一种抗癌干性的药物 |
| WO2019040511A1 (en) * | 2017-08-22 | 2019-02-28 | University Of Maryland Batimore | DOUBLE INHIBITORS OF BCL-2 AND HDM2 FAMILIES BY CO-MIMETTISM OF ALPHA BH3 AND P53 PROPELLERS |
| EP3710451A1 (en) | 2017-11-17 | 2020-09-23 | Bayer Aktiengesellschaft | Substituted macrocyclic indole derivatives |
| WO2019096914A1 (en) | 2017-11-17 | 2019-05-23 | Bayer Aktiengesellschaft | Macrocyclic chlorine substituted indole derivatives |
| AR113887A1 (es) | 2017-11-17 | 2020-06-24 | Bayer Ag | Derivados de indol macrocíclicos sustituidos con cloro |
| EP3710449B1 (en) | 2017-11-17 | 2022-07-06 | The Broad Institute, Inc. | Macrocyclic fluorine substituted indole derivatives as mcl-1 inhibitors, for use in the treatment of cancer |
| EP3710456B1 (en) | 2017-11-17 | 2022-09-21 | The Broad Institute, Inc. | Macrocyclic indole derivatives |
| WO2019096907A1 (en) | 2017-11-17 | 2019-05-23 | Bayer Aktiengesellschaft | Aryl annulated macrocyclic indole derivatives |
| CN109988151B (zh) * | 2017-12-29 | 2021-04-23 | 北京赛特明强医药科技有限公司 | 一种炔类化合物、制备方法及其应用 |
| JP7050165B2 (ja) | 2018-02-26 | 2022-04-07 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｂｖ複製阻害剤としての置換ピロリジン化合物 |
| CN108251104B (zh) * | 2018-02-27 | 2019-11-05 | 山东大学 | 一种取代吲哚-2-羧酸类Bcl-2小分子荧光探针及其应用 |
| JP6899975B2 (ja) * | 2018-05-14 | 2021-07-07 | ギリアード サイエンシーズ， インコーポレイテッド | Ｍｃｌ−１阻害剤 |
| US11718614B2 (en) | 2018-06-25 | 2023-08-08 | Suzhou Mednes Pharma Tech Co., Ltd. | Compounds and methods for treatment of hedgehog pathway associated conditions |
| CN113453724B (zh) | 2018-09-27 | 2025-02-25 | 皮埃尔法布雷医药公司 | 基于磺酰基马来酰亚胺的连接子和相应的偶联物 |
| TWI749404B (zh) * | 2018-11-22 | 2021-12-11 | 大陸商蘇州亞盛藥業有限公司 | 作為mcl-1抑制劑的大環吲哚 |
| WO2020147802A1 (en) * | 2019-01-18 | 2020-07-23 | Ascentage Pharma (Suzhou) Co., Ltd. | Macrocyclic spiroethers as mcl-1 inhibitors |
| EP3969457B1 (en) | 2019-05-17 | 2025-08-13 | The Broad Institute Inc. | Methods of preparing macrocyclic indoles |
| WO2021092053A1 (en) * | 2019-11-08 | 2021-05-14 | Unity Biotechnology, Inc. | Mcl-1 inhibitor macrocycle compounds for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer |
| WO2021092061A1 (en) * | 2019-11-08 | 2021-05-14 | Unity Biotechnology, Inc. | Combination treatment for senescence-associated diseases |
| WO2024123195A1 (en) * | 2022-12-06 | 2024-06-13 | Captor Therapeutics S.A. | Targeted protein degradation using prodrugs of bifunctional compounds that bind ubiquitin ligase and target mcl-1 protein |
| JP2025540970A (ja) * | 2022-12-06 | 2025-12-17 | キャプター セラピューティクス エス．エー． | ユビキチンリガーゼ及びターゲットｍｃｌ－１タンパク質に結合する二機能性化合物を使用するターゲティングされたタンパク質分解 |
| WO2025104079A1 (en) * | 2023-11-17 | 2025-05-22 | Helmholtz-Zentrum für Infektionsforschung GmbH | Salicylic acid and picolinic acid derivatives as inhibitors of energy coupling factor (ecf) transporters for the treatment of bacterial infections |
| WO2026148303A1 (en) * | 2025-01-06 | 2026-07-09 | Vanderbilt University | Macrocyclic mcl-1 inhibitors |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4703053A (en) | 1985-10-28 | 1987-10-27 | Warner-Lambert Company | Benzothiophenes and benzofurans and antiallergic use thereof |
| GB8531612D0 (en) | 1985-12-23 | 1986-02-05 | Beecham Wuelfing Gmbh & Co Kg | Compounds |
| US4994477A (en) | 1988-03-24 | 1991-02-19 | Abbott Laboratories | Heterocyclic renin inhibitors |
| DE4128015A1 (de) | 1991-08-23 | 1993-02-25 | Kali Chemie Pharma Gmbh | 1,7-anellierte 2-(piperazinoalkyl)indol-derivate sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindugnen enthaltende arzneimittel |
| EP0639573A1 (de) | 1993-08-03 | 1995-02-22 | Hoechst Aktiengesellschaft | Benzokondensierte 5-Ringheterocyclen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, ihre Verwendung als Diagnostikum, sowie sie enthaltendes Medikament |
| US5436264A (en) * | 1993-08-19 | 1995-07-25 | Syntex (U.S.A.) Inc. | N-aryloxyalkyl tryptamine α1 -adrenergic receptor antagonists |
| JP3739432B2 (ja) | 1994-02-25 | 2006-01-25 | ダイセル化学工業株式会社 | オゾン開裂反応 |
| AU2651297A (en) | 1996-05-08 | 1997-11-26 | Ihara Chemical Industry Co. Ltd. | Indolyl-substituted uracil derivatives and herbicides comprising them as active ingredients |
| ATE310528T1 (de) | 1996-09-12 | 2005-12-15 | Idun Pharmaceuticals Inc | Hemmung der apoptose unter verwendung von inhibitoren der interleukin-1 beta converting enzym (ice)/ced-3 familie |
| FR2761070B1 (fr) | 1997-03-20 | 1999-04-23 | Synthelabo | Derives de dihydropyrazino[1,2-a]indole-1-one, leur preparation et leur application en therapeutique |
| FR2761073B1 (fr) * | 1997-03-20 | 1999-04-23 | Synthelabo | Derives de pyrazino[1,2-a]indole-1-one, leur preparation et leur application en therapeutique |
| US6500853B1 (en) | 1998-02-28 | 2002-12-31 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
| IL154981A0 (en) | 2000-10-10 | 2003-10-31 | Smithkline Beecham Corp | Substituted indoles, pharmaceutical compositions containing such indoles and their use as ppay-y-binding agents |
| FR2827287B1 (fr) | 2001-07-13 | 2003-10-31 | Servier Lab | Nouveaux derives de benzene sulfonamide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2005056522A2 (en) | 2003-12-04 | 2005-06-23 | National Health Research Institutes | Indole compounds |
| US7429611B2 (en) | 2004-09-23 | 2008-09-30 | Bristol-Myers Squibb Company | Indole inhibitors of 15-lipoxygenase |
| US8097644B2 (en) | 2006-03-28 | 2012-01-17 | Allergan, Inc. | Indole compounds having sphingosine-1-phosphate (S1P) receptor antagonist |
| DE102006033109A1 (de) | 2006-07-18 | 2008-01-31 | Grünenthal GmbH | Substituierte Heteroaryl-Derivate |
| EP2094662B1 (en) | 2006-12-14 | 2012-04-11 | Astellas Pharma Inc. | Polycyclic acid compounds useful as crth2 antagonists and antiallergic agents |
| MX2009011210A (es) * | 2007-04-16 | 2009-10-30 | Abbott Lab | Inhibidores de mcl1 de indol 7-no sustituido. |
| KR101511074B1 (ko) * | 2007-04-16 | 2015-04-13 | 애브비 인코포레이티드 | 7-치환된 인돌 Ｍｃｌ-1 억제제 |
| US20090270497A1 (en) | 2008-04-24 | 2009-10-29 | Pharmacyclics, Inc. | Treatment of Non-Localized Inflammation with pan-HDAC Inhibitors |
| EP2161266A1 (en) | 2008-08-22 | 2010-03-10 | EVOTEC Neurosciences GmbH | Benzofuran derivatives as orexin receptor antagonists |
| EP3549951A3 (en) | 2008-12-09 | 2019-11-20 | Dana Farber Cancer Institute, Inc. | Methods and compositions for specific modulation of mcl-1 |
| FR2961393B1 (fr) | 2010-06-16 | 2013-02-15 | Oreal | Procede de coloration capillaire a partir d'une composition comprenant au moins un compose indolique ou une indolinique, un sel metallique, du peroxyde d'hydrogene et un agent alcalinisant |
| JP2013537191A (ja) | 2010-09-08 | 2013-09-30 | ユニバーシティー オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション | ｐ５３−Ｍｄｍ２アンタゴニスト |
| CN103597073B (zh) | 2011-03-06 | 2019-06-07 | 默克雪兰诺有限公司 | 低岩藻糖细胞系及其应用 |
| EP2785720B1 (en) | 2011-11-29 | 2017-08-09 | Nanjing Allgen Pharma Co. Ltd. | Heterocyclic amides compounds which are hdac6 inhibitors and used as anti-tumoral agents |
| WO2013112878A1 (en) | 2012-01-26 | 2013-08-01 | The Penn State Research Foundation | Mcl-1 modulating compositions |
| US10093640B2 (en) | 2012-09-21 | 2018-10-09 | Vanderbilt University | Substituted benzofuran, benzothiophene and indole MCL-1 inhibitors |
| WO2015031608A1 (en) | 2013-08-28 | 2015-03-05 | Vanderbilt University | Substituted indole mcl-1 inhibitors |
| US10533010B2 (en) | 2014-03-27 | 2020-01-14 | Vanderbilt University | Substituted indole Mcl-1 inhibitors |
| US9949965B2 (en) | 2014-10-17 | 2018-04-24 | Vanderbilt University | Tricyclic indole Mcl-1 inhibitors and uses thereof |
| JP7086395B2 (ja) | 2016-03-04 | 2022-06-20 | ヴァンダービルト ユニバーシティー | 置換インドールＭｃｌ－１阻害剤 |
-
2015
- 2015-03-26 US US15/129,042 patent/US10533010B2/en active Active
- 2015-03-26 CA CA2943815A patent/CA2943815C/en active Active
- 2015-03-26 WO PCT/US2015/022841 patent/WO2015148854A1/en not_active Ceased
- 2015-03-26 EP EP15768818.5A patent/EP3122353B1/en active Active
- 2015-03-26 CN CN201580028206.8A patent/CN106456602B/zh not_active Expired - Fee Related
- 2015-03-26 AU AU2015235944A patent/AU2015235944B2/en not_active Ceased
- 2015-03-26 JP JP2017502932A patent/JP6757312B2/ja not_active Expired - Fee Related
-
2019
- 2019-11-19 US US16/688,872 patent/US11208415B2/en active Active
-
2021
- 2021-11-04 US US17/518,732 patent/US12195472B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110776507B (zh) | Bcl-2抑制剂与化疗药的组合产品及其在预防和/或治疗疾病中的用途 | |
| CN103200822B (zh) | 2-取代-8-烷基-7-氧代-7,8-二氢吡啶并[2,3-d]嘧啶-6-腈和其应用 | |
| CN110772639B (zh) | Bcl-2抑制剂与MDM2抑制剂的组合产品及其在预防和/或治疗疾病中的用途 | |
| JP7028809B2 (ja) | コルテキソロン１７α－バレレートを含む腫瘍治療に用いるための組成物 | |
| CN105163584A (zh) | 用于治疗癌症的化合物 | |
| JP2019516759A5 (enExample) | ||
| JP2013529200A5 (enExample) | ||
| JP2013526540A5 (enExample) | ||
| RU2019101220A (ru) | Кристаллические формы соединения триазолопиримидина | |
| JP2013529199A5 (enExample) | ||
| JP2016528246A5 (enExample) | ||
| JP2013526538A5 (enExample) | ||
| EP3716978B1 (en) | N-(phenyl)-n'-(6-quinoxalinyl)-urea derivatives as ikkb inhibitors for the treatment of cancer | |
| JP6889101B2 (ja) | グルタミナーゼ阻害剤の結晶形態 | |
| TW202019409A (zh) | Bcl-2抑制劑與利妥昔單抗和/或苯達莫司汀或bcl-2抑制劑與chop聯合用藥的協同抗腫瘤作用 | |
| CN104755455B (zh) | 可用于治疗癌症的巨大戟醇衍生化合物 | |
| JP2019527239A5 (enExample) | ||
| JP2019529475A5 (enExample) | ||
| AU2016301212A1 (en) | Inhibitors of ACK1/TNK2 tyrosine kinase | |
| CN104470509A (zh) | 剂量范围在2至30mg/kg的地塞米诺或其衍生物在癌症治疗中的用途 | |
| CN105935357A (zh) | 癌细胞凋亡 | |
| Banik et al. | Novel 6, 12-disubstituted chrysene as potent anticancer agent: synthesis, in vitro and in vivo study | |
| CN107638426B (zh) | 噻唑类化合物在制备治疗肿瘤的药物中的用途 | |
| JP2020533399A (ja) | 新規低分子化合物 | |
| TW201231470A (en) | 4-anilinofuro[2,3-b]quinoline derivatives, their preparation processes, and pharmaceutical compositions comprising the same |