JP2017533249A5 - - Google Patents
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- Publication number
- JP2017533249A5 JP2017533249A5 JP2017525078A JP2017525078A JP2017533249A5 JP 2017533249 A5 JP2017533249 A5 JP 2017533249A5 JP 2017525078 A JP2017525078 A JP 2017525078A JP 2017525078 A JP2017525078 A JP 2017525078A JP 2017533249 A5 JP2017533249 A5 JP 2017533249A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- oxo
- alkyl
- phenyl
- heterocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462077707P | 2014-11-10 | 2014-11-10 | |
| US62/077,707 | 2014-11-10 | ||
| PCT/US2015/060007 WO2016077380A1 (en) | 2014-11-10 | 2015-11-10 | Substituted pyrrolopyridines as inhibitors of bromodomain |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017533249A JP2017533249A (ja) | 2017-11-09 |
| JP2017533249A5 true JP2017533249A5 (enExample) | 2018-12-20 |
| JP6669745B2 JP6669745B2 (ja) | 2020-03-18 |
Family
ID=54602075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017525078A Expired - Fee Related JP6669745B2 (ja) | 2014-11-10 | 2015-11-10 | ブロモドメインのインヒビターとしての置換ピロロピリジン |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10150767B2 (enExample) |
| EP (1) | EP3218374B1 (enExample) |
| JP (1) | JP6669745B2 (enExample) |
| CN (1) | CN107108614B (enExample) |
| MA (1) | MA40940A (enExample) |
| WO (1) | WO2016077380A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA40943A (fr) * | 2014-11-10 | 2017-09-19 | Constellation Pharmaceuticals Inc | Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines |
| WO2016077375A1 (en) | 2014-11-10 | 2016-05-19 | Genentech, Inc. | Bromodomain inhibitors and uses thereof |
| CN107531692B (zh) | 2015-01-29 | 2020-12-25 | 基因泰克公司 | 治疗化合物及其用途 |
| WO2016139361A1 (en) | 2015-03-05 | 2016-09-09 | Boehringer Ingelheim International Gmbh | New pyridinones and isoquinolinones as inhibitors of the bromodomain brd9 |
| AR104259A1 (es) * | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
| HRP20200728T1 (hr) | 2016-04-15 | 2020-07-24 | Abbvie Inc. | Inhibitori bromodomene |
| EP3892272B1 (en) | 2016-04-22 | 2024-07-24 | Dana-Farber Cancer Institute, Inc. | Bifunctional molecules for degradation of egfr and methods of use |
| WO2018130174A1 (zh) * | 2017-01-11 | 2018-07-19 | 江苏豪森药业集团有限公司 | 吡咯并[2,3-c]吡啶类衍生物、其制备方法及其在医药上的应用 |
| US11040027B2 (en) | 2017-01-17 | 2021-06-22 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| US20210130346A1 (en) * | 2017-04-14 | 2021-05-06 | Abbvie Inc. | Bromodomain Inhibitors |
| CN108976278B (zh) * | 2017-06-05 | 2021-04-06 | 海创药业股份有限公司 | 一种嵌合分子及其制备和应用 |
| WO2019120234A2 (zh) * | 2017-12-20 | 2019-06-27 | 贝达药业股份有限公司 | 作为溴结构域蛋白质抑制剂的化合物和组合物 |
| US20210261539A1 (en) * | 2018-02-06 | 2021-08-26 | Shanghai Haihe Pharmaceutical Co., Ltd. | Compound having bet inhibitory activity and preparation method and use therefor |
| CN108465108B (zh) * | 2018-03-12 | 2020-07-07 | 上海宇玫博生物科技有限公司 | 一种预防或治疗脑胶质瘤的特异性基因靶点 |
| US10442799B1 (en) | 2018-04-07 | 2019-10-15 | Fuqiang Ruan | Heterocyclic compounds and uses thereof |
| CN110372693B (zh) * | 2018-07-04 | 2022-05-03 | 清华大学 | 一种靶向降解bet蛋白的化合物及其应用 |
| CN110776508B (zh) * | 2018-07-27 | 2021-07-16 | 海创药业股份有限公司 | 一种brd4抑制剂及其制备方法和用途 |
| CN110818609A (zh) * | 2018-08-11 | 2020-02-21 | 中国药科大学 | 3-乙酰基吲哚类brpf1抑制剂的制备方法及其用途 |
| WO2020041308A1 (en) * | 2018-08-20 | 2020-02-27 | University Of Georgia Research Foundation, Inc. | Compositions and methods for increasing beiging of white adipose tissue |
| CN109125729A (zh) * | 2018-09-06 | 2019-01-04 | 苏州吉玛基因股份有限公司 | 与非小细胞肺癌诊疗相关的基因BRD9及其siRNAs和应用 |
| US20220079951A1 (en) * | 2018-12-20 | 2022-03-17 | Saint Louis University | Bet inhibitors for modulating dux4 expression in fshd |
| JP7603613B2 (ja) * | 2019-04-24 | 2024-12-20 | コンバージーン・リミテッド・ライアビリティ・カンパニー | 小分子ブロモドメイン阻害剤およびそれらの使用 |
| GB201905721D0 (en) * | 2019-04-24 | 2019-06-05 | Univ Dundee | Compounds |
| US11171132B2 (en) * | 2019-10-03 | 2021-11-09 | Globalfoundries U.S. Inc. | Bi-directional breakdown silicon controlled rectifiers |
| CN112625036A (zh) * | 2019-10-08 | 2021-04-09 | 上海海和药物研究开发股份有限公司 | 一类具有brd4抑制活性的化合物、其制备方法及用途 |
| WO2022012456A1 (en) * | 2020-07-17 | 2022-01-20 | Chengdu Easton Biopharmaceuticals Co., Ltd. | Novel heterocyclic compounds as bet inhibitors |
| TW202237095A (zh) | 2020-12-03 | 2022-10-01 | 德商艾斯巴赫生物有限公司 | Ａｌｃ１抑制劑及與ｐａｒｐｉ之協同性 |
| WO2023275542A1 (en) * | 2021-06-29 | 2023-01-05 | Tay Therapeutics Limited | Pyrrolopyridone derivatives useful in the treatment of cancer |
| CN115611890B (zh) * | 2021-07-15 | 2024-05-31 | 成都硕德药业有限公司 | 一种新型噻吩类bet溴结构域抑制剂、其制备方法及医药用途 |
| TW202330519A (zh) * | 2021-09-29 | 2023-08-01 | 香港商德琪研發有限公司 | 作為ｔａｍ抑制劑的吡唑并吡啶化合物 |
| EP4518862A1 (en) | 2022-05-02 | 2025-03-12 | Eisbach Bio GmbH | Use of alc1 inhibitors and synergy with parpi |
| CN117304205A (zh) * | 2022-06-20 | 2023-12-29 | 中国科学院广州生物医药与健康研究院 | 一种苯并咪唑类三元并环化合物、其药学上可接受的盐及其应用 |
| CN117304204A (zh) * | 2022-06-20 | 2023-12-29 | 中国科学院广州生物医药与健康研究院 | 一种苯并咪唑类三元并环化合物、其药学上可接受的盐及其应用 |
| CN120583947A (zh) * | 2022-12-23 | 2025-09-02 | 泰治疗有限公司 | 选择性bet抑制剂及其用途 |
| WO2024193527A1 (zh) * | 2023-03-20 | 2024-09-26 | 山东新时代药业有限公司 | 作为溴结构域抑制剂的吡咯并[2,3-c]吡啶类化合物 |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU22545A1 (es) | 1994-11-18 | 1999-03-31 | Centro Inmunologia Molecular | Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico |
| US4943533A (en) | 1984-03-01 | 1990-07-24 | The Regents Of The University Of California | Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor |
| EP0491007B1 (en) | 1989-09-08 | 1996-03-13 | The Johns Hopkins University | Structural alterations of the egf receptor gene in human gliomas |
| AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
| GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
| EP0659439B1 (en) | 1993-12-24 | 2001-10-24 | MERCK PATENT GmbH | Immunoconjugates |
| IL112248A0 (en) | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
| US5654307A (en) | 1994-01-25 | 1997-08-05 | Warner-Lambert Company | Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
| IL112249A (en) | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| EP0772609B1 (en) | 1994-07-21 | 1999-02-24 | Akzo Nobel N.V. | Cyclic ketone peroxide formulations |
| US5804396A (en) | 1994-10-12 | 1998-09-08 | Sugen, Inc. | Assay for agents active in proliferative disorders |
| DE122005000053I2 (de) | 1995-03-30 | 2008-01-17 | Pfizer Prod Inc | Chinazolinderivate |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| GB9508565D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quiazoline derivative |
| US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| CA2222231A1 (en) | 1995-06-07 | 1996-12-19 | Imclone Systems Incorporated | Antibody and antibody fragments for inhibiting the growth of tumors |
| PT836605E (pt) | 1995-07-06 | 2002-07-31 | Novartis Ag | Pirrolopirimidinas e processos para a sua preparacao |
| US5760041A (en) | 1996-02-05 | 1998-06-02 | American Cyanamid Company | 4-aminoquinazoline EGFR Inhibitors |
| GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| US6344459B1 (en) | 1996-04-12 | 2002-02-05 | Warner-Lambert Company | Irreversible inhibitors of tyrosine kinases |
| ES2186908T3 (es) | 1996-07-13 | 2003-05-16 | Glaxo Group Ltd | Compuestos heterociciclos condensados como inhibidores de pproteina-tirosina-quinasas. |
| ID18494A (id) | 1996-10-02 | 1998-04-16 | Novartis Ag | Turunan pirazola leburan dan proses pembuatannya |
| UA73073C2 (uk) | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
| US6002008A (en) | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| AU7165698A (en) | 1997-05-06 | 1998-11-27 | American Cyanamid Company | Use of quinazoline compounds for the treatment of polycystic kidney disease |
| ZA986729B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitors of tyrosine kinases |
| ZA986732B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
| TW436485B (en) | 1997-08-01 | 2001-05-28 | American Cyanamid Co | Substituted quinazoline derivatives |
| HUP0004286A3 (en) | 1997-11-06 | 2002-01-28 | American Cyanamid Co Madison | Use of quinazoline derivatives for producing pharmaceutical compositions for treating colonic polyps |
| HUP0104211A3 (en) | 1998-11-19 | 2003-01-28 | Warner Lambert Co | N-[4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide, an irreversible inhibitor of tyrosine kinases and pharmaceutical composition containing it |
| EP1953147A1 (en) | 2005-11-21 | 2008-08-06 | Japan Tobacco, Inc. | Heterocyclic compound and medicinal application thereof |
| WO2013097052A1 (en) * | 2011-12-30 | 2013-07-04 | Abbott Laboratories | Bromodomain inhibitors |
| US20140094456A1 (en) * | 2012-10-02 | 2014-04-03 | Intermune, Inc. | Anti-fibrotic pyridinones |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| WO2014125408A2 (en) * | 2013-02-12 | 2014-08-21 | Aurigene Discovery Technologies Limited | Substituted 1h-pyrrolopyridinone derivatives as kinase inhibitors |
| CA2904049A1 (en) | 2013-03-11 | 2014-10-09 | Abbvie Inc. | Fused tetracyclic bromodomain inhibitors |
| AR095266A1 (es) * | 2013-03-12 | 2015-09-30 | Abbvie Inc | Inhibidores de bromodominios tetraciclicos |
| CN104211639A (zh) | 2013-06-05 | 2014-12-17 | 中国科学院上海药物研究所 | 一类炔基杂环类化合物及其应用 |
| KR20160018811A (ko) | 2013-06-12 | 2016-02-17 | 비아멧 파마슈티컬즈, 인코포레이티드 | 금속 효소 억제 화합물 |
| HK1224297A1 (zh) * | 2013-06-28 | 2017-08-18 | Abbvie Inc. | 布罗莫结构域抑制剂 |
| WO2015081280A1 (en) * | 2013-11-26 | 2015-06-04 | Coferon, Inc. | Bromodomain ligands capable of dimerizing in an aqueous solution |
| US9399640B2 (en) * | 2013-11-26 | 2016-07-26 | Incyte Corporation | Substituted pyrrolo[2,3-c]pyridines and pyrazolo[3,4-c]pyridines as BET protein inhibitors |
| US20150148372A1 (en) * | 2013-11-26 | 2015-05-28 | Incyte Corporation | Bicyclic heterocycles as bet protein inhibitors |
| MX382781B (es) | 2014-04-02 | 2025-03-13 | Intermune Inc | Piridinonas anti-fibroticas. |
| NZ725930A (en) * | 2014-04-23 | 2023-04-28 | Incyte Holdings Corp | 1h-pyrrolo[2,3-c]pyridin-7(6h)-ones and pyrazolo[3,4-c]pyridin-7(6h)-ones as inhibitors of bet proteins |
| WO2016077375A1 (en) | 2014-11-10 | 2016-05-19 | Genentech, Inc. | Bromodomain inhibitors and uses thereof |
| MA40943A (fr) | 2014-11-10 | 2017-09-19 | Constellation Pharmaceuticals Inc | Pyrrolopyridines substituées utilisées en tant qu'inhibiteurs de bromodomaines |
| CN107531690B (zh) * | 2014-11-27 | 2020-11-06 | 基因泰克公司 | 用作CBP和/或EP300抑制剂的4,5,6,7-四氢-1H-吡唑并[4,3-c]吡啶-3-胺化合物 |
| US9695200B2 (en) | 2015-01-23 | 2017-07-04 | Confluence Life Sciences, Inc. | Heterocyclic ITK inhibitors for treating inflammation and cancer |
| CN107531692B (zh) | 2015-01-29 | 2020-12-25 | 基因泰克公司 | 治疗化合物及其用途 |
-
2015
- 2015-11-09 MA MA040940A patent/MA40940A/fr unknown
- 2015-11-10 JP JP2017525078A patent/JP6669745B2/ja not_active Expired - Fee Related
- 2015-11-10 WO PCT/US2015/060007 patent/WO2016077380A1/en not_active Ceased
- 2015-11-10 EP EP15797572.3A patent/EP3218374B1/en active Active
- 2015-11-10 CN CN201580072518.9A patent/CN107108614B/zh not_active Expired - Fee Related
-
2017
- 2017-05-10 US US15/592,017 patent/US10150767B2/en active Active
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