JP2019516757A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019516757A5 JP2019516757A5 JP2018561543A JP2018561543A JP2019516757A5 JP 2019516757 A5 JP2019516757 A5 JP 2019516757A5 JP 2018561543 A JP2018561543 A JP 2018561543A JP 2018561543 A JP2018561543 A JP 2018561543A JP 2019516757 A5 JP2019516757 A5 JP 2019516757A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- alkyl
- membered
- oxo
- arbitrary
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022164864A JP2023002643A (ja) | 2016-05-24 | 2022-10-13 | Ｃｂｐ／ｅｐ３００の複素環式インヒビターおよびがんの処置におけるそれらの使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2016083124 | 2016-05-24 | ||
| CNPCT/CN2016/083124 | 2016-05-24 | ||
| PCT/US2017/034320 WO2017205536A2 (en) | 2016-05-24 | 2017-05-24 | Therapeutic compounds and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022164864A Division JP2023002643A (ja) | 2016-05-24 | 2022-10-13 | Ｃｂｐ／ｅｐ３００の複素環式インヒビターおよびがんの処置におけるそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019516757A JP2019516757A (ja) | 2019-06-20 |
| JP2019516757A5 true JP2019516757A5 (enExample) | 2020-07-09 |
| JP7160688B2 JP7160688B2 (ja) | 2022-10-25 |
Family
ID=59014798
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018561543A Active JP7160688B2 (ja) | 2016-05-24 | 2017-05-24 | Ｃｂｐ／ｅｐ３００の複素環式インヒビターおよびがんの処置におけるそれらの使用 |
| JP2022164864A Pending JP2023002643A (ja) | 2016-05-24 | 2022-10-13 | Ｃｂｐ／ｅｐ３００の複素環式インヒビターおよびがんの処置におけるそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022164864A Pending JP2023002643A (ja) | 2016-05-24 | 2022-10-13 | Ｃｂｐ／ｅｐ３００の複素環式インヒビターおよびがんの処置におけるそれらの使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10696655B2 (enExample) |
| EP (2) | EP3464270B1 (enExample) |
| JP (2) | JP7160688B2 (enExample) |
| CN (2) | CN109476641B (enExample) |
| MA (1) | MA45122A (enExample) |
| WO (1) | WO2017205536A2 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3021645A1 (en) | 2016-04-29 | 2017-11-02 | Icahn School Of Medicine At Mount Sinai | Targeting the innate immune system to induce long-term tolerance and to resolve macrophage accumulation in atherosclerosis |
| WO2017205536A2 (en) | 2016-05-24 | 2017-11-30 | Genentech, Inc. | Therapeutic compounds and uses thereof |
| CN110291089B (zh) | 2017-01-17 | 2022-05-27 | 海帕瑞吉尼克斯股份有限公司 | 用于促进肝再生或者减少或预防肝细胞死亡的蛋白激酶抑制剂 |
| CN110573501B (zh) * | 2017-06-30 | 2023-09-29 | 北京泰德制药股份有限公司 | Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途 |
| WO2019000683A1 (zh) | 2017-06-30 | 2019-01-03 | 北京泰德制药股份有限公司 | Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途 |
| AU2018294054B2 (en) * | 2017-06-30 | 2022-05-26 | Beijing Tide Pharmaceutical Co., Ltd. | Rho-associated protein kinase inhibitor, pharmaceutical composition comprising same, and preparation method and use thereof |
| WO2019055877A1 (en) | 2017-09-15 | 2019-03-21 | Forma Therapeutics, Inc. | TETRAHYDROIMIDAZO QUINOLINE COMPOSITIONS AS INHIBITORS OF CBP / P300 |
| US11414384B2 (en) | 2018-02-16 | 2022-08-16 | Constellation Pharmaceuticals, Inc. | P300/CBP hat inhibitors |
| RS65966B1 (sr) | 2018-02-16 | 2024-10-31 | Constellation Pharmaceuticals Inc | Inhibitori p300/cbp hat |
| AU2019245403B2 (en) | 2018-03-29 | 2025-02-06 | Board Of Regents, The University Of Texas System | Imidazopiperazine inhibitors of transcription activating proteins |
| WO2019195846A1 (en) | 2018-04-06 | 2019-10-10 | Board Of Regents, The University Of Texas System | Imidazopiperazinone inhibitors of transcription activating proteins |
| WO2019201291A1 (zh) * | 2018-04-20 | 2019-10-24 | 中国科学院上海药物研究所 | 组蛋白乙酰转移酶(hat)抑制剂及其用途 |
| US11578124B2 (en) | 2018-05-18 | 2023-02-14 | Janssen Biotech, Inc. | Safe and effective method of treating lupus with anti-IL12/IL23 antibody |
| KR20250067962A (ko) | 2018-06-29 | 2025-05-15 | 포르마 세라퓨틱스 인크. | Creb 결합 단백질(cbp)의 저해 |
| CN112770752A (zh) | 2018-08-02 | 2021-05-07 | 波士顿大学董事会 | 晚期sv40因子(lsf)抑制剂 |
| CN111635356A (zh) * | 2018-11-23 | 2020-09-08 | 厦门大学 | Carm1小分子抑制剂的化合物、可药用盐、药物组合及用途 |
| TWI850342B (zh) * | 2019-02-27 | 2024-08-01 | 美商星座製藥公司 | P300/cbp hat抑制劑及其使用方法 |
| WO2020173440A1 (en) * | 2019-02-27 | 2020-09-03 | Cullgen (Shanghai), Inc. | Cyclic-amp response element binding protein (cbp) and/or adenoviral e1a binding protein of 300 kda (p300) degradation compounds and methods of use |
| US12351577B2 (en) | 2019-03-15 | 2025-07-08 | Forma Therapeutics, Inc. | Inhibiting cyclic AMP-responsive element-binding protein (CREB) |
| CN111763180B (zh) * | 2019-04-02 | 2023-06-09 | 中国医学科学院药物研究所 | 苯并氮杂环类化合物及其制法和药物用途 |
| TW202120095A (zh) * | 2019-08-05 | 2021-06-01 | 美商美國禮來大藥廠 | 7,8-二氫-4H-吡唑并[4,3-c]氮呯-6-酮化合物 |
| CN112574189B (zh) | 2019-09-27 | 2024-05-31 | 海创药业股份有限公司 | 一种ep300/cbp抑制剂 |
| JP2022549506A (ja) | 2019-09-27 | 2022-11-25 | ディスク・メディシン・インコーポレイテッド | 骨髄線維症および関連状態を処置するための方法 |
| WO2021150835A1 (en) * | 2020-01-24 | 2021-07-29 | Trustees Of Boston University | Heterocyclic lsf inhibitors and their uses |
| WO2021213521A1 (zh) * | 2020-04-25 | 2021-10-28 | 南京药石科技股份有限公司 | Cbp/ep300抑制剂及其用途 |
| KR20230012539A (ko) | 2020-05-13 | 2023-01-26 | 디스크 메디슨, 인크. | 골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체 |
| US11458132B2 (en) | 2020-09-01 | 2022-10-04 | Trustees Of Boston University | Quinolin-2(1H)-one inhibitors of Late SV40 Factor |
| JP2023539931A (ja) * | 2020-09-09 | 2023-09-20 | オーリジーン オンコロジー リミテッド | Ｃｂｐ／ｅｐ３００ブロモドメイン阻害剤としての複素環式化合物 |
| US11801243B2 (en) | 2020-09-23 | 2023-10-31 | Forma Therapeutics, Inc. | Bromodomain inhibitors for androgen receptor-driven cancers |
| US11795168B2 (en) | 2020-09-23 | 2023-10-24 | Forma Therapeutics, Inc. | Inhibiting cyclic amp-responsive element-binding protein (CREB) binding protein (CBP) |
| CN116348112A (zh) * | 2020-10-02 | 2023-06-27 | 德州大学系统董事会 | 转录激活蛋白的咪唑并哌嗪抑制剂 |
| JP2023544173A (ja) | 2020-10-02 | 2023-10-20 | ボード オブ レジェンツ，ザ ユニバーシティ オブ テキサス システム | 転写活性化タンパク質のイミダゾピペラジン阻害剤 |
| AU2022239614A1 (en) * | 2021-03-19 | 2023-10-12 | Icahn School Of Medicine At Mount Sinai | Compounds for regulating trained immunity, and their methods of use |
| CN113087683B (zh) * | 2021-03-22 | 2022-04-22 | 华南理工大学 | 氮取代苯并噻唑啉酮类xor/urat1双重抑制剂及其制备方法与应用 |
| TW202409023A (zh) | 2022-07-14 | 2024-03-01 | 美商富曼西公司 | 除草苯并𠯤 |
| CN117843618A (zh) * | 2022-08-29 | 2024-04-09 | 北京沐华生物科技有限责任公司 | 一种ep300/cbp调节剂及其制备方法和用途 |
| AU2024333590A1 (en) * | 2023-08-30 | 2026-03-12 | Oncopia Therapeutics, Inc. D/B/A Sk Life Science Labs | Compounds and compositions as cbp/p300 degraders and uses thereof |
| WO2025111184A1 (en) | 2023-11-21 | 2025-05-30 | Fmc Corporation | Substituted tetrahydroquinoline and tetrahydroquinoxaline herbicides |
Family Cites Families (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US533A (en) | 1837-12-26 | Truss for hermta | ||
| US4943A (en) | 1847-01-26 | Harness-buckle | ||
| CU22545A1 (es) | 1994-11-18 | 1999-03-31 | Centro Inmunologia Molecular | Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico |
| US4943533A (en) | 1984-03-01 | 1990-07-24 | The Regents Of The University Of California | Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor |
| CA2066428C (en) | 1989-09-08 | 2000-11-28 | Bert Vogelstein | Structural alterations of the egf receptor gene in human gliomas |
| GB9300059D0 (en) | 1992-01-20 | 1993-03-03 | Zeneca Ltd | Quinazoline derivatives |
| GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
| DK0659439T3 (da) | 1993-12-24 | 2002-01-14 | Merck Patent Gmbh | Immunkonjugater |
| IL112249A (en) | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| US5654307A (en) | 1994-01-25 | 1997-08-05 | Warner-Lambert Company | Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
| IL112248A0 (en) | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
| HU216142B (hu) | 1994-07-21 | 1999-04-28 | Akzo Nobel N.V. | Ciklusos keton-peroxidokat tartalmazó kompozíciók, és azok alkalmazása (ko)polimerek módosítására |
| US5804396A (en) | 1994-10-12 | 1998-09-08 | Sugen, Inc. | Assay for agents active in proliferative disorders |
| DE69536015D1 (de) | 1995-03-30 | 2009-12-10 | Pfizer Prod Inc | Chinazolinone Derivate |
| GB9508565D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quiazoline derivative |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| JPH11507535A (ja) | 1995-06-07 | 1999-07-06 | イムクローン システムズ インコーポレイテッド | 腫瘍の成長を抑制する抗体および抗体フラグメント類 |
| EP0836605B1 (en) | 1995-07-06 | 2002-02-06 | Novartis AG | Pyrrolopyrimidines and processes for the preparation thereof |
| US5760041A (en) | 1996-02-05 | 1998-06-02 | American Cyanamid Company | 4-aminoquinazoline EGFR Inhibitors |
| GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| US6011029A (en) * | 1996-02-26 | 2000-01-04 | Bristol-Myers Squibb Company | Inhibitors of farnesyl protein transferase |
| JP3370340B2 (ja) | 1996-04-12 | 2003-01-27 | ワーナー―ランバート・コンパニー | チロシンキナーゼの不可逆的阻害剤 |
| DE69716916T2 (de) | 1996-07-13 | 2003-07-03 | Glaxo Group Ltd., Greenford | Kondensierte heterozyklische verbindungen als protein kinase inhibitoren |
| ID18494A (id) | 1996-10-02 | 1998-04-16 | Novartis Ag | Turunan pirazola leburan dan proses pembuatannya |
| UA73073C2 (uk) | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
| US6002008A (en) | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| ES2201484T3 (es) | 1997-05-06 | 2004-03-16 | Wyeth Holdings Corporation | Utilizacion de compuestos de quinazolina para el tratamiento de la enfermedad de la poliquistosis renal. |
| ZA986732B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
| ZA986729B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitors of tyrosine kinases |
| TW436485B (en) | 1997-08-01 | 2001-05-28 | American Cyanamid Co | Substituted quinazoline derivatives |
| NZ503991A (en) | 1997-11-06 | 2001-11-30 | American Cyanamid Co | Use of quinazoline derivatives as tyrosine kinase inhibitors for treating colonic polyps |
| ES2188254T3 (es) | 1998-11-19 | 2003-06-16 | Warner Lambert Co | N-(4-(3-chloro-4-fluoro-fenilamino)-7-(3-morfolin-4-il-propoxi)-quin azolin-6-il)-acrilamada, un inhibidor irreversible de tirosina quinasas. |
| PL2161336T5 (pl) | 2005-05-09 | 2017-10-31 | Ono Pharmaceutical Co | Ludzkie przeciwciała monoklonalne przeciwko białku Programmed Death 1 (PD-1) oraz sposoby leczenia raka z zastosowaniem samych przeciwciał anty-PD-1 lub w połączeniu z innymi środkami immunoterapeutycznymi |
| CA2612241C (en) | 2005-07-01 | 2018-11-06 | Medarex, Inc. | Human monoclonal antibodies to programmed death ligand 1 (pd-l1) |
| US20090258853A1 (en) * | 2006-03-13 | 2009-10-15 | Brian Eastman | Somatostatin Agonists |
| EP2001472A2 (en) * | 2006-03-23 | 2008-12-17 | Merck and Co., Inc. | Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use |
| CA2651072A1 (en) * | 2006-05-01 | 2007-11-08 | Pfizer Products Inc. | Substituted 2-amino-fused heterocyclic compounds |
| GB0620059D0 (en) * | 2006-10-10 | 2006-11-22 | Ucb Sa | Therapeutic agents |
| WO2009053694A1 (en) * | 2007-10-24 | 2009-04-30 | Cancer Research Technology Limited | Therapeutic oxy-phenyl-aryl compounds and their use |
| WO2009071890A1 (en) * | 2007-12-04 | 2009-06-11 | Ucb Pharma S.A. | Tricyclic kinase inhibitors |
| GB0723747D0 (en) * | 2007-12-04 | 2008-12-31 | Ucb Pharma Sa | Therapeutic agents |
| WO2009071895A1 (en) * | 2007-12-04 | 2009-06-11 | Ucb Pharma S.A. | Fused thiazole and thiophene derivatives as kinase inhibitors |
| RU2531758C2 (ru) | 2008-02-11 | 2014-10-27 | Куретек Лтд. | Моноклональные антитела для лечения опухолей |
| US8168757B2 (en) | 2008-03-12 | 2012-05-01 | Merck Sharp & Dohme Corp. | PD-1 binding proteins |
| JP2012500652A (ja) | 2008-08-25 | 2012-01-12 | アンプリミューン、インコーポレーテッド | 標的化共刺激ポリペプチドおよび癌を処置するための使用方法 |
| EP4209510B1 (en) | 2008-12-09 | 2024-01-31 | F. Hoffmann-La Roche AG | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| EP2379523A1 (en) * | 2008-12-22 | 2011-10-26 | Incyte Corporation | 4, 6-disubstituted 2-amino-pyrimidines as histamine h4 receptor modulators |
| EP2241557A1 (de) * | 2009-04-02 | 2010-10-20 | Æterna Zentaris GmbH | Chinoxalin-Derivate und deren Anwendung zur Behandlung gutartiger und bösartiger Tumorerkrankungen |
| US20100305093A1 (en) * | 2009-04-09 | 2010-12-02 | Exelixis, Inc. | Inhibitors of mTOR and Methods of Making and Using |
| CA2763008A1 (en) | 2009-05-26 | 2010-12-02 | Exelixis, Inc. | Benzoxazepines as inhibitors of pi3k/mtor and methods of their use and manufacture |
| WO2010138490A1 (en) * | 2009-05-26 | 2010-12-02 | Exelixis, Inc. | Benzoxazepines as inhibitors of mtor and methods of their use and manufacture |
| GB0919431D0 (en) * | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| GB0919434D0 (en) * | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| US20130017199A1 (en) | 2009-11-24 | 2013-01-17 | AMPLIMMUNE ,Inc. a corporation | Simultaneous inhibition of pd-l1/pd-l2 |
| AR079814A1 (es) * | 2009-12-31 | 2012-02-22 | Otsuka Pharma Co Ltd | Compuestos heterociclicos, composiciones farmaceuticas que los contienen y sus usos |
| US8440662B2 (en) * | 2010-10-31 | 2013-05-14 | Endo Pharmaceuticals, Inc. | Substituted quinazoline and pyrido-pyrimidine derivatives |
| TW201307292A (zh) * | 2010-12-17 | 2013-02-16 | Hoffmann La Roche | 經取代之６，６－稠合含氮雜環化合物及其用途 |
| UA111075C2 (uk) * | 2011-02-25 | 2016-03-25 | Еррей Біофарма Інк. | Триазолопіридинові сполуки як інгібітори кінази рім |
| JP6121658B2 (ja) * | 2011-06-29 | 2017-04-26 | 大塚製薬株式会社 | 治療用化合物、及び関連する使用の方法 |
| TWI622583B (zh) * | 2011-07-01 | 2018-05-01 | 基利科學股份有限公司 | 作為離子通道調節劑之稠合雜環化合物 |
| US9145411B2 (en) * | 2012-08-02 | 2015-09-29 | Asana Biosciences, Llc | Substituted amino-pyrimidine derivatives |
| RU2543485C2 (ru) * | 2013-02-26 | 2015-03-10 | Андрей Александрович Иващенко | Гетероциклические агонисты рецепторов желчных кислот tgr5, фармацевтическая композиция, способы их получения и применения |
| ES2704048T3 (es) * | 2013-03-14 | 2019-03-14 | Glaxosmithkline Ip No 2 Ltd | Derivados de 1-acil-4-amino-1,2,3,4-tetrahidroquinolina-2,3-disustituida y su uso como inhibidores de bromodominio |
| JP2017529358A (ja) * | 2014-09-19 | 2017-10-05 | ジェネンテック， インコーポレイテッド | がんの処置のためのｃｂｐ／ｅｐ３００阻害剤およびｂｅｔ阻害剤の使用 |
| CN107108512B (zh) * | 2014-10-10 | 2021-05-04 | 基因泰克公司 | 治疗性化合物及其用途 |
| WO2016086200A1 (en) * | 2014-11-27 | 2016-06-02 | Genentech, Inc. | 4,5,6,7-tetrahydro-1 h-pyrazolo[4,3-c]pyridin-3-amine compounds as cbp and/or ep300 inhibitors |
| EP3317278B1 (en) * | 2015-07-01 | 2021-04-14 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
| CN105039258B (zh) | 2015-07-03 | 2018-04-17 | 北京大学 | 将非神经元细胞重编程为神经元样细胞的方法和组合物 |
| AR108326A1 (es) * | 2016-04-27 | 2018-08-08 | Samumed Llc | Isoquinolin-3-il carboxamidas y preparación y uso de las mismas |
| AR108325A1 (es) * | 2016-04-27 | 2018-08-08 | Samumed Llc | Isoquinolin-3-il carboxamidas y preparación y uso de las mismas |
| WO2017205536A2 (en) | 2016-05-24 | 2017-11-30 | Genentech, Inc. | Therapeutic compounds and uses thereof |
-
2017
- 2017-05-24 WO PCT/US2017/034320 patent/WO2017205536A2/en not_active Ceased
- 2017-05-24 CN CN201780045651.4A patent/CN109476641B/zh not_active Expired - Fee Related
- 2017-05-24 EP EP17728375.1A patent/EP3464270B1/en active Active
- 2017-05-24 CN CN202210701205.7A patent/CN115028617A/zh active Pending
- 2017-05-24 EP EP22152776.5A patent/EP4067347B1/en active Active
- 2017-05-24 MA MA045122A patent/MA45122A/fr unknown
- 2017-05-24 JP JP2018561543A patent/JP7160688B2/ja active Active
-
2018
- 2018-11-21 US US16/198,597 patent/US10696655B2/en active Active
-
2020
- 2020-05-28 US US16/886,541 patent/US11168070B2/en not_active Expired - Fee Related
-
2022
- 2022-10-13 JP JP2022164864A patent/JP2023002643A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019516759A5 (enExample) | ||
| JP2017530176A5 (enExample) | ||
| JP2017533250A5 (enExample) | ||
| JP2018510851A5 (enExample) | ||
| JP2017537100A5 (enExample) | ||
| JP2017526696A5 (enExample) | ||
| JP2017533249A5 (enExample) | ||
| JP2017533248A5 (enExample) | ||
| JP2018501287A5 (enExample) | ||
| JP2017525740A5 (enExample) | ||
| JP6835472B2 (ja) | 癌の処置のための組成物 | |
| JP2018505169A5 (enExample) | ||
| RU2018138828A (ru) | Уменьшение массы опухоли путем введения ccr1 антагонистов в комбинации с pd-1 ингибиторами или pd-l1 ингибиторами | |
| KR102712584B1 (ko) | 종양 치료에 사용하기 위한 코르텍솔론의 17ａ,21-디에스테르 | |
| JP2018507191A5 (enExample) | ||
| JP6039549B2 (ja) | 化学療法または放射線療法によって誘発される嘔吐を予防および／または治療するためのシグマリガンド | |
| JP2024521706A5 (enExample) | ||
| JP2019529444A5 (enExample) | ||
| AR063872A1 (es) | Derivados de acetileno como inhibidores de estearoil coa desaturasa | |
| JP2014510078A5 (enExample) | ||
| MX2016016538A (es) | Derivados de quinazolinona como inhibidores de fosfatidilinositol 3-cinasa. | |
| JP2009541223A5 (enExample) | ||
| JP2011521938A5 (enExample) | ||
| WO2008120004A1 (en) | Combination of a mek- inhibitor and a b-raf inhibitor for the treatment of cancer | |
| Akhtar et al. | Recent advances in the synthesis and anticancer activity of some molecules other than nitrogen containing heterocyclic moeities |