JP2018510851A5 - - Google Patents
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- JP2018510851A5 JP2018510851A5 JP2017544916A JP2017544916A JP2018510851A5 JP 2018510851 A5 JP2018510851 A5 JP 2018510851A5 JP 2017544916 A JP2017544916 A JP 2017544916A JP 2017544916 A JP2017544916 A JP 2017544916A JP 2018510851 A5 JP2018510851 A5 JP 2018510851A5
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- JP
- Japan
- Prior art keywords
- cancer
- composition
- compound
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- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 *c1c(*)nnc(*)c1 Chemical compound *c1c(*)nnc(*)c1 0.000 description 16
- VUKHQPGJNTXTPY-NSCUHMNNSA-N C/C=C/Cc1ccccc1 Chemical compound C/C=C/Cc1ccccc1 VUKHQPGJNTXTPY-NSCUHMNNSA-N 0.000 description 1
- VJNJUWJHKJQYIF-UHFFFAOYSA-N CC(C)(CN(C)CC1)N1C(C)=O Chemical compound CC(C)(CN(C)CC1)N1C(C)=O VJNJUWJHKJQYIF-UHFFFAOYSA-N 0.000 description 1
- MSZXDTUUUMSSQS-UHFFFAOYSA-N CC(C)(CN(C)CC1)N1S(C)(=O)=O Chemical compound CC(C)(CN(C)CC1)N1S(C)(=O)=O MSZXDTUUUMSSQS-UHFFFAOYSA-N 0.000 description 1
- UFUZCUFUKAHDSB-IYBDPMFKSA-N CC(C)N1C[C@H](CN(Cc2ccccc2)C2)[C@H]2C1 Chemical compound CC(C)N1C[C@H](CN(Cc2ccccc2)C2)[C@H]2C1 UFUZCUFUKAHDSB-IYBDPMFKSA-N 0.000 description 1
- YGUJCUMSQULQEU-UHFFFAOYSA-N CC(C)[n]1ncc(CN2CCNCC2)c1 Chemical compound CC(C)[n]1ncc(CN2CCNCC2)c1 YGUJCUMSQULQEU-UHFFFAOYSA-N 0.000 description 1
- HNNHJSSSTNIYHO-UHFFFAOYSA-N CC(CCc1ccccc1)C(N1C(C)CN(C)CC1)=O Chemical compound CC(CCc1ccccc1)C(N1C(C)CN(C)CC1)=O HNNHJSSSTNIYHO-UHFFFAOYSA-N 0.000 description 1
- SNORQMCMXKTQSU-UHFFFAOYSA-N CC(CN(C)CC1)N1C(C1(C)COC1)=O Chemical compound CC(CN(C)CC1)N1C(C1(C)COC1)=O SNORQMCMXKTQSU-UHFFFAOYSA-N 0.000 description 1
- RKMLMSGVPZXOTA-UHFFFAOYSA-N CC(CN(C)CC1)N1C(c1cnccc1)=O Chemical compound CC(CN(C)CC1)N1C(c1cnccc1)=O RKMLMSGVPZXOTA-UHFFFAOYSA-N 0.000 description 1
- PYJUEKVBNIROGK-UHFFFAOYSA-N CC(CN(C)CC1)N1S(C1CC1)(=O)=O Chemical compound CC(CN(C)CC1)N1S(C1CC1)(=O)=O PYJUEKVBNIROGK-UHFFFAOYSA-N 0.000 description 1
- BZTWODHNEMLJEI-UHFFFAOYSA-N CC(CN(CC1)N)N1C(C(C)(C)O)=O Chemical compound CC(CN(CC1)N)N1C(C(C)(C)O)=O BZTWODHNEMLJEI-UHFFFAOYSA-N 0.000 description 1
- GCFFVKUNULPIKW-UHFFFAOYSA-N CC(N)N(CC1)CC(C)N1S(c1ccccc1)(=O)=O Chemical compound CC(N)N(CC1)CC(C)N1S(c1ccccc1)(=O)=O GCFFVKUNULPIKW-UHFFFAOYSA-N 0.000 description 1
- UESXDJWPFOVOSR-UHFFFAOYSA-N CC(N1C(Cc2ccccc2)CN(C)CC1)=O Chemical compound CC(N1C(Cc2ccccc2)CN(C)CC1)=O UESXDJWPFOVOSR-UHFFFAOYSA-N 0.000 description 1
- UZJLYRRDVFWSGA-UHFFFAOYSA-N CC(NCc1ccccc1)=O Chemical compound CC(NCc1ccccc1)=O UZJLYRRDVFWSGA-UHFFFAOYSA-N 0.000 description 1
- OKNYZIGDRLPEEJ-WDEREUQCSA-N CC(N[C@H](C1)[C@@H]1c1ccccc1)=O Chemical compound CC(N[C@H](C1)[C@@H]1c1ccccc1)=O OKNYZIGDRLPEEJ-WDEREUQCSA-N 0.000 description 1
- FZLJNEILFLTBCP-UHFFFAOYSA-N CC1N(Cc2ccccc2)CCN(C)C1 Chemical compound CC1N(Cc2ccccc2)CCN(C)C1 FZLJNEILFLTBCP-UHFFFAOYSA-N 0.000 description 1
- ROBUKNKOVCATJT-UHFFFAOYSA-N CCN1CCN(Cc2c[n](C)nc2)CC1 Chemical compound CCN1CCN(Cc2c[n](C)nc2)CC1 ROBUKNKOVCATJT-UHFFFAOYSA-N 0.000 description 1
- XQLBXAYDYAWRNK-UHFFFAOYSA-N CCS(N1C(C)CN(C)CC1)(=O)=O Chemical compound CCS(N1C(C)CN(C)CC1)(=O)=O XQLBXAYDYAWRNK-UHFFFAOYSA-N 0.000 description 1
- YNQLUTRBYVCPMQ-UHFFFAOYSA-N CCc1ccccc1 Chemical compound CCc1ccccc1 YNQLUTRBYVCPMQ-UHFFFAOYSA-N 0.000 description 1
- COJMYCSMNZBNCW-UHFFFAOYSA-N CN(C1)CC1OCc1ccccc1 Chemical compound CN(C1)CC1OCc1ccccc1 COJMYCSMNZBNCW-UHFFFAOYSA-N 0.000 description 1
- PJGCYUIHITYYHT-UHFFFAOYSA-N CN(CC1)CC(Cc2ccccc2)N1S(C)(=O)=O Chemical compound CN(CC1)CC(Cc2ccccc2)N1S(C)(=O)=O PJGCYUIHITYYHT-UHFFFAOYSA-N 0.000 description 1
- BRIWHPAJCKTPIP-UHFFFAOYSA-N CN(CC1)CC1(Cc1ccccc1)O Chemical compound CN(CC1)CC1(Cc1ccccc1)O BRIWHPAJCKTPIP-UHFFFAOYSA-N 0.000 description 1
- FLVFPAIGVBQGET-UHFFFAOYSA-N CN(CC1)CC1O Chemical compound CN(CC1)CC1O FLVFPAIGVBQGET-UHFFFAOYSA-N 0.000 description 1
- QRYWRVHZEBEZDQ-UHFFFAOYSA-N CN(CC1)CCN1C(c1ccccc1)=O Chemical compound CN(CC1)CCN1C(c1ccccc1)=O QRYWRVHZEBEZDQ-UHFFFAOYSA-N 0.000 description 1
- NCKYKYNYJREWCI-UHFFFAOYSA-N CN(CC1)CCN1S(c1ccccc1)(=O)=O Chemical compound CN(CC1)CCN1S(c1ccccc1)(=O)=O NCKYKYNYJREWCI-UHFFFAOYSA-N 0.000 description 1
- WQDDXVGJRSTLED-UHFFFAOYSA-N CN(CC1)CCN1c1ccccc1 Chemical compound CN(CC1)CCN1c1ccccc1 WQDDXVGJRSTLED-UHFFFAOYSA-N 0.000 description 1
- AWYQDNIZEIQOKM-UHFFFAOYSA-N CN(CCN1Cc2ccccc2)CC1=O Chemical compound CN(CCN1Cc2ccccc2)CC1=O AWYQDNIZEIQOKM-UHFFFAOYSA-N 0.000 description 1
- PZNQMJBVNDWXDY-UHFFFAOYSA-N CN(CCN1c2ccccc2)CC1=O Chemical compound CN(CCN1c2ccccc2)CC1=O PZNQMJBVNDWXDY-UHFFFAOYSA-N 0.000 description 1
- QSDUADMNMGNPLU-UHFFFAOYSA-N CN1CC(CC2)N(Cc3ccccc3)C2C1 Chemical compound CN1CC(CC2)N(Cc3ccccc3)C2C1 QSDUADMNMGNPLU-UHFFFAOYSA-N 0.000 description 1
- NJHPPXZJEYFKMD-UHFFFAOYSA-N CN1CC(Cc2ccccc2)NCC1 Chemical compound CN1CC(Cc2ccccc2)NCC1 NJHPPXZJEYFKMD-UHFFFAOYSA-N 0.000 description 1
- NNYDAONDPGWBRI-UHFFFAOYSA-N CN1CCN(Cc2cc(C#N)ccc2)CC1 Chemical compound CN1CCN(Cc2cc(C#N)ccc2)CC1 NNYDAONDPGWBRI-UHFFFAOYSA-N 0.000 description 1
- UFRQXKOKLIMLBO-UHFFFAOYSA-N CN1CCN(Cc2ccncc2)CC1 Chemical compound CN1CCN(Cc2ccncc2)CC1 UFRQXKOKLIMLBO-UHFFFAOYSA-N 0.000 description 1
- TVKCKGFYMZDMBA-STQMWFEESA-N CN1[C@@H](C2)CN(Cc3ccccc3)[C@@H]2C1 Chemical compound CN1[C@@H](C2)CN(Cc3ccccc3)[C@@H]2C1 TVKCKGFYMZDMBA-STQMWFEESA-N 0.000 description 1
- CQTKDGNXBCFBTR-LBPRGKRZSA-N C[C@@H](c1ccccc1)N1CCN(C)CC1 Chemical compound C[C@@H](c1ccccc1)N1CCN(C)CC1 CQTKDGNXBCFBTR-LBPRGKRZSA-N 0.000 description 1
- CGGBSNOQTQFSIN-UHFFFAOYSA-N C[n]1nc(CN2CCN(C)CC2)cc1 Chemical compound C[n]1nc(CN2CCN(C)CC2)cc1 CGGBSNOQTQFSIN-UHFFFAOYSA-N 0.000 description 1
- VAVNNDTVDOJAFD-UHFFFAOYSA-N Cc1nc(CN2CCN(C)CC2)c[o]1 Chemical compound Cc1nc(CN2CCN(C)CC2)c[o]1 VAVNNDTVDOJAFD-UHFFFAOYSA-N 0.000 description 1
- XBEALJJZQWXEDH-UHFFFAOYSA-N NCCN(CC1C2)C2CN1c1ncccc1 Chemical compound NCCN(CC1C2)C2CN1c1ncccc1 XBEALJJZQWXEDH-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562120732P | 2015-02-25 | 2015-02-25 | |
| US62/120,732 | 2015-02-25 | ||
| PCT/US2016/019328 WO2016138114A1 (en) | 2015-02-25 | 2016-02-24 | Therapeutic pyridazine compounds and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018510851A JP2018510851A (ja) | 2018-04-19 |
| JP2018510851A5 true JP2018510851A5 (enExample) | 2019-03-07 |
| JP6847844B2 JP6847844B2 (ja) | 2021-03-24 |
Family
ID=55456970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017544916A Active JP6847844B2 (ja) | 2015-02-25 | 2016-02-24 | 治療用ピリダジン化合物およびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10308614B2 (enExample) |
| EP (1) | EP3262036B1 (enExample) |
| JP (1) | JP6847844B2 (enExample) |
| CN (1) | CN107531668B (enExample) |
| MA (1) | MA41598A (enExample) |
| WO (1) | WO2016138114A1 (enExample) |
Families Citing this family (57)
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| GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| US20180228907A1 (en) | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| US12282014B2 (en) | 2015-11-19 | 2025-04-22 | Dana-Farber Cancer Institute, Inc. | Methods of identifying compounds that interfere with ERG-driven misguidance of BAF complexes in TMPRSS2-ERG driven prostate cancers |
| CN106674127A (zh) * | 2016-11-18 | 2017-05-17 | 山东友帮生化科技有限公司 | 一种n‑(6‑氯‑3‑哒嗪基)乙酰胺的合成方法 |
| AU2018209164B2 (en) | 2017-01-17 | 2021-11-04 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| MX2019010149A (es) * | 2017-02-28 | 2020-02-05 | Epizyme Inc | Inhibicion del smarca2 para el tratamiento del cancer. |
| WO2019084030A1 (en) | 2017-10-24 | 2019-05-02 | Genentech, Inc. | (4-HYDROXYPYRROLIDIN-2-YL) -HYDROXAMATE COMPOUNDS AND METHODS OF USE |
| WO2019084026A1 (en) | 2017-10-24 | 2019-05-02 | Genentech, Inc. | (4-HYDROXYPYRROLIDIN-2-YL) -HETEROCYCLIC COMPOUNDS AND METHODS OF USE |
| HRP20220991T1 (hr) * | 2017-10-27 | 2022-11-11 | Boehringer Ingelheim International Gmbh | Derivati piridina i njihova terapeutska uporaba kao inhibitora trpc6 |
| EP3746124A4 (en) * | 2018-01-30 | 2021-10-27 | Foghorn Therapeutics Inc. | COMPOUNDS AND THEIR USES |
| WO2019183523A1 (en) | 2018-03-23 | 2019-09-26 | Genentech, Inc. | Hetero-bifunctional degrader compounds and their use as modulators of targeted ubiquination (vhl) |
| AU2019249849C1 (en) * | 2018-04-01 | 2022-09-29 | Arvinas Operations, Inc. | BRM targeting compounds and associated methods of use |
| JP7387630B2 (ja) * | 2018-04-26 | 2023-11-28 | オーリジーン オンコロジー リミテッド | Ｓｍａｒｃａ２／４分解剤としてのピリダジン誘導体 |
| CA3093405C (en) * | 2018-04-30 | 2025-06-17 | Dana Farber Cancer Inst Inc | POLYBROMO-1 SMALL MOLECULE DEGRADING AGENTS (PBRM1) |
| EP3817822A4 (en) | 2018-07-06 | 2022-07-27 | Kymera Therapeutics, Inc. | PROTEIN DEGRADANTS AND USES THEREOF |
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| US11958846B2 (en) | 2018-08-17 | 2024-04-16 | Novartis Ag | Urea compounds and compositions as SMARCA2/BRM ATPase inhibitors |
| US12187719B2 (en) | 2018-10-16 | 2025-01-07 | Boehringer Ingelheim International Gmbh | Proteolysis targeting chimera (PROTACS) as degraders of SMARCA2 and /or SMARCA4 |
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| EP3883580A4 (en) * | 2018-11-21 | 2023-01-04 | Foghorn Therapeutics Inc. | Methods of treating cancers |
| WO2020160180A1 (en) * | 2019-01-29 | 2020-08-06 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| US12384776B2 (en) | 2019-01-29 | 2025-08-12 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| UY38687A (es) * | 2019-05-17 | 2023-05-15 | Novartis Ag | Inhibidores del inflamasoma nlrp3, composiciones, combinaciones de los mismos y métodos para su uso |
| WO2020251969A1 (en) * | 2019-06-10 | 2020-12-17 | Kymera Therapeutics, Inc. | Smarca degraders and uses thereof |
| US20220324880A1 (en) * | 2019-06-10 | 2022-10-13 | Kymara Therapeutics, Inc. | Smarca inhibitors and uses thereof |
| PH12022550578A1 (en) | 2019-09-12 | 2024-02-19 | Aurigene Discovery Tech Ltd | Method for identifying responders to smarca2/4 degraders |
| JP7502425B2 (ja) * | 2019-10-01 | 2024-06-18 | アルヴィナス・オペレーションズ・インコーポレイテッド | Ｂｒｍ標的化化合物および関連使用方法 |
| JP2023511472A (ja) * | 2019-10-29 | 2023-03-20 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | がんの治療のための二官能性化合物 |
| IL294150A (en) | 2019-12-23 | 2022-08-01 | Kymera Therapeutics Inc | Smarca joints and their uses |
| JP7561195B2 (ja) | 2020-01-29 | 2024-10-03 | フォグホーン セラピューティクス インコーポレイテッド | 化合物及びその使用 |
| BR112022019991A2 (pt) * | 2020-04-06 | 2022-11-22 | Foghorn Therapeutics Inc | Compostos, composição farmacêutica compreendendo o mesmo, e usos dos mesmos |
| US12383555B2 (en) | 2020-05-20 | 2025-08-12 | Foghorn Therapeutics Inc. | Methods of treating cancers |
| KR20230037549A (ko) * | 2020-06-09 | 2023-03-16 | 프렐루드 테라퓨틱스, 인코포레이티드 | Brm 표적화 화합물 및 관련 사용 방법 |
| BR112023002089A2 (pt) * | 2020-08-04 | 2023-02-28 | Aurigene Oncology Ltd | Compostos de piridazina 6-substituídos como degradadores de smarca2 e/ou smarca4 |
| EP4196118A1 (en) | 2020-08-13 | 2023-06-21 | Boehringer Ingelheim International GmbH | Treatment of cognitive impairement associated with schizophrenia |
| CA3195702A1 (en) | 2020-10-13 | 2022-04-21 | Boehringer Ingelheim International Gmbh | Process of reworking |
| WO2022109396A1 (en) * | 2020-11-20 | 2022-05-27 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
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| WO2022166890A1 (zh) * | 2021-02-08 | 2022-08-11 | 南京明德新药研发有限公司 | 取代的哒嗪苯酚类衍生物 |
| JP2024516253A (ja) * | 2021-04-30 | 2024-04-12 | オンタリオ・インスティテュート・フォー・キャンサー・リサーチ（オーアイシーアール） | 造血前駆キナーゼ１（ｈｐｋ１）の阻害剤としてのハロ置換アミノアザヘテロアリール化合物 |
| CA3225467A1 (en) | 2021-08-09 | 2023-02-16 | Genentech, Inc. | Phenol derivatives for use in the modulation of brm |
| US20250049929A1 (en) | 2021-09-29 | 2025-02-13 | Boehringer Ingelheim International Gmbh | Novel tetrahydroquinolines and proteolysis targeting chimera (protacs) comprising them as degraders of smarca |
| JP2024541479A (ja) | 2021-11-24 | 2024-11-08 | アルビナス・オペレーションズ・インコーポレイテッド | Ｂｒｍ標的化化合物及び関連使用方法 |
| US20250059198A1 (en) | 2021-11-24 | 2025-02-20 | Arvinas Operations, Inc. | Brm degrading compounds and associated methods of use |
| CN118871440A (zh) * | 2022-02-09 | 2024-10-29 | 奥瑞基尼肿瘤有限公司 | 3-取代的哒嗪化合物作为smarca2和/或smarca4降解剂 |
| CN119654318A (zh) * | 2022-06-16 | 2025-03-18 | 普莱克斯姆公司 | 降解swi/snf相关基质相关肌动蛋白依赖性染色质亚家族a调控剂的化合物和药物组合物 |
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| UA73073C2 (uk) | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| AU7165698A (en) | 1997-05-06 | 1998-11-27 | American Cyanamid Company | Use of quinazoline compounds for the treatment of polycystic kidney disease |
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| ZA986732B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
| TW436485B (en) | 1997-08-01 | 2001-05-28 | American Cyanamid Co | Substituted quinazoline derivatives |
| CN1278176A (zh) | 1997-11-06 | 2000-12-27 | 美国氰胺公司 | 喹唑啉衍生物作为用于治疗结肠息肉的酪氨酸激酶抑制剂的应用 |
| EA003786B1 (ru) | 1998-11-19 | 2003-10-30 | Варнер Ламберт Компани | N-[4-(3-хлор-4-фторфениламино)-7-(3-морфолин-4-илпропокси)хиназолин-6-ил]акриламид - необратимый ингибитор тирозинкиназ |
| AU2004215428B2 (en) * | 2003-02-26 | 2009-08-27 | Sugen LLC | Aminoheteroaryl compounds as protein kinase inhibitors |
| ATE372323T1 (de) | 2004-03-26 | 2007-09-15 | Smithkline Beecham Corp | Als antivirale mittel geeignete 4- carboxypyrazolderivate |
| EP2004625B1 (en) * | 2006-03-22 | 2009-12-30 | Vertex Pharmaceuticals Incorporated | C-met protein kinase inhibitors for the treatment of proliferative disorders |
| JP2013504604A (ja) | 2009-09-18 | 2013-02-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ウイルスポリメラーゼ阻害剤としてのキナゾリノン誘導体 |
| US8916593B2 (en) * | 2010-05-04 | 2014-12-23 | Pfizer Inc. | Alkoxy-substituted 2-aminopyridines as ALK inhibitors |
| US9273029B2 (en) * | 2011-05-23 | 2016-03-01 | Merck Patent Gmbh | Pyridine-and pyrazine derivatives |
-
2016
- 2016-02-23 MA MA041598A patent/MA41598A/fr unknown
- 2016-02-24 JP JP2017544916A patent/JP6847844B2/ja active Active
- 2016-02-24 WO PCT/US2016/019328 patent/WO2016138114A1/en not_active Ceased
- 2016-02-24 EP EP16708332.8A patent/EP3262036B1/en active Active
- 2016-02-24 CN CN201680023840.7A patent/CN107531668B/zh active Active
-
2017
- 2017-08-24 US US15/686,028 patent/US10308614B2/en active Active
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