JP2018510851A5 - - Google Patents
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- JP2018510851A5 JP2018510851A5 JP2017544916A JP2017544916A JP2018510851A5 JP 2018510851 A5 JP2018510851 A5 JP 2018510851A5 JP 2017544916 A JP2017544916 A JP 2017544916A JP 2017544916 A JP2017544916 A JP 2017544916A JP 2018510851 A5 JP2018510851 A5 JP 2018510851A5
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- cancer
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- 0 *c1c(*)nnc(*)c1 Chemical compound *c1c(*)nnc(*)c1 0.000 description 16
- VUKHQPGJNTXTPY-NSCUHMNNSA-N C/C=C/Cc1ccccc1 Chemical compound C/C=C/Cc1ccccc1 VUKHQPGJNTXTPY-NSCUHMNNSA-N 0.000 description 1
- VJNJUWJHKJQYIF-UHFFFAOYSA-N CC(C)(CN(C)CC1)N1C(C)=O Chemical compound CC(C)(CN(C)CC1)N1C(C)=O VJNJUWJHKJQYIF-UHFFFAOYSA-N 0.000 description 1
- MSZXDTUUUMSSQS-UHFFFAOYSA-N CC(C)(CN(C)CC1)N1S(C)(=O)=O Chemical compound CC(C)(CN(C)CC1)N1S(C)(=O)=O MSZXDTUUUMSSQS-UHFFFAOYSA-N 0.000 description 1
- UFUZCUFUKAHDSB-IYBDPMFKSA-N CC(C)N1C[C@H](CN(Cc2ccccc2)C2)[C@H]2C1 Chemical compound CC(C)N1C[C@H](CN(Cc2ccccc2)C2)[C@H]2C1 UFUZCUFUKAHDSB-IYBDPMFKSA-N 0.000 description 1
- YGUJCUMSQULQEU-UHFFFAOYSA-N CC(C)[n]1ncc(CN2CCNCC2)c1 Chemical compound CC(C)[n]1ncc(CN2CCNCC2)c1 YGUJCUMSQULQEU-UHFFFAOYSA-N 0.000 description 1
- HNNHJSSSTNIYHO-UHFFFAOYSA-N CC(CCc1ccccc1)C(N1C(C)CN(C)CC1)=O Chemical compound CC(CCc1ccccc1)C(N1C(C)CN(C)CC1)=O HNNHJSSSTNIYHO-UHFFFAOYSA-N 0.000 description 1
- SNORQMCMXKTQSU-UHFFFAOYSA-N CC(CN(C)CC1)N1C(C1(C)COC1)=O Chemical compound CC(CN(C)CC1)N1C(C1(C)COC1)=O SNORQMCMXKTQSU-UHFFFAOYSA-N 0.000 description 1
- RKMLMSGVPZXOTA-UHFFFAOYSA-N CC(CN(C)CC1)N1C(c1cnccc1)=O Chemical compound CC(CN(C)CC1)N1C(c1cnccc1)=O RKMLMSGVPZXOTA-UHFFFAOYSA-N 0.000 description 1
- PYJUEKVBNIROGK-UHFFFAOYSA-N CC(CN(C)CC1)N1S(C1CC1)(=O)=O Chemical compound CC(CN(C)CC1)N1S(C1CC1)(=O)=O PYJUEKVBNIROGK-UHFFFAOYSA-N 0.000 description 1
- BZTWODHNEMLJEI-UHFFFAOYSA-N CC(CN(CC1)N)N1C(C(C)(C)O)=O Chemical compound CC(CN(CC1)N)N1C(C(C)(C)O)=O BZTWODHNEMLJEI-UHFFFAOYSA-N 0.000 description 1
- GCFFVKUNULPIKW-UHFFFAOYSA-N CC(N)N(CC1)CC(C)N1S(c1ccccc1)(=O)=O Chemical compound CC(N)N(CC1)CC(C)N1S(c1ccccc1)(=O)=O GCFFVKUNULPIKW-UHFFFAOYSA-N 0.000 description 1
- UESXDJWPFOVOSR-UHFFFAOYSA-N CC(N1C(Cc2ccccc2)CN(C)CC1)=O Chemical compound CC(N1C(Cc2ccccc2)CN(C)CC1)=O UESXDJWPFOVOSR-UHFFFAOYSA-N 0.000 description 1
- UZJLYRRDVFWSGA-UHFFFAOYSA-N CC(NCc1ccccc1)=O Chemical compound CC(NCc1ccccc1)=O UZJLYRRDVFWSGA-UHFFFAOYSA-N 0.000 description 1
- OKNYZIGDRLPEEJ-WDEREUQCSA-N CC(N[C@H](C1)[C@@H]1c1ccccc1)=O Chemical compound CC(N[C@H](C1)[C@@H]1c1ccccc1)=O OKNYZIGDRLPEEJ-WDEREUQCSA-N 0.000 description 1
- FZLJNEILFLTBCP-UHFFFAOYSA-N CC1N(Cc2ccccc2)CCN(C)C1 Chemical compound CC1N(Cc2ccccc2)CCN(C)C1 FZLJNEILFLTBCP-UHFFFAOYSA-N 0.000 description 1
- ROBUKNKOVCATJT-UHFFFAOYSA-N CCN1CCN(Cc2c[n](C)nc2)CC1 Chemical compound CCN1CCN(Cc2c[n](C)nc2)CC1 ROBUKNKOVCATJT-UHFFFAOYSA-N 0.000 description 1
- XQLBXAYDYAWRNK-UHFFFAOYSA-N CCS(N1C(C)CN(C)CC1)(=O)=O Chemical compound CCS(N1C(C)CN(C)CC1)(=O)=O XQLBXAYDYAWRNK-UHFFFAOYSA-N 0.000 description 1
- YNQLUTRBYVCPMQ-UHFFFAOYSA-N CCc1ccccc1 Chemical compound CCc1ccccc1 YNQLUTRBYVCPMQ-UHFFFAOYSA-N 0.000 description 1
- COJMYCSMNZBNCW-UHFFFAOYSA-N CN(C1)CC1OCc1ccccc1 Chemical compound CN(C1)CC1OCc1ccccc1 COJMYCSMNZBNCW-UHFFFAOYSA-N 0.000 description 1
- PJGCYUIHITYYHT-UHFFFAOYSA-N CN(CC1)CC(Cc2ccccc2)N1S(C)(=O)=O Chemical compound CN(CC1)CC(Cc2ccccc2)N1S(C)(=O)=O PJGCYUIHITYYHT-UHFFFAOYSA-N 0.000 description 1
- BRIWHPAJCKTPIP-UHFFFAOYSA-N CN(CC1)CC1(Cc1ccccc1)O Chemical compound CN(CC1)CC1(Cc1ccccc1)O BRIWHPAJCKTPIP-UHFFFAOYSA-N 0.000 description 1
- FLVFPAIGVBQGET-UHFFFAOYSA-N CN(CC1)CC1O Chemical compound CN(CC1)CC1O FLVFPAIGVBQGET-UHFFFAOYSA-N 0.000 description 1
- QRYWRVHZEBEZDQ-UHFFFAOYSA-N CN(CC1)CCN1C(c1ccccc1)=O Chemical compound CN(CC1)CCN1C(c1ccccc1)=O QRYWRVHZEBEZDQ-UHFFFAOYSA-N 0.000 description 1
- NCKYKYNYJREWCI-UHFFFAOYSA-N CN(CC1)CCN1S(c1ccccc1)(=O)=O Chemical compound CN(CC1)CCN1S(c1ccccc1)(=O)=O NCKYKYNYJREWCI-UHFFFAOYSA-N 0.000 description 1
- WQDDXVGJRSTLED-UHFFFAOYSA-N CN(CC1)CCN1c1ccccc1 Chemical compound CN(CC1)CCN1c1ccccc1 WQDDXVGJRSTLED-UHFFFAOYSA-N 0.000 description 1
- AWYQDNIZEIQOKM-UHFFFAOYSA-N CN(CCN1Cc2ccccc2)CC1=O Chemical compound CN(CCN1Cc2ccccc2)CC1=O AWYQDNIZEIQOKM-UHFFFAOYSA-N 0.000 description 1
- PZNQMJBVNDWXDY-UHFFFAOYSA-N CN(CCN1c2ccccc2)CC1=O Chemical compound CN(CCN1c2ccccc2)CC1=O PZNQMJBVNDWXDY-UHFFFAOYSA-N 0.000 description 1
- QSDUADMNMGNPLU-UHFFFAOYSA-N CN1CC(CC2)N(Cc3ccccc3)C2C1 Chemical compound CN1CC(CC2)N(Cc3ccccc3)C2C1 QSDUADMNMGNPLU-UHFFFAOYSA-N 0.000 description 1
- NJHPPXZJEYFKMD-UHFFFAOYSA-N CN1CC(Cc2ccccc2)NCC1 Chemical compound CN1CC(Cc2ccccc2)NCC1 NJHPPXZJEYFKMD-UHFFFAOYSA-N 0.000 description 1
- NNYDAONDPGWBRI-UHFFFAOYSA-N CN1CCN(Cc2cc(C#N)ccc2)CC1 Chemical compound CN1CCN(Cc2cc(C#N)ccc2)CC1 NNYDAONDPGWBRI-UHFFFAOYSA-N 0.000 description 1
- UFRQXKOKLIMLBO-UHFFFAOYSA-N CN1CCN(Cc2ccncc2)CC1 Chemical compound CN1CCN(Cc2ccncc2)CC1 UFRQXKOKLIMLBO-UHFFFAOYSA-N 0.000 description 1
- TVKCKGFYMZDMBA-STQMWFEESA-N CN1[C@@H](C2)CN(Cc3ccccc3)[C@@H]2C1 Chemical compound CN1[C@@H](C2)CN(Cc3ccccc3)[C@@H]2C1 TVKCKGFYMZDMBA-STQMWFEESA-N 0.000 description 1
- CQTKDGNXBCFBTR-LBPRGKRZSA-N C[C@@H](c1ccccc1)N1CCN(C)CC1 Chemical compound C[C@@H](c1ccccc1)N1CCN(C)CC1 CQTKDGNXBCFBTR-LBPRGKRZSA-N 0.000 description 1
- CGGBSNOQTQFSIN-UHFFFAOYSA-N C[n]1nc(CN2CCN(C)CC2)cc1 Chemical compound C[n]1nc(CN2CCN(C)CC2)cc1 CGGBSNOQTQFSIN-UHFFFAOYSA-N 0.000 description 1
- VAVNNDTVDOJAFD-UHFFFAOYSA-N Cc1nc(CN2CCN(C)CC2)c[o]1 Chemical compound Cc1nc(CN2CCN(C)CC2)c[o]1 VAVNNDTVDOJAFD-UHFFFAOYSA-N 0.000 description 1
- XBEALJJZQWXEDH-UHFFFAOYSA-N NCCN(CC1C2)C2CN1c1ncccc1 Chemical compound NCCN(CC1C2)C2CN1c1ncccc1 XBEALJJZQWXEDH-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562120732P | 2015-02-25 | 2015-02-25 | |
| US62/120,732 | 2015-02-25 | ||
| PCT/US2016/019328 WO2016138114A1 (en) | 2015-02-25 | 2016-02-24 | Therapeutic pyridazine compounds and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018510851A JP2018510851A (ja) | 2018-04-19 |
| JP2018510851A5 true JP2018510851A5 (enExample) | 2019-03-07 |
| JP6847844B2 JP6847844B2 (ja) | 2021-03-24 |
Family
ID=55456970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017544916A Active JP6847844B2 (ja) | 2015-02-25 | 2016-02-24 | 治療用ピリダジン化合物およびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10308614B2 (enExample) |
| EP (1) | EP3262036B1 (enExample) |
| JP (1) | JP6847844B2 (enExample) |
| CN (1) | CN107531668B (enExample) |
| MA (1) | MA41598A (enExample) |
| WO (1) | WO2016138114A1 (enExample) |
Families Citing this family (66)
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| GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| US20180228907A1 (en) | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| US12282014B2 (en) | 2015-11-19 | 2025-04-22 | Dana-Farber Cancer Institute, Inc. | Methods of identifying compounds that interfere with ERG-driven misguidance of BAF complexes in TMPRSS2-ERG driven prostate cancers |
| CN106674127A (zh) * | 2016-11-18 | 2017-05-17 | 山东友帮生化科技有限公司 | 一种n‑(6‑氯‑3‑哒嗪基)乙酰胺的合成方法 |
| US11040027B2 (en) | 2017-01-17 | 2021-06-22 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| KR20190140438A (ko) * | 2017-02-28 | 2019-12-19 | 에피자임, 인코포레이티드 | 암 치료를 위한 smarca2의 저해 |
| WO2019084030A1 (en) | 2017-10-24 | 2019-05-02 | Genentech, Inc. | (4-HYDROXYPYRROLIDIN-2-YL) -HYDROXAMATE COMPOUNDS AND METHODS OF USE |
| WO2019084026A1 (en) | 2017-10-24 | 2019-05-02 | Genentech, Inc. | (4-HYDROXYPYRROLIDIN-2-YL) -HETEROCYCLIC COMPOUNDS AND METHODS OF USE |
| KR20200125758A (ko) * | 2017-10-27 | 2020-11-04 | 베링거 인겔하임 인터내셔날 게엠베하 | 피리딘 카보닐 유도체 및 trpc6 억제제로서 이의 치료학적 용도 |
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| EP3746124A4 (en) * | 2018-01-30 | 2021-10-27 | Foghorn Therapeutics Inc. | COMPOUNDS AND THEIR USES |
| WO2019183523A1 (en) | 2018-03-23 | 2019-09-26 | Genentech, Inc. | Hetero-bifunctional degrader compounds and their use as modulators of targeted ubiquination (vhl) |
| AU2019249849C1 (en) * | 2018-04-01 | 2022-09-29 | Arvinas Operations, Inc. | BRM targeting compounds and associated methods of use |
| US12539292B2 (en) | 2018-04-01 | 2026-02-03 | Arvinas Operations, Inc. | BRM targeting compounds and associated methods of use |
| SG11202104495YA (en) | 2018-04-26 | 2021-05-28 | Aurigene Discovery Tech Ltd | Pyridazine derivatives as smarca2/4 degraders |
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| US12454520B2 (en) | 2018-07-06 | 2025-10-28 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| AU2019302534B2 (en) * | 2018-07-09 | 2024-10-03 | Lieber Institute, Inc. | Pyridazine compounds for inhibiting NaV1.8 |
| CN112585136B (zh) * | 2018-08-17 | 2024-06-25 | 诺华股份有限公司 | 作为smarca2/brm atp酶抑制剂的脲化合物和组合物 |
| CN112996800B (zh) * | 2018-10-16 | 2024-06-25 | 勃林格殷格翰国际有限公司 | 作为smarca2和/或smarca4的降解剂的新型蛋白水解靶向嵌合体（protac）及其衍生物 |
| US12473334B2 (en) | 2018-10-17 | 2025-11-18 | Dana-Farber Cancer Institute, Inc. | SWI/SNF family chromatin remodeling complexes and uses thereof |
| EP3883580A4 (en) * | 2018-11-21 | 2023-01-04 | Foghorn Therapeutics Inc. | Methods of treating cancers |
| US12384776B2 (en) | 2019-01-29 | 2025-08-12 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| AU2020214308A1 (en) * | 2019-01-29 | 2021-08-12 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| US12509453B2 (en) | 2019-01-29 | 2025-12-30 | Foghorn Therapeutics Inc. | BRM/BRG1 inhibitors and uses thereof |
| AR119731A1 (es) | 2019-05-17 | 2022-01-05 | Novartis Ag | Inhibidores del inflamasoma nlrp3 |
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| US20230087825A1 (en) * | 2019-06-10 | 2023-03-23 | Kymera Therapeutics, Inc. | Smarca degraders and uses thereof |
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| US12624044B2 (en) | 2019-06-10 | 2026-05-12 | Kymera Therapeutics, Inc. | SMARCA degraders and uses thereof |
| CA3150354A1 (en) | 2019-09-12 | 2021-03-18 | Muralidhara Ramachandra | METHOD FOR IDENTIFYING RESPONDERS TO SMARCA2/4 DEGRADATION AGENTS |
| JP7502425B2 (ja) * | 2019-10-01 | 2024-06-18 | アルヴィナス・オペレーションズ・インコーポレイテッド | Ｂｒｍ標的化化合物および関連使用方法 |
| CN114728936A (zh) * | 2019-10-29 | 2022-07-08 | 豪夫迈·罗氏有限公司 | 用于治疗癌症的双功能化合物 |
| US11679109B2 (en) | 2019-12-23 | 2023-06-20 | Kymera Therapeutics, Inc. | SMARCA degraders and uses thereof |
| WO2021133917A1 (en) | 2019-12-23 | 2021-07-01 | Kymera Therapeutics, Inc. | Smarca inhibitors and uses thereof |
| WO2021155262A1 (en) | 2020-01-29 | 2021-08-05 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| WO2021155264A1 (en) | 2020-01-29 | 2021-08-05 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| JP7508578B2 (ja) * | 2020-04-06 | 2024-07-01 | フォグホーン セラピューティクス インコーポレイテッド | 化合物及びその使用 |
| US12383555B2 (en) | 2020-05-20 | 2025-08-12 | Foghorn Therapeutics Inc. | Methods of treating cancers |
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| MX2023001445A (es) * | 2020-08-04 | 2023-05-08 | Aurigene Oncology Ltd | Compuestos de piridazina 6-sustituidos como degradadores de smarca2 y/o smarca4. |
| CA3188340A1 (en) | 2020-08-13 | 2022-02-17 | Boehringer Ingelheim International Gmbh | Treatment of cognitive impairement associated with schizophrenia |
| KR20230088761A (ko) | 2020-10-13 | 2023-06-20 | 베링거 인겔하임 인터내셔날 게엠베하 | 재가공하는 방법 |
| US12552775B2 (en) * | 2020-11-20 | 2026-02-17 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| US12606568B2 (en) | 2020-12-09 | 2026-04-21 | Kymera Therapeutics, Inc. | SMARCA degraders and uses thereof |
| EP4289823A4 (en) * | 2021-02-08 | 2025-02-26 | Medshine Discovery Inc. | SUBSTITUTED PYRIDAZINE PHENOL DERIVATIVES |
| US12606553B2 (en) | 2021-03-09 | 2026-04-21 | Foghorn Therapeutics Inc. | Crystalline forms, compositions containing same, and methods of their use |
| CN117597336A (zh) * | 2021-04-30 | 2024-02-23 | 安大略省癌症研究所(Oicr) | 作为造血祖细胞激酶1(hpk1)抑制剂的卤素取代的氨基氮杂-杂芳基化合物 |
| JP2024533990A (ja) * | 2021-08-09 | 2024-09-18 | ジェネンテック， インコーポレイテッド | Ｂｒｍの調節に使用するためのフェノール誘導体 |
| WO2023052363A1 (en) | 2021-09-29 | 2023-04-06 | Boehringer Ingelheim International Gmbh | Novel tetrahydroquinolines and proteolysis targeting chimera (protacs) comprising them as degraders of smarca |
| JP2024541479A (ja) | 2021-11-24 | 2024-11-08 | アルビナス・オペレーションズ・インコーポレイテッド | Ｂｒｍ標的化化合物及び関連使用方法 |
| CN118679160A (zh) | 2021-11-24 | 2024-09-20 | 阿维纳斯运营公司 | Brm靶向化合物和相关的使用方法 |
| JP2025506452A (ja) * | 2022-02-09 | 2025-03-11 | オーリジーン オンコロジー リミテッド | Ｓｍａｒｃａ２及び／又はｓｍａｒｃａ４分解剤としての３－置換ピリダジン化合物 |
| JP2025525340A (ja) * | 2022-06-16 | 2025-08-05 | プレキシウム インコーポレイテッド | Ｓｗｉ／ｓｎｆ－ｒｅｌａｔｅｄ ｍａｔｒｉｘ－ａｓｓｏｃｉａｔｅｄ ａｃｔｉｎ－ｄｅｐｅｎｄｅｎｔ ｒｅｇｕｌａｔｏｒ ｏｆ ｃｈｒｏｍａｔｉｎ ｓｕｂｆａｍｉｌｙ ａを分解する化合物および医薬組成物 |
| CN119384414A (zh) * | 2022-06-30 | 2025-01-28 | 甘李药业股份有限公司 | 一种用作smarca2/4抑制剂的化合物及其应用 |
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| CN120752233A (zh) * | 2023-02-28 | 2025-10-03 | 上海海雁医药科技有限公司 | 取代的三环衍生物及其药物组合物和用途 |
| EP4695250A1 (en) | 2023-04-12 | 2026-02-18 | Aurigene Oncology Limited | Tetracyclic compounds as smarca2 and/or smarca4 degraders |
| PE20260307A1 (es) * | 2023-06-14 | 2026-02-11 | Astrazeneca Ab | Degradadores de smarca2 y usos de estos |
| EP4727543A2 (en) * | 2023-06-16 | 2026-04-22 | Plexium, Inc. | Compounds and pharmaceutical compositions that degrade swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily a |
| CN121620368A (zh) * | 2023-06-16 | 2026-03-06 | 普莱克斯姆公司 | 降解swi/snf相关基质相关联肌动蛋白依赖性染色质调控因子a亚家族的化合物和药物组合物 |
| CN122161593A (zh) * | 2023-09-07 | 2026-06-05 | 利普弗罗格生物公司 | 用于治疗癌症的bet抑制剂 |
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| WO2025196686A1 (en) | 2024-03-20 | 2025-09-25 | Aurigene Oncology Limited | Fused bicyclic compounds as smarca2 and/or smarca4 degraders |
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| JP2013504604A (ja) | 2009-09-18 | 2013-02-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ウイルスポリメラーゼ阻害剤としてのキナゾリノン誘導体 |
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-
2016
- 2016-02-23 MA MA041598A patent/MA41598A/fr unknown
- 2016-02-24 WO PCT/US2016/019328 patent/WO2016138114A1/en not_active Ceased
- 2016-02-24 JP JP2017544916A patent/JP6847844B2/ja active Active
- 2016-02-24 CN CN201680023840.7A patent/CN107531668B/zh active Active
- 2016-02-24 EP EP16708332.8A patent/EP3262036B1/en active Active
-
2017
- 2017-08-24 US US15/686,028 patent/US10308614B2/en active Active
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