CN109476663B - 用于治疗癌症的吡唑并吡啶衍生物 - Google Patents

用于治疗癌症的吡唑并吡啶衍生物 Download PDF

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Publication number
CN109476663B
CN109476663B CN201780045658.6A CN201780045658A CN109476663B CN 109476663 B CN109476663 B CN 109476663B CN 201780045658 A CN201780045658 A CN 201780045658A CN 109476663 B CN109476663 B CN 109476663B
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compound
cancer
inhibitors
carcinoma
mixture
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CN109476663A (zh
Inventor
P·西尔
S·布朗纳
F·A·罗梅罗
S·马格努森
V·H-W·徐
J·M·默里
J·瓦伊
K·W·赖
F·王
K·X·陈
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Genentech Inc
Constellation Pharmaceuticals Inc
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Genentech Inc
Constellation Pharmaceuticals Inc
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
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CN201780045658.6A 2016-05-24 2017-05-24 用于治疗癌症的吡唑并吡啶衍生物 Expired - Fee Related CN109476663B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2016083118 2016-05-24
CNPCT/CN2016/083118 2016-05-24
PCT/US2017/034326 WO2017205538A1 (en) 2016-05-24 2017-05-24 Pyrazolopyridine derivatives for the treatment of cancer

Publications (2)

Publication Number Publication Date
CN109476663A CN109476663A (zh) 2019-03-15
CN109476663B true CN109476663B (zh) 2021-11-09

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US (2) US11247989B2 (enExample)
EP (1) EP3464286B1 (enExample)
JP (1) JP7014736B2 (enExample)
CN (1) CN109476663B (enExample)
MA (1) MA45146A (enExample)
WO (1) WO2017205538A1 (enExample)

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WO2019195846A1 (en) 2018-04-06 2019-10-10 Board Of Regents, The University Of Texas System Imidazopiperazinone inhibitors of transcription activating proteins
CN110878042B (zh) * 2018-09-05 2021-06-01 新发药业有限公司 一种n-取代基哌啶-3-酮的制备方法
CN111320621B (zh) * 2018-12-14 2022-10-04 中国科学院广州生物医药与健康研究院 一种吲嗪类化合物及其制备方法和应用
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JP7636646B2 (ja) * 2019-04-09 2025-02-27 オプナ バイオ ソシエテ アノニム Ｅｐ３００またはｃｂｐの調節のための縮合アジンおよびその適応
WO2021020363A1 (ja) 2019-07-29 2021-02-04 武田薬品工業株式会社 複素環化合物
TW202120095A (zh) * 2019-08-05 2021-06-01 美商美國禮來大藥廠 7,8-二氫-4H-吡唑并[4,3-c]氮呯-6-酮化合物
JP7684316B2 (ja) * 2020-01-27 2025-05-27 ブリストル－マイヤーズ スクイブ カンパニー トール様受容体７（ＴＬＲ７）アゴニストとしての１Ｈ－ピラゾロ［４，３－ｄ］ピリミジン化合物
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CN112079826B (zh) * 2020-09-17 2022-07-29 广州中医药大学(广州中医药研究院) 一类甾体合成酶抑制剂及其治疗应用
JP7777131B2 (ja) 2020-10-02 2025-11-27 ボード オブ レジェンツ，ザ ユニバーシティ オブ テキサス システム 転写活性化タンパク質のイミダゾピペラジン阻害剤
KR20230080441A (ko) 2020-10-02 2023-06-07 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 전사 활성화 단백질의 이미다조피페라진 억제제
US20230399303A1 (en) * 2020-10-26 2023-12-14 Yale University Macrophage Migration Inhibitory Factor Inhibitors, and Methods of Making and Using Same
US11919908B2 (en) 2020-12-21 2024-03-05 Incyte Corporation Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors
US20240122941A1 (en) * 2020-12-25 2024-04-18 National Cancer Center Therapy based on synthetic lethality in swi/snf complex-dysfunction cancer
CA3211748A1 (en) 2021-02-25 2022-09-01 Incyte Corporation Spirocyclic lactams as jak2 v617f inhibitors
SMT202500447T1 (it) 2021-11-02 2026-01-12 Flare Therapeutics Inc Agonisti inversi di pparg e loro usi
KR20240117556A (ko) 2021-11-12 2024-08-01 인실리코 메디신 아이피 리미티드 유비퀴틴 특이적 프로테아제 1(usp1)의 소분자 억제제 및 이의 용도
IL315647A (en) 2022-03-17 2024-11-01 Incyte Corp Tricyclic urea compounds as Jak2 and 617f inhibitors
WO2024019698A1 (en) 2022-07-18 2024-01-25 Jsr Corporation Photocatalytic synthesis of alpha, beta unsaturated carbonyl compounds and their intermediates
CN117843618A (zh) * 2022-08-29 2024-04-09 北京沐华生物科技有限责任公司 一种ep300/cbp调节剂及其制备方法和用途
CN115710249B (zh) * 2022-11-14 2024-11-19 广东工业大学 一种多取代异喹啉和1,6-萘啶化合物的制备方法及光电材料常见分子骨架
CN122535608A (zh) 2024-01-17 2026-08-07 株式会社Lg化学 用作cbp/p300抑制剂的新型化合物以及包含其作为活性成分的用于预防或治疗癌症、炎性障碍或自身免疫性疾病的药物组合物
KR20250113346A (ko) 2024-01-17 2025-07-25 주식회사 엘지화학 CBP/p300 저해제로 사용되는 신규 화합물, 및 이를 유효성분으로 포함하는 암, 염증성 장애 또는 자가면역 질환의 예방 또는 치료용 약학 조성물
TW202542135A (zh) 2024-01-17 2025-11-01 南韓商Ｌｇ化學股份有限公司 作為ＣＢＰ／ｐ３００抑制劑之新穎化合物和含有彼作為活性成分以預防或治療癌症、發炎病症或自體免疫疾病之醫藥組成物
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