BR9814116A - Uso de derivados de quinazolina como inibidores de cinase de tirosina para tratamento de pólipo colÈnico - Google Patents

Uso de derivados de quinazolina como inibidores de cinase de tirosina para tratamento de pólipo colÈnico

Info

Publication number
BR9814116A
BR9814116A BR9814116-3A BR9814116A BR9814116A BR 9814116 A BR9814116 A BR 9814116A BR 9814116 A BR9814116 A BR 9814116A BR 9814116 A BR9814116 A BR 9814116A
Authority
BR
Brazil
Prior art keywords
treatment
tyrosine kinase
kinase inhibitors
alkyl
quinazoline derivatives
Prior art date
Application number
BR9814116-3A
Other languages
English (en)
Inventor
Philip Frost
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of BR9814116A publication Critical patent/BR9814116A/pt

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Patente de Invenção: <B>"USO DE DERIVADOS DE QUINAZOLINA COMO INIBIDORES DE CINASE DE TIROSINA PARA TRATAMENTO DE PóLIPO COLÈNICO"<D>. Esta invenção provê um método para tratamento e inibição de pólipos colónicos em um mamífero com necessidade dele que compreende a administração ao dito mamífero de um composto tendo a fórmula (I), onde X é fenila que é opcionalmente substituída; R e R~ 1~ são cada um independentemente hidrogênio, halogêneo, alquila, alcóxi, hidróxi ou trifluormetila; R~ 2~ é hidrogênio, alquila, alcóxi, hidróxi ou trifluormetila; Y é um radical selecionado do grupo consistindo nas fórmulas (II), (III), (IV), (V), (VI), (VII) e (VIII). R~ 3~ é independentemente hidrogênio, alquila, carbóxi, carboalcóxi, fenila ou carboalquila; n=2-4; ou um seu sal farmaceuticamente aceitável, com a condição que cada R~ 3~ de Y possa ser igual ou diferente.
BR9814116-3A 1997-11-06 1998-11-04 Uso de derivados de quinazolina como inibidores de cinase de tirosina para tratamento de pólipo colÈnico BR9814116A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96508497A 1997-11-06 1997-11-06
PCT/US1998/023549 WO1999024037A1 (en) 1997-11-06 1998-11-04 Use of quinazoline derivatives as tyrosine kinase inhibitors for treating colonic polyps

Publications (1)

Publication Number Publication Date
BR9814116A true BR9814116A (pt) 2000-10-03

Family

ID=25509419

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9814116-3A BR9814116A (pt) 1997-11-06 1998-11-04 Uso de derivados de quinazolina como inibidores de cinase de tirosina para tratamento de pólipo colÈnico

Country Status (15)

Country Link
EP (1) EP1039910A1 (pt)
JP (1) JP2001522802A (pt)
KR (1) KR20010031813A (pt)
CN (1) CN1278176A (pt)
AR (1) AR016415A1 (pt)
AU (1) AU1308799A (pt)
BR (1) BR9814116A (pt)
CA (1) CA2306155A1 (pt)
HU (1) HUP0004286A3 (pt)
IL (1) IL135622A0 (pt)
NO (1) NO20002166L (pt)
NZ (1) NZ503991A (pt)
PL (1) PL340800A1 (pt)
WO (1) WO1999024037A1 (pt)
ZA (1) ZA9810134B (pt)

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