CA2827673C - Mtor/jak inhibitor combination therapy - Google Patents
Mtor/jak inhibitor combination therapy Download PDFInfo
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- CA2827673C CA2827673C CA2827673A CA2827673A CA2827673C CA 2827673 C CA2827673 C CA 2827673C CA 2827673 A CA2827673 A CA 2827673A CA 2827673 A CA2827673 A CA 2827673A CA 2827673 C CA2827673 C CA 2827673C
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- mtor inhibitor
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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Landscapes
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| US61/444,581 | 2011-02-18 | ||
| US201161503785P | 2011-07-01 | 2011-07-01 | |
| US201161503789P | 2011-07-01 | 2011-07-01 | |
| US61/503,789 | 2011-07-01 | ||
| US61/503,785 | 2011-07-01 | ||
| PCT/US2012/025581 WO2012112847A1 (en) | 2011-02-18 | 2012-02-17 | mTOR/JAK INHIBITOR COMBINATION THERAPY |
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| CA2827673A1 CA2827673A1 (en) | 2012-08-23 |
| CA2827673C true CA2827673C (en) | 2020-10-27 |
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| SI1966202T1 (sl) | 2005-12-13 | 2012-01-31 | Incyte Corp | S heteroarilom substituirani pirolo (2,3-b)piridini in pirolo (2,3-b)pirimidini kot zaviralci janus kinaze |
| CL2008001709A1 (es) | 2007-06-13 | 2008-11-03 | Incyte Corp | Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras. |
| EP2173752B2 (en) | 2007-06-13 | 2022-07-13 | Incyte Holdings Corporation | Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
| JOP20190230A1 (ar) | 2009-01-15 | 2017-06-16 | Incyte Corp | طرق لاصلاح مثبطات انزيم jak و المركبات الوسيطة المتعلقة به |
| CN106967070A (zh) | 2009-05-22 | 2017-07-21 | 因塞特控股公司 | 作为jak抑制剂的化合物 |
| CA2762174C (en) | 2009-05-22 | 2018-02-20 | Incyte Corporation | N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
| AR078012A1 (es) | 2009-09-01 | 2011-10-05 | Incyte Corp | Derivados heterociclicos de las pirazol-4-il- pirrolo (2,3-d) pirimidinas como inhibidores de la quinasa janus |
| EP3715347B1 (en) | 2010-03-10 | 2021-12-22 | Incyte Holdings Corporation | Piperidin-4-yl azetidine derivatives as jak1 inhibitors |
| NZ603686A (en) | 2010-05-21 | 2014-11-28 | Incyte Corp | Topical formulation for a jak inhibitor |
| JP5917544B2 (ja) | 2010-11-19 | 2016-05-18 | インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ | Ｊａｋ阻害剤としての複素環置換ピロロピリジンおよびピロロピリミジン |
| PE20140146A1 (es) | 2010-11-19 | 2014-02-06 | Incyte Corp | Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jak |
| JP5936628B2 (ja) | 2011-02-18 | 2016-06-22 | ノバルティス・ファルマ・アクチェンゲゼルシャフトＮｏｖａｒｔｉｓ Ｐｈａｒｍａ ＡＧ | ｍＴＯＲ／ＪＡＫ阻害剤併用療法 |
| US20140113919A1 (en) * | 2011-06-14 | 2014-04-24 | Novartis Ag | Combination of panobinostat and ruxolitinib in the treatment of cancer such as a myeloproliferative neoplasm |
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| JP5858434B2 (ja) | 2010-02-18 | 2016-02-10 | インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ | Ｊａｎｕｓキナーゼ阻害薬としてのシクロブタンおよびメチルシクロブタン誘導体 |
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| JP5917544B2 (ja) | 2010-11-19 | 2016-05-18 | インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ | Ｊａｋ阻害剤としての複素環置換ピロロピリジンおよびピロロピリミジン |
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| JP5936628B2 (ja) | 2011-02-18 | 2016-06-22 | ノバルティス・ファルマ・アクチェンゲゼルシャフトＮｏｖａｒｔｉｓ Ｐｈａｒｍａ ＡＧ | ｍＴＯＲ／ＪＡＫ阻害剤併用療法 |
| TWI577676B (zh) | 2011-06-20 | 2017-04-11 | 英塞特控股公司 | 作為ｊａｋ抑制劑之吖丁啶基苯基、吡啶基或吡基羧醯胺衍生物 |
| EP2741747A1 (en) | 2011-08-10 | 2014-06-18 | Novartis Pharma AG | JAK P13K/mTOR COMBINATION THERAPY |
| TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物 |
| UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
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2012
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- 2012-02-17 WO PCT/US2012/025581 patent/WO2012112847A1/en not_active Ceased
- 2012-02-17 KR KR1020137024424A patent/KR102024948B1/ko active Active
- 2012-02-17 ES ES12705608.3T patent/ES2547916T3/es active Active
- 2012-02-17 MX MX2013009351A patent/MX357939B/es active IP Right Grant
- 2012-02-17 AU AU2012219395A patent/AU2012219395B2/en active Active
- 2012-02-17 US US13/399,274 patent/US9993480B2/en active Active
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- 2012-02-17 CN CN201280009417.3A patent/CN103732226B/zh active Active
- 2012-02-17 PL PL12705608T patent/PL2675451T3/pl unknown
- 2012-02-17 EA EA201391208A patent/EA026317B1/ru unknown
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Also Published As
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| US20120214825A1 (en) | 2012-08-23 |
| PL2675451T3 (pl) | 2016-05-31 |
| EP2675451B9 (en) | 2017-07-26 |
| EP2675451B1 (en) | 2015-06-24 |
| KR102024948B1 (ko) | 2019-11-04 |
| JP5936628B2 (ja) | 2016-06-22 |
| AU2012219395B2 (en) | 2017-05-25 |
| BR112013020798A2 (pt) | 2016-10-04 |
| ES2547916T3 (es) | 2015-10-09 |
| EA026317B1 (ru) | 2017-03-31 |
| KR20140082591A (ko) | 2014-07-02 |
| BR112013020798B1 (pt) | 2022-03-15 |
| EP2675451A1 (en) | 2013-12-25 |
| PT2675451E (pt) | 2015-10-16 |
| WO2012112847A1 (en) | 2012-08-23 |
| MX357939B (es) | 2018-07-31 |
| EA201391208A1 (ru) | 2013-12-30 |
| MX2013009351A (es) | 2014-01-08 |
| JP2014505735A (ja) | 2014-03-06 |
| CN103732226B (zh) | 2016-01-06 |
| AU2012219395A1 (en) | 2013-08-29 |
| US9993480B2 (en) | 2018-06-12 |
| CA2827673A1 (en) | 2012-08-23 |
| CN103732226A (zh) | 2014-04-16 |
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