AU2012219395B2 - mTOR/JAK inhibitor combination therapy - Google Patents

mTOR/JAK inhibitor combination therapy Download PDF

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Publication number
AU2012219395B2
AU2012219395B2 AU2012219395A AU2012219395A AU2012219395B2 AU 2012219395 B2 AU2012219395 B2 AU 2012219395B2 AU 2012219395 A AU2012219395 A AU 2012219395A AU 2012219395 A AU2012219395 A AU 2012219395A AU 2012219395 B2 AU2012219395 B2 AU 2012219395B2
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AU
Australia
Prior art keywords
compound
formula
mtor inhibitor
mtor
pharmaceutically acceptable
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Active
Application number
AU2012219395A
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English (en)
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AU2012219395A1 (en
Inventor
Costanza BOGANI
Paola Guglielmelli
Alessandro M. Vannucchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Pharma AG
Incyte Corp
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Novartis Pharma AG
Incyte Corp
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Application filed by Novartis Pharma AG, Incyte Corp filed Critical Novartis Pharma AG
Publication of AU2012219395A1 publication Critical patent/AU2012219395A1/en
Application granted granted Critical
Publication of AU2012219395B2 publication Critical patent/AU2012219395B2/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2012219395A 2011-02-18 2012-02-17 mTOR/JAK inhibitor combination therapy Active AU2012219395B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161444581P 2011-02-18 2011-02-18
US61/444,581 2011-02-18
US201161503789P 2011-07-01 2011-07-01
US201161503785P 2011-07-01 2011-07-01
US61/503,789 2011-07-01
US61/503,785 2011-07-01
PCT/US2012/025581 WO2012112847A1 (en) 2011-02-18 2012-02-17 mTOR/JAK INHIBITOR COMBINATION THERAPY

Publications (2)

Publication Number Publication Date
AU2012219395A1 AU2012219395A1 (en) 2013-08-29
AU2012219395B2 true AU2012219395B2 (en) 2017-05-25

Family

ID=45755586

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012219395A Active AU2012219395B2 (en) 2011-02-18 2012-02-17 mTOR/JAK inhibitor combination therapy

Country Status (14)

Country Link
US (1) US9993480B2 (enExample)
EP (1) EP2675451B9 (enExample)
JP (1) JP5936628B2 (enExample)
KR (1) KR102024948B1 (enExample)
CN (1) CN103732226B (enExample)
AU (1) AU2012219395B2 (enExample)
BR (1) BR112013020798B1 (enExample)
CA (1) CA2827673C (enExample)
EA (1) EA026317B1 (enExample)
ES (1) ES2547916T3 (enExample)
MX (1) MX357939B (enExample)
PL (1) PL2675451T3 (enExample)
PT (1) PT2675451E (enExample)
WO (1) WO2012112847A1 (enExample)

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