JP7493939B2 - 関節リウマチの治療用組成物および治療方法 - Google Patents
関節リウマチの治療用組成物および治療方法 Download PDFInfo
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- JP7493939B2 JP7493939B2 JP2019563766A JP2019563766A JP7493939B2 JP 7493939 B2 JP7493939 B2 JP 7493939B2 JP 2019563766 A JP2019563766 A JP 2019563766A JP 2019563766 A JP2019563766 A JP 2019563766A JP 7493939 B2 JP7493939 B2 JP 7493939B2
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Description
本開示は、一部は、STAT5活性が関節リウマチ、ループスおよび多発性硬化症を含む自己免疫疾患に関係しているという新規な驚くべき発見に基づいている。
表3.4つの予防群の群間差の一対比較分析。
Claims (6)
- ヒト対象における関節リウマチの治療または予防のための組成物であって、治療有効量の化合物を含み、ここで前記化合物がピモジド、ピモジドの薬学的に許容される塩及びピモジドの溶媒和物から選択されるものであり、ここで前記化合物が、1日あたり約0.1 mg/kg体重~約5 mg/kg体重の量で前記対象に投与される、組成物。
- 前記化合物がピモジドである、請求項1に記載の組成物。
- ピモジドが1日あたり約1mg/kg体重~約5 mg/kg体重の量で前記対象に投与される、請求項2に記載の組成物。
- 前記化合物がピモジドの薬学的に許容される塩である、請求項1に記載の組成物。
- 前記化合物がピモジドの溶媒和物である、請求項1に記載の組成物。
- 前記対象が抗TNF非応答者である、請求項1に記載の組成物。
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PCT/US2018/031217 WO2018213027A1 (en) | 2017-05-16 | 2018-05-04 | Compositions and methods for treating rheumatoid arthritis |
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US20220202801A1 (en) * | 2019-04-26 | 2022-06-30 | Generos Biopharma Ltd. | Use of compound in preparation of drug for treating atherosclerosis |
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WO2016048247A1 (en) | 2014-09-26 | 2016-03-31 | National University Of Singapore | Methods and compositions for modulating th-gm cell function |
Non-Patent Citations (2)
Title |
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Miklossy, G. et al.,Therapeutic modulators of STAT signalling for human diseases,Nature Reviews. Drug Discovery,2013年,Vol.12, No.8,p.611-629,doi:10.1038/nrd4088 |
宮野 良子 ほか,多発性硬化症に伴う疼痛に対するpimozideの臨床効果,神経治療学,1992年,第9巻, 第1号,p.85-90 |
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EP3628006A1 (en) | 2020-04-01 |
CA3063100A1 (en) | 2018-11-22 |
CN111032041A (zh) | 2020-04-17 |
JP2020520374A (ja) | 2020-07-09 |
AU2018270772A1 (en) | 2019-12-19 |
KR20200007876A (ko) | 2020-01-22 |
TW201900215A (zh) | 2019-01-01 |
KR102707515B1 (ko) | 2024-09-19 |
WO2018213027A1 (en) | 2018-11-22 |
US20200306235A1 (en) | 2020-10-01 |
US11612595B2 (en) | 2023-03-28 |
EP3628006A4 (en) | 2021-07-21 |
AU2018270772B2 (en) | 2024-06-06 |
US20230364072A1 (en) | 2023-11-16 |
CN117085015A (zh) | 2023-11-21 |
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