JP2013532959A5 - - Google Patents
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- JP2013532959A5 JP2013532959A5 JP2013510339A JP2013510339A JP2013532959A5 JP 2013532959 A5 JP2013532959 A5 JP 2013532959A5 JP 2013510339 A JP2013510339 A JP 2013510339A JP 2013510339 A JP2013510339 A JP 2013510339A JP 2013532959 A5 JP2013532959 A5 JP 2013532959A5
- Authority
- JP
- Japan
- Prior art keywords
- binding protein
- seq
- amino acid
- acid sequence
- polypeptide chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920001184 polypeptide Polymers 0.000 claims 36
- 102000004196 processed proteins & peptides Human genes 0.000 claims 36
- 108090000765 processed proteins & peptides Proteins 0.000 claims 36
- 108091008324 binding proteins Proteins 0.000 claims 35
- 102000023732 binding proteins Human genes 0.000 claims 35
- 125000003275 alpha amino acid group Chemical group 0.000 claims 30
- 239000003814 drug Substances 0.000 claims 14
- 239000003795 chemical substances by application Substances 0.000 claims 13
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 229940124597 therapeutic agent Drugs 0.000 claims 8
- 108090000695 Cytokines Proteins 0.000 claims 6
- 102000004127 Cytokines Human genes 0.000 claims 6
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 6
- 229940121369 angiogenesis inhibitor Drugs 0.000 claims 6
- -1 antibiotic Substances 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 6
- 229940127089 cytotoxic agent Drugs 0.000 claims 5
- 239000002254 cytotoxic agent Substances 0.000 claims 5
- 231100000599 cytotoxic agent Toxicity 0.000 claims 5
- 101001002634 Homo sapiens Interleukin-1 alpha Proteins 0.000 claims 4
- 101001033249 Homo sapiens Interleukin-1 beta Proteins 0.000 claims 4
- 229940100198 alkylating agent Drugs 0.000 claims 4
- 239000002168 alkylating agent Substances 0.000 claims 4
- 239000005557 antagonist Substances 0.000 claims 4
- 229940045799 anthracyclines and related substance Drugs 0.000 claims 4
- 230000000340 anti-metabolite Effects 0.000 claims 4
- 229940100197 antimetabolite Drugs 0.000 claims 4
- 239000002256 antimetabolite Substances 0.000 claims 4
- 230000001640 apoptogenic effect Effects 0.000 claims 4
- 239000002872 contrast media Substances 0.000 claims 4
- 239000003102 growth factor Substances 0.000 claims 4
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 4
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 4
- 239000003053 toxin Substances 0.000 claims 4
- 231100000765 toxin Toxicity 0.000 claims 4
- 108700012359 toxins Proteins 0.000 claims 4
- VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 claims 3
- 229940121849 Mitotic inhibitor Drugs 0.000 claims 3
- 230000003115 biocidal effect Effects 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 claims 2
- 229930182837 (R)-adrenaline Natural products 0.000 claims 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 2
- 108010036949 Cyclosporine Proteins 0.000 claims 2
- 102000003951 Erythropoietin Human genes 0.000 claims 2
- 108090000394 Erythropoietin Proteins 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 2
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 2
- 239000003263 anabolic agent Substances 0.000 claims 2
- 229940070021 anabolic steroids Drugs 0.000 claims 2
- 230000003444 anaesthetic effect Effects 0.000 claims 2
- 230000000202 analgesic effect Effects 0.000 claims 2
- 230000003092 anti-cytokine Effects 0.000 claims 2
- 230000002682 anti-psoriatic effect Effects 0.000 claims 2
- 229940124350 antibacterial drug Drugs 0.000 claims 2
- 239000000935 antidepressant agent Substances 0.000 claims 2
- 229940005513 antidepressants Drugs 0.000 claims 2
- 239000000164 antipsychotic agent Substances 0.000 claims 2
- 229940005529 antipsychotics Drugs 0.000 claims 2
- 239000003435 antirheumatic agent Substances 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 229940125388 beta agonist Drugs 0.000 claims 2
- 229960001265 ciclosporin Drugs 0.000 claims 2
- 239000003246 corticosteroid Substances 0.000 claims 2
- 229960001334 corticosteroids Drugs 0.000 claims 2
- 230000000139 costimulatory effect Effects 0.000 claims 2
- 229930182912 cyclosporin Natural products 0.000 claims 2
- 229960005139 epinephrine Drugs 0.000 claims 2
- 229940105423 erythropoietin Drugs 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 239000000122 growth hormone Substances 0.000 claims 2
- 239000005556 hormone Substances 0.000 claims 2
- 229940088597 hormone Drugs 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 238000002649 immunization Methods 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 229940072221 immunoglobulins Drugs 0.000 claims 2
- 229960003444 immunosuppressant agent Drugs 0.000 claims 2
- 239000003018 immunosuppressive agent Substances 0.000 claims 2
- 229940043355 kinase inhibitor Drugs 0.000 claims 2
- 239000003589 local anesthetic agent Substances 0.000 claims 2
- 229960000485 methotrexate Drugs 0.000 claims 2
- 239000003158 myorelaxant agent Substances 0.000 claims 2
- 230000003533 narcotic effect Effects 0.000 claims 2
- 239000000842 neuromuscular blocking agent Substances 0.000 claims 2
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims 2
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 2
- 239000012217 radiopharmaceutical Substances 0.000 claims 2
- 229940121896 radiopharmaceutical Drugs 0.000 claims 2
- 230000002799 radiopharmaceutical effect Effects 0.000 claims 2
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 2
- 239000000932 sedative agent Substances 0.000 claims 2
- 230000001624 sedative effect Effects 0.000 claims 2
- 229960002930 sirolimus Drugs 0.000 claims 2
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 2
- 150000003431 steroids Chemical class 0.000 claims 2
- 239000000021 stimulant Substances 0.000 claims 2
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000000394 mitotic effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33491710P | 2010-05-14 | 2010-05-14 | |
| US61/334,917 | 2010-05-14 | ||
| US201061425701P | 2010-12-21 | 2010-12-21 | |
| US61/425,701 | 2010-12-21 | ||
| PCT/US2011/036444 WO2011143562A2 (en) | 2010-05-14 | 2011-05-13 | Il-1 binding proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014085634A Division JP5881766B2 (ja) | 2010-05-14 | 2014-04-17 | Ｉｌ−１結合タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013532959A JP2013532959A (ja) | 2013-08-22 |
| JP2013532959A5 true JP2013532959A5 (enExample) | 2014-06-05 |
| JP5684372B2 JP5684372B2 (ja) | 2015-03-11 |
Family
ID=44911961
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013510339A Active JP5684372B2 (ja) | 2010-05-14 | 2011-05-13 | Ｉｌ−１結合タンパク質 |
| JP2014085634A Active JP5881766B2 (ja) | 2010-05-14 | 2014-04-17 | Ｉｌ−１結合タンパク質 |
| JP2016016871A Active JP6189980B2 (ja) | 2010-05-14 | 2016-02-01 | Ｉｌ−１結合タンパク質 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014085634A Active JP5881766B2 (ja) | 2010-05-14 | 2014-04-17 | Ｉｌ−１結合タンパク質 |
| JP2016016871A Active JP6189980B2 (ja) | 2010-05-14 | 2016-02-01 | Ｉｌ−１結合タンパク質 |
Country Status (36)
Families Citing this family (94)
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