ES2635594T3 - Proteínas de unión a IL-1 - Google Patents
Proteínas de unión a IL-1 Download PDFInfo
- Publication number
- ES2635594T3 ES2635594T3 ES11781350.1T ES11781350T ES2635594T3 ES 2635594 T3 ES2635594 T3 ES 2635594T3 ES 11781350 T ES11781350 T ES 11781350T ES 2635594 T3 ES2635594 T3 ES 2635594T3
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- Prior art date
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- 108010002352 Interleukin-1 Proteins 0.000 title 1
- 108091008324 binding proteins Proteins 0.000 abstract description 8
- 229920001184 polypeptide Polymers 0.000 abstract description 8
- 108090000765 processed proteins & peptides Proteins 0.000 abstract description 8
- 102000004196 processed proteins & peptides Human genes 0.000 abstract description 8
- 101001033249 Homo sapiens Interleukin-1 beta Proteins 0.000 abstract description 6
- 101001002634 Homo sapiens Interleukin-1 alpha Proteins 0.000 abstract description 3
- 102000014914 Carrier Proteins Human genes 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 description 88
- 239000002699 waste material Substances 0.000 description 62
- 108090000623 proteins and genes Proteins 0.000 description 56
- 102000004169 proteins and genes Human genes 0.000 description 52
- 101001005360 Homo sapiens Immunoglobulin lambda variable 3-1 Proteins 0.000 description 24
- 102100025921 Immunoglobulin lambda variable 3-1 Human genes 0.000 description 24
- 150000001413 amino acids Chemical group 0.000 description 11
- 101000839781 Homo sapiens Immunoglobulin heavy variable 4-59 Proteins 0.000 description 8
- 102100028405 Immunoglobulin heavy variable 4-59 Human genes 0.000 description 8
- 238000002965 ELISA Methods 0.000 description 7
- 102000023732 binding proteins Human genes 0.000 description 6
- 108060003951 Immunoglobulin Proteins 0.000 description 5
- 125000000539 amino acid group Chemical group 0.000 description 5
- 239000000427 antigen Substances 0.000 description 5
- 102000036639 antigens Human genes 0.000 description 5
- 108091007433 antigens Proteins 0.000 description 5
- 102000018358 immunoglobulin Human genes 0.000 description 5
- 230000035772 mutation Effects 0.000 description 5
- 101001037151 Homo sapiens Immunoglobulin heavy variable 2-70 Proteins 0.000 description 4
- 101001037136 Homo sapiens Immunoglobulin heavy variable 3-15 Proteins 0.000 description 4
- 101000839665 Homo sapiens Immunoglobulin heavy variable 3-43 Proteins 0.000 description 4
- 101000839658 Homo sapiens Immunoglobulin heavy variable 3-66 Proteins 0.000 description 4
- 101000989062 Homo sapiens Immunoglobulin heavy variable 5-51 Proteins 0.000 description 4
- 101001008263 Homo sapiens Immunoglobulin kappa variable 3D-15 Proteins 0.000 description 4
- 101000604674 Homo sapiens Immunoglobulin kappa variable 4-1 Proteins 0.000 description 4
- 101001008317 Homo sapiens Immunoglobulin kappa variable 6D-21 Proteins 0.000 description 4
- 102100040233 Immunoglobulin heavy variable 2-70 Human genes 0.000 description 4
- 102100040224 Immunoglobulin heavy variable 3-15 Human genes 0.000 description 4
- 102100028315 Immunoglobulin heavy variable 3-43 Human genes 0.000 description 4
- 102100027821 Immunoglobulin heavy variable 3-66 Human genes 0.000 description 4
- 102100029414 Immunoglobulin heavy variable 5-51 Human genes 0.000 description 4
- 102100027410 Immunoglobulin kappa variable 3D-15 Human genes 0.000 description 4
- 102100038198 Immunoglobulin kappa variable 4-1 Human genes 0.000 description 4
- 102100027402 Immunoglobulin kappa variable 6D-21 Human genes 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
- 238000012512 characterization method Methods 0.000 description 4
- 210000004602 germ cell Anatomy 0.000 description 4
- 108091035707 Consensus sequence Proteins 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 3
- 229920001213 Polysorbate 20 Polymers 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
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- 238000002703 mutagenesis Methods 0.000 description 3
- 231100000350 mutagenesis Toxicity 0.000 description 3
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 3
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 3
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 description 2
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 210000004899 c-terminal region Anatomy 0.000 description 2
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- 241000894007 species Species 0.000 description 2
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- 239000004475 Arginine Substances 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 238000008157 ELISA kit Methods 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 101001055222 Homo sapiens Interleukin-8 Proteins 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 230000004988 N-glycosylation Effects 0.000 description 1
- 230000004989 O-glycosylation Effects 0.000 description 1
- 229920002684 Sepharose Polymers 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
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- 238000000605 extraction Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000012239 gene modification Methods 0.000 description 1
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- 235000013617 genetically modified food Nutrition 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
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- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
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Classifications
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- C07—ORGANIC CHEMISTRY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/245—IL-1
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- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
- G01N2333/545—IL-1
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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| US425701P | 2010-12-21 | ||
| PCT/US2011/036444 WO2011143562A2 (en) | 2010-05-14 | 2011-05-13 | Il-1 binding proteins |
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| ES11781350.1T Active ES2635594T3 (es) | 2010-05-14 | 2011-05-13 | Proteínas de unión a IL-1 |
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