JP2013532181A5 - - Google Patents

Info

Publication number

JP2013532181A5

JP2013532181A5 JP2013519174A JP2013519174A JP2013532181A5 JP 2013532181 A5 JP2013532181 A5 JP 2013532181A5 JP 2013519174 A JP2013519174 A JP 2013519174A JP 2013519174 A JP2013519174 A JP 2013519174A JP 2013532181 A5 JP2013532181 A5 JP 2013532181A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

composition according

activation

seq

antibody against

Prior art date

2011-07-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000008194 pharmaceutical composition Substances 0.000 claims 30
• 210000001035 gastrointestinal tract Anatomy 0.000 claims 10
• 201000010099 disease Diseases 0.000 claims 9
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
• 208000002551 irritable bowel syndrome Diseases 0.000 claims 8
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 7
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 7
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 7
• NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 claims 6
• 102000013674 S-100 Human genes 0.000 claims 6
• 108700021018 S100 Proteins 0.000 claims 6
• 230000004913 activation Effects 0.000 claims 5
• 230000001632 homeopathic effect Effects 0.000 claims 5
• 239000012895 dilution Substances 0.000 claims 4
• 238000010790 dilution Methods 0.000 claims 4
• 239000000203 mixture Substances 0.000 claims 4
• 208000004998 Abdominal Pain Diseases 0.000 claims 3
• 206010010774 Constipation Diseases 0.000 claims 3
• 206010012735 Diarrhoea Diseases 0.000 claims 3
• 229960001340 histamine Drugs 0.000 claims 3
• 102000004169 proteins and genes Human genes 0.000 claims 3
• 108090000623 proteins and genes Proteins 0.000 claims 3
• 239000000243 solution Substances 0.000 claims 3
• 239000004480 active ingredient Substances 0.000 claims 2
• 230000002708 enhancing effect Effects 0.000 claims 2
• 206010016766 flatulence Diseases 0.000 claims 2
• 230000008506 pathogenesis Effects 0.000 claims 2
• 239000003369 serotonin 5-HT3 receptor antagonist Substances 0.000 claims 2
• SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 claims 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 241000283690 Bos taurus Species 0.000 claims 1
• 108010056643 Corticotropin-Releasing Hormone Receptors Proteins 0.000 claims 1
• 239000000556 agonist Substances 0.000 claims 1
• 230000001430 anti-depressive effect Effects 0.000 claims 1
• 230000002921 anti-spasmodic effect Effects 0.000 claims 1
• 239000000935 antidepressant agent Substances 0.000 claims 1
• 229940005513 antidepressants Drugs 0.000 claims 1
• 229940125714 antidiarrheal agent Drugs 0.000 claims 1
• 239000003793 antidiarrheal agent Substances 0.000 claims 1
• 229940049706 benzodiazepine Drugs 0.000 claims 1
• 230000003115 biocidal effect Effects 0.000 claims 1
• 239000003467 chloride channel stimulating agent Substances 0.000 claims 1
• 239000003754 cholecystokinin receptor blocking agent Substances 0.000 claims 1
• 239000000812 cholinergic antagonist Substances 0.000 claims 1
• 230000029142 excretion Effects 0.000 claims 1
• 239000012634 fragment Substances 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 239000003149 muscarinic antagonist Substances 0.000 claims 1
• 229940124636 opioid drug Drugs 0.000 claims 1
• 239000006186 oral dosage form Substances 0.000 claims 1
• 229940126409 proton pump inhibitor Drugs 0.000 claims 1
• 239000000612 proton pump inhibitor Substances 0.000 claims 1
• 239000002464 receptor antagonist Substances 0.000 claims 1
• 229940044551 receptor antagonist Drugs 0.000 claims 1
• 239000003523 serotonin 4 antagonist Substances 0.000 claims 1
• 239000000387 serotonin 5-HT4 receptor agonist Substances 0.000 claims 1
• 239000000050 smooth muscle relaxant Substances 0.000 claims 1
• 239000007787 solid Substances 0.000 claims 1
• 239000002462 tachykinin receptor antagonist Substances 0.000 claims 1