PE20130397A1 - Composicion farmaceutica combinada y metodos para el tratamiento de las enfermedades o condiciones funcionales del tracto gastrointestinal - Google Patents
Composicion farmaceutica combinada y metodos para el tratamiento de las enfermedades o condiciones funcionales del tracto gastrointestinalInfo
- Publication number
- PE20130397A1 PE20130397A1 PE2013000075A PE2013000075A PE20130397A1 PE 20130397 A1 PE20130397 A1 PE 20130397A1 PE 2013000075 A PE2013000075 A PE 2013000075A PE 2013000075 A PE2013000075 A PE 2013000075A PE 20130397 A1 PE20130397 A1 PE 20130397A1
- Authority
- PE
- Peru
- Prior art keywords
- seq
- treatment
- pharmaceutical composition
- diseases
- methods
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 210000001035 gastrointestinal tract Anatomy 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- 241000283690 Bos taurus Species 0.000 abstract 1
- 206010010774 Constipation Diseases 0.000 abstract 1
- 206010012735 Diarrhoea Diseases 0.000 abstract 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical class C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 239000012895 dilution Substances 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000001632 homeopathic effect Effects 0.000 abstract 1
- 210000000936 intestine Anatomy 0.000 abstract 1
- 239000008101 lactose Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0004—Homeopathy; Vitalisation; Resonance; Dynamisation, e.g. esoteric applications; Oxygenation of blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nutrition Science (AREA)
- Neurosurgery (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE: A) UNA FORMA ACTIVADA-POTENCIADA DE UN ANTICUERPO DE LA PROTEINA S-100 BOVINA QUE TIENE LAS SECUENCIAS DE AMINOACIDOS SEC ID Nº 13 O SEC ID Nº 16; B) UNA FORMA ACTIVADA-POTENCIADA DE UN ANTICUERPO ANTI-HISTAMINA; C) UNA FORMA ACTIVADA-POTENCIADA DE UN ANTICUERPO ANTI-TNF-ALFA QUE TIENE LA SECUENCIA DE AMINOACIDOS SEC ID Nº 1 O UN FRAGMENTO DE TNF-ALFA QUE TIENE LAS SECUENCIAS DE AMINOACIDOS DE SEC ID Nº 2, SEC ID Nº 3, SEC ID Nº 4, SEC ID Nº 5, ENTRE OTROS; Y D) UN VEHICULO TAL COMO LACTOSA O ISOMALTA; EN DONDE DICHOS ANTICUERPOS SE PRESENTAN COMO UNA MEZCLA DE DILUCIONES HOMEOPATICAS CENTESIMALES C12, C30 Y C200 QUE SON IMPREGNADAS SOBRE EL VEHICULO SOLIDO. DICHA COMPOSICION ES UNA FORMA SOLIDA DE DOSIFICACION ORAL TAL COMO UNA TABLETA SIENDO UTIL EN EL TRATAMIENTO DEL SINDROME DEL INTESTINO IRRITABLE, DIARREA, CONSTIPACION
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2010129293/15A RU2500427C2 (ru) | 2010-07-15 | 2010-07-15 | Лекарственное средство для лечения функциональных нарушений желудочно-кишечного тракта и способ лечения функциональных нарушений желудочно-кишечного тракта |
| RU2011124809/15A RU2532323C2 (ru) | 2011-06-20 | 2011-06-20 | Лекарственное средство для лечения патологического синдрома и способ лечения функциональных нарушений кишечника |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20130397A1 true PE20130397A1 (es) | 2013-04-10 |
Family
ID=44863147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2013000075A PE20130397A1 (es) | 2010-07-15 | 2011-07-15 | Composicion farmaceutica combinada y metodos para el tratamiento de las enfermedades o condiciones funcionales del tracto gastrointestinal |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8637030B2 (es) |
| EP (1) | EP2593138A2 (es) |
| JP (2) | JP2013532181A (es) |
| KR (1) | KR101901465B1 (es) |
| CN (1) | CN103096927A (es) |
| AR (1) | AR082245A1 (es) |
| AU (1) | AU2011278032B2 (es) |
| BR (1) | BR112013000842A2 (es) |
| CA (1) | CA2804964C (es) |
| CL (1) | CL2013000097A1 (es) |
| DE (1) | DE112011102355T5 (es) |
| EA (1) | EA030542B1 (es) |
| ES (1) | ES2425004R1 (es) |
| FR (1) | FR2962651A1 (es) |
| GB (1) | GB2496794B (es) |
| IL (1) | IL224215A (es) |
| IT (1) | ITTO20110628A1 (es) |
| MX (1) | MX2013000542A (es) |
| MY (1) | MY157564A (es) |
| NZ (1) | NZ606765A (es) |
| PE (1) | PE20130397A1 (es) |
| SG (1) | SG187035A1 (es) |
| WO (1) | WO2012007839A2 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2181297C2 (ru) * | 2000-06-20 | 2002-04-20 | Эпштейн Олег Ильич | Способ лечения патологического синдрома и лекарственное средство |
| UA76638C2 (en) | 2002-08-02 | 2006-08-15 | Oleh Illich Epshtein | Homeopathic medication based on anti-interferon antibodies and method for treating a pathological syndrome associated with interferon |
| RU2309732C1 (ru) * | 2006-03-13 | 2007-11-10 | Олег Ильич Эпштейн | Спрессованная твердая оральная форма лекарственного препарата и способ получения твердой оральной формы лекарственного препарата |
| NZ606767A (en) | 2010-07-15 | 2015-08-28 | Oleg Iliich Epshtein | A method of increasing the effect of an activated-potentiated form of an antibody |
| AU2011287288A1 (en) | 2010-07-15 | 2013-03-07 | Oleg Iliich Epshtein | Combination pharmaceutical composition and methods of treating diseases or conditions associated with neurodegenerative diseases |
| CA2805091A1 (en) | 2010-07-15 | 2012-01-19 | Oleg Iliich Epshtein | Pharmaceutical compositions comprising a homopathically potentized form of an antibody to human cannabinoid receptor |
| GB2495885B (en) * | 2010-07-15 | 2017-11-22 | Iliich Epshtein Oleg | Combination pharmaceutical composition and methods of treating genitourinary system disorders |
| MX2013000807A (es) | 2010-07-21 | 2013-10-28 | Oleg Iliich Epshtein | Un metodo para el tratamiento del trastorno de hiperactividad con deficit de atencion. |
| DE112011102412T5 (de) | 2010-07-21 | 2013-07-04 | Oleg Iliich Epshtein | Pharmazeutische Kombinationszusammensetzung und Verfahren zur Behandlung von mit Atemwegserkrankungen bzw. Atemwegsleiden assoziierten Erkrankungen bzw. Leiden |
| UY33679A (es) | 2010-10-22 | 2012-03-30 | Esbatech | Anticuerpos estables y solubles |
| RU2013111962A (ru) | 2013-03-18 | 2014-09-27 | Олег Ильич Эпштейн | Способ определения выраженности модифицирующей активности, ассоциированной с носителем |
| RU2013111961A (ru) | 2013-03-18 | 2014-09-27 | Олег Ильич Эпштейн | Способ определения выраженности модифицирующей активности, ассоциированной с носителем |
| CN106349388B (zh) * | 2015-07-17 | 2021-04-02 | 上海佳文英莉生物技术有限公司 | 一种促细胞程序性坏死抗体及其应用 |
| CN207908510U (zh) | 2016-09-21 | 2018-09-25 | 维布兰特公司 | 安装在抽水马桶上的传感器 |
| WO2024111633A1 (ja) * | 2022-11-24 | 2024-05-30 | 国立大学法人徳島大学 | タンパク質に対する抗体の作製 |
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| EA000885B1 (ru) | 1996-02-12 | 2000-06-26 | Олег Ильич ЭПШТЕЙН | Лекарственное средство и способ медикаментозного воздействия на организм |
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| IL118096A0 (en) | 1996-05-01 | 1996-09-12 | Yeda Res & Dev | Antibodies against interferon alpha/beta receptor |
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| RU2103999C1 (ru) | 1997-01-31 | 1998-02-10 | Олег Ильич Эпштейн | Способ лечения алкоголизма |
| RU2104006C1 (ru) | 1997-02-14 | 1998-02-10 | Олег Ильич Эпштейн | Способ лечения наркомании |
| RU2104032C1 (ru) | 1997-03-11 | 1998-02-10 | Общество с ограниченной ответственностью "Снежный барс" | Способ усиления лечебного эффекта лекарственных средств |
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| RU2187334C2 (ru) | 1998-05-22 | 2002-08-20 | Эпштейн Олег Ильич | Способ коррекции нарушенного иммунного гомеостаза и лекарственное средство |
| RU2161955C1 (ru) | 1999-07-16 | 2001-01-20 | Эпштейн Олег Ильич | Способ изменения физико-химических или физико-химических и биологических свойств вещества |
| RU2181297C2 (ru) | 2000-06-20 | 2002-04-20 | Эпштейн Олег Ильич | Способ лечения патологического синдрома и лекарственное средство |
| RU2177795C1 (ru) | 2001-02-15 | 2002-01-10 | Эпштей Олег Ильич | Гомеопатическое лекарственное средство для лечения и профилактики аденовирусных инфекций у детей |
| RU2192882C1 (ru) | 2001-04-18 | 2002-11-20 | Эпштейн Олег Ильич | Лекарственное средство и способ лечения патологического синдрома, обусловленного нарушением кроветворения |
| RU2197266C1 (ru) * | 2001-06-01 | 2003-01-27 | Эпштейн Олег Ильич | Лекарственное средство и способ лечения эрозивных и воспалительных заболеваний желудочно-кишечного тракта |
| WO2003037372A1 (fr) | 2001-10-31 | 2003-05-08 | Oleg Iliich Epshtein | Procede de retablissement de processus physiologiques perturbes et medicament |
| RU2201255C1 (ru) | 2001-12-26 | 2003-03-27 | Эпштейн Олег Ильич | Лекарственное средство и способ регуляции сосудистого тонуса |
| RU2001134982A (ru) | 2001-12-26 | 2004-02-20 | Олег Ильич Эпштейн | Способ коррекции иммунного ответа и лекарственное средство |
| RU2205026C1 (ru) | 2002-03-15 | 2003-05-27 | Эпштейн Олег Ильич | Лекарственное средство и способ лечения патологического синдрома, обусловленного нарушением кроветворения |
| UA76641C2 (uk) | 2002-08-02 | 2006-08-15 | Олєг Ільіч Епштєйн | Гомеопатичний лікарський засіб та спосіб лікування захворювань передміхурової залози |
| UA76640C2 (uk) | 2002-08-02 | 2006-08-15 | Олєг Ільіч Епштєйн | Спосіб корекції патологічних імунних реакцій та гомеопатичний лікарський засіб |
| UA76638C2 (en) | 2002-08-02 | 2006-08-15 | Oleh Illich Epshtein | Homeopathic medication based on anti-interferon antibodies and method for treating a pathological syndrome associated with interferon |
| TWI345470B (en) | 2003-03-14 | 2011-07-21 | Nutrition Res Inc | Homeopathic formulations useful for treating pain and/or inflammation |
-
2011
- 2011-07-15 BR BR112013000842A patent/BR112013000842A2/pt not_active IP Right Cessation
- 2011-07-15 WO PCT/IB2011/002178 patent/WO2012007839A2/en active Application Filing
- 2011-07-15 NZ NZ606765A patent/NZ606765A/en not_active IP Right Cessation
- 2011-07-15 MX MX2013000542A patent/MX2013000542A/es active IP Right Grant
- 2011-07-15 GB GB1302654.7A patent/GB2496794B/en not_active Expired - Fee Related
- 2011-07-15 DE DE112011102355T patent/DE112011102355T5/de not_active Withdrawn
- 2011-07-15 MY MYPI2013000109A patent/MY157564A/en unknown
- 2011-07-15 SG SG2013002290A patent/SG187035A1/en unknown
- 2011-07-15 IT IT000628A patent/ITTO20110628A1/it unknown
- 2011-07-15 CA CA2804964A patent/CA2804964C/en not_active Expired - Fee Related
- 2011-07-15 US US13/135,888 patent/US8637030B2/en not_active Expired - Fee Related
- 2011-07-15 JP JP2013519174A patent/JP2013532181A/ja active Pending
- 2011-07-15 PE PE2013000075A patent/PE20130397A1/es not_active Application Discontinuation
- 2011-07-15 ES ES201390001A patent/ES2425004R1/es active Pending
- 2011-07-15 EP EP11775833.4A patent/EP2593138A2/en not_active Withdrawn
- 2011-07-15 FR FR1156469A patent/FR2962651A1/fr active Pending
- 2011-07-15 KR KR1020137003751A patent/KR101901465B1/ko active IP Right Grant
- 2011-07-15 AU AU2011278032A patent/AU2011278032B2/en not_active Ceased
- 2011-07-15 EA EA201300125A patent/EA030542B1/ru not_active IP Right Cessation
- 2011-07-15 CN CN2011800429401A patent/CN103096927A/zh active Pending
- 2011-07-18 AR ARP110102575A patent/AR082245A1/es unknown
-
2013
- 2013-01-10 CL CL2013000097A patent/CL2013000097A1/es unknown
- 2013-01-14 IL IL224215A patent/IL224215A/en active IP Right Grant
-
2016
- 2016-07-01 JP JP2016131657A patent/JP2016210787A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN103096927A (zh) | 2013-05-08 |
| MY157564A (en) | 2016-06-30 |
| NZ606765A (en) | 2015-08-28 |
| EP2593138A2 (en) | 2013-05-22 |
| GB2496794A (en) | 2013-05-22 |
| EA030542B1 (ru) | 2018-08-31 |
| CL2013000097A1 (es) | 2015-01-09 |
| US20130004574A1 (en) | 2013-01-03 |
| KR20130060264A (ko) | 2013-06-07 |
| EA201300125A1 (ru) | 2013-12-30 |
| KR101901465B1 (ko) | 2018-09-21 |
| ITTO20110628A1 (it) | 2012-01-16 |
| AU2011278032A1 (en) | 2013-03-07 |
| GB201302654D0 (en) | 2013-04-03 |
| ES2425004R1 (es) | 2014-07-09 |
| SG187035A1 (en) | 2013-02-28 |
| WO2012007839A3 (en) | 2012-04-26 |
| FR2962651A1 (fr) | 2012-01-20 |
| JP2016210787A (ja) | 2016-12-15 |
| AU2011278032B2 (en) | 2015-07-23 |
| MX2013000542A (es) | 2013-06-28 |
| ES2425004A2 (es) | 2013-10-10 |
| DE112011102355T5 (de) | 2013-04-25 |
| CA2804964C (en) | 2016-06-28 |
| AR082245A1 (es) | 2012-11-21 |
| IL224215A (en) | 2016-03-31 |
| WO2012007839A2 (en) | 2012-01-19 |
| CA2804964A1 (en) | 2012-01-19 |
| BR112013000842A2 (pt) | 2016-06-07 |
| JP2013532181A (ja) | 2013-08-15 |
| US8637030B2 (en) | 2014-01-28 |
| GB2496794B (en) | 2017-11-01 |
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