JP2013520993A5 - - Google Patents
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- JP2013520993A5 JP2013520993A5 JP2012556139A JP2012556139A JP2013520993A5 JP 2013520993 A5 JP2013520993 A5 JP 2013520993A5 JP 2012556139 A JP2012556139 A JP 2012556139A JP 2012556139 A JP2012556139 A JP 2012556139A JP 2013520993 A5 JP2013520993 A5 JP 2013520993A5
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- JP
- Japan
- Prior art keywords
- cdr
- seq
- residues
- sequence number
- binding protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000023732 binding proteins Human genes 0.000 claims 39
- 108091008324 binding proteins Proteins 0.000 claims 39
- 101000872077 Homo sapiens Delta-like protein 4 Proteins 0.000 claims 15
- 102100033553 Delta-like protein 4 Human genes 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 6
- 108060003951 Immunoglobulin Proteins 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 102000018358 immunoglobulin Human genes 0.000 claims 5
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 claims 4
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 4
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 102000003800 Selectins Human genes 0.000 claims 4
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- 229960002949 fluorouracil Drugs 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- AAEVYOVXGOFMJO-UHFFFAOYSA-N prometryn Chemical compound CSC1=NC(NC(C)C)=NC(NC(C)C)=N1 AAEVYOVXGOFMJO-UHFFFAOYSA-N 0.000 claims 4
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 3
- 108010036949 Cyclosporine Proteins 0.000 claims 3
- 108090000695 Cytokines Proteins 0.000 claims 3
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- 102000044457 human DLL4 Human genes 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 3
- 229960002930 sirolimus Drugs 0.000 claims 3
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 3
- 150000003431 steroids Chemical class 0.000 claims 3
- 229930182837 (R)-adrenaline Natural products 0.000 claims 2
- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 claims 2
- 190000008236 Carboplatin Chemical compound 0.000 claims 2
- 229940126161 DNA alkylating agent Drugs 0.000 claims 2
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- 208000023281 Fallot tetralogy Diseases 0.000 claims 2
- 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 claims 2
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 2
- 239000005411 L01XE02 - Gefitinib Substances 0.000 claims 2
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims 2
- 229930012538 Paclitaxel Natural products 0.000 claims 2
- 208000029052 T-cell acute lymphoblastic leukemia Diseases 0.000 claims 2
- 201000003005 Tetralogy of Fallot Diseases 0.000 claims 2
- 229960002833 aflibercept Drugs 0.000 claims 2
- 108010081667 aflibercept Proteins 0.000 claims 2
- 230000003444 anaesthetic effect Effects 0.000 claims 2
- 230000000202 analgesic effect Effects 0.000 claims 2
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- 229940045799 anthracyclines and related substance Drugs 0.000 claims 2
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- 229940034982 antineoplastic agent Drugs 0.000 claims 2
- 239000003435 antirheumatic agent Substances 0.000 claims 2
- 230000008827 biological function Effects 0.000 claims 2
- 229960004562 carboplatin Drugs 0.000 claims 2
- RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 claims 2
- 229960000590 celecoxib Drugs 0.000 claims 2
- 229960004316 cisplatin Drugs 0.000 claims 2
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 2
- 239000002872 contrast media Substances 0.000 claims 2
- 230000000139 costimulatory effect Effects 0.000 claims 2
- 229940111134 coxibs Drugs 0.000 claims 2
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 230000001627 detrimental effect Effects 0.000 claims 2
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- 229960005139 epinephrine Drugs 0.000 claims 2
- 229960001433 erlotinib Drugs 0.000 claims 2
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims 2
- 229940105423 erythropoietin Drugs 0.000 claims 2
- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 claims 2
- 235000008191 folinic acid Nutrition 0.000 claims 2
- 239000011672 folinic acid Substances 0.000 claims 2
- 229960002584 gefitinib Drugs 0.000 claims 2
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 claims 2
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 2
- 239000000122 growth hormone Substances 0.000 claims 2
- 229940088597 hormone Drugs 0.000 claims 2
- 239000005556 hormone Substances 0.000 claims 2
- 238000002649 immunization Methods 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 229940072221 immunoglobulins Drugs 0.000 claims 2
- 229960003444 immunosuppressant agent Drugs 0.000 claims 2
- 239000003018 immunosuppressive agent Substances 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 229960004768 irinotecan Drugs 0.000 claims 2
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 2
- 229960001691 leucovorin Drugs 0.000 claims 2
- 239000003589 local anesthetic agent Substances 0.000 claims 2
- 229960000485 methotrexate Drugs 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 239000003158 myorelaxant agent Substances 0.000 claims 2
- 230000003533 narcotic effect Effects 0.000 claims 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 229960001592 paclitaxel Drugs 0.000 claims 2
- 201000010065 polycystic ovary syndrome Diseases 0.000 claims 2
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 2
- 239000012217 radiopharmaceutical Substances 0.000 claims 2
- 229940121896 radiopharmaceutical Drugs 0.000 claims 2
- 230000002799 radiopharmaceutical effect Effects 0.000 claims 2
- 229940124617 receptor tyrosine kinase inhibitor Drugs 0.000 claims 2
- 239000000932 sedative agent Substances 0.000 claims 2
- 230000001624 sedative effect Effects 0.000 claims 2
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 2
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 claims 1
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- 229940088872 Apoptosis inhibitor Drugs 0.000 claims 1
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 claims 1
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- 206010003445 Ascites Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 101150017888 Bcl2 gene Proteins 0.000 claims 1
- 101150008012 Bcl2l1 gene Proteins 0.000 claims 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 1
- 206010004593 Bile duct cancer Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000021910 Cerebral Arterial disease Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 229940124087 DNA topoisomerase II inhibitor Drugs 0.000 claims 1
- 208000001976 Endocrine Gland Neoplasms Diseases 0.000 claims 1
- 201000009273 Endometriosis Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000022072 Gallbladder Neoplasms Diseases 0.000 claims 1
- 101000851018 Homo sapiens Vascular endothelial growth factor receptor 1 Proteins 0.000 claims 1
- 206010021042 Hypopharyngeal cancer Diseases 0.000 claims 1
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- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 102000004195 Isomerases Human genes 0.000 claims 1
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- 208000034800 Leukoencephalopathies Diseases 0.000 claims 1
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- 206010027476 Metastases Diseases 0.000 claims 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
- 206010029113 Neovascularisation Diseases 0.000 claims 1
- 102100023181 Neurogenic locus notch homolog protein 1 Human genes 0.000 claims 1
- 108700037638 Neurogenic locus notch homolog protein 1 Proteins 0.000 claims 1
- 102100025246 Neurogenic locus notch homolog protein 2 Human genes 0.000 claims 1
- 108700037064 Neurogenic locus notch homolog protein 2 Proteins 0.000 claims 1
- 102100025247 Neurogenic locus notch homolog protein 3 Human genes 0.000 claims 1
- 102100025254 Neurogenic locus notch homolog protein 4 Human genes 0.000 claims 1
- 108010070047 Notch Receptors Proteins 0.000 claims 1
- 102000005650 Notch Receptors Human genes 0.000 claims 1
- 108010029756 Notch3 Receptor Proteins 0.000 claims 1
- 108010029741 Notch4 Receptor Proteins 0.000 claims 1
- 206010030113 Oedema Diseases 0.000 claims 1
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- 206010057444 Oropharyngeal neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 208000008469 Peptic Ulcer Diseases 0.000 claims 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 239000000317 Topoisomerase II Inhibitor Substances 0.000 claims 1
- 208000006593 Urologic Neoplasms Diseases 0.000 claims 1
- 206010046798 Uterine leiomyoma Diseases 0.000 claims 1
- 102100033178 Vascular endothelial growth factor receptor 1 Human genes 0.000 claims 1
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 229940009456 adriamycin Drugs 0.000 claims 1
- 239000003263 anabolic agent Substances 0.000 claims 1
- 229940070021 anabolic steroids Drugs 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 229940121369 angiogenesis inhibitor Drugs 0.000 claims 1
- 210000004102 animal cell Anatomy 0.000 claims 1
- 230000002682 anti-psoriatic effect Effects 0.000 claims 1
- 229940124350 antibacterial drug Drugs 0.000 claims 1
- 239000000164 antipsychotic agent Substances 0.000 claims 1
- 229940005529 antipsychotics Drugs 0.000 claims 1
- 239000000158 apoptosis inhibitor Substances 0.000 claims 1
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 1
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- 229940125388 beta agonist Drugs 0.000 claims 1
- 208000026900 bile duct neoplasm Diseases 0.000 claims 1
- 206010008118 cerebral infarction Diseases 0.000 claims 1
- 239000012829 chemotherapy agent Substances 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 229960001334 corticosteroids Drugs 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 239000000430 cytokine receptor antagonist Substances 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 125000002228 disulfide group Chemical group 0.000 claims 1
- 229960003668 docetaxel Drugs 0.000 claims 1
- 229960004679 doxorubicin Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 208000024519 eye neoplasm Diseases 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 201000010175 gallbladder cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 229960005277 gemcitabine Drugs 0.000 claims 1
- 229940020967 gemzar Drugs 0.000 claims 1
- 210000004392 genitalia Anatomy 0.000 claims 1
- 230000013595 glycosylation Effects 0.000 claims 1
- 238000006206 glycosylation reaction Methods 0.000 claims 1
- 230000003394 haemopoietic effect Effects 0.000 claims 1
- 201000011066 hemangioma Diseases 0.000 claims 1
- 102000055590 human KDR Human genes 0.000 claims 1
- 102000057041 human TNF Human genes 0.000 claims 1
- 201000006866 hypopharynx cancer Diseases 0.000 claims 1
- 229940127121 immunoconjugate Drugs 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 229940043355 kinase inhibitor Drugs 0.000 claims 1
- 201000010260 leiomyoma Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 201000005831 male reproductive organ cancer Diseases 0.000 claims 1
- 208000029559 malignant endocrine neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000022006 malignant tumor of meninges Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
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- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 239000000842 neuromuscular blocking agent Substances 0.000 claims 1
- 201000008106 ocular cancer Diseases 0.000 claims 1
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- 239000003757 phosphotransferase inhibitor Substances 0.000 claims 1
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- 201000000306 sarcoidosis Diseases 0.000 claims 1
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- 239000000021 stimulant Substances 0.000 claims 1
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- 238000006467 substitution reaction Methods 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30949410P | 2010-03-02 | 2010-03-02 | |
| US61/309,494 | 2010-03-02 | ||
| PCT/US2011/026489 WO2011109298A2 (en) | 2010-03-02 | 2011-02-28 | Therapeutic dll4 binding proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016092639A Division JP2016185961A (ja) | 2010-03-02 | 2016-05-02 | 治療用ｄｌｌ４結合タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013520993A JP2013520993A (ja) | 2013-06-10 |
| JP2013520993A5 true JP2013520993A5 (enExample) | 2014-04-17 |
| JP5964249B2 JP5964249B2 (ja) | 2016-08-03 |
Family
ID=44531508
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012556139A Expired - Fee Related JP5964249B2 (ja) | 2010-03-02 | 2011-02-28 | 治療用ｄｌｌ４結合タンパク質 |
| JP2016092639A Pending JP2016185961A (ja) | 2010-03-02 | 2016-05-02 | 治療用ｄｌｌ４結合タンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016092639A Pending JP2016185961A (ja) | 2010-03-02 | 2016-05-02 | 治療用ｄｌｌ４結合タンパク質 |
Country Status (27)
| Country | Link |
|---|---|
| US (4) | US9115195B2 (enExample) |
| EP (3) | EP2542582A4 (enExample) |
| JP (2) | JP5964249B2 (enExample) |
| KR (2) | KR101853278B1 (enExample) |
| CN (2) | CN102906113B (enExample) |
| AR (1) | AR080452A1 (enExample) |
| AU (1) | AU2011223919B2 (enExample) |
| BR (1) | BR112012021941A2 (enExample) |
| CA (1) | CA2791631A1 (enExample) |
| CL (1) | CL2012002416A1 (enExample) |
| CO (1) | CO6612264A2 (enExample) |
| CR (1) | CR20120454A (enExample) |
| DO (2) | DOP2012000240A (enExample) |
| EC (1) | ECSP12012194A (enExample) |
| GT (1) | GT201200253A (enExample) |
| MX (1) | MX348312B (enExample) |
| MY (1) | MY160628A (enExample) |
| NZ (1) | NZ602734A (enExample) |
| PE (1) | PE20130580A1 (enExample) |
| PH (1) | PH12012501720A1 (enExample) |
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