JP2013502932A5 - - Google Patents
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- JP2013502932A5 JP2013502932A5 JP2012527035A JP2012527035A JP2013502932A5 JP 2013502932 A5 JP2013502932 A5 JP 2013502932A5 JP 2012527035 A JP2012527035 A JP 2012527035A JP 2012527035 A JP2012527035 A JP 2012527035A JP 2013502932 A5 JP2013502932 A5 JP 2013502932A5
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- 102000014914 Carrier Proteins Human genes 0.000 claims 66
- 108091008324 binding proteins Proteins 0.000 claims 66
- 125000003275 alpha amino acid group Chemical group 0.000 claims 26
- 101000872077 Homo sapiens Delta-like protein 4 Proteins 0.000 claims 23
- 108060003951 Immunoglobulin Proteins 0.000 claims 16
- 102000018358 immunoglobulin Human genes 0.000 claims 16
- 210000004027 cell Anatomy 0.000 claims 14
- 102000044457 human DLL4 Human genes 0.000 claims 13
- 102100033553 Delta-like protein 4 Human genes 0.000 claims 10
- 230000003472 neutralizing effect Effects 0.000 claims 8
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 229920001184 polypeptide Polymers 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 208000035475 disorder Diseases 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 229910052727 yttrium Inorganic materials 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 2
- 108010036949 Cyclosporine Proteins 0.000 claims 2
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 2
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 2
- 102100023181 Neurogenic locus notch homolog protein 1 Human genes 0.000 claims 2
- 108700037638 Neurogenic locus notch homolog protein 1 Proteins 0.000 claims 2
- 102100025254 Neurogenic locus notch homolog protein 4 Human genes 0.000 claims 2
- 108010029741 Notch4 Receptor Proteins 0.000 claims 2
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 2
- 230000033115 angiogenesis Effects 0.000 claims 2
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 2
- 210000004102 animal cell Anatomy 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 229960001265 ciclosporin Drugs 0.000 claims 2
- 239000003246 corticosteroid Substances 0.000 claims 2
- 229930182912 cyclosporin Natural products 0.000 claims 2
- 239000002254 cytotoxic agent Substances 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 231100000599 cytotoxic agent Toxicity 0.000 claims 2
- 230000001627 detrimental effect Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- 210000003527 eukaryotic cell Anatomy 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 229940127121 immunoconjugate Drugs 0.000 claims 2
- 230000003993 interaction Effects 0.000 claims 2
- 229910052740 iodine Inorganic materials 0.000 claims 2
- 229960000485 methotrexate Drugs 0.000 claims 2
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 2
- 229960002930 sirolimus Drugs 0.000 claims 2
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- 206010003445 Ascites Diseases 0.000 claims 1
- 241000271566 Aves Species 0.000 claims 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 1
- 206010004593 Bile duct cancer Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 201000009273 Endometriosis Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000022072 Gallbladder Neoplasms Diseases 0.000 claims 1
- 208000002250 Hematologic Neoplasms Diseases 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 claims 1
- 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 claims 1
- 206010021042 Hypopharyngeal cancer Diseases 0.000 claims 1
- 206010056305 Hypopharyngeal neoplasm Diseases 0.000 claims 1
- 108010073807 IgG Receptors Proteins 0.000 claims 1
- 102000009490 IgG Receptors Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 241000282567 Macaca fascicularis Species 0.000 claims 1
- 208000015021 Meningeal Neoplasms Diseases 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 101100387419 Mus musculus Dll4 gene Proteins 0.000 claims 1
- 206010029113 Neovascularisation Diseases 0.000 claims 1
- 102100025246 Neurogenic locus notch homolog protein 2 Human genes 0.000 claims 1
- 108700037064 Neurogenic locus notch homolog protein 2 Proteins 0.000 claims 1
- 102100025247 Neurogenic locus notch homolog protein 3 Human genes 0.000 claims 1
- 102000005650 Notch Receptors Human genes 0.000 claims 1
- 108010070047 Notch Receptors Proteins 0.000 claims 1
- 108010029756 Notch3 Receptor Proteins 0.000 claims 1
- 206010030113 Oedema Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010031096 Oropharyngeal cancer Diseases 0.000 claims 1
- 206010057444 Oropharyngeal neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 208000008469 Peptic Ulcer Diseases 0.000 claims 1
- 206010036049 Polycystic ovaries Diseases 0.000 claims 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 1
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 101100387420 Rattus norvegicus Dll4 gene Proteins 0.000 claims 1
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000006593 Urologic Neoplasms Diseases 0.000 claims 1
- 206010046798 Uterine leiomyoma Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 208000009956 adenocarcinoma Diseases 0.000 claims 1
- 229940100198 alkylating agent Drugs 0.000 claims 1
- 239000002168 alkylating agent Substances 0.000 claims 1
- 229940121369 angiogenesis inhibitor Drugs 0.000 claims 1
- -1 anthracyclines Substances 0.000 claims 1
- 229940045799 anthracyclines and related substance Drugs 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 230000003092 anti-cytokine Effects 0.000 claims 1
- 229940124599 anti-inflammatory drug Drugs 0.000 claims 1
- 230000000340 anti-metabolite Effects 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 229940100197 antimetabolite Drugs 0.000 claims 1
- 239000002256 antimetabolite Substances 0.000 claims 1
- 239000003080 antimitotic agent Substances 0.000 claims 1
- 230000001640 apoptogenic effect Effects 0.000 claims 1
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 1
- 208000026900 bile duct neoplasm Diseases 0.000 claims 1
- 230000008827 biological function Effects 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 229960001334 corticosteroids Drugs 0.000 claims 1
- 230000000139 costimulatory effect Effects 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002124 endocrine Effects 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 208000024519 eye neoplasm Diseases 0.000 claims 1
- 210000005002 female reproductive tract Anatomy 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 201000010175 gallbladder cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 230000013595 glycosylation Effects 0.000 claims 1
- 238000006206 glycosylation reaction Methods 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 201000011066 hemangioma Diseases 0.000 claims 1
- 230000009033 hematopoietic malignancy Effects 0.000 claims 1
- 102000055590 human KDR Human genes 0.000 claims 1
- 102000057041 human TNF Human genes 0.000 claims 1
- 201000006866 hypopharynx cancer Diseases 0.000 claims 1
- 229940043355 kinase inhibitor Drugs 0.000 claims 1
- 201000010260 leiomyoma Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 210000005001 male reproductive tract Anatomy 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 208000022006 malignant tumor of meninges Diseases 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 108010068617 neonatal Fc receptor Proteins 0.000 claims 1
- 230000001537 neural effect Effects 0.000 claims 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- 201000006958 oropharynx cancer Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 208000011906 peptic ulcer disease Diseases 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims 1
- 201000010065 polycystic ovary syndrome Diseases 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 201000000306 sarcoidosis Diseases 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 201000002314 small intestine cancer Diseases 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 108700012359 toxins Proteins 0.000 claims 1
- 210000005253 yeast cell Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23815209P | 2009-08-29 | 2009-08-29 | |
| US61/238,152 | 2009-08-29 | ||
| US26172809P | 2009-11-16 | 2009-11-16 | |
| US61/261,728 | 2009-11-16 | ||
| PCT/US2010/047006 WO2011025964A2 (en) | 2009-08-29 | 2010-08-27 | Therapeutic dll4 binding proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016020501A Division JP2016147853A (ja) | 2009-08-29 | 2016-02-05 | 治療用ｄｌｌ４結合タンパク質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013502932A JP2013502932A (ja) | 2013-01-31 |
| JP2013502932A5 true JP2013502932A5 (enExample) | 2013-11-07 |
| JP5903382B2 JP5903382B2 (ja) | 2016-04-13 |
Family
ID=43035018
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012527035A Expired - Fee Related JP5903382B2 (ja) | 2009-08-29 | 2010-08-27 | 治療用ｄｌｌ４結合タンパク質 |
| JP2016020501A Pending JP2016147853A (ja) | 2009-08-29 | 2016-02-05 | 治療用ｄｌｌ４結合タンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016020501A Pending JP2016147853A (ja) | 2009-08-29 | 2016-02-05 | 治療用ｄｌｌ４結合タンパク質 |
Country Status (25)
| Country | Link |
|---|---|
| US (5) | US8623358B2 (enExample) |
| EP (2) | EP2470568A2 (enExample) |
| JP (2) | JP5903382B2 (enExample) |
| KR (1) | KR20120089659A (enExample) |
| CN (2) | CN102741288B (enExample) |
| AR (1) | AR077998A1 (enExample) |
| AU (2) | AU2010286518C1 (enExample) |
| BR (1) | BR112012004546A8 (enExample) |
| CA (2) | CA2952742A1 (enExample) |
| CL (1) | CL2012000520A1 (enExample) |
| CO (1) | CO6612215A2 (enExample) |
| CR (1) | CR20120105A (enExample) |
| DO (1) | DOP2012000052A (enExample) |
| HK (1) | HK1225743A1 (enExample) |
| IL (1) | IL218401A (enExample) |
| MX (2) | MX336152B (enExample) |
| MY (1) | MY159837A (enExample) |
| NZ (1) | NZ598524A (enExample) |
| PE (1) | PE20121647A1 (enExample) |
| RU (1) | RU2570639C2 (enExample) |
| SG (1) | SG178930A1 (enExample) |
| TW (1) | TWI465250B (enExample) |
| UY (1) | UY32869A (enExample) |
| WO (1) | WO2011025964A2 (enExample) |
| ZA (1) | ZA201201298B (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5620626B2 (ja) | 2005-03-31 | 2014-11-05 | 中外製薬株式会社 | 会合制御によるポリペプチド製造方法 |
| DK2006381T3 (en) | 2006-03-31 | 2016-02-22 | Chugai Pharmaceutical Co Ltd | PROCEDURE FOR REGULATING ANTIBODIES BLOOD PHARMACOKINETICS |
| DK2202245T3 (en) | 2007-09-26 | 2016-11-21 | Chugai Pharmaceutical Co Ltd | A method of modifying an antibody isoelectric point VIA amino acid substitution in CDR |
| CN102076355B (zh) | 2008-04-29 | 2014-05-07 | Abbvie公司 | 双重可变结构域免疫球蛋白及其用途 |
| SG191639A1 (en) | 2008-06-03 | 2013-07-31 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| PE20121647A1 (es) | 2009-08-29 | 2012-12-31 | Abbvie Inc | Proteinas terapeuticas de union a dll4 |
| EP3485908B1 (en) | 2009-10-16 | 2021-08-18 | Mereo BioPharma 5, Inc. | Therapeutic combination and use of dll4 antagonist antibodies and anti-hypertensive agents |
| JO3183B1 (ar) * | 2010-01-29 | 2018-03-08 | Regeneron Pharma | طرق لمعالجة أمراض المناعة الذاتية مضادات dll4 |
| SG10201501562VA (en) | 2010-03-02 | 2015-04-29 | Abbvie Inc | Therapeutic dll4 binding proteins |
| TW201206473A (en) | 2010-08-03 | 2012-02-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| CN103260639A (zh) | 2010-08-26 | 2013-08-21 | Abbvie公司 | 双重可变结构域免疫球蛋白及其用途 |
| LT2647707T (lt) | 2010-11-30 | 2018-11-12 | Chugai Seiyaku Kabushiki Kaisha | Citotoksiškumą indukuojantis terapinis agentas |
| HRP20190044T1 (hr) | 2011-09-23 | 2019-02-22 | Oncomed Pharmaceuticals, Inc. | Agensi koji vežu vegf/dll4 i njihove uporabe |
| DK2794658T3 (en) * | 2011-12-19 | 2017-06-19 | Synimmune Gmbh | BISPECIFIC ANTIBODY MOLECULE |
| WO2013102042A2 (en) | 2011-12-30 | 2013-07-04 | Abbvie Inc. | Dual specific binding proteins directed against il-13 and/or il-17 |
| WO2013135748A1 (en) * | 2012-03-13 | 2013-09-19 | Universitätsklinikum Heidelberg | Polypeptides binding to dll4 and uses thereof |
| WO2013135747A1 (en) * | 2012-03-13 | 2013-09-19 | Universitätsklinikum Heidelberg | Polypeptides binding to dll4 and uses thereof |
| JP2015520172A (ja) * | 2012-05-31 | 2015-07-16 | ソレント・セラピューティクス・インコーポレイテッドＳｏｒｒｅｎｔｏ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | Ｄｌｌ−４に結合する抗原結合蛋白質 |
| KR101535341B1 (ko) * | 2012-07-02 | 2015-07-13 | 한화케미칼 주식회사 | Dll4에 특이적으로 결합하는 신규한 단일클론항체 및 이의 용도 |
| WO2014062659A2 (en) * | 2012-10-15 | 2014-04-24 | Oncomed Pharmaceuticals, Inc. | Methods of treating ocular diseases |
| AU2013337811A1 (en) | 2012-10-31 | 2015-05-14 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a DLL4 antagonist |
| HK1212359A1 (en) | 2012-11-01 | 2016-06-10 | Abbvie Inc. | Anti-vegf/dll4 dual variable domain immunoglobulins and uses thereof |
| WO2014111458A2 (en) * | 2013-01-17 | 2014-07-24 | Medizinische Hochschule Hannover | Factor 1 protein, factor 2 protein and inhibitors thereof for use in treating or preventing diseases |
| JP2016522793A (ja) | 2013-03-15 | 2016-08-04 | アッヴィ・インコーポレイテッド | ＩＬ−１βおよび／またはＩＬ−１７に対して指向された二重特異的結合タンパク質 |
| ES2881306T3 (es) | 2013-09-27 | 2021-11-29 | Chugai Pharmaceutical Co Ltd | Método para la producción de heteromultímeros de polipéptidos |
| KR20170029490A (ko) | 2014-07-11 | 2017-03-15 | 제넨테크, 인크. | 노치 경로 억제 |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
| US20170079966A1 (en) * | 2014-10-14 | 2017-03-23 | Deciphera Pharmaceuticals, Llc | Inhibition of tumor cell interactions with the microenvironment resulting in a reduction in tumor growth and disease progression |
| MX382902B (es) | 2014-10-31 | 2025-03-13 | Oncomed Pharm Inc | Inhibidor de la vía noth en combinación con un agente inmunoterapéutico para usarse en el tratamiento de cáncer. |
| JP6506534B2 (ja) * | 2014-11-07 | 2019-04-24 | 三星ディスプレイ株式會社Ｓａｍｓｕｎｇ Ｄｉｓｐｌａｙ Ｃｏ．，Ｌｔｄ． | 有機電界発光素子用材料及びこれを用いた有機電界発光素子 |
| WO2016094881A2 (en) | 2014-12-11 | 2016-06-16 | Abbvie Inc. | Lrp-8 binding proteins |
| WO2016159213A1 (ja) | 2015-04-01 | 2016-10-06 | 中外製薬株式会社 | ポリペプチド異種多量体の製造方法 |
| TWI609687B (zh) * | 2015-04-14 | 2018-01-01 | 美國禮來大藥廠 | 平滑肌肉瘤之標靶性治療 |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| KR101943989B1 (ko) | 2015-06-05 | 2019-01-30 | 삼성전자주식회사 | 데이터를 송수신하는 방법, 서버 및 단말기 |
| TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白 |
| WO2017053705A1 (en) | 2015-09-23 | 2017-03-30 | Oncomed Pharmaceuticals, Inc. | Methods and compositions for treatment of cancer |
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2010
- 2010-08-27 PE PE2012000270A patent/PE20121647A1/es not_active Application Discontinuation
- 2010-08-27 JP JP2012527035A patent/JP5903382B2/ja not_active Expired - Fee Related
- 2010-08-27 CA CA2952742A patent/CA2952742A1/en not_active Abandoned
- 2010-08-27 US US12/870,276 patent/US8623358B2/en active Active
- 2010-08-27 CN CN201080049088.6A patent/CN102741288B/zh not_active Expired - Fee Related
- 2010-08-27 BR BR112012004546A patent/BR112012004546A8/pt not_active IP Right Cessation
- 2010-08-27 NZ NZ59852410A patent/NZ598524A/en not_active IP Right Cessation
- 2010-08-27 CN CN201510501472.XA patent/CN105131112A/zh active Pending
- 2010-08-27 EP EP10752666A patent/EP2470568A2/en not_active Withdrawn
- 2010-08-27 MY MYPI2012000879A patent/MY159837A/en unknown
- 2010-08-27 AU AU2010286518A patent/AU2010286518C1/en not_active Ceased
- 2010-08-27 MX MX2014007925A patent/MX336152B/es unknown
- 2010-08-27 MX MX2012002605A patent/MX2012002605A/es active IP Right Grant
- 2010-08-27 SG SG2012014403A patent/SG178930A1/en unknown
- 2010-08-27 EP EP15203274.4A patent/EP3029070A1/en not_active Withdrawn
- 2010-08-27 TW TW99129046A patent/TWI465250B/zh not_active IP Right Cessation
- 2010-08-27 KR KR20127008084A patent/KR20120089659A/ko not_active Ceased
- 2010-08-27 WO PCT/US2010/047006 patent/WO2011025964A2/en not_active Ceased
- 2010-08-27 CA CA2771575A patent/CA2771575A1/en not_active Abandoned
- 2010-08-27 RU RU2012112067/10A patent/RU2570639C2/ru not_active IP Right Cessation
- 2010-08-30 UY UY32869A patent/UY32869A/es not_active Application Discontinuation
- 2010-08-30 AR ARP100103173 patent/AR077998A1/es unknown
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2012
- 2012-02-21 ZA ZA2012/01298A patent/ZA201201298B/en unknown
- 2012-02-22 CO CO12031220A patent/CO6612215A2/es unknown
- 2012-02-28 CR CR20120105A patent/CR20120105A/es unknown
- 2012-02-28 CL CL2012000520A patent/CL2012000520A1/es unknown
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- 2012-02-29 IL IL218401A patent/IL218401A/en not_active IP Right Cessation
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2013
- 2013-01-04 HK HK16113936.2A patent/HK1225743A1/en unknown
- 2013-11-26 US US14/090,778 patent/US9132190B2/en active Active
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2015
- 2015-06-04 AU AU2015202977A patent/AU2015202977A1/en not_active Abandoned
- 2015-08-10 US US14/822,329 patent/US9469688B2/en active Active
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- 2017-04-28 US US15/582,065 patent/US20180371071A1/en not_active Abandoned
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- 2019-09-19 US US16/576,078 patent/US20200255508A1/en not_active Abandoned
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