MX2021015966A - Producto farmacológico para terapia enzimática para el tratamiento de la homocistinuria. - Google Patents
Producto farmacológico para terapia enzimática para el tratamiento de la homocistinuria.Info
- Publication number
- MX2021015966A MX2021015966A MX2021015966A MX2021015966A MX2021015966A MX 2021015966 A MX2021015966 A MX 2021015966A MX 2021015966 A MX2021015966 A MX 2021015966A MX 2021015966 A MX2021015966 A MX 2021015966A MX 2021015966 A MX2021015966 A MX 2021015966A
- Authority
- MX
- Mexico
- Prior art keywords
- homocystinuria
- treatment
- pegylated
- cystathionine beta
- enzyme therapy
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/51—Lyases (4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/01—Hydro-lyases (4.2.1)
- C12Y402/01022—Cystathionine beta-synthase (4.2.1.22)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Inorganic Chemistry (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente descripción proporciona formulaciones para un producto farmacológico que comprende una proteína CBS PEGilada que tiene la secuencia de aminoácidos de SEQ ID NO: 1. Se proporcionan dosis y regímenes de dosificación para el tratamiento de la homocistinuria en un sujeto que lo necesite. Además, también se proporcionan las dosis y los regímenes de dosificación para reducir el nivel de homocisteína (Hcy) o aumentar los niveles de cisteína (Cys) y/o cistationina (Cth) en un sujeto que lo necesite.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962866810P | 2019-06-26 | 2019-06-26 | |
US202062983860P | 2020-03-02 | 2020-03-02 | |
PCT/US2020/039870 WO2020264333A1 (en) | 2019-06-26 | 2020-06-26 | Pegylated cystathionine beta synthase for enzyme therapy for treatment of homocystinuria |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021015966A true MX2021015966A (es) | 2022-04-06 |
Family
ID=71670437
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021015966A MX2021015966A (es) | 2019-06-26 | 2020-06-26 | Producto farmacológico para terapia enzimática para el tratamiento de la homocistinuria. |
Country Status (12)
Country | Link |
---|---|
US (1) | US20220265835A1 (es) |
EP (1) | EP3990005A1 (es) |
JP (1) | JP2022539077A (es) |
KR (1) | KR20220044726A (es) |
CN (1) | CN114786712A (es) |
AU (1) | AU2020302079A1 (es) |
BR (1) | BR112021026292A2 (es) |
CA (1) | CA3145426A1 (es) |
CL (1) | CL2021003474A1 (es) |
IL (1) | IL289245A (es) |
MX (1) | MX2021015966A (es) |
WO (1) | WO2020264333A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021046190A1 (en) * | 2019-09-03 | 2021-03-11 | Orphan Technologies Ltd. | Cystathionine beta-synthase enzyme therapy for treatment of elevated homocysteine levels |
CN115721735A (zh) * | 2022-10-13 | 2023-03-03 | 呈诺再生医学科技(北京)有限公司 | Cbs基因在制备糖尿病视网膜病变治疗药物中的应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20121647A1 (es) * | 2009-08-29 | 2012-12-31 | Abbvie Inc | Proteinas terapeuticas de union a dll4 |
EP2510100B1 (en) * | 2009-12-09 | 2017-10-11 | CureVac AG | Mannose-containing solution for lyophilization, transfection and/or injection of nucleic acids |
US9034318B2 (en) * | 2011-08-30 | 2015-05-19 | The Regents Of The University Of Colorado, A Body Corporate | Chemically modified cystathionine beta-synthase enzyme for treatment of homocystinuria |
US9243239B2 (en) * | 2012-03-26 | 2016-01-26 | The Regents Of The University Of Colorado, A Body Corporate | Purification of cystathionine beta-synthase |
AU2015241422B2 (en) | 2014-04-01 | 2020-12-03 | Rubius Therapeutics, Inc. | Methods and compositions for immunomodulation |
WO2016183482A1 (en) | 2015-05-13 | 2016-11-17 | Rubius Therapeutics, Inc. | Membrane-receiver complex therapeutics |
LT3373922T (lt) * | 2015-11-09 | 2022-04-11 | The Regents Of The University Of Colorado, A Body Corporate | Kompozicijos ir būdai skirti naudoti homocistinurijos gydyme |
BR112019000195A2 (pt) | 2016-07-07 | 2019-04-24 | Rubius Therapeutics, Inc. | composições e métodos relacionados a sistemas celulares terapêuticos que expressam rna exógeno |
-
2020
- 2020-06-26 US US17/622,112 patent/US20220265835A1/en active Pending
- 2020-06-26 JP JP2021576921A patent/JP2022539077A/ja active Pending
- 2020-06-26 KR KR1020227002804A patent/KR20220044726A/ko unknown
- 2020-06-26 EP EP20743019.0A patent/EP3990005A1/en active Pending
- 2020-06-26 AU AU2020302079A patent/AU2020302079A1/en active Pending
- 2020-06-26 CN CN202080060487.6A patent/CN114786712A/zh active Pending
- 2020-06-26 MX MX2021015966A patent/MX2021015966A/es unknown
- 2020-06-26 WO PCT/US2020/039870 patent/WO2020264333A1/en active Application Filing
- 2020-06-26 BR BR112021026292A patent/BR112021026292A2/pt unknown
- 2020-06-26 CA CA3145426A patent/CA3145426A1/en active Pending
-
2021
- 2021-12-22 IL IL289245A patent/IL289245A/en unknown
- 2021-12-24 CL CL2021003474A patent/CL2021003474A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
IL289245A (en) | 2022-02-01 |
CN114786712A (zh) | 2022-07-22 |
WO2020264333A1 (en) | 2020-12-30 |
CA3145426A1 (en) | 2020-12-30 |
CL2021003474A1 (es) | 2022-09-02 |
KR20220044726A (ko) | 2022-04-11 |
BR112021026292A2 (pt) | 2022-05-31 |
US20220265835A1 (en) | 2022-08-25 |
AU2020302079A1 (en) | 2022-02-17 |
EP3990005A1 (en) | 2022-05-04 |
JP2022539077A (ja) | 2022-09-07 |
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