MX336187B - Metodo para tratar el mal de parkinson. - Google Patents

Metodo para tratar el mal de parkinson.

Info

Publication number
MX336187B
MX336187B MX2012010161A MX2012010161A MX336187B MX 336187 B MX336187 B MX 336187B MX 2012010161 A MX2012010161 A MX 2012010161A MX 2012010161 A MX2012010161 A MX 2012010161A MX 336187 B MX336187 B MX 336187B
Authority
MX
Mexico
Prior art keywords
carbidopa
dosage form
amount ranging
entacapone
disease
Prior art date
Application number
MX2012010161A
Other languages
English (en)
Other versions
MX2012010161A (es
Inventor
Pekka Männistö
Juha Rouru
Mikko Kuoppamäki
Juha Ellmen
Original Assignee
Orion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corp filed Critical Orion Corp
Publication of MX2012010161A publication Critical patent/MX2012010161A/es
Publication of MX336187B publication Critical patent/MX336187B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets

Abstract

La presente descripción proporciona un método pata el tratamiento del mal de Parkinson que comprende administrar de manera simultánea o secuencial a un paciente que necesite del tratamiento del mal de Parkinson una forma de dosificación que comprende (i) levodopa en una cantidad que va desde 50 mg a 300 mg, (ii) carbidopa en una cantidad que va desde 25 mg a 150 mg o una cantidad terapéuticamente equivalente de otro inhibidor de descarboxilasa aminoácido aromático, y (iii) entacapona en una cantidad que va desde 50 mg a 300 mg, en donde la proporción de entacapona a carbidopa en dicha forma de dosificación está en un intervalo de 0.3:1.0 a 3.2:1.0 por peso, un inhibidor COMT moderadamente potente en una cantidad que va desde 25 mg a 200 mg, en donde la proporción de dicho inhibidor COMT a carbidopa en dicha forma de dosificación está en un intervalo de 0.16:1.0 a 3.08:1.0 por peso, o un inhibidor CQMT altamente potente en una, cantidad que va desde 1 mg a 100 mg, en donde la proporción de dicho inhibidor COMT a carbidopa en dicha forma de dosificación está en un intervalo, de 0.006:1.0 a 1.54:1.0 por peso. También se describe la forma de dosificación farmacéutica utilizada en dicho método.
MX2012010161A 2010-03-04 2011-03-03 Metodo para tratar el mal de parkinson. MX336187B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US31039810P 2010-03-04 2010-03-04
US41282110P 2010-11-12 2010-11-12
US201161438416P 2011-02-01 2011-02-01
PCT/FI2011/000013 WO2011107653A2 (en) 2010-03-04 2011-03-03 Method for treating parkinson's disease

Publications (2)

Publication Number Publication Date
MX2012010161A MX2012010161A (es) 2012-10-03
MX336187B true MX336187B (es) 2016-01-07

Family

ID=44065577

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012010161A MX336187B (es) 2010-03-04 2011-03-03 Metodo para tratar el mal de parkinson.

Country Status (15)

Country Link
US (4) US20130137729A1 (es)
EP (1) EP2542220B1 (es)
JP (2) JP5774610B2 (es)
KR (1) KR101868326B1 (es)
CN (1) CN102781424B (es)
AU (1) AU2011222856B2 (es)
BR (1) BR112012018256A8 (es)
CA (1) CA2784819C (es)
EA (1) EA026419B1 (es)
ES (1) ES2614179T3 (es)
HK (1) HK1177896A1 (es)
IL (1) IL221744A (es)
MX (1) MX336187B (es)
WO (1) WO2011107653A2 (es)
ZA (1) ZA201205836B (es)

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KR101522157B1 (ko) 2007-01-31 2015-05-28 바이알 - 포르텔라 앤드 씨에이 에스에이 Ｃｏｍｔ 억제제의 투약 방법
BRPI0908731A2 (pt) 2008-03-17 2017-05-16 Bial - Portela & C A S A formas cristalinas de 5-[3-(2,5-dicloro-4,6-dimetil-1-óxi-piridina-3-il)[1,2,4]oxadiazol-5-il]-3-nitrobenzeno-1,2-diol
PT2413912T (pt) 2009-04-01 2019-06-11 Bial Portela & Ca Sa Formulações farmacêuticas compreendendo derivados de nitrocatecol e métodos para as produzir
EP2542220B1 (en) * 2010-03-04 2016-11-02 Orion Corporation Use of levodopa, carbidopa and entacapone for treating parkinson's disease
US20140045900A1 (en) * 2011-02-11 2014-02-13 Bial-Portela & Ca, S.A. Administration regime for nitrocatechols
WO2012147099A1 (en) * 2011-04-25 2012-11-01 Suven Nishtaa Pharma Pvt. Ltd. Pharmaceutical compositions of levodopa, carbidopa and entacapone
EP2791134B1 (en) 2011-12-13 2019-09-25 BIAL - Portela & Cª S.A. Chemical compound useful as intermediate for preparing a catechol-o-methyltransferase inhibitor
JP6154025B2 (ja) 2012-12-24 2017-06-28 ニューロガストルクス，インコーポレイテッド Ｇｉ管障害を治療するための方法
WO2014151742A1 (en) * 2013-03-15 2014-09-25 Mylan, Inc. Formulation containing carbidopa, levodopa, and entacapone
EP2799065A1 (en) * 2013-04-30 2014-11-05 Deva Holding Anonim Sirketi Levodopa carbidopa entacapone pharmaceutical formulations
WO2015200369A1 (en) 2014-06-24 2015-12-30 Neurogastrx, Inc. Prodrugs of metopimazine
RU2017120184A (ru) 2014-11-28 2018-12-28 БИАЛ - ПОРТЕЛА ЭНД Ка, С.А. Лекарства для замедления течения болезни паркинсона
CN112261940B (zh) * 2018-03-23 2024-02-27 劳波索尔制药有限公司 用于治疗神经退行性疾病的药物组合物的连续施用
CN112741808B (zh) * 2019-10-29 2024-02-06 南京济群医药科技股份有限公司 一种提高含盐酸苄丝肼口服固体组合物稳定性的方法
US10836757B1 (en) 2020-04-02 2020-11-17 Neurogastrx, Inc. Polymorphic forms of metopimazine
WO2021207634A1 (en) * 2020-04-10 2021-10-14 Senda Biosciences, Inc. Biomarkers related to parkinson's disease and methods of using the same
EP4223288B1 (en) 2022-02-07 2024-03-06 Berlirem GmbH Novel kit of pharmaceutical preparations for the treatment of parkinson's disease
GB202212082D0 (en) * 2022-08-18 2022-10-05 Bial Portela & Ca Sa Treatment regimens for parkinson's disease

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Also Published As

Publication number Publication date
ES2614179T3 (es) 2017-05-30
EA201290865A1 (ru) 2013-02-28
AU2011222856A1 (en) 2012-07-26
EP2542220A2 (en) 2013-01-09
WO2011107653A2 (en) 2011-09-09
CN102781424A (zh) 2012-11-14
HK1177896A1 (zh) 2013-08-30
CN102781424B (zh) 2016-03-30
US20210085635A1 (en) 2021-03-25
IL221744A (en) 2016-11-30
AU2011222856B2 (en) 2015-10-15
ZA201205836B (en) 2014-01-29
CA2784819A1 (en) 2011-09-09
JP5774610B2 (ja) 2015-09-09
KR101868326B1 (ko) 2018-06-19
JP2015180644A (ja) 2015-10-15
EP2542220B1 (en) 2016-11-02
US11771675B2 (en) 2023-10-03
US20130137729A1 (en) 2013-05-30
US20240050394A1 (en) 2024-02-15
EA026419B1 (ru) 2017-04-28
US20150150839A1 (en) 2015-06-04
WO2011107653A8 (en) 2012-08-02
BR112012018256A2 (es) 2011-09-09
MX2012010161A (es) 2012-10-03
WO2011107653A3 (en) 2011-11-03
JP2013521263A (ja) 2013-06-10
US10857120B2 (en) 2020-12-08
BR112012018256A8 (pt) 2017-12-19
KR20130006638A (ko) 2013-01-17
CA2784819C (en) 2018-02-13

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