AR124078A1 - Método para el tratamiento de la enfermedad de parkinson - Google Patents

Método para el tratamiento de la enfermedad de parkinson

Info

Publication number
AR124078A1
AR124078A1 ARP210103172A ARP210103172A AR124078A1 AR 124078 A1 AR124078 A1 AR 124078A1 AR P210103172 A ARP210103172 A AR P210103172A AR P210103172 A ARP210103172 A AR P210103172A AR 124078 A1 AR124078 A1 AR 124078A1
Authority
AR
Argentina
Prior art keywords
ddci
levodopa
combination
salt
prodrug
Prior art date
Application number
ARP210103172A
Other languages
English (en)
Inventor
Tal Birnberg
Liat Adar
Itay Perlstein
Original Assignee
Neuroderm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuroderm Ltd filed Critical Neuroderm Ltd
Publication of AR124078A1 publication Critical patent/AR124078A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs

Abstract

Se divulga un método para el tratamiento de un trastorno neurológico o del movimiento, p. ej., la enfermedad de Parkinson, en un individuo que lo necesita, mediante la administración parenteral de levodopa y un inhibidor de la descarboxilasa dopa (DDCI), tal como carbidopa, benserazida o cualquier combinación de estos, de manera concomitante con la administración oral de levodopa, un DDCI, tal como carbidopa, benserazida, o cualquier combinación de estos. Reivindicación 30: Una primera composición farmacéutica caracterizada porque comprende: levodopa, una sal de levodopa, un profármaco de levodopa, o cualquier combinación de estos; y un inhibidor de la dopa descarboxilasa (DDCI), una sal de DDCI, un profármaco de DDCI, o cualquier combinación de estos; y, una segunda composición farmacéutica que comprende: levodopa, una sal de levodopa, un profármaco de levodopa, un inhibidor de la dopa descarboxilasa (DDCI), una sal de DDCI, un profármaco de DDCI; o cualquier combinación de estos, para su uso como combinación en el tratamiento de un trastorno neurológico o del movimiento, donde la primera composición farmacéutica se formula como una composición parenteral y la segunda composición farmacéutica se formula como una composición oral. Reivindicación 31: Un equipo caracterizado porque comprende: una primera composición farmacéutica en forma parenteral que comprende: levodopa, una sal de levodopa, un profármaco de levodopa, o cualquier combinación de estos; y un inhibidor de la dopa descarboxilasa (DDCI), una sal de DDCI, un profármaco de DDCI, o cualquier combinación de estos; una segunda composición farmacéutica en forma oral que comprende: levodopa, una sal de levodopa, un profármaco de levodopa, un inhibidor de la dopa descarboxilasa (DDCI), una sal de DDCI, un profármaco de DDCI; o cualquier combinación de estos; y instrucciones para la administración concomitante de la primera composición farmacéutica y la segunda composición farmacéutica para el tratamiento de un trastorno neurológico o del movimiento.
ARP210103172A 2020-11-17 2021-11-17 Método para el tratamiento de la enfermedad de parkinson AR124078A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202063114688P 2020-11-17 2020-11-17

Publications (1)

Publication Number Publication Date
AR124078A1 true AR124078A1 (es) 2023-02-08

Family

ID=79169649

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP210103172A AR124078A1 (es) 2020-11-17 2021-11-17 Método para el tratamiento de la enfermedad de parkinson

Country Status (12)

Country Link
US (2) US11213502B1 (es)
EP (1) EP4247357A1 (es)
JP (1) JP2023552700A (es)
KR (1) KR20230110542A (es)
CN (1) CN117120045A (es)
AR (1) AR124078A1 (es)
AU (1) AU2021383322A1 (es)
CA (1) CA3198748A1 (es)
IL (1) IL302826A (es)
MX (1) MX2023005725A (es)
TW (1) TW202233171A (es)
WO (1) WO2022107125A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11331293B1 (en) 2020-11-17 2022-05-17 Neuroderm, Ltd. Method for treatment of Parkinson's disease
US11844754B2 (en) 2020-11-17 2023-12-19 Neuroderm, Ltd. Methods for treatment of Parkinson's disease
WO2023126945A1 (en) * 2022-01-03 2023-07-06 Neuroderm, Ltd. Methods and compositions for treating parkinson's disease

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Publication number Publication date
EP4247357A1 (en) 2023-09-27
AU2021383322A1 (en) 2023-06-22
US20220151965A1 (en) 2022-05-19
IL302826A (en) 2023-07-01
KR20230110542A (ko) 2023-07-24
TW202233171A (zh) 2022-09-01
CA3198748A1 (en) 2022-05-27
WO2022107125A1 (en) 2022-05-27
JP2023552700A (ja) 2023-12-19
CN117120045A (zh) 2023-11-24
MX2023005725A (es) 2023-05-25
US11213502B1 (en) 2022-01-04

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