CY1120005T1 - Συνεχης χορηγηση αναστολεων l-ντοπα, αποκαρβοξυλασης ντοπα, αναστολεων κατεχολ-ο-μεθυλ τρανσφερασης και συνθεσεις αυτων - Google Patents
Συνεχης χορηγηση αναστολεων l-ντοπα, αποκαρβοξυλασης ντοπα, αναστολεων κατεχολ-ο-μεθυλ τρανσφερασης και συνθεσεις αυτωνInfo
- Publication number
- CY1120005T1 CY1120005T1 CY20181100276T CY181100276T CY1120005T1 CY 1120005 T1 CY1120005 T1 CY 1120005T1 CY 20181100276 T CY20181100276 T CY 20181100276T CY 181100276 T CY181100276 T CY 181100276T CY 1120005 T1 CY1120005 T1 CY 1120005T1
- Authority
- CY
- Cyprus
- Prior art keywords
- dopa
- inhibitors
- catechol
- syntheses
- decarboxylation
- Prior art date
Links
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 title abstract 3
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 title abstract 2
- 229960004502 levodopa Drugs 0.000 title abstract 2
- 239000003543 catechol methyltransferase inhibitor Substances 0.000 title 1
- 238000006114 decarboxylation reaction Methods 0.000 title 1
- MHUWZNTUIIFHAS-CLFAGFIQSA-N dioleoyl phosphatidic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(O)=O)OC(=O)CCCCCCC\C=C/CCCCCCCC MHUWZNTUIIFHAS-CLFAGFIQSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- 208000019430 Motor disease Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 229960004205 carbidopa Drugs 0.000 abstract 1
- TZFNLOMSOLWIDK-JTQLQIEISA-N carbidopa (anhydrous) Chemical compound NN[C@@](C(O)=O)(C)CC1=CC=C(O)C(O)=C1 TZFNLOMSOLWIDK-JTQLQIEISA-N 0.000 abstract 1
- 229960003337 entacapone Drugs 0.000 abstract 1
- JRURYQJSLYLRLN-BJMVGYQFSA-N entacapone Chemical compound CCN(CC)C(=O)C(\C#N)=C\C1=CC(O)=C(O)C([N+]([O-])=O)=C1 JRURYQJSLYLRLN-BJMVGYQFSA-N 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 229960004603 tolcapone Drugs 0.000 abstract 1
- MIQPIUSUKVNLNT-UHFFFAOYSA-N tolcapone Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC(O)=C(O)C([N+]([O-])=O)=C1 MIQPIUSUKVNLNT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
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- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
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- Psychology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Στο παρόν παρέχεται, εν μέρει, μέθοδος θεραπείας νευρολογικής ή κινητικής διαταραχής σε έναν ασθενή που έχει ανάγκη αυτής, που περιλαμβάνει υποδόρια χορήγηση στον εν λόγω ασθενή φαρμακευτικώς αποδεκτής σύνθεσης περιέχουσας λεβοντόπα και προαιρετικώς καρβιντόπα και προαιρετικώς εντακαπόνη ή τολκαπόνη ή φαρμακευτικώς αποδεκτά άλατα αυτών, όπου η εν λόγω σύνθεση χορηγείται ουσιαστικώς συνεχώς και συνθέσεις που μπορεί να χρησιμοποιηθούν στις αποκαλυπτόμενες μεθόδους.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41363710P | 2010-11-15 | 2010-11-15 | |
| US201161524064P | 2011-08-16 | 2011-08-16 | |
| PCT/IL2011/000881 WO2012066538A1 (en) | 2010-11-15 | 2011-11-15 | Continuous administration of l-dopa, dopa decarboxylase inhibitors, catechol-o-methyl transferase inhibitors and compositions for same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1120005T1 true CY1120005T1 (el) | 2018-12-12 |
Family
ID=45478410
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20181100276T CY1120005T1 (el) | 2010-11-15 | 2018-03-06 | Συνεχης χορηγηση αναστολεων l-ντοπα, αποκαρβοξυλασης ντοπα, αναστολεων κατεχολ-ο-μεθυλ τρανσφερασης και συνθεσεις αυτων |
Country Status (26)
| Country | Link |
|---|---|
| US (6) | US9421267B2 (el) |
| EP (3) | EP3692982A1 (el) |
| JP (3) | JP5902705B2 (el) |
| KR (1) | KR101859242B1 (el) |
| CN (2) | CN103442693A (el) |
| AU (1) | AU2011330757B2 (el) |
| BR (1) | BR112013011685B1 (el) |
| CA (1) | CA2817888C (el) |
| CL (1) | CL2013001368A1 (el) |
| CY (1) | CY1120005T1 (el) |
| DK (2) | DK3326615T3 (el) |
| ES (2) | ES2776734T3 (el) |
| HR (2) | HRP20180514T1 (el) |
| HU (2) | HUE037005T2 (el) |
| IL (1) | IL263954A (el) |
| LT (1) | LT2640358T (el) |
| MX (1) | MX348225B (el) |
| NZ (1) | NZ610911A (el) |
| PL (2) | PL2640358T3 (el) |
| PT (2) | PT2640358T (el) |
| RS (1) | RS57047B1 (el) |
| RU (2) | RU2607497C2 (el) |
| SG (2) | SG10201509316SA (el) |
| SI (1) | SI2640358T1 (el) |
| WO (1) | WO2012066538A1 (el) |
| ZA (1) | ZA201303509B (el) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2432454B1 (en) | 2009-05-19 | 2017-03-01 | Neuroderm Ltd | Compositions for continuous administration of dopa decarboxylase inhibitors |
| ES2673219T3 (es) | 2010-11-15 | 2018-06-20 | Neuroderm Ltd | Composición para la entrega transdérmica de agentes activos |
| DK3326615T3 (da) | 2010-11-15 | 2020-03-09 | Neuroderm Ltd | Kontinuerlig indgivelse af l-dopa-, dopa- decarboxylase-inhibitorer, catechol-o-methyltransferaseinhibitorer og sammensætninger til samme |
| CA2875446A1 (en) | 2012-06-05 | 2013-12-12 | Neuroderm Ltd. | Compositions comprising apomorphine and organic acids and uses thereof |
| RU2677278C2 (ru) | 2013-03-13 | 2019-01-16 | Неуродерм Лтд | Способ лечения болезни паркинсона |
| US10646532B2 (en) | 2014-01-29 | 2020-05-12 | National Institute Of Advanced Industrial Science And Technology | Method for preparing water extract of ashwagandha leaves which has enhanced anti-cancer activity utilizing cyclodextrin, and pharmaceutical composition containing ashwagandha leaves |
| BR112016021034A8 (pt) * | 2014-03-13 | 2021-06-29 | Neuroderm Ltd | composição farmacêutica, uso da mesma e kit |
| US10258585B2 (en) | 2014-03-13 | 2019-04-16 | Neuroderm, Ltd. | DOPA decarboxylase inhibitor compositions |
| PT3782617T (pt) | 2014-09-04 | 2024-02-29 | Lobsor Pharmaceuticals Ab | Composições farmacêuticas de gel compreendendo levodopa, carbidopa e entacapona |
| BR112017008198B1 (pt) | 2014-10-21 | 2021-02-09 | Abbvie Inc | combinação farmacêutica compreendendo pró-fármacos de carbidopa e l-dopa e uso da mesma para a preparação de uma composição farmacêutica para tratar doença de parkinson |
| MA41377A (fr) | 2015-01-20 | 2017-11-28 | Abbvie Inc | Gel intestinal de lévodopa et de carbidona et procédés d'utilisation |
| EP3075723B1 (en) | 2015-03-30 | 2017-05-24 | Berlirem GmbH | Highly soluble l-dopa glycerol esters |
| CN107848954A (zh) | 2015-03-30 | 2018-03-27 | 伯里兰有限责任公司 | 水溶性l‑dopa酯 |
| CN113197851A (zh) | 2015-05-06 | 2021-08-03 | 辛纳吉勒公司 | 包含药物粒子的药用悬浮液、用于其配给的装置、以及其使用方法 |
| US10555922B2 (en) | 2015-09-04 | 2020-02-11 | Lobsor Pharmaceuticals Aktiebolag | Method of treating a dopamine related disorder in a subject by administering levodopa, in combination with a dopamine decarboxylase inhibitor and a catechol-o-methyltransferase inhibitor |
| US20190224220A1 (en) * | 2016-04-20 | 2019-07-25 | Abbvie Inc. | Carbidopa and L-Dopa Prodrugs and Methods of Use |
| EP3275433A1 (en) * | 2016-07-29 | 2018-01-31 | Som Innovation Biotech S.L. | Sustained release composition comprising micronized tolcapone |
| CN106619490A (zh) * | 2017-01-19 | 2017-05-10 | 云南白药集团无锡药业有限公司 | 一种左旋多巴透皮贴剂及其制备方法 |
| EA201992685A1 (ru) | 2017-06-05 | 2020-06-05 | Дизлин Фармасьютикалз Аб | Раствор леводопы для инфузий |
| WO2019008529A1 (en) | 2017-07-07 | 2019-01-10 | Neuroderm Ltd | DEVICE FOR SUBCUTANEOUS DELIVERY OF LIQUID MEDICINE |
| AU2019237857A1 (en) | 2018-03-23 | 2020-10-08 | Lobsor Pharmaceuticals Aktiebolag | Continuous administration of pharmaceutical composition for treatment of neurodegenerative disorders |
| CN111643493B (zh) * | 2020-05-26 | 2023-01-10 | 上海京新生物医药有限公司 | 一种高浓度左旋多巴制剂及其制备方法及其应用 |
| CN111701024B (zh) * | 2020-05-26 | 2022-05-24 | 上海京新生物医药有限公司 | 一种左旋多巴制剂及其制备方法及其应用 |
| US11331293B1 (en) | 2020-11-17 | 2022-05-17 | Neuroderm, Ltd. | Method for treatment of Parkinson's disease |
| US11844754B2 (en) | 2020-11-17 | 2023-12-19 | Neuroderm, Ltd. | Methods for treatment of Parkinson's disease |
| US11213502B1 (en) | 2020-11-17 | 2022-01-04 | Neuroderm, Ltd. | Method for treatment of parkinson's disease |
| WO2023126945A1 (en) * | 2022-01-03 | 2023-07-06 | Neuroderm, Ltd. | Methods and compositions for treating parkinson's disease |
| EP4223288B1 (en) | 2022-02-07 | 2024-03-06 | Berlirem GmbH | Novel kit of pharmaceutical preparations for the treatment of parkinson's disease |
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