JPS56115749A - Dopa derivative - Google Patents

Dopa derivative

Info

Publication number
JPS56115749A
JPS56115749A JP1785680A JP1785680A JPS56115749A JP S56115749 A JPS56115749 A JP S56115749A JP 1785680 A JP1785680 A JP 1785680A JP 1785680 A JP1785680 A JP 1785680A JP S56115749 A JPS56115749 A JP S56115749A
Authority
JP
Japan
Prior art keywords
formula
compound
dopa
amino
dopa derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1785680A
Other languages
Japanese (ja)
Inventor
Iwao Oshima
Shigemi Suga
Rumiko Abe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Priority to JP1785680A priority Critical patent/JPS56115749A/en
Publication of JPS56115749A publication Critical patent/JPS56115749A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A dopa derivative of formula I (R1 and R2 are H, lower alkyl, benzyl, acyl or R1 and R2 together form alkylene; R3 is H, alkyl, aryl, or heteroaromatic group).
EXAMPLE: N-Phenyl-[2-amino-3-(3,4-dimethoxyphenyl)]propionamide.
USE: An intermediate for preparing dopa which is useful as a remedy for Parkinson's disease.
PROCESS: A β-lactam compound of formula II (X is amino or azido) is subjected to the hydrogenolysis to give the compound of formula I. The compound of formula II is obtained by reacting an azidoacetyl chloride with a Schiff base prepared from veratrum aldehyde and aniline quantitatively in the presence of triethylamine.
COPYRIGHT: (C)1981,JPO&Japio
JP1785680A 1980-02-18 1980-02-18 Dopa derivative Pending JPS56115749A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1785680A JPS56115749A (en) 1980-02-18 1980-02-18 Dopa derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1785680A JPS56115749A (en) 1980-02-18 1980-02-18 Dopa derivative

Publications (1)

Publication Number Publication Date
JPS56115749A true JPS56115749A (en) 1981-09-11

Family

ID=11955291

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1785680A Pending JPS56115749A (en) 1980-02-18 1980-02-18 Dopa derivative

Country Status (1)

Country Link
JP (1) JPS56115749A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02231457A (en) * 1988-07-12 1990-09-13 Italia Method for synthesizing l-(-)-2-amino-3-(3,4- dihydroxyphenyl)propanoic acid, product thereby, and use of said product in said synthesis
US8048926B2 (en) * 2003-02-07 2011-11-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem L-DOPA amide derivatives and uses thereof
US10624839B2 (en) 2014-03-13 2020-04-21 Neuroderm, Ltd. Dopa decarboxylase inhibitor compositions
US10813902B2 (en) 2014-03-13 2020-10-27 Neuroderm, Ltd. DOPA decarboxylase inhibitor compositions
US11213502B1 (en) 2020-11-17 2022-01-04 Neuroderm, Ltd. Method for treatment of parkinson's disease
US11331293B1 (en) 2020-11-17 2022-05-17 Neuroderm, Ltd. Method for treatment of Parkinson's disease
US11844754B2 (en) 2020-11-17 2023-12-19 Neuroderm, Ltd. Methods for treatment of Parkinson's disease

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02231457A (en) * 1988-07-12 1990-09-13 Italia Method for synthesizing l-(-)-2-amino-3-(3,4- dihydroxyphenyl)propanoic acid, product thereby, and use of said product in said synthesis
US8048926B2 (en) * 2003-02-07 2011-11-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem L-DOPA amide derivatives and uses thereof
US10624839B2 (en) 2014-03-13 2020-04-21 Neuroderm, Ltd. Dopa decarboxylase inhibitor compositions
US10813902B2 (en) 2014-03-13 2020-10-27 Neuroderm, Ltd. DOPA decarboxylase inhibitor compositions
US11213502B1 (en) 2020-11-17 2022-01-04 Neuroderm, Ltd. Method for treatment of parkinson's disease
US11331293B1 (en) 2020-11-17 2022-05-17 Neuroderm, Ltd. Method for treatment of Parkinson's disease
US11458115B2 (en) 2020-11-17 2022-10-04 Neuroderm, Ltd. Method for treatment of Parkinson's disease
US11844754B2 (en) 2020-11-17 2023-12-19 Neuroderm, Ltd. Methods for treatment of Parkinson's disease

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