JP2013515472A5 - - Google Patents
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- JP2013515472A5 JP2013515472A5 JP2012545347A JP2012545347A JP2013515472A5 JP 2013515472 A5 JP2013515472 A5 JP 2013515472A5 JP 2012545347 A JP2012545347 A JP 2012545347A JP 2012545347 A JP2012545347 A JP 2012545347A JP 2013515472 A5 JP2013515472 A5 JP 2013515472A5
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28952909P | 2009-12-23 | 2009-12-23 | |
| US61/289,529 | 2009-12-23 | ||
| PCT/EP2010/070659 WO2011076922A1 (en) | 2009-12-23 | 2010-12-23 | Anti-flt3 antibodies and methods of using the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013515472A JP2013515472A (ja) | 2013-05-09 |
| JP2013515472A5 true JP2013515472A5 (enExample) | 2014-02-06 |
| JP5944831B2 JP5944831B2 (ja) | 2016-07-05 |
Family
ID=43719470
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012545347A Active JP5944831B2 (ja) | 2009-12-23 | 2010-12-23 | 抗ｆｌｔ３抗体及びその使用方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9023996B2 (enExample) |
| EP (1) | EP2516468B1 (enExample) |
| JP (1) | JP5944831B2 (enExample) |
| CN (1) | CN102770453B (enExample) |
| BR (1) | BR112012015740B1 (enExample) |
| CA (1) | CA2785178C (enExample) |
| DK (1) | DK2516468T3 (enExample) |
| EA (1) | EA027502B1 (enExample) |
| ES (1) | ES2573642T3 (enExample) |
| HR (1) | HRP20160422T1 (enExample) |
| HU (1) | HUE028629T2 (enExample) |
| SI (1) | SI2516468T1 (enExample) |
| WO (1) | WO2011076922A1 (enExample) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2794658B1 (en) * | 2011-12-19 | 2017-03-15 | Synimmune GmbH | Bispecific antibody molecule |
| CN104520321A (zh) * | 2012-01-09 | 2015-04-15 | 斯克利普斯研究所 | 超长互补决定区及其用途 |
| US10072093B2 (en) * | 2013-07-04 | 2018-09-11 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Fusion protein to target and treat acute myeloid leukemia cells |
| EP3593812A3 (en) | 2014-03-15 | 2020-05-27 | Novartis AG | Treatment of cancer using chimeric antigen receptor |
| CN104288765A (zh) * | 2014-07-03 | 2015-01-21 | 成都中联生科基因科技有限公司 | 一种利用具有中和FLT3生物学活性的McAb应用于肿瘤的靶向治疗的新方法 |
| WO2016014530A1 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Combinations of low, immune enhancing. doses of mtor inhibitors and cars |
| EP2985294A1 (en) | 2014-08-14 | 2016-02-17 | Deutsches Krebsforschungszentrum | Recombinant antibody molecule and its use for target cell restricted T cell activation |
| MX386942B (es) * | 2014-11-21 | 2025-03-19 | Bristol Myers Squibb Co | Anticuerpos que comprenden regiones constantes pesadas modificadas. |
| WO2016126608A1 (en) | 2015-02-02 | 2016-08-11 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
| US9974865B2 (en) * | 2015-03-09 | 2018-05-22 | Agensys, Inc. | Antibody drug conjugates (ADC) that bind to FLT3 proteins |
| US12128069B2 (en) | 2015-04-23 | 2024-10-29 | The Trustees Of The University Of Pennsylvania | Treatment of cancer using chimeric antigen receptor and protein kinase a blocker |
| TWI829617B (zh) | 2015-07-31 | 2024-01-21 | 德商安美基研究（慕尼黑）公司 | Ｆｌｔ３及ｃｄ３抗體構築體 |
| EA039859B1 (ru) | 2015-07-31 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
| TWI744242B (zh) | 2015-07-31 | 2021-11-01 | 德商安美基研究（慕尼黑）公司 | Egfrviii及cd3抗體構築體 |
| TWI796283B (zh) | 2015-07-31 | 2023-03-21 | 德商安美基研究（慕尼黑）公司 | Ｍｓｌｎ及ｃｄ３抗體構築體 |
| EP3331913A1 (en) | 2015-08-07 | 2018-06-13 | Novartis AG | Treatment of cancer using chimeric cd3 receptor proteins |
| HK1258921A1 (zh) * | 2015-09-23 | 2019-11-22 | Cytoimmune Therapeutics, Inc. | Flt3 定向 car 细胞免疫疗法 |
| DK3380620T3 (da) | 2015-11-23 | 2024-09-23 | Novartis Ag | Optimerede lentivirale transfervektorer og anvendelse heraf |
| MX2018008106A (es) | 2015-12-30 | 2019-03-14 | Novartis Ag | Terapias con celulas inmunoefectoras de una eficacia mejorada. |
| IL260920B (en) | 2016-02-03 | 2022-09-01 | Amgen Res Munich Gmbh | Constructs of psma and cd3 bispecific antigens that bind to t-cells, preparations containing them and uses thereof |
| EP3432924A1 (en) | 2016-03-23 | 2019-01-30 | Novartis AG | Cell secreted minibodies and uses thereof |
| UA128326C2 (uk) * | 2016-04-01 | 2024-06-12 | Амджен Інк. | Химерний рецептор до flt3 та спосіб його застосування |
| EP3439699A4 (en) * | 2016-04-04 | 2019-11-20 | Hemogenyx LLC | METHOD FOR ELIMINATING HEMATOPOETIC STEM CELLS / HEMATOPOIDIC PRECURSOR CELLS (HSC / HP) IN A PATIENT WITH BI-SPECIFIC ANTIBODIES |
| US11104738B2 (en) | 2016-04-04 | 2021-08-31 | Hemogenyx Pharmaceuticals Llc | Monoclonal antibodies to human FLT3/FLK2 receptor protein |
| CA3028134A1 (en) | 2016-06-17 | 2017-12-21 | Magenta Therapeutics, Inc. | Compositions and methods for the depletion of cd117+ cells |
| WO2018111340A1 (en) | 2016-12-16 | 2018-06-21 | Novartis Ag | Methods for determining potency and proliferative function of chimeric antigen receptor (car)-t cells |
| AU2017382883B2 (en) | 2016-12-21 | 2024-07-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Human monoclonal antibodies specific for FLT3 and uses thereof |
| SG10202102897PA (en) | 2017-01-20 | 2021-04-29 | Magenta Therapeutics Inc | Compositions and methods for the depletion of cd137+ cells |
| EP3574005B1 (en) | 2017-01-26 | 2021-12-15 | Novartis AG | Cd28 compositions and methods for chimeric antigen receptor therapy |
| US20190375815A1 (en) | 2017-01-31 | 2019-12-12 | Novartis Ag | Treatment of cancer using chimeric t cell receptor proteins having multiple specificities |
| WO2018160731A1 (en) | 2017-02-28 | 2018-09-07 | Novartis Ag | Shp inhibitor compositions and uses for chimeric antigen receptor therapy |
| JP7116736B2 (ja) * | 2017-03-02 | 2022-08-10 | ノバルティス アーゲー | 操作されたヘテロ二量体タンパク質 |
| CN110831970B (zh) * | 2017-06-02 | 2024-12-17 | 辉瑞公司 | 靶向flt3的嵌合抗原受体 |
| MX2019014465A (es) | 2017-06-02 | 2020-01-23 | Pfizer | Anticuerpos especificos para flt3 y sus usos. |
| WO2018229715A1 (en) | 2017-06-16 | 2018-12-20 | Novartis Ag | Compositions comprising anti-cd32b antibodies and methods of use thereof |
| KR20200033302A (ko) * | 2017-07-31 | 2020-03-27 | 드래곤플라이 쎄라퓨틱스, 인크. | Nkg2d, cd16 및 flt3에 결합하는 단백질 |
| EP3661511A1 (en) * | 2017-08-01 | 2020-06-10 | Julius-Maximilians-Universität Würzburg | Use of flt3 car-t cells and flt3 inhibitors to treat acute myeloid leukemia |
| CN111566124A (zh) | 2017-10-25 | 2020-08-21 | 诺华股份有限公司 | 制备表达嵌合抗原受体的细胞的方法 |
| US20210040205A1 (en) | 2017-10-25 | 2021-02-11 | Novartis Ag | Antibodies targeting cd32b and methods of use thereof |
| US20210179709A1 (en) | 2017-10-31 | 2021-06-17 | Novartis Ag | Anti-car compositions and methods |
| JP7399880B2 (ja) * | 2018-01-26 | 2023-12-18 | ジェンザイム・コーポレーション | ＦｃＲｎへの増強された結合及び延長された半減期を有するＦｃ変異体 |
| CN112119093A (zh) | 2018-02-20 | 2020-12-22 | 蜻蜓治疗公司 | 结合cd33、nkg2d和cd16的多特异性结合蛋白和使用方法 |
| WO2019210153A1 (en) | 2018-04-27 | 2019-10-31 | Novartis Ag | Car t cell therapies with enhanced efficacy |
| US20210396739A1 (en) | 2018-05-01 | 2021-12-23 | Novartis Ag | Biomarkers for evaluating car-t cells to predict clinical outcome |
| WO2019227003A1 (en) | 2018-05-25 | 2019-11-28 | Novartis Ag | Combination therapy with chimeric antigen receptor (car) therapies |
| WO2019237035A1 (en) | 2018-06-08 | 2019-12-12 | Intellia Therapeutics, Inc. | Compositions and methods for immunooncology |
| AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
| CN113164570B (zh) | 2018-08-08 | 2024-05-14 | 蜻蜓疗法股份有限公司 | 结合nkg2d、cd16和肿瘤相关抗原的蛋白质 |
| CN112823022B (zh) | 2018-08-08 | 2025-02-14 | 蜻蜓治疗公司 | 结合bcma、nkg2d和cd16的多特异性结合蛋白以及使用方法 |
| EP3623383A1 (en) | 2018-09-11 | 2020-03-18 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Improved bispecific flt3xcd3 antigen binding proteins |
| MY205658A (en) * | 2018-09-11 | 2024-11-04 | Deutsches Krebsforschungszentrumstiftung Des Ffentlichen Rechts | Improved anti-flt₃ antigen binding proteins |
| WO2020061482A1 (en) | 2018-09-21 | 2020-03-26 | Harpoon Therapeutics, Inc. | Egfr binding proteins and methods of use |
| CR20210327A (es) | 2018-12-18 | 2021-09-27 | Boehringer Ingelheim Io Canada Inc | Anticuerpos agonistas de flt3 y usos de estos |
| EP3897637A1 (en) | 2018-12-20 | 2021-10-27 | Novartis AG | Dosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives |
| CA3123519A1 (en) | 2019-02-15 | 2020-08-20 | Novartis Ag | Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| EP3924054B1 (en) | 2019-02-15 | 2025-04-02 | Novartis AG | 3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| TW202110873A (zh) | 2019-04-30 | 2021-03-16 | 美商聖堤生物科技股份有限公司 | 嵌合受體及其使用方法 |
| CU20210096A7 (es) | 2019-05-21 | 2022-06-06 | Novartis Ag | Moléculas de unión a cd19 |
| BR112022011998A2 (pt) | 2019-12-20 | 2022-08-30 | Novartis Ag | Usos de anticorpos anti-tgfss e inibidores de checkpoint para o tratamento de doenças proliferativas |
| IL295448A (en) * | 2020-02-21 | 2022-10-01 | Harpoon Therapeutics Inc | flt3 binding proteins and methods of use |
| JP7525109B2 (ja) * | 2020-03-18 | 2024-07-30 | 学校法人金沢医科大学 | Ｃｄ１３５＋細胞を含む医薬組成物 |
| EP4136114A1 (en) * | 2020-04-14 | 2023-02-22 | Les Laboratoires Servier | Anti-flt3 antibodies and compositions |
| TW202208428A (zh) | 2020-05-06 | 2022-03-01 | 美商蜻蜓醫療公司 | 結合ｎｋｇ２ｄ、ｃｄ１６及ｃｌｅｃ１２ａ之蛋白質 |
| WO2021252920A1 (en) | 2020-06-11 | 2021-12-16 | Novartis Ag | Zbtb32 inhibitors and uses thereof |
| EP4168007A1 (en) | 2020-06-23 | 2023-04-26 | Novartis AG | Dosing regimen comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives |
| EP4188549A1 (en) | 2020-08-03 | 2023-06-07 | Novartis AG | Heteroaryl substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| IL302700A (en) | 2020-11-13 | 2023-07-01 | Novartis Ag | Combination therapies with chimeric antigen receptor (car)-expressing cells |
| WO2022187539A1 (en) | 2021-03-03 | 2022-09-09 | Dragonfly Therapeutics, Inc. | Methods of treating cancer using multi-specific binding proteins that bind nkg2d, cd16 and a tumor-associated antigen |
| TW202304979A (zh) | 2021-04-07 | 2023-02-01 | 瑞士商諾華公司 | 抗ＴＧＦβ抗體及其他治療劑用於治療增殖性疾病之用途 |
| CA3218362A1 (en) | 2021-04-27 | 2022-11-03 | Novartis Ag | Viral vector production system |
| EP4388008A1 (en) * | 2021-08-16 | 2024-06-26 | Hemogenyx Pharmaceuticals Llc | Anti-flt3 antibodies, cars, car t cells and methods of use |
| WO2023214325A1 (en) | 2022-05-05 | 2023-11-09 | Novartis Ag | Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors |
| EP4608983A1 (en) | 2022-10-26 | 2025-09-03 | Novartis AG | Lentiviral formulations |
| WO2024206669A2 (en) * | 2023-03-29 | 2024-10-03 | Virtuoso Binco, Inc. | Antibodies for targeting cd47 and b7h3 and methods of use thereof |
| AU2024276994A1 (en) | 2023-05-24 | 2025-10-23 | Kumquat Biosciences Inc. | Heterocyclic compounds and uses thereof |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
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-
2010
- 2010-12-23 EP EP10798340.5A patent/EP2516468B1/en active Active
- 2010-12-23 ES ES10798340.5T patent/ES2573642T3/es active Active
- 2010-12-23 JP JP2012545347A patent/JP5944831B2/ja active Active
- 2010-12-23 CA CA2785178A patent/CA2785178C/en active Active
- 2010-12-23 DK DK10798340.5T patent/DK2516468T3/en active
- 2010-12-23 HR HRP20160422TT patent/HRP20160422T1/hr unknown
- 2010-12-23 SI SI201031176A patent/SI2516468T1/sl unknown
- 2010-12-23 EA EA201290370A patent/EA027502B1/ru unknown
- 2010-12-23 CN CN201080064659.3A patent/CN102770453B/zh active Active
- 2010-12-23 HU HUE10798340A patent/HUE028629T2/en unknown
- 2010-12-23 US US13/518,779 patent/US9023996B2/en active Active
- 2010-12-23 BR BR112012015740-0A patent/BR112012015740B1/pt active IP Right Grant
- 2010-12-23 WO PCT/EP2010/070659 patent/WO2011076922A1/en not_active Ceased
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