JP2013515472A5 - - Google Patents
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- JP2013515472A5 JP2013515472A5 JP2012545347A JP2012545347A JP2013515472A5 JP 2013515472 A5 JP2013515472 A5 JP 2013515472A5 JP 2012545347 A JP2012545347 A JP 2012545347A JP 2012545347 A JP2012545347 A JP 2012545347A JP 2013515472 A5 JP2013515472 A5 JP 2013515472A5
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28952909P | 2009-12-23 | 2009-12-23 | |
| US61/289,529 | 2009-12-23 | ||
| PCT/EP2010/070659 WO2011076922A1 (en) | 2009-12-23 | 2010-12-23 | Anti-flt3 antibodies and methods of using the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013515472A JP2013515472A (ja) | 2013-05-09 |
| JP2013515472A5 true JP2013515472A5 (enExample) | 2014-02-06 |
| JP5944831B2 JP5944831B2 (ja) | 2016-07-05 |
Family
ID=43719470
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012545347A Active JP5944831B2 (ja) | 2009-12-23 | 2010-12-23 | 抗ｆｌｔ３抗体及びその使用方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9023996B2 (enExample) |
| EP (1) | EP2516468B1 (enExample) |
| JP (1) | JP5944831B2 (enExample) |
| CN (1) | CN102770453B (enExample) |
| BR (1) | BR112012015740B1 (enExample) |
| CA (1) | CA2785178C (enExample) |
| DK (1) | DK2516468T3 (enExample) |
| EA (1) | EA027502B1 (enExample) |
| ES (1) | ES2573642T3 (enExample) |
| HR (1) | HRP20160422T1 (enExample) |
| HU (1) | HUE028629T2 (enExample) |
| SI (1) | SI2516468T1 (enExample) |
| WO (1) | WO2011076922A1 (enExample) |
Families Citing this family (77)
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| EP2794658B1 (en) * | 2011-12-19 | 2017-03-15 | Synimmune GmbH | Bispecific antibody molecule |
| US10774132B2 (en) * | 2012-01-09 | 2020-09-15 | The Scripps Research Instittue | Ultralong complementarity determining regions and uses thereof |
| WO2015001078A1 (en) * | 2013-07-04 | 2015-01-08 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | A new fusion protein to target and treat acute myloid leukemia cells |
| JP2017513818A (ja) | 2014-03-15 | 2017-06-01 | ノバルティス アーゲー | キメラ抗原受容体を使用する癌の処置 |
| CN104288765A (zh) * | 2014-07-03 | 2015-01-21 | 成都中联生科基因科技有限公司 | 一种利用具有中和FLT3生物学活性的McAb应用于肿瘤的靶向治疗的新方法 |
| EP3193915A1 (en) | 2014-07-21 | 2017-07-26 | Novartis AG | Combinations of low, immune enhancing. doses of mtor inhibitors and cars |
| EP2985294A1 (en) | 2014-08-14 | 2016-02-17 | Deutsches Krebsforschungszentrum | Recombinant antibody molecule and its use for target cell restricted T cell activation |
| LT3221346T (lt) * | 2014-11-21 | 2020-11-10 | Bristol-Myers Squibb Company | Antikūnai, apimantys modifikuotas sunkiosios grandinės pastoviąsias sritis |
| US11161907B2 (en) | 2015-02-02 | 2021-11-02 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
| ES2884844T3 (es) * | 2015-03-09 | 2021-12-13 | Agensys Inc | Conjugados de anticuerpo fármaco (ADC) que se unen a proteínas FLT3 |
| EP3286211A1 (en) | 2015-04-23 | 2018-02-28 | Novartis AG | Treatment of cancer using chimeric antigen receptor and protein kinase a blocker |
| TWI744242B (zh) | 2015-07-31 | 2021-11-01 | 德商安美基研究（慕尼黑）公司 | Egfrviii及cd3抗體構築體 |
| EA039859B1 (ru) | 2015-07-31 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
| TWI796283B (zh) | 2015-07-31 | 2023-03-21 | 德商安美基研究（慕尼黑）公司 | Ｍｓｌｎ及ｃｄ３抗體構築體 |
| TWI829617B (zh) | 2015-07-31 | 2024-01-21 | 德商安美基研究（慕尼黑）公司 | Ｆｌｔ３及ｃｄ３抗體構築體 |
| US11667691B2 (en) | 2015-08-07 | 2023-06-06 | Novartis Ag | Treatment of cancer using chimeric CD3 receptor proteins |
| KR20180053744A (ko) * | 2015-09-23 | 2018-05-23 | 사이토이뮨 테라퓨틱스 엘엘씨 | 면역 요법을 위한 flt3 유도된 car 세포 |
| CN108603200B (zh) | 2015-11-23 | 2022-08-19 | 诺华股份有限公司 | 优化的慢病毒转移载体及其用途 |
| CN109072195A (zh) | 2015-12-30 | 2018-12-21 | 诺华股份有限公司 | 具有增强功效的免疫效应细胞疗法 |
| TN2018000266A1 (en) | 2016-02-03 | 2020-01-16 | Amgen Res Munich Gmbh | Psma and cd3 bispecific t cell engaging antibody constructs. |
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| KR102694879B1 (ko) * | 2016-04-01 | 2024-08-16 | 암젠 인크 | Flt3에 대한 키메라 수용체 및 이의 사용 방법 |
| US11104738B2 (en) | 2016-04-04 | 2021-08-31 | Hemogenyx Pharmaceuticals Llc | Monoclonal antibodies to human FLT3/FLK2 receptor protein |
| US11021536B2 (en) | 2016-04-04 | 2021-06-01 | Hemogenyx Pharmaceuticals Llc | Method of eliminating hematopoietic stem cells/hematopoietic progenitors (HSC/HP) in a patient using bi-specific antibodies |
| KR20230066647A (ko) | 2016-06-17 | 2023-05-16 | 마젠타 테라퓨틱스 인코포레이티드 | Cd117+ 세포의 고갈을 위한 조성물 및 방법 |
| WO2018111340A1 (en) | 2016-12-16 | 2018-06-21 | Novartis Ag | Methods for determining potency and proliferative function of chimeric antigen receptor (car)-t cells |
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| EP3574005B1 (en) | 2017-01-26 | 2021-12-15 | Novartis AG | Cd28 compositions and methods for chimeric antigen receptor therapy |
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| US20200048359A1 (en) | 2017-02-28 | 2020-02-13 | Novartis Ag | Shp inhibitor compositions and uses for chimeric antigen receptor therapy |
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| US12296012B2 (en) | 2017-06-02 | 2025-05-13 | Pfizer Inc. | Chimeric antigen receptors targeting FLT3 |
| TWI843344B (zh) | 2017-06-02 | 2024-05-21 | 美商輝瑞大藥廠 | 對ｆｌｔ３具特異性之抗體及其用途 |
| WO2018229715A1 (en) | 2017-06-16 | 2018-12-20 | Novartis Ag | Compositions comprising anti-cd32b antibodies and methods of use thereof |
| MX2020001257A (es) * | 2017-07-31 | 2020-08-17 | Dragonfly Therapeutics Inc | Proteinas que se unen a nkg2d, cd16 y flt3. |
| EP3661511A1 (en) * | 2017-08-01 | 2020-06-10 | Julius-Maximilians-Universität Würzburg | Use of flt3 car-t cells and flt3 inhibitors to treat acute myeloid leukemia |
| RU2020116579A (ru) | 2017-10-25 | 2021-11-25 | Новартис Аг | Способы получения клеток, экспрессирующих химерный антигенный рецептор |
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| WO2019210153A1 (en) | 2018-04-27 | 2019-10-31 | Novartis Ag | Car t cell therapies with enhanced efficacy |
| EP3788369A1 (en) | 2018-05-01 | 2021-03-10 | Novartis Ag | Biomarkers for evaluating car-t cells to predict clinical outcome |
| EP3801769A1 (en) | 2018-05-25 | 2021-04-14 | Novartis AG | Combination therapy with chimeric antigen receptor (car) therapies |
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| AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
| KR20250112921A (ko) | 2018-08-08 | 2025-07-24 | 드래곤플라이 쎄라퓨틱스, 인크. | Nkg2d, cd16 및 종양 관련 항원에 결합하는 단백질 |
| EA202190468A1 (ru) | 2018-08-08 | 2021-07-06 | Драгонфлай Терапьютикс, Инк. | Мультиспецифические связывающие белки, которые связывают bcma, nkg2d и cd16, и способы их применения |
| EP3623383A1 (en) | 2018-09-11 | 2020-03-18 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Improved bispecific flt3xcd3 antigen binding proteins |
| US12195543B2 (en) * | 2018-09-11 | 2025-01-14 | Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts | Anti-FLT3 antigen binding proteins |
| US12195544B2 (en) | 2018-09-21 | 2025-01-14 | Harpoon Therapeutics, Inc. | EGFR binding proteins and methods of use |
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| BR112021015783A2 (pt) | 2019-02-15 | 2021-10-05 | Novartis Ag | Derivados de 3-(1-oxo-5-(piperidin-4-il)isoindolin-2-il)piperidina-2,6-diona e usos dos mesmos |
| WO2020165834A1 (en) | 2019-02-15 | 2020-08-20 | Novartis Ag | Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
| CA3133333A1 (en) | 2019-04-30 | 2020-04-30 | Brian Scott GARRISON | Chimeric receptors and methods of use thereof |
| TWI905099B (zh) | 2019-05-21 | 2025-11-21 | 瑞士商諾華公司 | Cd19 結合分子及其用途 |
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| KR20230024967A (ko) | 2020-06-11 | 2023-02-21 | 노파르티스 아게 | Zbtb32 억제제 및 이의 용도 |
| WO2021260528A1 (en) | 2020-06-23 | 2021-12-30 | Novartis Ag | Dosing regimen comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives |
| JP7819176B2 (ja) | 2020-08-03 | 2026-02-24 | ノバルティス アーゲー | ヘテロアリール置換３－（１－オキソイソインドリン－２－イル）ピペリジン－２，６－ジオン誘導体及びその使用 |
| MX2023005609A (es) | 2020-11-13 | 2023-05-29 | Novartis Ag | Terapias de combinacion con celulas que expresan receptores quimericos para el antigeno (car). |
| US12377144B2 (en) | 2021-03-03 | 2025-08-05 | Dragonfly Therapeutics, Inc. | Methods of treating cancer using multi-specific binding proteins that bind NKG2D, CD16 and a tumor-associated antigen |
| TW202304979A (zh) | 2021-04-07 | 2023-02-01 | 瑞士商諾華公司 | 抗ＴＧＦβ抗體及其他治療劑用於治療增殖性疾病之用途 |
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| US20240216432A1 (en) * | 2021-08-16 | 2024-07-04 | Hemogenyx Pharmaceuticals Llc | Anti-flt3 antibodies, cars, car t cells and methods of use |
| WO2023214325A1 (en) | 2022-05-05 | 2023-11-09 | Novartis Ag | Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors |
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| WO2024206669A2 (en) * | 2023-03-29 | 2024-10-03 | Virtuoso Binco, Inc. | Antibodies for targeting cd47 and b7h3 and methods of use thereof |
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-
2010
- 2010-12-23 JP JP2012545347A patent/JP5944831B2/ja active Active
- 2010-12-23 CA CA2785178A patent/CA2785178C/en active Active
- 2010-12-23 CN CN201080064659.3A patent/CN102770453B/zh active Active
- 2010-12-23 WO PCT/EP2010/070659 patent/WO2011076922A1/en not_active Ceased
- 2010-12-23 EA EA201290370A patent/EA027502B1/ru unknown
- 2010-12-23 BR BR112012015740-0A patent/BR112012015740B1/pt active IP Right Grant
- 2010-12-23 DK DK10798340.5T patent/DK2516468T3/en active
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- 2010-12-23 HU HUE10798340A patent/HUE028629T2/en unknown
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- 2010-12-23 SI SI201031176A patent/SI2516468T1/sl unknown
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