ES2573642T3 - Anticuerpos anti-FLT3 y métodos de usar los mismos - Google Patents

Anticuerpos anti-FLT3 y métodos de usar los mismos Download PDF

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Publication number
ES2573642T3
ES2573642T3 ES10798340.5T ES10798340T ES2573642T3 ES 2573642 T3 ES2573642 T3 ES 2573642T3 ES 10798340 T ES10798340 T ES 10798340T ES 2573642 T3 ES2573642 T3 ES 2573642T3
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Prior art keywords
antibodies
antibody
amino acid
modifications
fcγr
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ES10798340.5T
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English (en)
Spanish (es)
Inventor
Ludger Grosse-Hovest
Hans-Jörg BÜHRING
Martin Hofmann
Steffen Aulwurm
Grundram Jung
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Synimmune GmbH
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Synimmune GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES10798340.5T 2009-12-23 2010-12-23 Anticuerpos anti-FLT3 y métodos de usar los mismos Active ES2573642T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28952909P 2009-12-23 2009-12-23
US289529P 2009-12-23
PCT/EP2010/070659 WO2011076922A1 (en) 2009-12-23 2010-12-23 Anti-flt3 antibodies and methods of using the same

Publications (1)

Publication Number Publication Date
ES2573642T3 true ES2573642T3 (es) 2016-06-09

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ES10798340.5T Active ES2573642T3 (es) 2009-12-23 2010-12-23 Anticuerpos anti-FLT3 y métodos de usar los mismos

Country Status (13)

Country Link
US (1) US9023996B2 (enExample)
EP (1) EP2516468B1 (enExample)
JP (1) JP5944831B2 (enExample)
CN (1) CN102770453B (enExample)
BR (1) BR112012015740B1 (enExample)
CA (1) CA2785178C (enExample)
DK (1) DK2516468T3 (enExample)
EA (1) EA027502B1 (enExample)
ES (1) ES2573642T3 (enExample)
HR (1) HRP20160422T1 (enExample)
HU (1) HUE028629T2 (enExample)
SI (1) SI2516468T1 (enExample)
WO (1) WO2011076922A1 (enExample)

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CA2785178A1 (en) 2011-06-30
EA201290370A1 (ru) 2013-04-30
HRP20160422T1 (hr) 2016-05-20
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US20120328612A1 (en) 2012-12-27

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