JP5944831B2 - 抗ｆｌｔ３抗体及びその使用方法 - Google Patents

抗ｆｌｔ３抗体及びその使用方法 Download PDF

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Publication number
JP5944831B2
JP5944831B2 JP2012545347A JP2012545347A JP5944831B2 JP 5944831 B2 JP5944831 B2 JP 5944831B2 JP 2012545347 A JP2012545347 A JP 2012545347A JP 2012545347 A JP2012545347 A JP 2012545347A JP 5944831 B2 JP5944831 B2 JP 5944831B2
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antibody
amino acid
acid sequence
antibodies
seq
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JP2013515472A5 (enExample
JP2013515472A (ja
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ルートガー グロセ−ホペスト
ルートガー グロセ−ホペスト
ハンス−イェルク ビューリング
ハンス−イェルク ビューリング
マルティン ホフマン
マルティン ホフマン
シュテフェン アウルヴュルム
シュテフェン アウルヴュルム
グルントラム ユング
グルントラム ユング
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Synimmune GmbH
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Synimmune GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2012545347A 2009-12-23 2010-12-23 抗ｆｌｔ３抗体及びその使用方法 Active JP5944831B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28952909P 2009-12-23 2009-12-23
US61/289,529 2009-12-23
PCT/EP2010/070659 WO2011076922A1 (en) 2009-12-23 2010-12-23 Anti-flt3 antibodies and methods of using the same

Publications (3)

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JP2013515472A JP2013515472A (ja) 2013-05-09
JP2013515472A5 JP2013515472A5 (enExample) 2014-02-06
JP5944831B2 true JP5944831B2 (ja) 2016-07-05

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US (1) US9023996B2 (enExample)
EP (1) EP2516468B1 (enExample)
JP (1) JP5944831B2 (enExample)
CN (1) CN102770453B (enExample)
BR (1) BR112012015740B1 (enExample)
CA (1) CA2785178C (enExample)
DK (1) DK2516468T3 (enExample)
EA (1) EA027502B1 (enExample)
ES (1) ES2573642T3 (enExample)
HR (1) HRP20160422T1 (enExample)
HU (1) HUE028629T2 (enExample)
SI (1) SI2516468T1 (enExample)
WO (1) WO2011076922A1 (enExample)

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CA2785178C (en) 2019-09-03
CN102770453A (zh) 2012-11-07
BR112012015740A2 (pt) 2017-04-25
JP2013515472A (ja) 2013-05-09
HRP20160422T1 (hr) 2016-05-20
WO2011076922A1 (en) 2011-06-30
EA027502B1 (ru) 2017-08-31
HUE028629T2 (en) 2016-12-28
EA201290370A1 (ru) 2013-04-30
CA2785178A1 (en) 2011-06-30
HK1172910A1 (zh) 2013-05-03
EP2516468B1 (en) 2016-03-02
BR112012015740B1 (pt) 2020-09-29
US9023996B2 (en) 2015-05-05
ES2573642T3 (es) 2016-06-09
CN102770453B (zh) 2014-10-08
EP2516468A1 (en) 2012-10-31
DK2516468T3 (en) 2016-05-23

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