MX2018008106A - Terapias con celulas inmunoefectoras de una eficacia mejorada. - Google Patents

Terapias con celulas inmunoefectoras de una eficacia mejorada.

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Publication number
MX2018008106A
MX2018008106A MX2018008106A MX2018008106A MX2018008106A MX 2018008106 A MX2018008106 A MX 2018008106A MX 2018008106 A MX2018008106 A MX 2018008106A MX 2018008106 A MX2018008106 A MX 2018008106A MX 2018008106 A MX2018008106 A MX 2018008106A
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Mexico
Prior art keywords
immune effector
effector cell
cell therapies
enhanced efficacy
cells
Prior art date
Application number
MX2018008106A
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English (en)
Inventor
Liu Lei
Motz Gregory
John Mavrakias Konstantinos
Liu Jinbiao
Zheng Qiangang
Xun Guoliang
Xiao Qitao
Original Assignee
Novartis Ag
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Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2018008106A publication Critical patent/MX2018008106A/es

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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464411—Immunoglobulin superfamily
    • A61K39/464412—CD19 or B4
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    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464416—Receptors for cytokines
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2815—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • A61K2239/27—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by targeting or presenting multiple antigens
    • A61K2239/28—Expressing multiple CARs, TCRs or antigens
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Abstract

Se proporciona el uso de inhibidores de LSD1 en relación con el uso y la elaboración de células inmunoefectoras (por ejemplo, células T, células NK). por ejemplo, que se diseñan para expresar un receptor de antígeno quimérico (CAR), con el fin de tratar a un sujeto que tenga una enfermedad, por ejemplo, una enfermedad asociada con la expresión de un antígeno de tumores.
MX2018008106A 2015-12-30 2016-12-30 Terapias con celulas inmunoefectoras de una eficacia mejorada. MX2018008106A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2015099882 2015-12-30
PCT/CN2016/113612 WO2017114497A1 (en) 2015-12-30 2016-12-30 Immune effector cell therapies with enhanced efficacy

Publications (1)

Publication Number Publication Date
MX2018008106A true MX2018008106A (es) 2019-03-14

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MX2018008106A MX2018008106A (es) 2015-12-30 2016-12-30 Terapias con celulas inmunoefectoras de una eficacia mejorada.

Country Status (14)

Country Link
US (1) US20190000880A1 (es)
EP (2) EP4219689A3 (es)
JP (1) JP2019500394A (es)
KR (1) KR20180099768A (es)
CN (1) CN109072195A (es)
AU (1) AU2016382512A1 (es)
BR (1) BR112018013074A2 (es)
CA (1) CA3009709A1 (es)
ES (1) ES2944597T3 (es)
IL (2) IL260269B (es)
MX (1) MX2018008106A (es)
RU (1) RU2018127657A (es)
SG (1) SG11201805451TA (es)
WO (1) WO2017114497A1 (es)

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