|
GB2148299B
(en)
|
1983-09-01 |
1988-01-06 |
Hybritech Inc |
Antibody compositions of therapeutic agents having an extended serum half-life
|
|
US4908431A
(en)
|
1986-01-22 |
1990-03-13 |
Temple University-Of The Commonwealth System Of Higher Education |
Monoclonal antibodies to human kininogen and methods of preparing same
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
WO1989006692A1
(en)
|
1988-01-12 |
1989-07-27 |
Genentech, Inc. |
Method of treating tumor cells by inhibiting growth factor receptor function
|
|
US5846534A
(en)
|
1988-02-12 |
1998-12-08 |
British Technology Group Limited |
Antibodies to the antigen campath-1
|
|
AU4128089A
(en)
|
1988-09-15 |
1990-03-22 |
Rorer International (Overseas) Inc. |
Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same
|
|
WO1990005144A1
(en)
|
1988-11-11 |
1990-05-17 |
Medical Research Council |
Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5859205A
(en)
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
|
US5976531A
(en)
|
1990-04-19 |
1999-11-02 |
The Dow Chemical Company |
Composite antibodies of human subgroup IV light chain capable of binding to tag-72
|
|
GB9022543D0
(en)
|
1990-10-17 |
1990-11-28 |
Wellcome Found |
Antibody production
|
|
US5650150A
(en)
|
1990-11-09 |
1997-07-22 |
Gillies; Stephen D. |
Recombinant antibody cytokine fusion proteins
|
|
CZ283717B6
(cs)
|
1991-03-06 |
1998-06-17 |
MERCK Patent Gesellschaft mit beschränkter Haftung |
Chimérická monoklonální protilátka, expresní vektory a farmaceutický prostředek
|
|
JP3370324B2
(ja)
|
1991-04-25 |
2003-01-27 |
中外製薬株式会社 |
ヒトインターロイキン−６受容体に対する再構成ヒト抗体
|
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
ES2136092T3
(es)
|
1991-09-23 |
1999-11-16 |
Medical Res Council |
Procedimientos para la produccion de anticuerpos humanizados.
|
|
US6042828A
(en)
|
1992-09-07 |
2000-03-28 |
Kyowa Hakko Kogyo Co., Ltd. |
Humanized antibodies to ganglioside GM2
|
|
EP0627932B1
(en)
|
1992-11-04 |
2002-05-08 |
City Of Hope |
Antibody construct
|
|
US5441734A
(en)
|
1993-02-25 |
1995-08-15 |
Schering Corporation |
Metal-interferon-alpha crystals
|
|
US5840299A
(en)
|
1994-01-25 |
1998-11-24 |
Athena Neurosciences, Inc. |
Humanized antibodies against leukocyte adhesion molecule VLA-4
|
|
CA2163012C
(en)
|
1994-03-17 |
2009-12-08 |
Catherine A. Kettleborough |
Anti-egfr single-chain fvs and anti-egfr antibodies
|
|
ES2167391T3
(es)
|
1994-09-16 |
2002-05-16 |
Merck Patent Gmbh |
Inmunoconjugados ii.
|
|
US20020164788A1
(en)
|
1994-12-02 |
2002-11-07 |
The Wellcome Foundation Limited |
Humanized antibodies to CD38
|
|
EP2258726A1
(en)
|
1995-06-14 |
2010-12-08 |
The Regents of the University of California |
High affinity human antibodies to c-erbB-2
|
|
DE69621940T2
(de)
|
1995-08-18 |
2003-01-16 |
Morphosys Ag |
Protein-/(poly)peptidbibliotheken
|
|
US5723125A
(en)
|
1995-12-28 |
1998-03-03 |
Tanox Biosystems, Inc. |
Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
|
|
IL126772A0
(en)
|
1996-05-04 |
1999-08-17 |
Zeneca Ltd |
Monoclonal antibody of cea conjugates comprising said antibody and their therapeutic use in an adept system
|
|
US6417337B1
(en)
|
1996-10-31 |
2002-07-09 |
The Dow Chemical Company |
High affinity humanized anti-CEA monoclonal antibodies
|
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
US6872568B1
(en)
|
1997-03-17 |
2005-03-29 |
Human Genome Sciences, Inc. |
Death domain containing receptor 5 antibodies
|
|
GB9709421D0
(en)
|
1997-05-10 |
1997-07-02 |
Zeneca Ltd |
Chemical compounds
|
|
EP1881005B1
(en)
|
1997-07-14 |
2013-04-03 |
Bolder Biotechnology, Inc. |
Derivatives of G-CSF and related proteins
|
|
AUPP221098A0
(en)
|
1998-03-06 |
1998-04-02 |
Diatech Pty Ltd |
V-like domain binding molecules
|
|
AU3657899A
(en)
|
1998-04-20 |
1999-11-08 |
James E. Bailey |
Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
|
|
AU766190B2
(en)
|
1998-10-16 |
2003-10-09 |
Biogen Idec Ma Inc. |
Interferon-beta fusion proteins and uses
|
|
JP2002543760A
(ja)
|
1998-12-09 |
2002-12-24 |
達治 関 |
ヒト型糖鎖をもつ糖タンパク質の生産方法
|
|
US7223397B1
(en)
|
1999-01-07 |
2007-05-29 |
Research Development Foundation |
Potentiation of anti-CD38-Immunotoxin cytotoxicity
|
|
NZ539776A
(en)
|
1999-01-15 |
2006-12-22 |
Genentech Inc |
Polypeptide variants with altered effector function
|
|
JP4778617B2
(ja)
|
1999-03-12 |
2011-09-21 |
ジョージタウン ユニバーシティ |
マトリプターゼ、セリンプロテアーゼおよびその応用
|
|
US6946129B1
(en)
|
1999-06-08 |
2005-09-20 |
Seattle Genetics, Inc. |
Recombinant anti-CD40 antibody and uses thereof
|
|
CN1406249B
(zh)
|
2000-02-11 |
2010-06-16 |
默克专利股份有限公司 |
增加基于抗体的融合蛋白的循环半衰期
|
|
US7063845B2
(en)
|
2000-04-28 |
2006-06-20 |
Gemini Science, Inc. |
Human anti-CD40 antibodies
|
|
US7521047B2
(en)
|
2000-05-12 |
2009-04-21 |
Gpc Biotech Ag |
Human polypeptides causing or leading to the killing of cells including lymphoid tumor cells
|
|
AU6541801A
(en)
|
2000-06-22 |
2002-01-02 |
Idec Pharma Corp |
Bispecific fusion protein and method of use for enhancing effector cell killing of target cells
|
|
CA2412701A1
(en)
|
2000-06-28 |
2002-01-03 |
Glycofi, Inc. |
Methods for producing modified glycoproteins
|
|
EP1174440A1
(en)
|
2000-07-19 |
2002-01-23 |
U-BISys B.V. |
A selectively-expressed epitope on the human CD38 molecule detected by a phage display library-derived human scFv antibody fragment
|
|
CA2431600C
(en)
|
2000-12-12 |
2012-04-17 |
Medimmune, Inc. |
Molecules with extended half-lives, compositions and uses thereof
|
|
EP1399483B1
(en)
|
2001-01-05 |
2010-04-14 |
Pfizer Inc. |
Antibodies to insulin-like growth factor i receptor
|
|
FR2823764B1
(fr)
|
2001-04-24 |
2003-12-12 |
Genodyssee |
Nouveaux polynucleotides et polypeptides du gene ifn alpha-17
|
|
US20020193569A1
(en)
|
2001-06-04 |
2002-12-19 |
Idec Pharmaceuticals Corporation |
Bispecific fusion protein and method of use for enhancing effector cell killing of target cells
|
|
CA2451680C
(en)
|
2001-07-03 |
2011-04-19 |
Genentech, Inc. |
Human dr4 antibodies and uses thereof
|
|
CN1671416B
(zh)
|
2001-07-12 |
2013-01-02 |
杰斐逊·富特 |
超人源化抗体
|
|
AR035119A1
(es)
|
2001-08-16 |
2004-04-14 |
Lilly Co Eli |
Anticuerpos humanos antagonistas anti-htnfsf13b
|
|
AR039067A1
(es)
|
2001-11-09 |
2005-02-09 |
Pfizer Prod Inc |
Anticuerpos para cd40
|
|
KR100668538B1
(ko)
|
2002-01-09 |
2007-01-16 |
메다렉스, 인코포레이티드 |
Ｃｄ３０에 대한 인간 모노클로날 항체
|
|
WO2003074567A2
(en)
|
2002-03-01 |
2003-09-12 |
Immunomedics, Inc. |
Internalizing anti-cd74 antibodies and methods of use
|
|
US7317091B2
(en)
|
2002-03-01 |
2008-01-08 |
Xencor, Inc. |
Optimized Fc variants
|
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
US7332585B2
(en)
|
2002-04-05 |
2008-02-19 |
The Regents Of The California University |
Bispecific single chain Fv antibody molecules and methods of use thereof
|
|
US7332580B2
(en)
|
2002-04-05 |
2008-02-19 |
The Regents Of The University Of California |
Bispecific single chain Fv antibody molecules and methods of use thereof
|
|
US7202346B2
(en)
|
2002-07-03 |
2007-04-10 |
Immunogen Inc. |
Antibodies to non-shed Muc1 and Muc16, and uses thereof
|
|
EP1539950A1
(en)
|
2002-09-09 |
2005-06-15 |
Nautilus Biotech |
Rational directed protein evolution using two-dimensional rational mutagenesis scanning
|
|
AU2003263552A1
(en)
|
2002-09-09 |
2004-03-29 |
Nautilus Biotech |
Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
|
|
US7217797B2
(en)
|
2002-10-15 |
2007-05-15 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
MXPA05008704A
(es)
|
2003-02-18 |
2005-10-05 |
Merck Patent Gmbh |
Proteinas de fusion de muteinas de interferon alfa con propiedades mejoradas.
|
|
US7709610B2
(en)
|
2003-05-08 |
2010-05-04 |
Facet Biotech Corporation |
Therapeutic use of anti-CS1 antibodies
|
|
PL1684869T3
(pl)
|
2003-11-04 |
2011-12-30 |
Novartis Vaccines & Diagnostics Inc |
Sposoby leczenia nowotworów wywodzących się z limfocytów B
|
|
SI2511297T1
(sl)
|
2004-02-06 |
2015-07-31 |
Morphosys Ag |
Proti -CD38 humana protitelesa in njihova uporaba
|
|
BRPI0507489A
(pt)
|
2004-02-06 |
2007-07-10 |
Morphosys Ag |
anticorpos humanos de anti-cd38 e para os seus usos
|
|
US8034352B2
(en)
|
2005-04-06 |
2011-10-11 |
Ibc Pharmaceuticals, Inc. |
Tetrameric cytokines with improved biological activity
|
|
WO2005086875A2
(en)
|
2004-03-11 |
2005-09-22 |
City Of Hope |
A humanized anti-cea t84.66 antibody and uses thereof
|
|
US7670595B2
(en)
|
2004-06-28 |
2010-03-02 |
Merck Patent Gmbh |
Fc-interferon-beta fusion proteins
|
|
AU2005259221B2
(en)
|
2004-07-01 |
2011-02-10 |
Innate Pharma |
Antibodies binding to receptors KIR2DL1, -2, 3 but not KIR2DS4 and their therapeutic use
|
|
WO2006044643A2
(en)
|
2004-10-15 |
2006-04-27 |
Seattle Genetics, Inc. |
Anti-cd70 antibody and its use for the treatment and prevention of cancer and immune disorders
|
|
IL316252A
(en)
*
|
2005-03-23 |
2024-12-01 |
Genmab As |
Antibodies against cd38 for treatment of multiple myeloma
|
|
AR053489A1
(es)
|
2005-05-24 |
2007-05-09 |
Morphosys Ag |
Generacion perfilado de anticuerpos terapeuticos totalmente derivados de hucal gold humanos especificos para cd38 humano
|
|
MX2007014889A
(es)
|
2005-05-26 |
2008-02-19 |
Schering Corp |
Fusion de interferon-inmunoglobulina g.
|
|
CN101304758B
(zh)
|
2005-06-29 |
2013-08-21 |
维兹曼科学研究所耶达研究与发展有限公司 |
重组干扰素α2（IFNα2）突变体
|
|
HRP20160875T1
(hr)
|
2005-07-18 |
2016-09-23 |
Amgen Inc. |
Humana anti-b7rp1 neutralizirajuća antitijela
|
|
EA016186B1
(ru)
|
2005-09-26 |
2012-03-30 |
Медарекс, Инк. |
Человеческие моноклональные антитела к cd70 и их применение
|
|
US20070190068A1
(en)
|
2005-10-10 |
2007-08-16 |
Richard Hart |
uPAR-binding molecule-drug conjugates and uses thereof
|
|
SG10201400973XA
(en)
|
2005-10-12 |
2014-08-28 |
Morphosys Ag |
Generation and profiling of fully human hucal gold-derived therapeutic antibodies specific for human cd38
|
|
EP1954720A1
(en)
|
2005-10-31 |
2008-08-13 |
The Government of the United States of America, as represented by the Secretary of Health and Human Services, National Institutes of Health |
Antibodies and immunotoxins that target human glycoprotein nmb
|
|
GB0525214D0
(en)
|
2005-12-12 |
2006-01-18 |
Bioinvent Int Ab |
Biological materials and uses thereof
|
|
CN101045156B
(zh)
|
2006-03-29 |
2012-05-02 |
刘宏利 |
特异靶向性药物及其用途
|
|
EP1878747A1
(en)
|
2006-07-11 |
2008-01-16 |
greenovation Biotech GmbH |
Glyco-engineered antibodies
|
|
FR2905375A1
(fr)
|
2006-08-29 |
2008-03-07 |
Biomethodes Sa |
Variants ameliores de l'interferon alpha humain
|
|
CA2660795C
(en)
|
2006-09-18 |
2014-11-18 |
Xencor, Inc. |
Optimized antibodies that target hm1.24
|
|
EP3753576A1
(en)
|
2006-09-26 |
2020-12-23 |
Genmab A/S |
Combination treatment of cd38-expressing tumors
|
|
EP1914242A1
(en)
|
2006-10-19 |
2008-04-23 |
Sanofi-Aventis |
Novel anti-CD38 antibodies for the treatment of cancer
|
|
DE102007001370A1
(de)
|
2007-01-09 |
2008-07-10 |
Curevac Gmbh |
RNA-kodierte Antikörper
|
|
US11535673B2
(en)
|
2007-04-05 |
2022-12-27 |
President and Fellows of Harvard CoHege |
Chimeric activators: quantitatively designed protein therapeutics and uses thereof
|
|
CN101687037B
(zh)
|
2007-05-08 |
2013-07-10 |
健泰科生物技术公司 |
半胱氨酸改造的抗muc16抗体和抗体药物偶联物
|
|
WO2008145139A1
(en)
|
2007-05-31 |
2008-12-04 |
Genmab A/S |
Fusion or linked proteins with extended half life
|
|
CA2695382A1
(en)
|
2007-08-01 |
2009-02-05 |
The Government Of The United States Of America, As Represented By The Se Cretary, Department Of Health Of Human Services, National Institutes Of |
A fold-back diabody diphtheria toxin immunotoxin and methods of use
|
|
US20090076249A1
(en)
|
2007-09-19 |
2009-03-19 |
Michel De Weers |
Antibodies against CD38 for treatment of multiple myeloma
|
|
EP2853267B1
(en)
|
2007-09-21 |
2016-12-07 |
The Regents of the University of California |
Targeted interferon demonstrates potent apoptotic and anti-tumor activities
|
|
CA2708291A1
(en)
|
2007-12-10 |
2009-06-18 |
National Research Council Of Canada |
Production of recombinant interferon proteins
|
|
US8092804B2
(en)
|
2007-12-21 |
2012-01-10 |
Medimmune Limited |
Binding members for interleukin-4 receptor alpha (IL-4Rα)-173
|
|
DK2238168T3
(da)
|
2007-12-26 |
2014-08-25 |
Biotest Ag |
Midler, der er målrettet mod cd138 og anvendelser deraf
|
|
US8187601B2
(en)
|
2008-07-01 |
2012-05-29 |
Aveo Pharmaceuticals, Inc. |
Fibroblast growth factor receptor 3 (FGFR3) binding proteins
|
|
BRPI1009460A2
(pt)
|
2009-03-16 |
2016-03-01 |
Cephalon Australia Pty Ltd |
domínio de ligação do anticorpo, anticorpo, uso de um domínio de ligação ou anticorpo, método para detectar a presença de células cancerígenas em uma amostra.
|
|
PT2580243T
(pt)
|
2010-06-09 |
2020-01-22 |
Genmab As |
Anticorpos contra cd38 humana
|
|
US8909257B2
(en)
|
2010-06-19 |
2014-12-09 |
Qualcomm Incorporated |
Positioning protocol conveyance
|
|
LT2621531T
(lt)
*
|
2010-09-27 |
2017-04-10 |
Morphosys Ag |
Anti-cd38 antikūnas ir lenalidomidas arba bortezomibas, skirti išsėtinės mielomos ir nhl (nehodžino limfoma) gydymui
|
|
US9505826B2
(en)
|
2010-12-22 |
2016-11-29 |
Teva Pharmaceuticals Australia Pty Ltd |
Modified antibody with improved half-life
|
|
JOP20210044A1
(ar)
|
2010-12-30 |
2017-06-16 |
Takeda Pharmaceuticals Co |
الأجسام المضادة لـ cd38
|
|
EA034989B1
(ru)
|
2011-10-28 |
2020-04-15 |
Тева Фармасьютикал Австралия Пти Лтд |
Полипептидная конструкция для применения при лечении рака, включающая аттенуированный альфа-интерферон
|
|
WO2013107791A1
(en)
|
2012-01-20 |
2013-07-25 |
Vib Vzw |
Targeted mutant alpha-helical bundle cytokines
|
|
WO2013134138A1
(en)
|
2012-03-03 |
2013-09-12 |
Immungene, Inc. |
Engineered antibody-interferon mutant fusion molecules
|
|
WO2014028502A1
(en)
|
2012-08-13 |
2014-02-20 |
ImmunGene Inc. |
Engineered antibody-interferon fusion molecules for treatment of autoimmune diseases
|
|
EP2948427A2
(de)
|
2013-01-25 |
2015-12-02 |
Covestro Deutschland AG |
Sicherheitselement mit volumenhologramm und druckmerkmal
|
|
US11117975B2
(en)
|
2013-04-29 |
2021-09-14 |
Teva Pharmaceuticals Australia Pty Ltd |
Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B
|
|
DK3677591T5
(da)
*
|
2013-04-29 |
2024-08-26 |
Teva Pharmaceuticals Australia Pty Ltd |
Anti-CD38 antistoffer og fusioner til svækket interferon alpha-2b
|
|
UA119352C2
(uk)
|
2014-05-01 |
2019-06-10 |
Тева Фармасьютикалз Острейліа Пті Лтд |
Комбінація леналідоміду або помалідоміду і конструкції анти-cd38 антитіло-атенуйований інтерферон альфа-2b та спосіб лікування суб'єкта, який має cd38-експресуючу пухлину
|
|
EA037749B1
(ru)
*
|
2014-10-29 |
2021-05-18 |
Тева Фармасьютикалз Острэйлиа Пти Лтд |
ВАРИАНТЫ ИНТЕРФЕРОНА 2b
|