JP2017515815A - レナリドミド及びポリペプチド構築物の組合せ、及びその使用 - Google Patents
レナリドミド及びポリペプチド構築物の組合せ、及びその使用 Download PDFInfo
- Publication number
- JP2017515815A JP2017515815A JP2016565473A JP2016565473A JP2017515815A JP 2017515815 A JP2017515815 A JP 2017515815A JP 2016565473 A JP2016565473 A JP 2016565473A JP 2016565473 A JP2016565473 A JP 2016565473A JP 2017515815 A JP2017515815 A JP 2017515815A
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- amino acid
- lenalidomide
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6867—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of a blood cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
本出願は、その全体が全ての目的に関して参照によって本明細書に組み込まれている、2014年5月1日に提出された米国仮出願第61/986,913号に対する優先権を主張する。
本出願は、284,000バイトのサイズで2015年5月1日に作成された、テキストファイルSEQ_LST_Lenalidomide_ST25.TXTとして電子的に提出された配列表を含む。配列表は、参照によって本明細書に組み込まれている。
腫、横紋筋肉腫、ロトムンド・トムソン症候群、唾液腺がん、肉腫、神経鞘腫、セザリー症候群、皮膚がん、小細胞肺がん(SCLC)、小腸がん、軟部組織肉腫、脊髄腫瘍、扁平上皮癌(皮膚)、胃がん、滑膜肉腫、精巣がん、胸腺がん、甲状腺がん、移行細胞がん(膀胱)、移行細胞がん(腎盂/尿管)、絨毛性がん、尿道がん、尿路系がん、ウロプラキン、子宮肉腫、子宮がん、膣がん、外陰がん、ワルデンシュトレームマクログロブリン血症及びウィルムス腫瘍のレナリドミド耐性型を含むが、これらに限定されない。ある実施形態では、腫瘍は、多発性骨髄腫又は非ホジキンリンパ腫の群から選択される。
多発性骨髄腫の治療における併用療法としての抗CD38抗体-減弱化インターフェロンアルファ-2b構築物及びレナリドミド若しくはポマリドミド、又は抗CD38抗体-減弱化インターフェロンアルファ-2b構築物の組成物及びレナリドミド若しくはポマリドミドの組成物の使用も特色とする。本開示は、前多発性骨髄腫の治療における併用療法としての抗CD38抗体-減弱化インターフェロンアルファ-2b構築物及びレナリドミド若しくはポマリドミド、又は抗CD38抗体-減弱化インターフェロンアルファ-2b構築物の組成物及びレナリドミド若しくはポマリドミドの組成物の使用も特色とする。本開示は、急性リンパ球性白血病、ワルデンシュトレームマクログロブリン血症の治療における併用療法としての抗CD38抗体-減弱化インターフェロンアルファ-2b構築物及びレナリドミド若しくはポマリドミド、又は抗CD38抗体-減弱化インターフェロンアルファ-2b構築物の組成物及びレナリドミド若しくはポマリドミドの組成物の使用も特色とする。
これらの実験では、8〜12週齢雌CB.17重症複合免疫不全(SCID)マウスに1000万のNCI-H929多発性骨髄腫細胞を含有する50%マトリゲル(登録商標)マトリックス0.2mlを側腹部に皮下移植した。腫瘍が200〜300mm3の平均サイズに達したとき、マウスを種々の群に対マッチさせ、次いで、ビヒクル(PBS)、0.5mg/kgでの遊離の非減弱化インターフェロンアルファ(IFN-アルファ)、最適以下の用量の抗CD38抗体-IFNアルファ-2b-145D構築物(2.5mg/kg、0.5mg/kg IFNとのモル当量;腹腔内、隔週、以前のin vivo有効性研究によって決定された)、アイソタイプ-マッチド抗体-IFNアルファ-2b-145D構築物(抗CD38特異性を有さない、抗CD38抗体にマッチしたアイソタイプ)、レナリドミド単独(2.5mg/kg)、遊離の非減弱化インターフェロンアルファ及びレナリドミドの組合せ、レナリドミド及び最適以下の用量の抗CD38抗体-IFNアルファ-2b-145D構築物の組合せ、又はアイソタイプ対照抗体-IFNアルファ-2b-145D構築物及びレナリドミドの組合せで処置した。投与した抗CD38抗体-減弱化IFNアルファ-2b構築物の量を、動物に投与した0.5mg/kgの遊離のインターフェロンのIFN-アルファモル当量に基準化した。これらの実験の結果を図1及び図2に示す。研究が完了する前に腫瘍が2000mm3を超える体積に増殖した場合、動物を殺した。
本実験では、8〜12週齢雌CB.17重症複合免疫不全(SCID)マウスに50%マトリゲル(登録商標)中の1×107 H929多発性骨髄腫腫瘍細胞を側腹部において皮下移植した。腫瘍体積を隔週でノギスによって測定した。腫瘍が170〜350mm3の平均サイズに達したとき、マウスをランダム化し、処置を開始した。研究が第60日に完了する前に腫瘍が2000mm3を超える体積に増殖した場合、動物を殺した。
これらの実験を、雌CB17 SCIDマウスにおけるH929ヒト多発性骨髄腫異種移植片モデルにおける減弱化インターフェロン-アルファ2bに融合した抗CD38抗体の非治癒的投与レジメン及びポマリドミドの非治癒的投与レジメンの組合せの有効性を決定するために行った。レナリドミドのように、ポマリドミドは、多発性骨髄腫に対する増加した効力及び低下した毒性を有するサリドマイドの誘導体及び類似体である。
Claims (41)
- B細胞リンパ腫、多発性骨髄腫、初期多発性骨髄腫、前多発性骨髄腫、ワルデンシュトレームマクログロブリン血症、非ホジキンリンパ腫、慢性骨髄性白血病、慢性リンパ球性白血病又は急性リンパ球性白血病のうちの1つの治療における使用のためのレナリドミド又はポマリドミド及び抗CD38抗体-減弱化インターフェロンアルファ-2b構築物の組合せ。
- B細胞リンパ腫の治療における使用のための、請求項1に記載の組合せ。
- 多発性骨髄腫の治療における使用のための、請求項1に記載の組合せ。
- 非ホジキンリンパ腫の治療における使用のための、請求項1に記載の組合せ。
- 慢性骨髄性白血病の治療における使用のための、請求項1に記載の組合せ。
- 慢性リンパ球性白血病の治療における使用のための、請求項1に記載の組合せ。
- 急性リンパ球性白血病の治療における使用のための、請求項1に記載の組合せ。
- 抗CD38抗体が配列番号18のアミノ酸配列を含む重鎖可変領域及び配列番号22のアミノ酸配列を含む軽鎖可変領域を含む、請求項1から7のいずれか一項に記載の組合せ。
- 抗CD38抗体が配列番号27のアミノ酸配列を含む重鎖可変領域及び配列番号29のアミノ酸配列を含む軽鎖可変領域を含む、請求項1から8のいずれか一項に記載の組合せ。
- 抗CD38抗体がヒトIgG4定常領域を含む、請求項1から9のいずれか一項に記載の組合せ。
- ヒトIgG4定常領域がEUナンバリングシステムによる位置228のプロリンを含む、請求項10に記載の組合せ。
- ヒトIgG4定常領域がEUナンバリングシステムによる定常領域の位置252のチロシン、位置254のトレオニン、及び位置256のグルタミン酸を更に含む、請求項11に記載の組合せ。
- 抗CD38抗体がヒトIgG1定常領域を含む、請求項1から9のいずれか一項に記載の組合せ。
- ヒトIgG1定常領域がEUナンバリングシステムによる定常領域の位置252のチロシン、位置254のトレオニン、及び位置256のグルタミン酸を含む、請求項13に記載の組合せ。
- B細胞リンパ腫、多発性骨髄腫、初期多発性骨髄腫、前多発性骨髄腫、ワルデンシュトレームマクログロブリン血症、非ホジキンリンパ腫、慢性骨髄性白血病、慢性リンパ球性白血病又は急性リンパ球性白血病のうちの1つの治療における使用のためのレナリドミド及び抗CD38抗体-減弱化インターフェロンアルファ-2b構築物を含む、請求項1から14のいずれか一項に記載の組合せ。
- B細胞リンパ腫、多発性骨髄腫、初期多発性骨髄腫、前多発性骨髄腫、ワルデンシュトレームマクログロブリン血症、非ホジキンリンパ腫、慢性骨髄性白血病、慢性リンパ球性白血病又は急性リンパ球性白血病のうちの1つの治療における使用のためのポマリドミド及び抗CD38抗体-減弱化インターフェロンアルファ-2b構築物を含む、請求項1から14のいずれか一項に記載の組合せ。
- 減弱化インターフェロンアルファ-2bが配列番号3、配列番号5、配列番号6、配列番号7、配列番号212、又は配列番号213のアミノ酸配列を有する、請求項1から16のいずれか一項に記載の組合せ。
- 減弱化インターフェロンアルファ-2bが配列番号212又は配列番号213のアミノ酸配列を有する、請求項1から17のいずれか一項に記載の組合せ。
- 減弱化インターフェロンアルファ-2bが配列番号212のアミノ酸配列を有する、請求項1から18のいずれか一項に記載の組合せ。
- 抗CD38抗体-減弱化インターフェロンアルファ-2b構築物が配列番号216のアミノ酸配列を含み、抗CD38抗体が配列番号29のアミノ酸配列を含む軽鎖可変領域を含む、請求項1に記載の組合せ。
- 腫瘍を有する対象に腫瘍を治療するのに有効な量でレナリドミド又はポマリドミド及び抗CD38抗体-減弱化インターフェロンアルファ-2b構築物を投与する工程を含む、腫瘍を治療するための方法。
- 抗CD38抗体が配列番号18のアミノ酸配列を含む重鎖可変領域及び配列番号22のアミノ酸配列を含む軽鎖可変領域を含む、請求項21に記載の方法。
- 抗CD38抗体が配列番号27のアミノ酸配列を含む重鎖可変領域及び配列番号29のアミノ酸配列を含む軽鎖可変領域を含む、請求項21又は22に記載の方法。
- 抗CD38抗体がヒトIgG4定常領域を含む、請求項21から23のいずれか一項に記載の方法。
- ヒトIgG4定常領域がEUナンバリングシステムによる位置228のプロリンを含む、請求項24に記載の方法。
- ヒトIgG4定常領域がEUナンバリングシステムによる定常領域の位置252のチロシン、位置254のトレオニン、及び位置256のグルタミン酸を更に含む、請求項25に記載の方法。
- 抗CD38抗体がヒトIgG1定常領域を含む、請求項21から23のいずれか一項に記載の方法。
- ヒトIgG1定常領域がEUナンバリングシステムによる定常領域の位置252のチロシン、位置254のトレオニン、及び位置256のグルタミン酸を含む、請求項27に記載の方法。
- 減弱化インターフェロンアルファ-2bが配列番号3、配列番号5、配列番号6、配列番号7、配列番号212、又は配列番号213のアミノ酸配列を含む、請求項21から28のいずれか一項に記載の方法。
- 減弱化インターフェロンアルファ-2bが配列番号212又は配列番号213のアミノ酸配列を含む、請求項21から29のいずれか一項に記載の方法。
- 減弱化インターフェロンアルファ-2bが配列番号212のアミノ酸配列を含む、請求項21から30のいずれか一項に記載の方法。
- 腫瘍がB細胞リンパ腫、多発性骨髄腫、初期多発性骨髄腫、前多発性骨髄腫、ワルデンシュトレームマクログロブリン血症、非ホジキンリンパ腫、慢性骨髄性白血病、慢性リンパ球性白血病又は急性リンパ球性白血病である、請求項21から31のいずれか一項に記載の方法。
- 腫瘍が多発性骨髄腫である、請求項21から32のいずれか一項に記載の方法。
- 腫瘍がレナリドミドに耐性である、請求項21から33のいずれか一項に記載の方法。
- 対象がヒトである、請求項21から24のいずれか一項に記載の方法。
- 方法が多発性骨髄腫を有するヒト対象に多発性骨髄腫を治療するのに有効な量でレナリドミド及び抗CD38抗体-減弱化IFNアルファ-2b構築物を投与する工程を含み、抗CD38抗体が配列番号27のアミノ酸配列を含む重鎖可変領域、配列番号29のアミノ酸配列を含む軽鎖可変領域、及びヒトIgG4定常領域を含み、減弱化インターフェロンアルファ-2bが配列番号212のアミノ酸配列を含む、請求項1に記載の方法。
- 方法が多発性骨髄腫を有するヒト対象に多発性骨髄腫を治療するのに有効な量でポマリドミド及び抗CD38抗体-減弱化IFNアルファ-2b構築物を投与する工程を含み、抗CD38抗体が配列番号27のアミノ酸配列を含む重鎖可変領域、配列番号29のアミノ酸配列を含む軽鎖可変領域、及びヒトIgG4定常領域を含み、減弱化インターフェロンアルファ-2bが配列番号212のアミノ酸配列を含む、請求項1に記載の方法。
- 抗CD38抗体-減弱化インターフェロンアルファ-2b構築物が配列番号216のアミノ酸配列を含み、抗CD38抗体が配列番号29のアミノ酸配列を含む軽鎖可変領域を含む、請求項1に記載の方法。
- 腫瘍がB細胞リンパ腫、多発性骨髄腫、初期多発性骨髄腫、前多発性骨髄腫、ワルデンシュトレームマクログロブリン血症、非ホジキンリンパ腫、慢性骨髄性白血病、慢性リンパ球性白血病又は急性リンパ球性白血病である、請求項38に記載の方法。
- 腫瘍が多発性骨髄腫である、請求項38又は39に記載の方法。
- 対象がヒトである、請求項38から40のいずれか一項に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461986913P | 2014-05-01 | 2014-05-01 | |
US61/986,913 | 2014-05-01 | ||
PCT/IB2015/001600 WO2015181641A2 (en) | 2014-05-01 | 2015-05-01 | Combination of lenalidomide and polypeptide construct, and uses thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2017515815A true JP2017515815A (ja) | 2017-06-15 |
JP2017515815A5 JP2017515815A5 (ja) | 2018-06-14 |
JP6550400B2 JP6550400B2 (ja) | 2019-07-24 |
Family
ID=54354398
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016565473A Active JP6550400B2 (ja) | 2014-05-01 | 2015-05-01 | レナリドミド及びポリペプチド構築物の組合せ、及びその使用 |
Country Status (19)
Country | Link |
---|---|
US (3) | US9636334B2 (ja) |
EP (1) | EP3137505B1 (ja) |
JP (1) | JP6550400B2 (ja) |
KR (1) | KR102412023B1 (ja) |
CN (1) | CN106536562B (ja) |
AU (1) | AU2015265624B2 (ja) |
BR (1) | BR112016025437A2 (ja) |
CA (1) | CA2945902C (ja) |
CL (1) | CL2016002733A1 (ja) |
EA (1) | EA033359B1 (ja) |
ES (1) | ES2736121T3 (ja) |
IL (1) | IL248394B (ja) |
MA (1) | MA39836A (ja) |
MX (1) | MX2016013863A (ja) |
NZ (1) | NZ725487A (ja) |
PE (1) | PE20161392A1 (ja) |
PT (1) | PT3137505T (ja) |
UA (1) | UA119352C2 (ja) |
WO (1) | WO2015181641A2 (ja) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013059885A2 (en) | 2011-10-28 | 2013-05-02 | Cephalon Australia Pty Ltd | Polypeptide constructs and uses thereof |
US11117975B2 (en) | 2013-04-29 | 2021-09-14 | Teva Pharmaceuticals Australia Pty Ltd | Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B |
EP3677591B1 (en) | 2013-04-29 | 2022-12-28 | Teva Pharmaceuticals Australia Pty Ltd | Anti-cd38 antibodies and fusions to attenuated interferon alpha-2b |
UA119352C2 (uk) | 2014-05-01 | 2019-06-10 | Тева Фармасьютикалз Острейліа Пті Лтд | Комбінація леналідоміду або помалідоміду і конструкції анти-cd38 антитіло-атенуйований інтерферон альфа-2b та спосіб лікування суб'єкта, який має cd38-експресуючу пухлину |
MX2017005481A (es) | 2014-10-29 | 2017-10-26 | Teva Pharmaceuticals Australia Pty Ltd | Variantes de interferon a2b. |
ES2877568T3 (es) | 2016-02-05 | 2021-11-17 | Orionis Biosciences Nv | Agentes de unión de Clec9A |
US11661455B2 (en) | 2016-02-05 | 2023-05-30 | Orionis Biosciences BV | Chimeric protein comprising an interferon alpha 2mutant and a PD-L1 binding moiety |
EP3544612A4 (en) * | 2016-11-23 | 2020-05-13 | Acetylon Pharmaceuticals, Inc. | PHARMACEUTICAL COMBINATIONS COMPRISING A HISTONE DEACETYLASE INHIBITOR AND A CD38 INHIBITOR AND METHODS OF USING THE SAME |
US11384154B2 (en) | 2017-02-06 | 2022-07-12 | Orionis Biosciences BV | Targeted chimeric proteins and uses thereof |
KR102618831B1 (ko) | 2017-06-21 | 2023-12-28 | 세파론 엘엘씨 | 양이온 교환 크로마토그래피 세척 완충액 |
SG10201913144TA (en) | 2017-07-11 | 2020-03-30 | Compass Therapeutics Llc | Agonist antibodies that bind human cd137 and uses thereof |
CN111328286A (zh) | 2017-08-09 | 2020-06-23 | 奥里尼斯生物科学有限公司 | Pd-1和pd-l1结合剂 |
JP7347899B2 (ja) | 2017-08-09 | 2023-09-20 | オリオンズ バイオサイエンス インコーポレイテッド | Cd8結合物質 |
WO2019035938A1 (en) | 2017-08-16 | 2019-02-21 | Elstar Therapeutics, Inc. | MULTISPECIFIC MOLECULES BINDING TO BCMA AND USES THEREOF |
WO2019089753A2 (en) | 2017-10-31 | 2019-05-09 | Compass Therapeutics Llc | Cd137 antibodies and pd-1 antagonists and uses thereof |
EP3713961A2 (en) | 2017-11-20 | 2020-09-30 | Compass Therapeutics LLC | Cd137 antibodies and tumor antigen-targeting antibodies and uses thereof |
WO2019199133A1 (ko) * | 2018-04-13 | 2019-10-17 | 주식회사 삼양바이오팜 | 레날리도마이드의 경구용 코팅 정제 조성물 |
KR102286500B1 (ko) * | 2018-04-13 | 2021-08-05 | 주식회사 삼양홀딩스 | 레날리도마이드를 포함하는 경구용 고형제제의 제조방법 |
KR102286497B1 (ko) * | 2018-04-13 | 2021-08-05 | 주식회사 삼양홀딩스 | 다양한 용량의 레날리도마이드의 경구용 정제 조성물 |
JP2021518422A (ja) * | 2018-04-13 | 2021-08-02 | サムヤン バイオファーマシューティカルズ コーポレイションSamyang Biopharmaceuticals Corporation | レナリドミドを含む医薬組成物 |
WO2019199135A1 (ko) * | 2018-04-13 | 2019-10-17 | 주식회사 삼양바이오팜 | 레날리도마이드를 포함하는 경구용 고형제제의 제조방법 |
RU2694672C1 (ru) * | 2018-04-27 | 2019-07-16 | Открытое акционерное общество "Всероссийский научный Центр молекулярной диагностики и лечения" (ОАО ВНЦМДЛ) | Вариабельные домены лёгкой и тяжёлой цепи мышиного моноклонального антитела против интерферона альфа (IFN-α) человека, антигенсвязывающий фрагмент (Fab) против IFN-α человека, содержащий указанные домены |
WO2020250033A1 (en) | 2019-06-10 | 2020-12-17 | Takeda Pharmaceutical Company Limited | Combination therapies using cd-38 antibodies |
WO2023223100A1 (en) | 2022-05-18 | 2023-11-23 | Takeda Pharmaceutical Company Limited | Anti-cd38 fusion protein formulation |
WO2023227949A1 (en) * | 2022-05-27 | 2023-11-30 | Takeda Pharmaceutical Company Limited | Dosing of cd38-binding fusion protein |
WO2024069240A2 (en) * | 2022-09-29 | 2024-04-04 | Takeda Pharmaceutical Company Limited | Cd38-binding fusion protein combination therapy |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008533977A (ja) * | 2005-03-23 | 2008-08-28 | ゲンマブ エー/エス | 多発性骨髄腫の治療のためのcd38に対する抗体 |
WO2013059885A2 (en) * | 2011-10-28 | 2013-05-02 | Cephalon Australia Pty Ltd | Polypeptide constructs and uses thereof |
JP2013542191A (ja) * | 2010-09-27 | 2013-11-21 | モルフォシス・アー・ゲー | 多発性骨髄腫およびnhl治療用の抗cd38抗体およびレナリドミドまたはボルテゾミブ |
Family Cites Families (113)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2148299B (en) | 1983-09-01 | 1988-01-06 | Hybritech Inc | Antibody compositions of therapeutic agents having an extended serum half-life |
US4908431A (en) | 1986-01-22 | 1990-03-13 | Temple University-Of The Commonwealth System Of Higher Education | Monoclonal antibodies to human kininogen and methods of preparing same |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
JP3040121B2 (ja) | 1988-01-12 | 2000-05-08 | ジェネンテク,インコーポレイテッド | 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法 |
US5846534A (en) | 1988-02-12 | 1998-12-08 | British Technology Group Limited | Antibodies to the antigen campath-1 |
AU4128089A (en) | 1988-09-15 | 1990-03-22 | Rorer International (Overseas) Inc. | Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same |
WO1990005144A1 (en) | 1988-11-11 | 1990-05-17 | Medical Research Council | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
US5976531A (en) | 1990-04-19 | 1999-11-02 | The Dow Chemical Company | Composite antibodies of human subgroup IV light chain capable of binding to tag-72 |
GB9022543D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Antibody production |
US5650150A (en) | 1990-11-09 | 1997-07-22 | Gillies; Stephen D. | Recombinant antibody cytokine fusion proteins |
HU219537B (hu) | 1991-03-06 | 2001-05-28 | Merck Patent Gmbh. | Humanizált és kiméra monoklonális antitestek, azokat tartalmazó gyógyászati készítmények, az antitesteket kódoló szekvenciát tartalmazó expressziós vektorok, valamint eljárás az antitestek előállítására |
RU2139351C1 (ru) | 1991-04-25 | 1999-10-10 | Чугаи Сейяку Кабусики Кайся | Н- и l-цепи моноклонального антитела рм1 (монат) к рецептору il-6r человека и их v-области, модифицированная монат, его н- и l-цепи и их v-области, cdr- последовательности, днк-последовательности |
WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
US6042828A (en) | 1992-09-07 | 2000-03-28 | Kyowa Hakko Kogyo Co., Ltd. | Humanized antibodies to ganglioside GM2 |
EP0627932B1 (en) | 1992-11-04 | 2002-05-08 | City Of Hope | Antibody construct |
US5441734A (en) | 1993-02-25 | 1995-08-15 | Schering Corporation | Metal-interferon-alpha crystals |
US5840299A (en) | 1994-01-25 | 1998-11-24 | Athena Neurosciences, Inc. | Humanized antibodies against leukocyte adhesion molecule VLA-4 |
RU2170257C2 (ru) | 1994-03-17 | 2001-07-10 | Мерк Патент Гмбх | Анти-эфрр одноцепочечный fv, химерное анти-эфрр антитело и способ его получения, фармацевтическая композиция для лечения опухолей, средство для диагностики локализации или оценки роста опухоли |
DE69523857T2 (de) | 1994-09-16 | 2002-06-13 | Merck Patent Gmbh | Immunokonjugate |
US20020164788A1 (en) | 1994-12-02 | 2002-11-07 | The Wellcome Foundation Limited | Humanized antibodies to CD38 |
EP0873363B1 (en) | 1995-06-14 | 2010-10-06 | The Regents of The University of California | High affinity human antibodies to tumor antigens |
AU725609C (en) | 1995-08-18 | 2002-01-03 | Morphosys Ag | Protein/(poly)peptide libraries |
US5723125A (en) | 1995-12-28 | 1998-03-03 | Tanox Biosystems, Inc. | Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide |
NZ331978A (en) | 1996-05-04 | 2000-05-26 | Zeneca Ltd | Monoclonal antibody to CEA (carcinomembryonic antigen), conjugates comprising said antibody, and their therapeutic use in an adept system |
US6417337B1 (en) | 1996-10-31 | 2002-07-09 | The Dow Chemical Company | High affinity humanized anti-CEA monoclonal antibodies |
US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
US6872568B1 (en) | 1997-03-17 | 2005-03-29 | Human Genome Sciences, Inc. | Death domain containing receptor 5 antibodies |
GB9709421D0 (en) | 1997-05-10 | 1997-07-02 | Zeneca Ltd | Chemical compounds |
IL133974A0 (en) | 1997-07-14 | 2001-04-30 | Bolder Biotechnology Inc | Derivatives of growth hormone and related proteins |
AUPP221098A0 (en) | 1998-03-06 | 1998-04-02 | Diatech Pty Ltd | V-like domain binding molecules |
WO1999054342A1 (en) | 1998-04-20 | 1999-10-28 | Pablo Umana | Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity |
CN100480266C (zh) | 1998-10-16 | 2009-04-22 | 拜奥根Idec马萨诸塞公司 | 干扰素-β融合蛋白及用途 |
ES2558160T3 (es) | 1998-12-09 | 2016-02-02 | Phyton Holdings, Llc | Glicoproteínas que tienen glicosilación de tipo humano |
US7223397B1 (en) | 1999-01-07 | 2007-05-29 | Research Development Foundation | Potentiation of anti-CD38-Immunotoxin cytotoxicity |
PL209786B1 (pl) | 1999-01-15 | 2011-10-31 | Genentech Inc | Przeciwciało zawierające wariant regionu Fc ludzkiej IgG1, przeciwciało wiążące czynnik wzrostu śródbłonka naczyń oraz immunoadhezyna |
WO2000053232A1 (en) | 1999-03-12 | 2000-09-14 | Georgetown University | Matriptase, a serine protease and its applications |
US6946129B1 (en) | 1999-06-08 | 2005-09-20 | Seattle Genetics, Inc. | Recombinant anti-CD40 antibody and uses thereof |
JP5179689B2 (ja) | 2000-02-11 | 2013-04-10 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 抗体ベース融合タンパク質の循環系内半減期の増強 |
US7063845B2 (en) | 2000-04-28 | 2006-06-20 | Gemini Science, Inc. | Human anti-CD40 antibodies |
US7521047B2 (en) | 2000-05-12 | 2009-04-21 | Gpc Biotech Ag | Human polypeptides causing or leading to the killing of cells including lymphoid tumor cells |
AU6541801A (en) | 2000-06-22 | 2002-01-02 | Idec Pharma Corp | Bispecific fusion protein and method of use for enhancing effector cell killing of target cells |
WO2002000879A2 (en) | 2000-06-28 | 2002-01-03 | Glycofi, Inc. | Methods for producing modified glycoproteins |
EP1174440A1 (en) | 2000-07-19 | 2002-01-23 | U-BISys B.V. | A selectively-expressed epitope on the human CD38 molecule detected by a phage display library-derived human scFv antibody fragment |
EP1355919B1 (en) | 2000-12-12 | 2010-11-24 | MedImmune, LLC | Molecules with extended half-lives, compositions and uses thereof |
CN1854157B (zh) | 2001-01-05 | 2013-01-02 | 辉瑞大药厂 | 胰岛素样生长因子i受体的抗体 |
FR2823764B1 (fr) | 2001-04-24 | 2003-12-12 | Genodyssee | Nouveaux polynucleotides et polypeptides du gene ifn alpha-17 |
US20020193569A1 (en) | 2001-06-04 | 2002-12-19 | Idec Pharmaceuticals Corporation | Bispecific fusion protein and method of use for enhancing effector cell killing of target cells |
PT1409544E (pt) | 2001-07-03 | 2009-09-16 | Genentech Inc | Anticorpos de dr4 humanos e suas utilizações |
MXPA05000511A (es) | 2001-07-12 | 2005-09-30 | Jefferson Foote | Anticuepros super humanizados. |
AR035119A1 (es) | 2001-08-16 | 2004-04-14 | Lilly Co Eli | Anticuerpos humanos antagonistas anti-htnfsf13b |
AR039067A1 (es) | 2001-11-09 | 2005-02-09 | Pfizer Prod Inc | Anticuerpos para cd40 |
MXPA04006490A (es) | 2002-01-09 | 2005-06-08 | Medarex Inc | Anticuerpos monoclonales humanos contra cd30. |
CN1649902B (zh) | 2002-03-01 | 2011-04-13 | 免疫医疗公司 | 内在化抗-cd74抗体和使用方法 |
US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
US7332585B2 (en) | 2002-04-05 | 2008-02-19 | The Regents Of The California University | Bispecific single chain Fv antibody molecules and methods of use thereof |
US7332580B2 (en) | 2002-04-05 | 2008-02-19 | The Regents Of The University Of California | Bispecific single chain Fv antibody molecules and methods of use thereof |
US7202346B2 (en) | 2002-07-03 | 2007-04-10 | Immunogen Inc. | Antibodies to non-shed Muc1 and Muc16, and uses thereof |
WO2004022747A1 (en) | 2002-09-09 | 2004-03-18 | Nautilus Biotech | Rational directed protein evolution using two-dimensional rational mutagenesis scanning |
DE60332358D1 (de) | 2002-09-09 | 2010-06-10 | Hanall Pharmaceutical Co Ltd | Protease-resistente modifizierte interferon alpha polypeptide |
US7217797B2 (en) | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
WO2004074486A2 (en) | 2003-02-18 | 2004-09-02 | Merck Patent Gmbh | Fusion proteins of interferon alpha muteins with improved properties |
US7709610B2 (en) | 2003-05-08 | 2010-05-04 | Facet Biotech Corporation | Therapeutic use of anti-CS1 antibodies |
CA2544368C (en) | 2003-11-04 | 2014-04-01 | Chiron Corporation | Methods of therapy for b cell-related cancers |
RS54056B1 (en) | 2004-02-06 | 2015-10-30 | Morphosys Ag | ANTI-CD38 HUMAN ANTIBODIES AND THEIR USES |
MXPA06008700A (es) | 2004-02-06 | 2007-01-19 | Morphosys Ag | Anticuerpos anti-cd38 humanos y usos para los mismos. |
US8034352B2 (en) | 2005-04-06 | 2011-10-11 | Ibc Pharmaceuticals, Inc. | Tetrameric cytokines with improved biological activity |
US7273608B2 (en) | 2004-03-11 | 2007-09-25 | City Of Hope | Humanized anti-CEA T84.66 antibody and uses thereof |
US7670595B2 (en) | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
WO2006003179A2 (en) | 2004-07-01 | 2006-01-12 | Novo Nordisk A/S | Antibodies binding to receptors kir2dl1, -2, 3 but not kir2ds4 and their therapeutic use |
CA2583208C (en) | 2004-10-15 | 2015-08-25 | Seattle Genetics, Inc. | Anti-cd70 antibody and its use for the treatment and prevention of cancer and immune disorders |
EP2799451A1 (en) * | 2005-05-24 | 2014-11-05 | MorphoSys AG | Generation and profiling of fully human HuCAL GOLD®-derived therapeutic antibodies specific for human CD38 |
EP1899368A2 (en) | 2005-05-26 | 2008-03-19 | Schering Corporation | Interferon-igg fusion |
WO2007000769A2 (en) | 2005-06-29 | 2007-01-04 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | RECOMBINANT INTERFERON α2 (IFNα2) MUTANTS |
NO345593B1 (no) | 2005-07-18 | 2021-05-03 | Amgen Inc | Humane anti-B7RP1 nøytraliserende antistoffer |
AU2006294663B2 (en) | 2005-09-26 | 2012-03-22 | Medarex, Inc. | Human monoclonal antibodies to CD70 |
WO2007044892A2 (en) | 2005-10-10 | 2007-04-19 | American Diagnostica, Inc. | Upar-binding molecule-drug conjugates and uses thereof |
EP3284756B1 (en) | 2005-10-12 | 2021-05-05 | MorphoSys AG | Generation and profiling of fully human hucal gold-derived therapeutic antibodies specific for human cd38 |
EP1954720A1 (en) | 2005-10-31 | 2008-08-13 | The Government of the United States of America, as represented by the Secretary of Health and Human Services, National Institutes of Health | Antibodies and immunotoxins that target human glycoprotein nmb |
GB0525214D0 (en) | 2005-12-12 | 2006-01-18 | Bioinvent Int Ab | Biological materials and uses thereof |
CN101045156B (zh) | 2006-03-29 | 2012-05-02 | 刘宏利 | 特异靶向性药物及其用途 |
EP1878747A1 (en) | 2006-07-11 | 2008-01-16 | greenovation Biotech GmbH | Glyco-engineered antibodies |
FR2905375A1 (fr) | 2006-08-29 | 2008-03-07 | Biomethodes Sa | Variants ameliores de l'interferon alpha humain |
EP2064240A2 (en) | 2006-09-18 | 2009-06-03 | Xencor, Inc. | Optimized antibodies that target hm1.24 |
JP5476122B2 (ja) | 2006-09-26 | 2014-04-23 | ゲンマブ エー/エス | Cd38発現腫瘍の併用処置法 |
EP1914242A1 (en) * | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
DE102007001370A1 (de) | 2007-01-09 | 2008-07-10 | Curevac Gmbh | RNA-kodierte Antikörper |
WO2008124086A2 (en) | 2007-04-05 | 2008-10-16 | President And Fellows Of Harvard College | Chimeric activators: quantitatively designed protein therapeutics and uses thereof |
JP5290276B2 (ja) | 2007-05-08 | 2013-09-18 | ジェネンテック, インコーポレイテッド | システイン改変抗muc16抗体および抗体−薬物結合体 |
WO2008145139A1 (en) | 2007-05-31 | 2008-12-04 | Genmab A/S | Fusion or linked proteins with extended half life |
CA2695382A1 (en) | 2007-08-01 | 2009-02-05 | The Government Of The United States Of America, As Represented By The Se Cretary, Department Of Health Of Human Services, National Institutes Of | A fold-back diabody diphtheria toxin immunotoxin and methods of use |
US20090076249A1 (en) | 2007-09-19 | 2009-03-19 | Michel De Weers | Antibodies against CD38 for treatment of multiple myeloma |
MX349306B (es) | 2007-09-21 | 2017-07-19 | Univ California | Interferón de objetivo demuestra actividades potentes apoptóticas y antitumorales. |
CA2708291A1 (en) | 2007-12-10 | 2009-06-18 | National Research Council Of Canada | Production of recombinant interferon proteins |
US8092804B2 (en) | 2007-12-21 | 2012-01-10 | Medimmune Limited | Binding members for interleukin-4 receptor alpha (IL-4Rα)-173 |
EP2238168B8 (en) | 2007-12-26 | 2014-07-23 | Biotest AG | Agents targeting cd138 and uses thereof |
EP2313435A4 (en) | 2008-07-01 | 2012-08-08 | Aveo Pharmaceuticals Inc | FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) BINDING PROTEINS |
CN102395604B (zh) | 2009-03-16 | 2015-11-25 | 梯瓦制药澳大利亚私人有限公司 | 具有抗肿瘤活性的人源化抗体 |
JP6093696B2 (ja) | 2010-06-09 | 2017-03-08 | ゲンマブ エー/エス | ヒトcd38に対する抗体 |
US8909257B2 (en) | 2010-06-19 | 2014-12-09 | Qualcomm Incorporated | Positioning protocol conveyance |
WO2012083370A1 (en) | 2010-12-22 | 2012-06-28 | Cephalon Australia Pty Ltd | Modified antibody with improved half-life |
JOP20210044A1 (ar) | 2010-12-30 | 2017-06-16 | Takeda Pharmaceuticals Co | الأجسام المضادة لـ cd38 |
JP6416628B2 (ja) | 2012-01-20 | 2018-10-31 | ブイアイビー ブイゼットダブリュVib Vzw | 標的変異体αヘリックスバンドルサイトカイン |
DK2822575T3 (da) | 2012-03-03 | 2020-06-15 | Immungene Inc | Manipulerede, muterede antistof-interferon-fusionsmolekyler |
WO2014028502A1 (en) | 2012-08-13 | 2014-02-20 | ImmunGene Inc. | Engineered antibody-interferon fusion molecules for treatment of autoimmune diseases |
JP2016511712A (ja) | 2013-01-25 | 2016-04-21 | バイエル・マテリアルサイエンス・アクチェンゲゼルシャフトBayer MaterialScience AG | 体積ホログラムと印刷されたフィーチャを有するセキュリティ要素 |
US11117975B2 (en) | 2013-04-29 | 2021-09-14 | Teva Pharmaceuticals Australia Pty Ltd | Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B |
EP3677591B1 (en) * | 2013-04-29 | 2022-12-28 | Teva Pharmaceuticals Australia Pty Ltd | Anti-cd38 antibodies and fusions to attenuated interferon alpha-2b |
UA119352C2 (uk) | 2014-05-01 | 2019-06-10 | Тева Фармасьютикалз Острейліа Пті Лтд | Комбінація леналідоміду або помалідоміду і конструкції анти-cd38 антитіло-атенуйований інтерферон альфа-2b та спосіб лікування суб'єкта, який має cd38-експресуючу пухлину |
MX2017005481A (es) * | 2014-10-29 | 2017-10-26 | Teva Pharmaceuticals Australia Pty Ltd | Variantes de interferon a2b. |
-
2015
- 2015-01-05 UA UAA201612122A patent/UA119352C2/uk unknown
- 2015-05-01 ES ES15799475T patent/ES2736121T3/es active Active
- 2015-05-01 MX MX2016013863A patent/MX2016013863A/es active IP Right Grant
- 2015-05-01 CA CA2945902A patent/CA2945902C/en active Active
- 2015-05-01 EP EP15799475.7A patent/EP3137505B1/en active Active
- 2015-05-01 NZ NZ725487A patent/NZ725487A/en unknown
- 2015-05-01 JP JP2016565473A patent/JP6550400B2/ja active Active
- 2015-05-01 MA MA039836A patent/MA39836A/fr unknown
- 2015-05-01 US US14/701,628 patent/US9636334B2/en active Active
- 2015-05-01 CN CN201580021884.1A patent/CN106536562B/zh active Active
- 2015-05-01 AU AU2015265624A patent/AU2015265624B2/en active Active
- 2015-05-01 KR KR1020167030484A patent/KR102412023B1/ko active IP Right Grant
- 2015-05-01 PE PE2016002163A patent/PE20161392A1/es unknown
- 2015-05-01 WO PCT/IB2015/001600 patent/WO2015181641A2/en active Application Filing
- 2015-05-01 BR BR112016025437A patent/BR112016025437A2/pt active Search and Examination
- 2015-05-01 PT PT15799475T patent/PT3137505T/pt unknown
- 2015-05-01 EA EA201692200A patent/EA033359B1/ru not_active IP Right Cessation
-
2016
- 2016-10-19 IL IL248394A patent/IL248394B/en active IP Right Grant
- 2016-10-27 CL CL2016002733A patent/CL2016002733A1/es unknown
-
2017
- 2017-01-31 US US15/420,152 patent/US10232041B2/en active Active
-
2019
- 2019-01-31 US US16/263,611 patent/US11253591B2/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008533977A (ja) * | 2005-03-23 | 2008-08-28 | ゲンマブ エー/エス | 多発性骨髄腫の治療のためのcd38に対する抗体 |
JP2013542191A (ja) * | 2010-09-27 | 2013-11-21 | モルフォシス・アー・ゲー | 多発性骨髄腫およびnhl治療用の抗cd38抗体およびレナリドミドまたはボルテゾミブ |
WO2013059885A2 (en) * | 2011-10-28 | 2013-05-02 | Cephalon Australia Pty Ltd | Polypeptide constructs and uses thereof |
Also Published As
Publication number | Publication date |
---|---|
US20170202962A1 (en) | 2017-07-20 |
CL2016002733A1 (es) | 2017-06-23 |
CN106536562B (zh) | 2023-04-14 |
IL248394B (en) | 2020-05-31 |
PE20161392A1 (es) | 2017-01-04 |
CN106536562A (zh) | 2017-03-22 |
US20190151447A1 (en) | 2019-05-23 |
IL248394A0 (en) | 2016-11-30 |
UA119352C2 (uk) | 2019-06-10 |
WO2015181641A3 (en) | 2016-01-21 |
CA2945902C (en) | 2023-10-03 |
KR102412023B1 (ko) | 2022-06-21 |
EA201692200A1 (ru) | 2017-03-31 |
BR112016025437A2 (pt) | 2017-12-12 |
MA39836A (fr) | 2017-03-08 |
US9636334B2 (en) | 2017-05-02 |
US20150313965A1 (en) | 2015-11-05 |
AU2015265624A1 (en) | 2016-11-10 |
CA2945902A1 (en) | 2015-12-03 |
EA033359B1 (ru) | 2019-10-31 |
JP6550400B2 (ja) | 2019-07-24 |
KR20160146770A (ko) | 2016-12-21 |
MX2016013863A (es) | 2017-07-24 |
US10232041B2 (en) | 2019-03-19 |
US11253591B2 (en) | 2022-02-22 |
WO2015181641A2 (en) | 2015-12-03 |
NZ725487A (en) | 2020-05-29 |
ES2736121T3 (es) | 2019-12-26 |
AU2015265624B2 (en) | 2021-02-18 |
PT3137505T (pt) | 2019-07-17 |
EP3137505A2 (en) | 2017-03-08 |
EP3137505A4 (en) | 2017-11-29 |
EP3137505B1 (en) | 2019-04-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11253591B2 (en) | Combination of lenalidomide and polypeptide construct, and uses thereof | |
KR102507537B1 (ko) | Cd3 결합 항체 | |
CA2549652C (en) | Cd40 antibody formulation and methods | |
JP2021514379A (ja) | B7−h4抗体製剤 | |
JP2022513350A (ja) | がんの併用療法 | |
CN113939315B (zh) | 治疗黑色素瘤的联用药物组合物 | |
TW202233684A (zh) | 結合於葉酸受體α之重鏈抗體 | |
WO2024041651A1 (en) | Methods of cancer treatment using anti-pd1 antibodies in combination with anti-tim3 antibodies and anti-lag3 antibodies | |
TWI835808B (zh) | 抗pd-1抗體及其用途 | |
WO2024026374A1 (en) | Anti-cd16a antibodies and methods of use thereof | |
NZ791361B2 (en) | Engineered anti-il-2 antibodies | |
WO2024044675A1 (en) | Methods of cancer treatment using anti-pd1 antibodies in combination with anti-tim3 antibodies | |
KR20230023650A (ko) | 항-cd30 항체-약물 컨쥬게이트의 조합을 사용하여 암을 치료하는 방법 | |
AU2022320670A1 (en) | Anti-pd-1 antibody pharmaceutical composition and use thereof | |
MXPA06006153A (en) | Cd40 antibody formulation and methods |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180501 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20180501 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20190204 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190507 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20190603 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20190701 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6550400 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |