JP2013521281A5 - - Google Patents
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- JP2013521281A5 JP2013521281A5 JP2012556056A JP2012556056A JP2013521281A5 JP 2013521281 A5 JP2013521281 A5 JP 2013521281A5 JP 2012556056 A JP2012556056 A JP 2012556056A JP 2012556056 A JP2012556056 A JP 2012556056A JP 2013521281 A5 JP2013521281 A5 JP 2013521281A5
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- JP
- Japan
- Prior art keywords
- cancer
- alkyl
- compound
- haloalkyl
- integer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 206010028980 Neoplasm Diseases 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 19
- 201000011510 cancer Diseases 0.000 claims 13
- 238000000034 method Methods 0.000 claims 12
- 125000001188 haloalkyl group Chemical group 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000004103 aminoalkyl group Chemical group 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 4
- 206010033128 Ovarian cancer Diseases 0.000 claims 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 3
- 206010060862 Prostate cancer Diseases 0.000 claims 3
- 125000003282 alkyl amino group Chemical group 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 201000001441 melanoma Diseases 0.000 claims 3
- 206010027480 Metastatic malignant melanoma Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 208000021039 metastatic melanoma Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 239000004215 Carbon black (E152) Substances 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 150000001204 N-oxides Chemical class 0.000 claims 1
- -1 O-alkyl Inorganic materials 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- AAXZBPGIFMJMRG-UHFFFAOYSA-N [1-methyl-2-(4-methylphenyl)imidazol-4-yl]-(3,4,5-trimethoxyphenyl)methanone Chemical compound COC1=C(OC)C(OC)=CC(C(=O)C=2N=C(N(C)C=2)C=2C=CC(C)=CC=2)=C1 AAXZBPGIFMJMRG-UHFFFAOYSA-N 0.000 claims 1
- HRYJJMQDEVGSAQ-UHFFFAOYSA-N [2-(4-bromophenyl)-1h-imidazol-5-yl]-(3,4,5-trimethoxyphenyl)methanone Chemical compound COC1=C(OC)C(OC)=CC(C(=O)C=2N=C(NC=2)C=2C=CC(Br)=CC=2)=C1 HRYJJMQDEVGSAQ-UHFFFAOYSA-N 0.000 claims 1
- XDODKXXXAHTIRD-UHFFFAOYSA-N [2-(4-chlorophenyl)-1h-imidazol-5-yl]-(3,4,5-trimethoxyphenyl)methanone Chemical compound COC1=C(OC)C(OC)=CC(C(=O)C=2N=C(NC=2)C=2C=CC(Cl)=CC=2)=C1 XDODKXXXAHTIRD-UHFFFAOYSA-N 0.000 claims 1
- NQHVDNDKHQBFKP-UHFFFAOYSA-N [2-(4-methylphenyl)-1h-imidazol-5-yl]-(3,4,5-trimethoxyphenyl)methanone Chemical compound COC1=C(OC)C(OC)=CC(C(=O)C=2N=C(NC=2)C=2C=CC(C)=CC=2)=C1 NQHVDNDKHQBFKP-UHFFFAOYSA-N 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 201000007455 central nervous system cancer Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229930195733 hydrocarbon Natural products 0.000 claims 1
- 150000002430 hydrocarbons Chemical class 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 201000001514 prostate carcinoma Diseases 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 0 CS1*CCC1 Chemical compound CS1*CCC1 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30936010P | 2010-03-01 | 2010-03-01 | |
| US61/309,360 | 2010-03-01 | ||
| US31579010P | 2010-03-19 | 2010-03-19 | |
| US61/315,790 | 2010-03-19 | ||
| US37667510P | 2010-08-24 | 2010-08-24 | |
| US61/376,675 | 2010-08-24 | ||
| PCT/US2010/062418 WO2011109059A1 (en) | 2010-03-01 | 2010-12-29 | Compounds for treatment of cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013521281A JP2013521281A (ja) | 2013-06-10 |
| JP2013521281A5 true JP2013521281A5 (enExample) | 2014-02-20 |
| JP5879273B2 JP5879273B2 (ja) | 2016-03-08 |
Family
ID=44542481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012556056A Expired - Fee Related JP5879273B2 (ja) | 2010-03-01 | 2010-12-29 | 癌を処置するための化合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9334242B2 (enExample) |
| EP (2) | EP3064204A1 (enExample) |
| JP (1) | JP5879273B2 (enExample) |
| KR (2) | KR20120130777A (enExample) |
| CN (2) | CN104592205A (enExample) |
| AU (1) | AU2010347233B2 (enExample) |
| CA (1) | CA2791738C (enExample) |
| IL (3) | IL221710A (enExample) |
| MX (2) | MX2012010115A (enExample) |
| RU (1) | RU2581367C2 (enExample) |
| WO (1) | WO2011109059A1 (enExample) |
Families Citing this family (110)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
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| US9447049B2 (en) | 2010-03-01 | 2016-09-20 | University Of Tennessee Research Foundation | Compounds for treatment of cancer |
| US9029408B2 (en) | 2008-06-16 | 2015-05-12 | Gtx, Inc. | Compounds for treatment of cancer |
| US8822513B2 (en) * | 2010-03-01 | 2014-09-02 | Gtx, Inc. | Compounds for treatment of cancer |
| US11084811B2 (en) | 2010-03-01 | 2021-08-10 | Oncternal Therapeutics, Inc. | Compounds for treatment of cancer |
| CA2791738C (en) * | 2010-03-01 | 2020-06-09 | Gtx, Inc. | Aryl imidazolyl compounds for the treatment of cancer |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| RU2569678C2 (ru) | 2010-04-22 | 2015-11-27 | Вертекс Фармасьютикалз Инкорпорейтед | Способ получения циклоалкилкарбоксамидо-индольных соединений |
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2010
- 2010-12-29 CA CA2791738A patent/CA2791738C/en not_active Expired - Fee Related
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- 2010-12-29 JP JP2012556056A patent/JP5879273B2/ja not_active Expired - Fee Related
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- 2010-12-29 WO PCT/US2010/062418 patent/WO2011109059A1/en not_active Ceased
- 2010-12-29 RU RU2012141590/04A patent/RU2581367C2/ru active
- 2010-12-29 CN CN201410729973.9A patent/CN104592205A/zh active Pending
- 2010-12-29 US US12/981,233 patent/US9334242B2/en active Active
- 2010-12-29 KR KR1020127025893A patent/KR20120130777A/ko not_active Ceased
- 2010-12-29 MX MX2014013753A patent/MX377405B/es unknown
- 2010-12-29 EP EP10847161.6A patent/EP2542081A4/en not_active Withdrawn
- 2010-12-29 KR KR1020187009872A patent/KR101939704B1/ko not_active Expired - Fee Related
- 2010-12-29 CN CN201080066561.1A patent/CN102883607B/zh not_active Expired - Fee Related
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2012
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2015
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