JP2013538213A5 - - Google Patents
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- Publication number
- JP2013538213A5 JP2013538213A5 JP2013526130A JP2013526130A JP2013538213A5 JP 2013538213 A5 JP2013538213 A5 JP 2013538213A5 JP 2013526130 A JP2013526130 A JP 2013526130A JP 2013526130 A JP2013526130 A JP 2013526130A JP 2013538213 A5 JP2013538213 A5 JP 2013538213A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- alkyl
- haloalkyl
- compound
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 23
- 206010028980 Neoplasm Diseases 0.000 claims 20
- 238000000034 method Methods 0.000 claims 15
- 201000011510 cancer Diseases 0.000 claims 10
- 125000001188 haloalkyl group Chemical group 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 125000003282 alkyl amino group Chemical group 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 5
- 229920006395 saturated elastomer Polymers 0.000 claims 5
- 206010027480 Metastatic malignant melanoma Diseases 0.000 claims 4
- 206010033128 Ovarian cancer Diseases 0.000 claims 4
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 4
- 206010060862 Prostate cancer Diseases 0.000 claims 4
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 4
- 201000001441 melanoma Diseases 0.000 claims 4
- 208000021039 metastatic melanoma Diseases 0.000 claims 4
- 238000011275 oncology therapy Methods 0.000 claims 4
- 206010006187 Breast cancer Diseases 0.000 claims 3
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 3
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 3
- 206010038389 Renal cancer Diseases 0.000 claims 3
- 208000000453 Skin Neoplasms Diseases 0.000 claims 3
- 125000004103 aminoalkyl group Chemical group 0.000 claims 3
- 201000007455 central nervous system cancer Diseases 0.000 claims 3
- 208000029742 colonic neoplasm Diseases 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 3
- 201000010982 kidney cancer Diseases 0.000 claims 3
- 208000032839 leukemia Diseases 0.000 claims 3
- 201000005202 lung cancer Diseases 0.000 claims 3
- 208000020816 lung neoplasm Diseases 0.000 claims 3
- 201000000849 skin cancer Diseases 0.000 claims 3
- 150000001204 N-oxides Chemical class 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 229940127557 pharmaceutical product Drugs 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 230000001629 suppression Effects 0.000 claims 2
- UJLSUSCHHHKRGD-UHFFFAOYSA-N (2-anilino-1,3-thiazol-4-yl)-(3,4,5-trimethoxyphenyl)methanone Chemical compound COC1=C(OC)C(OC)=CC(C(=O)C=2N=C(NC=3C=CC=CC=3)SC=2)=C1 UJLSUSCHHHKRGD-UHFFFAOYSA-N 0.000 claims 1
- PRVHTDXESPPRKL-UHFFFAOYSA-N [2-(4-chloroanilino)-1,3-thiazol-4-yl]-(3,4,5-trimethoxyphenyl)methanone Chemical compound COC1=C(OC)C(OC)=CC(C(=O)C=2N=C(NC=3C=CC(Cl)=CC=3)SC=2)=C1 PRVHTDXESPPRKL-UHFFFAOYSA-N 0.000 claims 1
- FJPUDKYDNBZBMV-UHFFFAOYSA-N [2-(4-fluoroanilino)-1,3-thiazol-4-yl]-(3,4,5-trimethoxyphenyl)methanone Chemical compound COC1=C(OC)C(OC)=CC(C(=O)C=2N=C(NC=3C=CC(F)=CC=3)SC=2)=C1 FJPUDKYDNBZBMV-UHFFFAOYSA-N 0.000 claims 1
- RFUBLMVNPXRJPA-UHFFFAOYSA-N [2-(4-methylanilino)-1,3-thiazol-4-yl]-(3,4,5-trimethoxyphenyl)methanone Chemical compound COC1=C(OC)C(OC)=CC(C(=O)C=2N=C(NC=3C=CC(C)=CC=3)SC=2)=C1 RFUBLMVNPXRJPA-UHFFFAOYSA-N 0.000 claims 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N benzopyrrole Natural products C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims 1
- 150000002475 indoles Chemical class 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37667510P | 2010-08-24 | 2010-08-24 | |
| US61/376,675 | 2010-08-24 | ||
| USPCT/US2010/062418 | 2010-12-29 | ||
| PCT/US2010/062418 WO2011109059A1 (en) | 2010-03-01 | 2010-12-29 | Compounds for treatment of cancer |
| PCT/US2011/048980 WO2012027481A1 (en) | 2010-08-24 | 2011-08-24 | Compounds for treatment of cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016164420A Division JP2017008091A (ja) | 2010-08-24 | 2016-08-25 | 癌の治療のための化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013538213A JP2013538213A (ja) | 2013-10-10 |
| JP2013538213A5 true JP2013538213A5 (enExample) | 2014-10-09 |
| JP5997156B2 JP5997156B2 (ja) | 2016-09-28 |
Family
ID=45723794
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013526130A Active JP5997156B2 (ja) | 2010-08-24 | 2011-08-24 | 癌の治療のための化合物 |
| JP2016164420A Pending JP2017008091A (ja) | 2010-08-24 | 2016-08-25 | 癌の治療のための化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016164420A Pending JP2017008091A (ja) | 2010-08-24 | 2016-08-25 | 癌の治療のための化合物 |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP2608671B1 (enExample) |
| JP (2) | JP5997156B2 (enExample) |
| KR (1) | KR101806255B1 (enExample) |
| CN (1) | CN103442566B (enExample) |
| AU (1) | AU2011293353B2 (enExample) |
| CA (2) | CA3030689C (enExample) |
| ES (1) | ES2718637T3 (enExample) |
| IL (1) | IL224863B (enExample) |
| MX (1) | MX336761B (enExample) |
| RU (2) | RU2609018C2 (enExample) |
| WO (1) | WO2012027481A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9447049B2 (en) | 2010-03-01 | 2016-09-20 | University Of Tennessee Research Foundation | Compounds for treatment of cancer |
| US11084811B2 (en) | 2010-03-01 | 2021-08-10 | Oncternal Therapeutics, Inc. | Compounds for treatment of cancer |
| KR101806255B1 (ko) * | 2010-08-24 | 2017-12-07 | 지티엑스, 인코포레이티드 | 암 치료용 화합물 |
| KR20170013891A (ko) * | 2014-05-06 | 2017-02-07 | 지티엑스, 인코포레이티드 | 암 치료용 화합물 |
| WO2016077648A1 (en) * | 2014-11-11 | 2016-05-19 | Neymeyer Calvin E | Method of treating pre-cancerous lesion with glyphosate, and compositions thereof |
| EP3353182A1 (en) | 2015-09-24 | 2018-08-01 | Pfizer Inc | Tetrahydropyrano[3,4-d][1,3]oxazin derivatives and their use as bace inhibitors |
| WO2019188456A1 (ja) * | 2018-03-26 | 2019-10-03 | 学校法人 川崎学園 | 新規抗腫瘍剤 |
| KR20210020022A (ko) * | 2018-05-15 | 2021-02-23 | 유니버시티 오브 테네시 리서치 파운데이션 | 삼중 음성 유방암 및 난소암 치료용 화합물 |
| AU2019270091A1 (en) * | 2018-05-15 | 2020-12-24 | University Of Tennessee Research Foundation | Compounds for treatment of pancreatic cancer |
| CN119409641A (zh) * | 2024-11-05 | 2025-02-11 | 杭州电子科技大学 | 一种磺酰基衍生物和用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0951291A1 (de) * | 1997-11-06 | 1999-10-27 | Pharmaceutical Research Center | Arzneimittel für krebs-therapie |
| HUP0303538A2 (hu) * | 2000-12-21 | 2005-02-28 | Bristol-Myers Squibb Co. | Tirozin kinázok Tec családjának tiazolil-vegyület inhibitorai és ezeket tartalmazó gyógyszerkészítmények |
| WO2003016338A1 (en) * | 2001-08-15 | 2003-02-27 | Parker Hughes Institute | Crystal structure of the btk kinase domain |
| US6818663B2 (en) * | 2002-05-17 | 2004-11-16 | Hoffmann-La Roches | Diaminothiazoles |
| SG164368A1 (en) * | 2005-07-18 | 2010-09-29 | Bipar Sciences Inc | Treatment of cancer |
| US20090246291A1 (en) * | 2008-03-27 | 2009-10-01 | Angelika Burger | Method and compositions for treatment of cancer |
| HUE060249T2 (hu) * | 2008-06-16 | 2023-02-28 | Univ Tennessee Res Found | Vegyületek rák kezelésére |
| AU2010347233B2 (en) * | 2010-03-01 | 2015-06-18 | Oncternal Therapeutics, Inc. | Compounds for treatment of cancer |
| KR101806255B1 (ko) * | 2010-08-24 | 2017-12-07 | 지티엑스, 인코포레이티드 | 암 치료용 화합물 |
-
2011
- 2011-08-24 KR KR1020137007388A patent/KR101806255B1/ko not_active Expired - Fee Related
- 2011-08-24 RU RU2013112871A patent/RU2609018C2/ru active
- 2011-08-24 MX MX2013002155A patent/MX336761B/es unknown
- 2011-08-24 RU RU2017102002A patent/RU2762111C1/ru active
- 2011-08-24 EP EP11820603.6A patent/EP2608671B1/en not_active Not-in-force
- 2011-08-24 ES ES11820603T patent/ES2718637T3/es active Active
- 2011-08-24 AU AU2011293353A patent/AU2011293353B2/en not_active Ceased
- 2011-08-24 CA CA3030689A patent/CA3030689C/en active Active
- 2011-08-24 CA CA2809256A patent/CA2809256C/en active Active
- 2011-08-24 JP JP2013526130A patent/JP5997156B2/ja active Active
- 2011-08-24 CN CN201180051231.XA patent/CN103442566B/zh not_active Expired - Fee Related
- 2011-08-24 WO PCT/US2011/048980 patent/WO2012027481A1/en not_active Ceased
-
2013
- 2013-02-21 IL IL224863A patent/IL224863B/en active IP Right Grant
-
2016
- 2016-08-25 JP JP2016164420A patent/JP2017008091A/ja active Pending
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