JP2014530811A5 - - Google Patents
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- JP2014530811A5 JP2014530811A5 JP2014534558A JP2014534558A JP2014530811A5 JP 2014530811 A5 JP2014530811 A5 JP 2014530811A5 JP 2014534558 A JP2014534558 A JP 2014534558A JP 2014534558 A JP2014534558 A JP 2014534558A JP 2014530811 A5 JP2014530811 A5 JP 2014530811A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutical composition
- composition according
- cancer
- occurrence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C*(C(*)(*)*(C)[Al]*)C(*)(*)[N+]([O-])=O Chemical compound C*(C(*)(*)*(C)[Al]*)C(*)(*)[N+]([O-])=O 0.000 description 15
- ZHQGNENHUGQMQL-UHFFFAOYSA-N CC(C)CCC(C(C)=O)N Chemical compound CC(C)CCC(C(C)=O)N ZHQGNENHUGQMQL-UHFFFAOYSA-N 0.000 description 3
- OKJIRPAQVSHGFK-UHFFFAOYSA-N CC(NCC(O)=O)=O Chemical compound CC(NCC(O)=O)=O OKJIRPAQVSHGFK-UHFFFAOYSA-N 0.000 description 3
- SCDKQMGVRIMMLR-QMMMGPOBSA-O CC(N[C@@H](CSCC(N(C1)CC1([N+]([O-])=O)[OH2+])=O)C(OC)=O)=O Chemical compound CC(N[C@@H](CSCC(N(C1)CC1([N+]([O-])=O)[OH2+])=O)C(OC)=O)=O SCDKQMGVRIMMLR-QMMMGPOBSA-O 0.000 description 1
- PAPLXXXYKRVNKK-QMMMGPOBSA-N C[C@@H](CSCC(N(CC[N+]([O-])=O)CC[N+]([O-])=O)=O)C(O)=O Chemical compound C[C@@H](CSCC(N(CC[N+]([O-])=O)CC[N+]([O-])=O)=O)C(O)=O PAPLXXXYKRVNKK-QMMMGPOBSA-N 0.000 description 1
- TXIBECGXJIBQLR-LURJTMIESA-N N[C@@H](CSCC(N(C1)CC1([N+]([O-])=O)[N+]([O-])=O)=O)C(NCC(O)=O)=O Chemical compound N[C@@H](CSCC(N(C1)CC1([N+]([O-])=O)[N+]([O-])=O)=O)C(NCC(O)=O)=O TXIBECGXJIBQLR-LURJTMIESA-N 0.000 description 1
- PRRWLOKOBULBHS-UHFFFAOYSA-N [O-][N+](C(C1)(CN1C=O)[N+]([O-])=O)=O Chemical compound [O-][N+](C(C1)(CN1C=O)[N+]([O-])=O)=O PRRWLOKOBULBHS-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161544378P | 2011-10-07 | 2011-10-07 | |
| US61/544,378 | 2011-10-07 | ||
| PCT/US2012/038592 WO2013052164A1 (en) | 2011-10-07 | 2012-05-18 | Organonitro thioether compounds and medical uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014530811A JP2014530811A (ja) | 2014-11-20 |
| JP2014530811A5 true JP2014530811A5 (enExample) | 2015-07-02 |
| JP6019126B2 JP6019126B2 (ja) | 2016-11-02 |
Family
ID=48044064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014534558A Expired - Fee Related JP6019126B2 (ja) | 2011-10-07 | 2012-05-18 | 有機ニトロチオエーテル化合物およびその医療用途 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9139519B2 (enExample) |
| EP (1) | EP2763667B1 (enExample) |
| JP (1) | JP6019126B2 (enExample) |
| AU (1) | AU2012319071B2 (enExample) |
| CA (1) | CA2850723C (enExample) |
| ES (1) | ES2935573T3 (enExample) |
| WO (1) | WO2013052164A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7507842B2 (en) * | 2005-08-12 | 2009-03-24 | Radiorx, Inc. | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof |
| WO2013052164A1 (en) * | 2011-10-07 | 2013-04-11 | Radiorx, Inc. | Organonitro thioether compounds and medical uses thereof |
| US20140308260A1 (en) | 2011-10-07 | 2014-10-16 | Radiorx, Inc. | Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products |
| KR101496681B1 (ko) * | 2014-05-19 | 2015-03-04 | 국방과학연구소 | N-치환된 3,3-디니트로아제티딘 고에너지 가소제 및 그의 제조방법 |
| US10342778B1 (en) | 2015-10-20 | 2019-07-09 | Epicentrx, Inc. | Treatment of brain metastases using organonitro compound combination therapy |
| US9987270B1 (en) | 2015-10-29 | 2018-06-05 | Epicentrix, Inc. | Treatment of gliomas using organonitro compound combination therapy |
| DK3402480T3 (da) * | 2016-01-11 | 2021-06-28 | Epicentrx Inc | Sammensætninger og fremgangsmåder til intravenøs administration af 2-brom-1-(3,3-dinitroazetidin-1-yl)ethanon |
| WO2018071741A1 (en) * | 2016-10-14 | 2018-04-19 | Epicentrix, Inc. | Sulfoxyalkyl organonitro and related compounds and pharmaceutical compositions for use in medicine |
| MX2020000265A (es) | 2017-07-07 | 2020-07-22 | Epicentrx Inc | Composiciones para la administración parenteral de agentes terapéuticos. |
| WO2019164593A2 (en) | 2018-01-08 | 2019-08-29 | Epicentrx, Inc. | Methods and compositions utilizing rrx-001 combination therapy for radioprotection |
| US12245355B2 (en) | 2021-02-19 | 2025-03-04 | Mevion Medical Systems, Inc. | Gantry for a particle therapy system |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2978453A (en) | 1956-12-12 | 1961-04-04 | Aerojet General Co | 3, 3, 5, 5-tetranitropiperidine |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4935450A (en) | 1982-09-17 | 1990-06-19 | Therapeutical Systems Corporation | Cancer therapy system for effecting oncolysis of malignant neoplasms |
| GB8504253D0 (en) | 1985-02-19 | 1985-03-20 | Ici Plc | Electrostatic spraying apparatus |
| GB8728418D0 (en) | 1987-12-04 | 1988-01-13 | Jenkins T C | Nitro-substituted aromatic/hetero-aromatic compounds for use in cancer treatment |
| DE3815221C2 (de) | 1988-05-04 | 1995-06-29 | Gradinger F Hermes Pharma | Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen |
| US5693794A (en) | 1988-09-30 | 1997-12-02 | The United States Of America As Represented By The Secretary Of The Navy | Caged polynitramine compound |
| JP2659614B2 (ja) | 1990-11-13 | 1997-09-30 | 株式会社日立製作所 | 表示制御装置 |
| US5698155A (en) | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
| US5679777A (en) | 1991-11-08 | 1997-10-21 | Somatogen, Inc. | Hemoglobins as drug delivery agents |
| US5336784A (en) | 1993-06-07 | 1994-08-09 | The Regents Of The University Of California | Synthesis of 1,3,3-trinitroazetidine |
| PT719145E (pt) | 1994-05-27 | 2001-01-31 | Cellegy Pharma Inc | Composicao dadora de oxido nitrico para tratamento de desordens anais |
| IL117473A (en) | 1995-03-14 | 2001-08-26 | Siemens Ag | Ultrasonic atomizer device with removable precision dosating unit |
| EP0814861B1 (en) | 1995-03-14 | 2002-06-05 | Siemens Aktiengesellschaft | Ultrasonic atomizer device with removable precision dosing unit |
| US5580988A (en) | 1995-05-15 | 1996-12-03 | The United States Of America As Represented By The Secretary Of The Army | Substituted azetidines and processes of using them |
| WO1996036602A1 (en) | 1995-05-15 | 1996-11-21 | The United States Of America | Adnaz, compositions and processes |
| US5898038A (en) | 1996-03-19 | 1999-04-27 | Board Of Regents, The University Of Texas System | Treatment of osteoporosis and metabolic bone disorders with nitric oxide substrate and/or donors |
| CA2268768A1 (en) | 1996-10-15 | 1998-04-23 | Eastman Chemical Company | Explosive formulations |
| GB9720797D0 (en) | 1997-09-30 | 1997-12-03 | Rhodes John | Pharmaceutical composition for the treatment of inflammatory bowel disease and irritable bowel syndrome |
| US5954047A (en) | 1997-10-17 | 1999-09-21 | Systemic Pulmonary Development, Ltd. | Methods and apparatus for delivering aerosolized medication |
| US6056966A (en) | 1998-05-18 | 2000-05-02 | Baker Norton Pharmaceuticals, Inc. | Method and compositions for treating impotence |
| US7635722B1 (en) | 1998-07-27 | 2009-12-22 | Saint Jude Pharmaceuticals, Inc. | Chemical induced intracellular hyperthermia |
| US6448253B1 (en) | 1998-09-16 | 2002-09-10 | King Pharmaceuticals Research And Development, Inc. | Adenosine A3 receptor modulators |
| US6245799B1 (en) | 1999-11-08 | 2001-06-12 | American Home Products Corp | [(Indol-3-yl)-cycloalkyl]-3-substituted azetidines for the treatment of central nervous system disorders |
| HUP0300413A2 (hu) | 2000-04-10 | 2003-06-28 | Pfizer Products Inc. | Amidcsoportot viselő benzolgyűrűs csoporttal helyettesített piperidint tartalmazó és rokonszerkezetű vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények |
| US6861530B2 (en) * | 2000-07-07 | 2005-03-01 | Kyowa Hakko Kogyo Co., Ltd. | Piperidine derivatives |
| DE10111049A1 (de) | 2001-03-06 | 2002-09-12 | Beiersdorf Ag | Verwendung von Substanzen, die verhindern, daß die NO-Synthese des warmblütigen Organismus ihre Wirkung entfaltet, zur Herstellung von kosmetischen oder dermatologischen Zubereitungen, zur Prophylaxe und Behandlung von entzündlichen Hautzuständen und/oder zum Hautschutz bei empfindlich determinierter trockener Haut |
| JP2005539089A (ja) * | 2002-07-03 | 2005-12-22 | ニトロメッド インコーポレーティッド | ニトロソ化非ステロイド性抗炎症化合物、組成物および使用方法 |
| EP1556056A4 (en) | 2002-10-07 | 2008-08-06 | Radiorx Inc | X-Nitro Compounds, Pharmaceutical Compositions And Their Uses |
| WO2004098538A2 (en) | 2003-03-13 | 2004-11-18 | Nitromed, Inc. | Nitrosated and nitrosylated compounds, compositions and methods of use |
| ES2358801T3 (es) | 2003-06-25 | 2011-05-13 | Je Il Pharmaceutical Co., Ltd. | Derivados tricíclicos o sales farmacéuticamente aceptables de los mismos, sus preparaciones y composiciones farmacéuticas que los contienen. |
| WO2005004884A2 (en) | 2003-07-09 | 2005-01-20 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Use of nitrite salts for the treatment of cardiovascular conditions |
| GB0326047D0 (en) | 2003-11-07 | 2003-12-10 | Univ Sheffield | Substance |
| JP2008512490A (ja) | 2004-09-08 | 2008-04-24 | チェルシー・セラピューティクス，インコーポレイテッド | 異常細胞増殖および炎症の障害を治療するための代謝的に不活性な葉酸拮抗剤 |
| US7507842B2 (en) | 2005-08-12 | 2009-03-24 | Radiorx, Inc. | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof |
| US20070135380A1 (en) | 2005-08-12 | 2007-06-14 | Radiorx, Inc. | O-nitro compounds, pharmaceutical compositions thereof and uses thereof |
| EP1996550A2 (en) | 2005-09-27 | 2008-12-03 | Novartis AG | Carboxyamine compounds and their use in the treatment of hdac dependent diseases |
| US8122281B2 (en) | 2007-04-13 | 2012-02-21 | International Business Machines Corporation | System and method for dependent failure-aware allocation of distributed data-processing systems |
| US8471041B2 (en) | 2010-02-09 | 2013-06-25 | Alliant Techsystems Inc. | Methods of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same |
| US20120149678A1 (en) | 2010-12-09 | 2012-06-14 | Oronsky Bryan T | Organonitro Compounds for Use in Treating Non-Hodgkin's Lymphoma and Leukemia, and Methods Relating Thereto |
| US8664247B2 (en) | 2011-08-26 | 2014-03-04 | Radiorx, Inc. | Acyclic organonitro compounds for use in treating cancer |
| WO2013052164A1 (en) * | 2011-10-07 | 2013-04-11 | Radiorx, Inc. | Organonitro thioether compounds and medical uses thereof |
-
2012
- 2012-05-18 WO PCT/US2012/038592 patent/WO2013052164A1/en not_active Ceased
- 2012-05-18 CA CA2850723A patent/CA2850723C/en active Active
- 2012-05-18 JP JP2014534558A patent/JP6019126B2/ja not_active Expired - Fee Related
- 2012-05-18 US US14/349,004 patent/US9139519B2/en active Active
- 2012-05-18 ES ES12839088T patent/ES2935573T3/es active Active
- 2012-05-18 EP EP12839088.7A patent/EP2763667B1/en active Active
- 2012-05-18 AU AU2012319071A patent/AU2012319071B2/en active Active
-
2015
- 2015-09-10 US US14/849,783 patent/US9468625B2/en active Active
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