JP2014530811A5 - - Google Patents
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- Publication number
- JP2014530811A5 JP2014530811A5 JP2014534558A JP2014534558A JP2014530811A5 JP 2014530811 A5 JP2014530811 A5 JP 2014530811A5 JP 2014534558 A JP2014534558 A JP 2014534558A JP 2014534558 A JP2014534558 A JP 2014534558A JP 2014530811 A5 JP2014530811 A5 JP 2014530811A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutical composition
- composition according
- cancer
- occurrence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008194 pharmaceutical composition Substances 0.000 claims 25
- 229910052739 hydrogen Inorganic materials 0.000 claims 19
- 239000001257 hydrogen Substances 0.000 claims 19
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 13
- 125000000753 cycloalkyl group Chemical group 0.000 claims 10
- 125000003710 aryl alkyl group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 8
- 125000006833 (C1-C5) alkylene group Chemical group 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 150000002828 nitro derivatives Chemical class 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 125000002837 carbocyclic group Chemical group 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 230000001678 irradiating effect Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 210000000664 rectum Anatomy 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
- 0 C*(C(*)(*)*(C)[Al]*)C(*)(*)[N+]([O-])=O Chemical compound C*(C(*)(*)*(C)[Al]*)C(*)(*)[N+]([O-])=O 0.000 description 15
- ZHQGNENHUGQMQL-UHFFFAOYSA-N CC(C)CCC(C(C)=O)N Chemical compound CC(C)CCC(C(C)=O)N ZHQGNENHUGQMQL-UHFFFAOYSA-N 0.000 description 3
- OKJIRPAQVSHGFK-UHFFFAOYSA-N CC(NCC(O)=O)=O Chemical compound CC(NCC(O)=O)=O OKJIRPAQVSHGFK-UHFFFAOYSA-N 0.000 description 3
- SCDKQMGVRIMMLR-QMMMGPOBSA-O CC(N[C@@H](CSCC(N(C1)CC1([N+]([O-])=O)[OH2+])=O)C(OC)=O)=O Chemical compound CC(N[C@@H](CSCC(N(C1)CC1([N+]([O-])=O)[OH2+])=O)C(OC)=O)=O SCDKQMGVRIMMLR-QMMMGPOBSA-O 0.000 description 1
- PAPLXXXYKRVNKK-QMMMGPOBSA-N C[C@@H](CSCC(N(CC[N+]([O-])=O)CC[N+]([O-])=O)=O)C(O)=O Chemical compound C[C@@H](CSCC(N(CC[N+]([O-])=O)CC[N+]([O-])=O)=O)C(O)=O PAPLXXXYKRVNKK-QMMMGPOBSA-N 0.000 description 1
- TXIBECGXJIBQLR-LURJTMIESA-N N[C@@H](CSCC(N(C1)CC1([N+]([O-])=O)[N+]([O-])=O)=O)C(NCC(O)=O)=O Chemical compound N[C@@H](CSCC(N(C1)CC1([N+]([O-])=O)[N+]([O-])=O)=O)C(NCC(O)=O)=O TXIBECGXJIBQLR-LURJTMIESA-N 0.000 description 1
- PRRWLOKOBULBHS-UHFFFAOYSA-N [O-][N+](C(C1)(CN1C=O)[N+]([O-])=O)=O Chemical compound [O-][N+](C(C1)(CN1C=O)[N+]([O-])=O)=O PRRWLOKOBULBHS-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161544378P | 2011-10-07 | 2011-10-07 | |
| US61/544,378 | 2011-10-07 | ||
| PCT/US2012/038592 WO2013052164A1 (en) | 2011-10-07 | 2012-05-18 | Organonitro thioether compounds and medical uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014530811A JP2014530811A (ja) | 2014-11-20 |
| JP2014530811A5 true JP2014530811A5 (enExample) | 2015-07-02 |
| JP6019126B2 JP6019126B2 (ja) | 2016-11-02 |
Family
ID=48044064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014534558A Active JP6019126B2 (ja) | 2011-10-07 | 2012-05-18 | 有機ニトロチオエーテル化合物およびその医療用途 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9139519B2 (enExample) |
| EP (1) | EP2763667B1 (enExample) |
| JP (1) | JP6019126B2 (enExample) |
| AU (1) | AU2012319071B2 (enExample) |
| CA (1) | CA2850723C (enExample) |
| ES (1) | ES2935573T3 (enExample) |
| WO (1) | WO2013052164A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7507842B2 (en) | 2005-08-12 | 2009-03-24 | Radiorx, Inc. | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof |
| WO2013052803A2 (en) | 2011-10-07 | 2013-04-11 | Radiorx, Inc. | Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products |
| US9139519B2 (en) * | 2011-10-07 | 2015-09-22 | Epicentrx, Inc. | Organonitro thioether compounds and medical uses thereof |
| KR101496681B1 (ko) * | 2014-05-19 | 2015-03-04 | 국방과학연구소 | N-치환된 3,3-디니트로아제티딘 고에너지 가소제 및 그의 제조방법 |
| US10342778B1 (en) | 2015-10-20 | 2019-07-09 | Epicentrx, Inc. | Treatment of brain metastases using organonitro compound combination therapy |
| US9987270B1 (en) | 2015-10-29 | 2018-06-05 | Epicentrix, Inc. | Treatment of gliomas using organonitro compound combination therapy |
| US11576895B2 (en) * | 2016-01-11 | 2023-02-14 | Epicentrx, Inc | Compositions and methods for intravenous administration of 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone |
| KR20190128619A (ko) * | 2016-10-14 | 2019-11-18 | 에피센트알엑스, 인코포레이티드 | 의약에서 사용하기 위한 술폭시알킬 오르가노니트로 및 관련 화합물 및 제약 조성물 |
| KR102869384B1 (ko) | 2017-07-07 | 2025-10-15 | 에피센트알엑스, 인코포레이티드 | 치료제의 비경구 투여를 위한 조성물 |
| WO2019164593A2 (en) | 2018-01-08 | 2019-08-29 | Epicentrx, Inc. | Methods and compositions utilizing rrx-001 combination therapy for radioprotection |
| WO2022178218A1 (en) | 2021-02-19 | 2022-08-25 | Mevion Medical Systems, Inc. | Gantry for a particle therapy system |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2978453A (en) | 1956-12-12 | 1961-04-04 | Aerojet General Co | 3, 3, 5, 5-tetranitropiperidine |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4935450A (en) | 1982-09-17 | 1990-06-19 | Therapeutical Systems Corporation | Cancer therapy system for effecting oncolysis of malignant neoplasms |
| GB8504253D0 (en) | 1985-02-19 | 1985-03-20 | Ici Plc | Electrostatic spraying apparatus |
| GB8728418D0 (en) | 1987-12-04 | 1988-01-13 | Jenkins T C | Nitro-substituted aromatic/hetero-aromatic compounds for use in cancer treatment |
| DE3815221C2 (de) | 1988-05-04 | 1995-06-29 | Gradinger F Hermes Pharma | Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen |
| US5693794A (en) | 1988-09-30 | 1997-12-02 | The United States Of America As Represented By The Secretary Of The Navy | Caged polynitramine compound |
| JP2659614B2 (ja) | 1990-11-13 | 1997-09-30 | 株式会社日立製作所 | 表示制御装置 |
| US5698155A (en) | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
| CA2122717C (en) | 1991-11-08 | 2003-07-15 | David C. Anderson | Hemoglobins as drug delivery agents |
| US5336784A (en) | 1993-06-07 | 1994-08-09 | The Regents Of The University Of California | Synthesis of 1,3,3-trinitroazetidine |
| EP0719145B1 (en) | 1994-05-27 | 2000-09-06 | Cellegy Pharmaceuticals, Inc. | Nitric oxide donor composition for treatment of anal disorders |
| US5950619A (en) | 1995-03-14 | 1999-09-14 | Siemens Aktiengesellschaft | Ultrasonic atomizer device with removable precision dosating unit |
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| AU5798996A (en) | 1995-05-15 | 1996-11-29 | Sachs, Michael C. | Adnaz, compositions and processes |
| US5580988A (en) | 1995-05-15 | 1996-12-03 | The United States Of America As Represented By The Secretary Of The Army | Substituted azetidines and processes of using them |
| US5898038A (en) | 1996-03-19 | 1999-04-27 | Board Of Regents, The University Of Texas System | Treatment of osteoporosis and metabolic bone disorders with nitric oxide substrate and/or donors |
| IL128589A0 (en) | 1996-10-15 | 2000-01-31 | Eastman Chem Co | Explosive formulations |
| GB9720797D0 (en) | 1997-09-30 | 1997-12-03 | Rhodes John | Pharmaceutical composition for the treatment of inflammatory bowel disease and irritable bowel syndrome |
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| GB0326047D0 (en) | 2003-11-07 | 2003-12-10 | Univ Sheffield | Substance |
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| US7507842B2 (en) | 2005-08-12 | 2009-03-24 | Radiorx, Inc. | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof |
| GT200600430A (es) * | 2005-09-27 | 2007-05-21 | Compuestos de carboxiamina y metodos de uso de los mismos | |
| US8122281B2 (en) | 2007-04-13 | 2012-02-21 | International Business Machines Corporation | System and method for dependent failure-aware allocation of distributed data-processing systems |
| US8471041B2 (en) | 2010-02-09 | 2013-06-25 | Alliant Techsystems Inc. | Methods of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same |
| WO2012078992A1 (en) | 2010-12-09 | 2012-06-14 | Radiorx, Inc. | Organonitro compounds for use in treating non-hodgkin's lymphoma and leukemia, and methods relating thereto |
| US8664247B2 (en) | 2011-08-26 | 2014-03-04 | Radiorx, Inc. | Acyclic organonitro compounds for use in treating cancer |
| US9139519B2 (en) * | 2011-10-07 | 2015-09-22 | Epicentrx, Inc. | Organonitro thioether compounds and medical uses thereof |
-
2012
- 2012-05-18 US US14/349,004 patent/US9139519B2/en active Active
- 2012-05-18 ES ES12839088T patent/ES2935573T3/es active Active
- 2012-05-18 WO PCT/US2012/038592 patent/WO2013052164A1/en not_active Ceased
- 2012-05-18 JP JP2014534558A patent/JP6019126B2/ja active Active
- 2012-05-18 EP EP12839088.7A patent/EP2763667B1/en active Active
- 2012-05-18 AU AU2012319071A patent/AU2012319071B2/en active Active
- 2012-05-18 CA CA2850723A patent/CA2850723C/en active Active
-
2015
- 2015-09-10 US US14/849,783 patent/US9468625B2/en active Active
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