CA2850723C - Organonitro thioether compounds and medical uses thereof - Google Patents
Organonitro thioether compounds and medical uses thereof Download PDFInfo
- Publication number
- CA2850723C CA2850723C CA2850723A CA2850723A CA2850723C CA 2850723 C CA2850723 C CA 2850723C CA 2850723 A CA2850723 A CA 2850723A CA 2850723 A CA2850723 A CA 2850723A CA 2850723 C CA2850723 C CA 2850723C
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- Prior art keywords
- compound
- c5alkyl
- cancer
- pharmaceutical composition
- hydrogen
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- -1 C1-C5haloalkyl Chemical group 0.000 claims description 65
- 229910052739 hydrogen Inorganic materials 0.000 claims description 63
- 239000001257 hydrogen Substances 0.000 claims description 62
- 150000003839 salts Chemical class 0.000 claims description 43
- 125000003118 aryl group Chemical group 0.000 claims description 40
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- 150000002431 hydrogen Chemical class 0.000 claims description 19
- 229910052757 nitrogen Inorganic materials 0.000 claims description 19
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 13
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 13
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 13
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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| PCT/US2012/038592 WO2013052164A1 (en) | 2011-10-07 | 2012-05-18 | Organonitro thioether compounds and medical uses thereof |
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| US7507842B2 (en) * | 2005-08-12 | 2009-03-24 | Radiorx, Inc. | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof |
| EP2763667B1 (en) * | 2011-10-07 | 2022-10-26 | EpicentRx, Inc. | Organonitro thioether compounds and medical uses thereof |
| WO2013052803A2 (en) | 2011-10-07 | 2013-04-11 | Radiorx, Inc. | Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products |
| KR101496681B1 (ko) * | 2014-05-19 | 2015-03-04 | 국방과학연구소 | N-치환된 3,3-디니트로아제티딘 고에너지 가소제 및 그의 제조방법 |
| US10342778B1 (en) | 2015-10-20 | 2019-07-09 | Epicentrx, Inc. | Treatment of brain metastases using organonitro compound combination therapy |
| US9987270B1 (en) | 2015-10-29 | 2018-06-05 | Epicentrix, Inc. | Treatment of gliomas using organonitro compound combination therapy |
| AU2017207304B2 (en) | 2016-01-11 | 2022-05-26 | Epicentrx, Inc. | Compositions and methods for intravenous administration of 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone |
| CA3040479A1 (en) * | 2016-10-14 | 2018-04-19 | Epicentrx, Inc. | Sulfoxyalkyl organonitro and related compounds and pharmaceutical compositions for use in medicine |
| IL311727A (en) | 2017-07-07 | 2024-05-01 | Epicentrx Inc | Preparations for intravenous administration of medical substances |
| WO2019164593A2 (en) | 2018-01-08 | 2019-08-29 | Epicentrx, Inc. | Methods and compositions utilizing rrx-001 combination therapy for radioprotection |
| JP2024511277A (ja) | 2021-02-19 | 2024-03-13 | メビオン・メディカル・システムズ・インコーポレーテッド | 粒子線治療システムのためのガントリー |
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| EP2763667B1 (en) * | 2011-10-07 | 2022-10-26 | EpicentRx, Inc. | Organonitro thioether compounds and medical uses thereof |
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| EP2763667A4 (en) | 2015-05-27 |
| EP2763667A1 (en) | 2014-08-13 |
| US20140349988A1 (en) | 2014-11-27 |
| JP2014530811A (ja) | 2014-11-20 |
| CA2850723A1 (en) | 2013-04-11 |
| US20160081981A1 (en) | 2016-03-24 |
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| AU2012319071A1 (en) | 2014-04-17 |
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| US9139519B2 (en) | 2015-09-22 |
| WO2013052164A1 (en) | 2013-04-11 |
| US9468625B2 (en) | 2016-10-18 |
| EP2763667B1 (en) | 2022-10-26 |
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