JP2012514982A5 - - Google Patents
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- JP2012514982A5 JP2012514982A5 JP2011545537A JP2011545537A JP2012514982A5 JP 2012514982 A5 JP2012514982 A5 JP 2012514982A5 JP 2011545537 A JP2011545537 A JP 2011545537A JP 2011545537 A JP2011545537 A JP 2011545537A JP 2012514982 A5 JP2012514982 A5 JP 2012514982A5
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- JP
- Japan
- Prior art keywords
- activatable antibody
- target
- tissue
- seq
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000001519 tissue Anatomy 0.000 claims 17
- 230000027455 binding Effects 0.000 claims 15
- 239000003795 chemical substances by application Substances 0.000 claims 11
- 108090000765 processed proteins & peptides Proteins 0.000 claims 11
- 238000010494 dissociation reaction Methods 0.000 claims 8
- 230000005593 dissociations Effects 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 239000012634 fragment Substances 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 5
- 238000003776 cleavage reaction Methods 0.000 claims 5
- 230000007017 scission Effects 0.000 claims 5
- 102000004190 Enzymes Human genes 0.000 claims 4
- 108090000790 Enzymes Proteins 0.000 claims 4
- 102000035195 Peptidases Human genes 0.000 claims 4
- 108091005804 Peptidases Proteins 0.000 claims 4
- 239000004365 Protease Substances 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 230000008878 coupling Effects 0.000 claims 4
- 238000010168 coupling process Methods 0.000 claims 4
- 238000005859 coupling reaction Methods 0.000 claims 4
- 229940088598 enzyme Drugs 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 230000000873 masking effect Effects 0.000 claims 4
- 239000000758 substrate Substances 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 2
- 101150013553 CD40 gene Proteins 0.000 claims 2
- 102100032912 CD44 antigen Human genes 0.000 claims 2
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 2
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 2
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 2
- 101000994439 Danio rerio Protein jagged-1a Proteins 0.000 claims 2
- 102100033553 Delta-like protein 4 Human genes 0.000 claims 2
- 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 claims 2
- 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 claims 2
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 2
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 2
- 101000872077 Homo sapiens Delta-like protein 4 Proteins 0.000 claims 2
- 101001034652 Homo sapiens Insulin-like growth factor 1 receptor Proteins 0.000 claims 2
- 101000916644 Homo sapiens Macrophage colony-stimulating factor 1 receptor Proteins 0.000 claims 2
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims 2
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 claims 2
- 102000004388 Interleukin-4 Human genes 0.000 claims 2
- 108090000978 Interleukin-4 Proteins 0.000 claims 2
- 108010038501 Interleukin-6 Receptors Proteins 0.000 claims 2
- 102100037792 Interleukin-6 receptor subunit alpha Human genes 0.000 claims 2
- 102100037795 Interleukin-6 receptor subunit beta Human genes 0.000 claims 2
- 101710152369 Interleukin-6 receptor subunit beta Proteins 0.000 claims 2
- 102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 claims 2
- 102100034256 Mucin-1 Human genes 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 102000001759 Notch1 Receptor Human genes 0.000 claims 2
- 108010029755 Notch1 Receptor Proteins 0.000 claims 2
- 102000001756 Notch2 Receptor Human genes 0.000 claims 2
- 108010029751 Notch2 Receptor Proteins 0.000 claims 2
- 102000001760 Notch3 Receptor Human genes 0.000 claims 2
- 108010029756 Notch3 Receptor Proteins 0.000 claims 2
- 102000001753 Notch4 Receptor Human genes 0.000 claims 2
- 108010029741 Notch4 Receptor Proteins 0.000 claims 2
- 102100032702 Protein jagged-1 Human genes 0.000 claims 2
- 102100032733 Protein jagged-2 Human genes 0.000 claims 2
- 101710170213 Protein jagged-2 Proteins 0.000 claims 2
- -1 TMPRSS-3 / 4 Proteins 0.000 claims 2
- 102000004338 Transferrin Human genes 0.000 claims 2
- 108090000901 Transferrin Proteins 0.000 claims 2
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 2
- 230000033115 angiogenesis Effects 0.000 claims 2
- 208000037979 autoimmune inflammatory disease Diseases 0.000 claims 2
- 208000035269 cancer or benign tumor Diseases 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 230000002829 reductive effect Effects 0.000 claims 2
- 230000009870 specific binding Effects 0.000 claims 2
- 229960003989 tocilizumab Drugs 0.000 claims 2
- 239000012581 transferrin Substances 0.000 claims 2
- JARGNLJYKBUKSJ-KGZKBUQUSA-N (2r)-2-amino-5-[[(2r)-1-(carboxymethylamino)-3-hydroxy-1-oxopropan-2-yl]amino]-5-oxopentanoic acid;hydrobromide Chemical compound Br.OC(=O)[C@H](N)CCC(=O)N[C@H](CO)C(=O)NCC(O)=O JARGNLJYKBUKSJ-KGZKBUQUSA-N 0.000 claims 1
- RTQWWZBSTRGEAV-PKHIMPSTSA-N 2-[[(2s)-2-[bis(carboxymethyl)amino]-3-[4-(methylcarbamoylamino)phenyl]propyl]-[2-[bis(carboxymethyl)amino]propyl]amino]acetic acid Chemical compound CNC(=O)NC1=CC=C(C[C@@H](CN(CC(C)N(CC(O)=O)CC(O)=O)CC(O)=O)N(CC(O)=O)CC(O)=O)C=C1 RTQWWZBSTRGEAV-PKHIMPSTSA-N 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 claims 1
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 claims 1
- 102000030431 Asparaginyl endopeptidase Human genes 0.000 claims 1
- 102100024217 CAMPATH-1 antigen Human genes 0.000 claims 1
- 108010065524 CD52 Antigen Proteins 0.000 claims 1
- 102000011727 Caspases Human genes 0.000 claims 1
- 108010076667 Caspases Proteins 0.000 claims 1
- 102000005600 Cathepsins Human genes 0.000 claims 1
- 108010084457 Cathepsins Proteins 0.000 claims 1
- 108010001857 Cell Surface Receptors Proteins 0.000 claims 1
- 102000000844 Cell Surface Receptors Human genes 0.000 claims 1
- 108091035707 Consensus sequence Proteins 0.000 claims 1
- 101000936738 Coturnix japonica Astacin-like metalloendopeptidase Proteins 0.000 claims 1
- 108010088842 Fibrinolysin Proteins 0.000 claims 1
- 101000851058 Homo sapiens Neutrophil elastase Proteins 0.000 claims 1
- 101000661807 Homo sapiens Suppressor of tumorigenicity 14 protein Proteins 0.000 claims 1
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 claims 1
- 101000610980 Homo sapiens Tumor protein D52 Proteins 0.000 claims 1
- 108010076557 Matrix Metalloproteinase 14 Proteins 0.000 claims 1
- 102100030216 Matrix metalloproteinase-14 Human genes 0.000 claims 1
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 claims 1
- 108010015302 Matrix metalloproteinase-9 Proteins 0.000 claims 1
- 101000794562 Naegleria gruberi Calmodulin, flagellar Proteins 0.000 claims 1
- 102100021768 Phosphoserine aminotransferase Human genes 0.000 claims 1
- 108010072866 Prostate-Specific Antigen Proteins 0.000 claims 1
- 206010039509 Scab Diseases 0.000 claims 1
- 102100037942 Suppressor of tumorigenicity 14 protein Human genes 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 102100040247 Tumor necrosis factor Human genes 0.000 claims 1
- 102100040418 Tumor protein D52 Human genes 0.000 claims 1
- 102100031358 Urokinase-type plasminogen activator Human genes 0.000 claims 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 claims 1
- 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 claims 1
- 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 claims 1
- 229960002964 adalimumab Drugs 0.000 claims 1
- 229960000548 alemtuzumab Drugs 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 108010055066 asparaginylendopeptidase Proteins 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 229960000397 bevacizumab Drugs 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 229960005395 cetuximab Drugs 0.000 claims 1
- 230000002860 competitive effect Effects 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 229940039227 diagnostic agent Drugs 0.000 claims 1
- 238000006073 displacement reaction Methods 0.000 claims 1
- 229960000284 efalizumab Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
- 108010044804 gamma-glutamyl-seryl-glycine Proteins 0.000 claims 1
- 108700026078 glutathione trisulfide Proteins 0.000 claims 1
- 102000052502 human ELANE Human genes 0.000 claims 1
- 229960001001 ibritumomab tiuxetan Drugs 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 229960000598 infliximab Drugs 0.000 claims 1
- 229960005386 ipilimumab Drugs 0.000 claims 1
- 210000005228 liver tissue Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
- 210000000653 nervous system Anatomy 0.000 claims 1
- 210000004923 pancreatic tissue Anatomy 0.000 claims 1
- 229940012957 plasmin Drugs 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 229960003876 ranibizumab Drugs 0.000 claims 1
- 229960004641 rituximab Drugs 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 229960005267 tositumomab Drugs 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14411009P | 2009-01-12 | 2009-01-12 | |
| US14410509P | 2009-01-12 | 2009-01-12 | |
| US61/144,110 | 2009-01-12 | ||
| US61/144,105 | 2009-01-12 | ||
| US24941609P | 2009-10-07 | 2009-10-07 | |
| US24944109P | 2009-10-07 | 2009-10-07 | |
| US61/249,441 | 2009-10-07 | ||
| US61/249,416 | 2009-10-07 | ||
| PCT/US2010/020820 WO2010081173A2 (en) | 2009-01-12 | 2010-01-12 | Modified antibody compositions, methods of making and using thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015146530A Division JP6271476B2 (ja) | 2009-01-12 | 2015-07-24 | 改変した抗体組成物、それを作製および使用する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012514982A JP2012514982A (ja) | 2012-07-05 |
| JP2012514982A5 true JP2012514982A5 (enExample) | 2012-12-06 |
| JP5851842B2 JP5851842B2 (ja) | 2016-02-03 |
Family
ID=42317225
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011545537A Active JP5851842B2 (ja) | 2009-01-12 | 2010-01-12 | 改変した抗体組成物、それを作製および使用する方法 |
| JP2015146530A Active JP6271476B2 (ja) | 2009-01-12 | 2015-07-24 | 改変した抗体組成物、それを作製および使用する方法 |
| JP2017157121A Active JP6571730B2 (ja) | 2009-01-12 | 2017-08-16 | 改変した抗体組成物、それを作製および使用する方法 |
| JP2019027222A Active JP6860601B2 (ja) | 2009-01-12 | 2019-02-19 | 改変した抗体組成物、それを作製および使用する方法 |
| JP2020156514A Active JP7221259B2 (ja) | 2009-01-12 | 2020-09-17 | 改変した抗体組成物、それを作製および使用する方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015146530A Active JP6271476B2 (ja) | 2009-01-12 | 2015-07-24 | 改変した抗体組成物、それを作製および使用する方法 |
| JP2017157121A Active JP6571730B2 (ja) | 2009-01-12 | 2017-08-16 | 改変した抗体組成物、それを作製および使用する方法 |
| JP2019027222A Active JP6860601B2 (ja) | 2009-01-12 | 2019-02-19 | 改変した抗体組成物、それを作製および使用する方法 |
| JP2020156514A Active JP7221259B2 (ja) | 2009-01-12 | 2020-09-17 | 改変した抗体組成物、それを作製および使用する方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (10) | US20100189651A1 (enExample) |
| EP (2) | EP3543256A1 (enExample) |
| JP (5) | JP5851842B2 (enExample) |
| CN (2) | CN102482347B (enExample) |
| AU (4) | AU2010203353B2 (enExample) |
| BR (1) | BRPI1006141B8 (enExample) |
| CA (1) | CA2749339A1 (enExample) |
| RU (1) | RU2636046C2 (enExample) |
| WO (1) | WO2010081173A2 (enExample) |
Families Citing this family (264)
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| US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
| ES2368387T5 (es) | 2000-10-09 | 2019-03-07 | Cytomx Therapeutics Inc | Anticuerpos terapéuticos y que inducen tolerancia |
| CA2646329C (en) | 2006-03-20 | 2018-07-03 | The Regents Of The University Of California | Engineered anti-prostate stem cell antigen (psca) antibodies for cancer targeting |
| EP3056568B1 (en) | 2006-03-31 | 2021-09-15 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
| US8293685B2 (en) | 2007-07-26 | 2012-10-23 | The Regents Of The University Of California | Methods for enhancing bacterial cell display of proteins and peptides |
| JP6035009B2 (ja) * | 2007-08-22 | 2016-11-30 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 活性化可能な結合ポリペプチドおよびその同定方法ならびに使用 |
| CA2698343C (en) | 2007-09-04 | 2018-06-12 | The Regents Of The University Of California | High affinity anti-prostate stem cell antigen (psca) antibodies for cancer targeting and detection |
| CN101874042B9 (zh) | 2007-09-26 | 2019-01-01 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
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| EP3543256A1 (en) * | 2009-01-12 | 2019-09-25 | Cytomx Therapeutics Inc. | Modified antibody compositions, methods of making and using thereof |
| US10517969B2 (en) | 2009-02-17 | 2019-12-31 | Cornell University | Methods and kits for diagnosis of cancer and prediction of therapeutic value |
| EP2398494A4 (en) | 2009-02-23 | 2015-10-28 | Cytomx Therapeutics Inc | Proproteins and their methods of use |
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| BR112013013083A2 (pt) | 2010-11-30 | 2016-12-13 | Genentech Inc | métodos para transportar um composto, para aumentar exposição do cns a um composto, para diminuir a depuração de um composto, para aumentar a retenção no cns de um composto, para otimizar a farmacocinética, para tratar um distúrbio neurológico em um mamífero, para desenvolver um anticorpo, anticorpo, fragmento de anticorpo, anticorpo multiespecífico e uso de um anticorpo |
| CN103328632A (zh) | 2010-11-30 | 2013-09-25 | 中外制药株式会社 | 与多分子的抗原重复结合的抗原结合分子 |
| CN112812184A (zh) | 2011-02-25 | 2021-05-18 | 中外制药株式会社 | FcγRIIb特异性Fc抗体 |
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| EP2686020B1 (en) | 2011-03-17 | 2017-02-22 | The University of Birmingham | Re-directed immunotherapy |
| AU2012253571A1 (en) | 2011-05-09 | 2014-01-09 | Mayo Foundation For Medical Education And Research | Cancer treatments |
| TW201817745A (zh) | 2011-09-30 | 2018-05-16 | 日商中外製藥股份有限公司 | 具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子 |
| WO2013047748A1 (ja) | 2011-09-30 | 2013-04-04 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
| KR20230143201A (ko) | 2011-11-30 | 2023-10-11 | 추가이 세이야쿠 가부시키가이샤 | 면역 복합체를 형성하는 세포내로의 운반체（캐리어）를 포함하는 의약 |
| EP4624490A3 (en) | 2012-02-09 | 2025-11-05 | Chugai Seiyaku Kabushiki Kaisha | Modified fc region of antibody |
| GB201203442D0 (en) * | 2012-02-28 | 2012-04-11 | Univ Birmingham | Immunotherapeutic molecules and uses |
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| BR112014031689A2 (pt) | 2012-06-22 | 2017-07-25 | Cytomx Therapeutics Inc | anticorpos reativos cruzados anti-jagged 1/jagged 2, anticorpos anti-jagged ativáveis e métodos de uso deles |
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| MX357675B (es) | 2012-08-13 | 2018-07-18 | Genentech Inc | Anticuerpos anti-jagged y métodos de uso. |
| WO2014030728A1 (ja) | 2012-08-24 | 2014-02-27 | 中外製薬株式会社 | FcγRIIb特異的Fc領域改変体 |
| US9487590B2 (en) | 2012-09-25 | 2016-11-08 | Cytomx Therapeutics, Inc. | Activatable antibodies that bind interleukin-6 receptor and methods of use thereof |
| US10413606B2 (en) | 2012-10-01 | 2019-09-17 | Mayo Foundation For Medical Education And Research | Methods for treating cancer with nanoparticle complexes of albumin-bound paclitaxel and anti-VEGF antibodies |
| JP6605957B2 (ja) * | 2013-01-04 | 2019-11-13 | シトムクス セラピューティクス，インコーポレイティド | 生体系におけるプロテアーゼ活性を検出するための組成物及び方法 |
| RU2519546C1 (ru) * | 2013-01-16 | 2014-06-10 | Общество С Ограниченной Ответственностью "Биоинтегратор" (Ооо "Биоинтегратор") | КОНЪЮГАТЫ И МАЛЫЕ МОЛЕКУЛЫ, ВЗАИМОДЕЙСТВУЮЩИЕ С РЕЦЕПТОРОМ CD16а |
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