JP2010536370A5 - - Google Patents
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- Publication number
- JP2010536370A5 JP2010536370A5 JP2010521883A JP2010521883A JP2010536370A5 JP 2010536370 A5 JP2010536370 A5 JP 2010536370A5 JP 2010521883 A JP2010521883 A JP 2010521883A JP 2010521883 A JP2010521883 A JP 2010521883A JP 2010536370 A5 JP2010536370 A5 JP 2010536370A5
- Authority
- JP
- Japan
- Prior art keywords
- activatable
- target
- antibody
- tbm
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 25
- 102000004196 processed proteins & peptides Human genes 0.000 claims 25
- 108090000765 processed proteins & peptides Proteins 0.000 claims 25
- 239000012634 fragment Substances 0.000 claims 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 239000000758 substrate Substances 0.000 claims 7
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims 3
- 229940045513 CTLA4 antagonist Drugs 0.000 claims 3
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 3
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 3
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 3
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 3
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 3
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 3
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 3
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 3
- 102100032912 CD44 antigen Human genes 0.000 claims 2
- 102000011727 Caspases Human genes 0.000 claims 2
- 108010076667 Caspases Proteins 0.000 claims 2
- 102000005600 Cathepsins Human genes 0.000 claims 2
- 108010084457 Cathepsins Proteins 0.000 claims 2
- 102100033553 Delta-like protein 4 Human genes 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 2
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 2
- 101000872077 Homo sapiens Delta-like protein 4 Proteins 0.000 claims 2
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 2
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 2
- 102000000588 Interleukin-2 Human genes 0.000 claims 2
- 108010002350 Interleukin-2 Proteins 0.000 claims 2
- 102000004889 Interleukin-6 Human genes 0.000 claims 2
- 108090001005 Interleukin-6 Proteins 0.000 claims 2
- 108010006035 Metalloproteases Proteins 0.000 claims 2
- 102000005741 Metalloproteases Human genes 0.000 claims 2
- 102000001759 Notch1 Receptor Human genes 0.000 claims 2
- 108010029755 Notch1 Receptor Proteins 0.000 claims 2
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
- 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 claims 2
- 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 229940088598 enzyme Drugs 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000000873 masking effect Effects 0.000 claims 2
- 239000011159 matrix material Substances 0.000 claims 2
- 229940012957 plasmin Drugs 0.000 claims 2
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 claims 2
- JARGNLJYKBUKSJ-KGZKBUQUSA-N (2r)-2-amino-5-[[(2r)-1-(carboxymethylamino)-3-hydroxy-1-oxopropan-2-yl]amino]-5-oxopentanoic acid;hydrobromide Chemical compound Br.OC(=O)[C@H](N)CCC(=O)N[C@H](CO)C(=O)NCC(O)=O JARGNLJYKBUKSJ-KGZKBUQUSA-N 0.000 claims 1
- 108010001857 Cell Surface Receptors Proteins 0.000 claims 1
- 102000000844 Cell Surface Receptors Human genes 0.000 claims 1
- 108010088842 Fibrinolysin Proteins 0.000 claims 1
- 102000009465 Growth Factor Receptors Human genes 0.000 claims 1
- 108010009202 Growth Factor Receptors Proteins 0.000 claims 1
- -1 IGF-1R Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102100021768 Phosphoserine aminotransferase Human genes 0.000 claims 1
- 108010072866 Prostate-Specific Antigen Proteins 0.000 claims 1
- 206010039509 Scab Diseases 0.000 claims 1
- 229960002964 adalimumab Drugs 0.000 claims 1
- 229960000397 bevacizumab Drugs 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 229960005395 cetuximab Drugs 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 229960000284 efalizumab Drugs 0.000 claims 1
- 108010044804 gamma-glutamyl-seryl-glycine Proteins 0.000 claims 1
- 108700026078 glutathione trisulfide Proteins 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 229960000598 infliximab Drugs 0.000 claims 1
- 229960005386 ipilimumab Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 229960001972 panitumumab Drugs 0.000 claims 1
- 229960003876 ranibizumab Drugs 0.000 claims 1
- 229950007217 tremelimumab Drugs 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95744907P | 2007-08-22 | 2007-08-22 | |
| US95745307P | 2007-08-22 | 2007-08-22 | |
| US60/957,449 | 2007-08-22 | ||
| US60/957,453 | 2007-08-22 | ||
| US5298608P | 2008-05-13 | 2008-05-13 | |
| US61/052,986 | 2008-05-13 | ||
| PCT/US2008/009974 WO2009025846A2 (en) | 2007-08-22 | 2008-08-21 | Activatable binding polypeptides and methods of identification and use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015012223A Division JP2015110619A (ja) | 2007-08-22 | 2015-01-26 | 活性化可能な結合ポリペプチドおよびその同定方法ならびに使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010536370A JP2010536370A (ja) | 2010-12-02 |
| JP2010536370A5 true JP2010536370A5 (enExample) | 2012-10-18 |
| JP6035009B2 JP6035009B2 (ja) | 2016-11-30 |
Family
ID=40378878
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010521883A Active JP6035009B2 (ja) | 2007-08-22 | 2008-08-21 | 活性化可能な結合ポリペプチドおよびその同定方法ならびに使用 |
| JP2015012223A Pending JP2015110619A (ja) | 2007-08-22 | 2015-01-26 | 活性化可能な結合ポリペプチドおよびその同定方法ならびに使用 |
| JP2016233739A Active JP6529952B2 (ja) | 2007-08-22 | 2016-12-01 | 活性化可能な結合ポリペプチドおよびその同定方法ならびに使用 |
| JP2019000459A Active JP6910380B2 (ja) | 2007-08-22 | 2019-01-07 | 活性化可能な結合ポリペプチドおよびその同定方法ならびに使用 |
| JP2021111358A Active JP7252278B2 (ja) | 2007-08-22 | 2021-07-05 | 活性化可能な結合ポリペプチドおよびその同定方法ならびに使用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015012223A Pending JP2015110619A (ja) | 2007-08-22 | 2015-01-26 | 活性化可能な結合ポリペプチドおよびその同定方法ならびに使用 |
| JP2016233739A Active JP6529952B2 (ja) | 2007-08-22 | 2016-12-01 | 活性化可能な結合ポリペプチドおよびその同定方法ならびに使用 |
| JP2019000459A Active JP6910380B2 (ja) | 2007-08-22 | 2019-01-07 | 活性化可能な結合ポリペプチドおよびその同定方法ならびに使用 |
| JP2021111358A Active JP7252278B2 (ja) | 2007-08-22 | 2021-07-05 | 活性化可能な結合ポリペプチドおよびその同定方法ならびに使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (8) | US20090304719A1 (enExample) |
| EP (2) | EP2190861A4 (enExample) |
| JP (5) | JP6035009B2 (enExample) |
| AU (1) | AU2008289441A1 (enExample) |
| CA (2) | CA3128656A1 (enExample) |
| GB (1) | GB2455449A (enExample) |
| WO (1) | WO2009025846A2 (enExample) |
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| CA3128656A1 (en) | 2007-08-22 | 2009-02-26 | The Regents Of The University Of California | Activatable binding polypeptides and methods of identification and use thereof |
| US8895702B2 (en) | 2008-12-08 | 2014-11-25 | City Of Hope | Development of masked therapeutic antibodies to limit off-target effects; application to anti-EGFR antibodies |
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| RU2011138951A (ru) | 2009-02-23 | 2013-03-27 | Сайтомкс Терапьютикс, Инк. | Пропротеины и способы их применения |
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2008
- 2008-08-21 CA CA3128656A patent/CA3128656A1/en active Pending
- 2008-08-21 EP EP08795508A patent/EP2190861A4/en not_active Withdrawn
- 2008-08-21 JP JP2010521883A patent/JP6035009B2/ja active Active
- 2008-08-21 US US12/196,269 patent/US20090304719A1/en not_active Abandoned
- 2008-08-21 EP EP18200815.1A patent/EP3492488A1/en active Pending
- 2008-08-21 AU AU2008289441A patent/AU2008289441A1/en not_active Abandoned
- 2008-08-21 WO PCT/US2008/009974 patent/WO2009025846A2/en not_active Ceased
- 2008-08-21 CA CA2697032A patent/CA2697032C/en active Active
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2009
- 2009-02-16 GB GB0902572A patent/GB2455449A/en not_active Withdrawn
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2012
- 2012-03-02 US US13/411,416 patent/US8541203B2/en active Active
- 2012-03-02 US US13/411,409 patent/US8518404B2/en active Active
- 2012-03-06 US US13/413,447 patent/US8529898B2/en active Active
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- 2013-07-24 US US13/950,174 patent/US9169321B2/en active Active
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2015
- 2015-01-26 JP JP2015012223A patent/JP2015110619A/ja active Pending
- 2015-09-14 US US14/853,840 patent/US10077300B2/en active Active
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- 2016-12-01 JP JP2016233739A patent/JP6529952B2/ja active Active
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2018
- 2018-08-13 US US16/102,531 patent/US11028162B2/en active Active
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- 2019-01-07 JP JP2019000459A patent/JP6910380B2/ja active Active
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2021
- 2021-04-30 US US17/245,713 patent/US12209120B2/en active Active
- 2021-07-05 JP JP2021111358A patent/JP7252278B2/ja active Active
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