JP2017523176A5 - - Google Patents
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- JP2017523176A5 JP2017523176A5 JP2017504058A JP2017504058A JP2017523176A5 JP 2017523176 A5 JP2017523176 A5 JP 2017523176A5 JP 2017504058 A JP2017504058 A JP 2017504058A JP 2017504058 A JP2017504058 A JP 2017504058A JP 2017523176 A5 JP2017523176 A5 JP 2017523176A5
- Authority
- JP
- Japan
- Prior art keywords
- activatable antibody
- seq
- antibody
- multispecific
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 72
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims 56
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims 56
- 125000003275 alpha amino acid group Chemical group 0.000 claims 48
- 102000004196 processed proteins & peptides Human genes 0.000 claims 42
- 239000012634 fragment Substances 0.000 claims 38
- 229920001184 polypeptide Polymers 0.000 claims 36
- 108091005804 Peptidases Proteins 0.000 claims 32
- 239000004365 Protease Substances 0.000 claims 32
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 30
- 238000010494 dissociation reaction Methods 0.000 claims 27
- 230000005593 dissociations Effects 0.000 claims 27
- 150000001413 amino acids Chemical class 0.000 claims 22
- 239000000427 antigen Substances 0.000 claims 22
- 108091007433 antigens Proteins 0.000 claims 22
- 102000036639 antigens Human genes 0.000 claims 22
- 206010028980 Neoplasm Diseases 0.000 claims 16
- 210000004027 cell Anatomy 0.000 claims 11
- 239000003795 chemical substances by application Substances 0.000 claims 11
- 239000000758 substrate Substances 0.000 claims 11
- 230000000873 masking effect Effects 0.000 claims 9
- 210000004899 c-terminal region Anatomy 0.000 claims 7
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 6
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 6
- 206010039509 Scab Diseases 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 239000002246 antineoplastic agent Substances 0.000 claims 3
- 239000000032 diagnostic agent Substances 0.000 claims 3
- 229940039227 diagnostic agent Drugs 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000003053 toxin Substances 0.000 claims 3
- 231100000765 toxin Toxicity 0.000 claims 3
- 108700012359 toxins Proteins 0.000 claims 3
- JARGNLJYKBUKSJ-KGZKBUQUSA-N (2r)-2-amino-5-[[(2r)-1-(carboxymethylamino)-3-hydroxy-1-oxopropan-2-yl]amino]-5-oxopentanoic acid;hydrobromide Chemical compound Br.OC(=O)[C@H](N)CCC(=O)N[C@H](CO)C(=O)NCC(O)=O JARGNLJYKBUKSJ-KGZKBUQUSA-N 0.000 claims 2
- 102000035195 Peptidases Human genes 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 108010044804 gamma-glutamyl-seryl-glycine Proteins 0.000 claims 2
- 108700026078 glutathione trisulfide Proteins 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 1
- 230000008045 co-localization Effects 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- OOYGSFOGFJDDHP-KMCOLRRFSA-N kanamycin A sulfate Chemical group OS(O)(=O)=O.O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N OOYGSFOGFJDDHP-KMCOLRRFSA-N 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462029325P | 2014-07-25 | 2014-07-25 | |
| US62/029,325 | 2014-07-25 | ||
| PCT/US2015/042053 WO2016014974A2 (en) | 2014-07-25 | 2015-07-24 | Anti-cd3 antibodies, activatable anti-cd3 antibodies, multispecific anti-cd3 antibodies, multispecific activatable anti-cd3 antibodies, and methods of using the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021012481A Division JP7168702B2 (ja) | 2014-07-25 | 2021-01-28 | 抗－ｃｄ３抗体、活性化可能抗－ｃｄ３抗体、多重特異的抗－ｃｄ３抗体、多重特異的活性化可能抗－ｃｄ３抗体、及びそれらの使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017523176A JP2017523176A (ja) | 2017-08-17 |
| JP2017523176A5 true JP2017523176A5 (enExample) | 2018-09-06 |
| JP7020909B2 JP7020909B2 (ja) | 2022-02-16 |
Family
ID=53765629
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017504058A Active JP7020909B2 (ja) | 2014-07-25 | 2015-07-24 | 抗－ｃｄ３抗体、活性化可能抗－ｃｄ３抗体、多重特異的抗－ｃｄ３抗体、多重特異的活性化可能抗－ｃｄ３抗体、及びそれらの使用方法 |
| JP2021012481A Active JP7168702B2 (ja) | 2014-07-25 | 2021-01-28 | 抗－ｃｄ３抗体、活性化可能抗－ｃｄ３抗体、多重特異的抗－ｃｄ３抗体、多重特異的活性化可能抗－ｃｄ３抗体、及びそれらの使用方法 |
| JP2022171196A Active JP7564853B2 (ja) | 2014-07-25 | 2022-10-26 | 抗－ｃｄ３抗体、活性化可能抗－ｃｄ３抗体、多重特異的抗－ｃｄ３抗体、多重特異的活性化可能抗－ｃｄ３抗体、及びそれらの使用方法 |
| JP2024168603A Pending JP2025000814A (ja) | 2014-07-25 | 2024-09-27 | 抗－ｃｄ３抗体、活性化可能抗－ｃｄ３抗体、多重特異的抗－ｃｄ３抗体、多重特異的活性化可能抗－ｃｄ３抗体、及びそれらの使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021012481A Active JP7168702B2 (ja) | 2014-07-25 | 2021-01-28 | 抗－ｃｄ３抗体、活性化可能抗－ｃｄ３抗体、多重特異的抗－ｃｄ３抗体、多重特異的活性化可能抗－ｃｄ３抗体、及びそれらの使用方法 |
| JP2022171196A Active JP7564853B2 (ja) | 2014-07-25 | 2022-10-26 | 抗－ｃｄ３抗体、活性化可能抗－ｃｄ３抗体、多重特異的抗－ｃｄ３抗体、多重特異的活性化可能抗－ｃｄ３抗体、及びそれらの使用方法 |
| JP2024168603A Pending JP2025000814A (ja) | 2014-07-25 | 2024-09-27 | 抗－ｃｄ３抗体、活性化可能抗－ｃｄ３抗体、多重特異的抗－ｃｄ３抗体、多重特異的活性化可能抗－ｃｄ３抗体、及びそれらの使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US10669337B2 (enExample) |
| EP (1) | EP3172235A2 (enExample) |
| JP (4) | JP7020909B2 (enExample) |
| CN (1) | CN107108738A (enExample) |
| AU (2) | AU2015292406B2 (enExample) |
| BR (1) | BR112017001579A2 (enExample) |
| CA (1) | CA2955947A1 (enExample) |
| WO (1) | WO2016014974A2 (enExample) |
Families Citing this family (177)
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2015
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- 2015-07-24 CA CA2955947A patent/CA2955947A1/en active Pending
- 2015-07-24 CN CN201580051713.3A patent/CN107108738A/zh active Pending
- 2015-07-24 EP EP15745116.2A patent/EP3172235A2/en active Pending
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- 2015-07-24 JP JP2017504058A patent/JP7020909B2/ja active Active
- 2015-07-24 BR BR112017001579A patent/BR112017001579A2/pt not_active Application Discontinuation
- 2015-07-24 WO PCT/US2015/042053 patent/WO2016014974A2/en not_active Ceased
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- 2020-04-24 US US16/858,480 patent/US11802158B2/en active Active
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2021
- 2021-01-28 JP JP2021012481A patent/JP7168702B2/ja active Active
- 2021-06-10 AU AU2021203876A patent/AU2021203876A1/en not_active Abandoned
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- 2023-09-22 US US18/472,748 patent/US20240084010A1/en active Pending
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- 2024-09-27 JP JP2024168603A patent/JP2025000814A/ja active Pending
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