JP2017523176A5 - - Google Patents

Info

Publication number

JP2017523176A5

JP2017523176A5 JP2017504058A JP2017504058A JP2017523176A5 JP 2017523176 A5 JP2017523176 A5 JP 2017523176A5 JP 2017504058 A JP2017504058 A JP 2017504058A JP 2017504058 A JP2017504058 A JP 2017504058A JP 2017523176 A5 JP2017523176 A5 JP 2017523176A5

Authority

JP

Japan

Prior art keywords

activatable antibody

seq

antibody

multispecific

binding

Prior art date

2015-07-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 108090000765 processed proteins & peptides Proteins 0.000 claims 72
• 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims 56
• 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims 56
• 125000003275 alpha amino acid group Chemical group 0.000 claims 48
• 102000004196 processed proteins & peptides Human genes 0.000 claims 42
• 239000012634 fragment Substances 0.000 claims 38
• 229920001184 polypeptide Polymers 0.000 claims 36
• 108091005804 Peptidases Proteins 0.000 claims 32
• 239000004365 Protease Substances 0.000 claims 32
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 30
• 238000010494 dissociation reaction Methods 0.000 claims 27
• 230000005593 dissociations Effects 0.000 claims 27
• 150000001413 amino acids Chemical class 0.000 claims 22
• 239000000427 antigen Substances 0.000 claims 22
• 108091007433 antigens Proteins 0.000 claims 22
• 102000036639 antigens Human genes 0.000 claims 22
• 206010028980 Neoplasm Diseases 0.000 claims 16
• 210000004027 cell Anatomy 0.000 claims 11
• 239000003795 chemical substances by application Substances 0.000 claims 11
• 239000000758 substrate Substances 0.000 claims 11
• 230000000873 masking effect Effects 0.000 claims 9
• 210000004899 c-terminal region Anatomy 0.000 claims 7
• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 6
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 6
• 206010039509 Scab Diseases 0.000 claims 6
• 102000039446 nucleic acids Human genes 0.000 claims 6
• 108020004707 nucleic acids Proteins 0.000 claims 6
• 150000007523 nucleic acids Chemical class 0.000 claims 6
• 239000003814 drug Substances 0.000 claims 5
• 238000000034 method Methods 0.000 claims 5
• 239000008194 pharmaceutical composition Substances 0.000 claims 5
• 229940124597 therapeutic agent Drugs 0.000 claims 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
• 239000002246 antineoplastic agent Substances 0.000 claims 3
• 239000000032 diagnostic agent Substances 0.000 claims 3
• 229940039227 diagnostic agent Drugs 0.000 claims 3
• 238000004519 manufacturing process Methods 0.000 claims 3
• 239000003053 toxin Substances 0.000 claims 3
• 231100000765 toxin Toxicity 0.000 claims 3
• 108700012359 toxins Proteins 0.000 claims 3
• JARGNLJYKBUKSJ-KGZKBUQUSA-N (2r)-2-amino-5-[[(2r)-1-(carboxymethylamino)-3-hydroxy-1-oxopropan-2-yl]amino]-5-oxopentanoic acid;hydrobromide Chemical compound Br.OC(=O)[C@H](N)CCC(=O)N[C@H](CO)C(=O)NCC(O)=O JARGNLJYKBUKSJ-KGZKBUQUSA-N 0.000 claims 2
• 102000035195 Peptidases Human genes 0.000 claims 2
• 201000011510 cancer Diseases 0.000 claims 2
• 238000012258 culturing Methods 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 108010044804 gamma-glutamyl-seryl-glycine Proteins 0.000 claims 2
• 108700026078 glutathione trisulfide Proteins 0.000 claims 2
• 230000004913 activation Effects 0.000 claims 1
• 230000008045 co-localization Effects 0.000 claims 1
• 230000008878 coupling Effects 0.000 claims 1
• 238000010168 coupling process Methods 0.000 claims 1
• 238000005859 coupling reaction Methods 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• OOYGSFOGFJDDHP-KMCOLRRFSA-N kanamycin A sulfate Chemical group OS(O)(=O)=O.O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N OOYGSFOGFJDDHP-KMCOLRRFSA-N 0.000 claims 1
• 208000024891 symptom Diseases 0.000 claims 1