JP2016521707A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016521707A5 JP2016521707A5 JP2016517967A JP2016517967A JP2016521707A5 JP 2016521707 A5 JP2016521707 A5 JP 2016521707A5 JP 2016517967 A JP2016517967 A JP 2016517967A JP 2016517967 A JP2016517967 A JP 2016517967A JP 2016521707 A5 JP2016521707 A5 JP 2016521707A5
- Authority
- JP
- Japan
- Prior art keywords
- activatable antibody
- target
- seq
- activatable
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361830913P | 2013-06-04 | 2013-06-04 | |
| US61/830,913 | 2013-06-04 | ||
| US201361919935P | 2013-12-23 | 2013-12-23 | |
| US61/919,935 | 2013-12-23 | ||
| PCT/US2014/040931 WO2014197612A1 (en) | 2013-06-04 | 2014-06-04 | Compositions and methods for conjugating activatable antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020019517A Division JP2020079292A (ja) | 2013-06-04 | 2020-02-07 | 活性化可能抗体を結合するための組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016521707A JP2016521707A (ja) | 2016-07-25 |
| JP2016521707A5 true JP2016521707A5 (enExample) | 2017-07-20 |
| JP6660294B2 JP6660294B2 (ja) | 2020-03-11 |
Family
ID=51023194
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016517967A Active JP6660294B2 (ja) | 2013-06-04 | 2014-06-04 | 活性化可能抗体を結合するための組成物及び方法 |
| JP2020019517A Pending JP2020079292A (ja) | 2013-06-04 | 2020-02-07 | 活性化可能抗体を結合するための組成物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020019517A Pending JP2020079292A (ja) | 2013-06-04 | 2020-02-07 | 活性化可能抗体を結合するための組成物及び方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US9517276B2 (enExample) |
| EP (1) | EP3003387A1 (enExample) |
| JP (2) | JP6660294B2 (enExample) |
| KR (1) | KR20160018579A (enExample) |
| CN (2) | CN105658240A (enExample) |
| AU (2) | AU2014274982B2 (enExample) |
| BR (1) | BR112015030514A2 (enExample) |
| CA (1) | CA2913732A1 (enExample) |
| RU (1) | RU2015156888A (enExample) |
| WO (1) | WO2014197612A1 (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201203442D0 (en) | 2012-02-28 | 2012-04-11 | Univ Birmingham | Immunotherapeutic molecules and uses |
| CN110078827A (zh) | 2012-04-27 | 2019-08-02 | 西托姆克斯治疗公司 | 结合表皮生长因子受体的可活化的抗体其使用方法 |
| BR112015030514A2 (pt) * | 2013-06-04 | 2017-08-29 | Cytomx Therapeutics Inc | Composições e métodos para conjugação de anticorpos ativáveis |
| JP6693872B2 (ja) * | 2013-07-25 | 2020-05-13 | シトムクス セラピューティクス,インコーポレイティド | 多重特異性抗体、多重特異性活性化可能抗体、及びそれらの使用方法 |
| PE20160674A1 (es) | 2013-08-28 | 2016-07-21 | Stemcentrx Inc | Metodos de conjugacion de anticuerpos especificos de sitio y composiciones |
| US9540440B2 (en) | 2013-10-30 | 2017-01-10 | Cytomx Therapeutics, Inc. | Activatable antibodies that bind epidermal growth factor receptor and methods of use thereof |
| BR112016010169A2 (pt) | 2013-11-06 | 2017-12-05 | Stemcentrx Inc | anticorpos anticlaudina e métodos de uso |
| WO2015089283A1 (en) | 2013-12-11 | 2015-06-18 | Cytomx Therapeutics, Inc. | Antibodies that bind activatable antibodies and methods of use thereof |
| PE20160993A1 (es) | 2013-12-12 | 2016-10-14 | Abbvie Stemcentrx Llc | Nuevos anticuerpos anti-dpep3 y metodos de uso |
| WO2015127407A1 (en) | 2014-02-21 | 2015-08-27 | Stemcentrx, Inc. | Anti-dll3 antibodies and drug conjugates for use in melanoma |
| WO2016014974A2 (en) | 2014-07-25 | 2016-01-28 | Cytomx Therapeutics, Inc. | Anti-cd3 antibodies, activatable anti-cd3 antibodies, multispecific anti-cd3 antibodies, multispecific activatable anti-cd3 antibodies, and methods of using the same |
| TW201617368A (zh) | 2014-09-05 | 2016-05-16 | 史坦森特瑞斯公司 | 新穎抗mfi2抗體及使用方法 |
| EP3733696A1 (en) * | 2015-01-13 | 2020-11-04 | City of Hope | Ctla4-binding protein peptide-linker masks |
| MA41374A (fr) * | 2015-01-20 | 2017-11-28 | Cytomx Therapeutics Inc | Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci |
| CN108367057B (zh) * | 2015-04-06 | 2022-11-22 | 赛通免疫股份有限公司 | 用于胶质母细胞瘤的egfr导向的car疗法 |
| SG10202110908WA (en) * | 2015-05-04 | 2021-11-29 | Cytomx Therapeutics Inc | Anti-cd166 antibodies, activatable anti-cd166 antibodies, and methods of use thereof |
| CN107709356A (zh) * | 2015-06-26 | 2018-02-16 | 南加利福尼亚大学 | 用于肿瘤特异性活化的掩蔽嵌合抗原受体t细胞 |
| CN106519037B (zh) * | 2015-09-11 | 2019-07-23 | 科济生物医药(上海)有限公司 | 可活化的嵌合受体 |
| EP3903818A1 (en) | 2015-11-19 | 2021-11-03 | Revitope Limited | Functional antibody fragment complementation for a two-components system for redirected killing of unwanted cells |
| CN105267982A (zh) * | 2015-11-20 | 2016-01-27 | 暨南大学 | 一种rhHER2抗体与MMAE偶联物及其制备方法与应用 |
| EP3895529B1 (en) * | 2016-02-29 | 2026-04-29 | Regeneron Pharmaceuticals, Inc. | Rodents having a humanized tmprss gene |
| US12128102B2 (en) | 2016-03-08 | 2024-10-29 | Takeda Pharmaceutical Company Limited | Constrained conditionally activated binding proteins |
| TW201741340A (zh) * | 2016-05-09 | 2017-12-01 | 賽基公司 | Cd47抗體及使用其之方法 |
| KR20190089034A (ko) | 2016-12-09 | 2019-07-29 | 시애틀 지네틱스, 인크. | 코일드 코일에 의해 차폐된 이가 항체 |
| SG11202000105QA (en) | 2017-07-14 | 2020-02-27 | Cytomx Therapeutics Inc | Anti-cd166 antibodies and uses thereof |
| WO2019051102A2 (en) | 2017-09-08 | 2019-03-14 | Maverick Therapeutics, Inc. | Constrained conditionally activated binding proteins |
| US11472889B2 (en) | 2017-10-14 | 2022-10-18 | Cytomx Therapeutics, Inc. | Antibodies, activatable antibodies, bispecific antibodies, and bispecific activatable antibodies and methods of use thereof |
| JP2021518603A (ja) | 2018-03-20 | 2021-08-02 | シートムエックス セラピューティクス,インコーポレイテッド | 哺乳動物対象における活性化可能抗体種の定量薬理学モデリングのためのシステムおよび方法 |
| CN108484781B (zh) * | 2018-04-23 | 2021-05-04 | 深圳市国创纳米抗体技术有限公司 | 一种纳米抗体与铜绿假单胞菌外毒素的融合蛋白及应用 |
| WO2019222294A1 (en) | 2018-05-14 | 2019-11-21 | Werewolf Therapeutics, Inc. | Activatable cytokine polypeptides and methods of use thereof |
| US20210130430A1 (en) | 2018-05-14 | 2021-05-06 | Werewolf Therapeutics, Inc. | Activatable cytokine polypeptides and methods of use thereof |
| CN113840832A (zh) | 2018-05-14 | 2021-12-24 | 狼人治疗公司 | 可活化白介素-2多肽及其使用方法 |
| US12458705B2 (en) * | 2018-06-12 | 2025-11-04 | Angiex, Inc. | Antibody-oligonucleotide conjugates |
| EP3829642A1 (en) | 2018-07-31 | 2021-06-09 | Amgen Inc. | Pharmaceutical formulations of masked antibodies |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| SG11202105476XA (en) | 2018-12-06 | 2021-06-29 | Cytomx Therapeutics Inc | Matrix metalloprotease-cleavable and serine or cysteine protease-cleavable substrates and methods of use thereof |
| US12109273B2 (en) | 2019-02-15 | 2024-10-08 | Wuxi Xdc Singapore Private Limited | Process for preparing antibody-drug conjugates with improved homogeneity |
| CN117679532A (zh) | 2019-02-15 | 2024-03-12 | 上海药明合联生物技术有限公司 | 用于制备具有改善的同质性的抗体-药物缀合物的方法 |
| US20220233705A1 (en) * | 2019-02-26 | 2022-07-28 | Cytomx Therapeutics, Inc. | Combined therapies of activatable immune checkpoint inhibitors and conjugated activatable antibodies |
| WO2020181140A1 (en) | 2019-03-05 | 2020-09-10 | Maverick Therapeutics, Inc. | Constrained conditionally activated binding proteins |
| KR20220023988A (ko) | 2019-05-14 | 2022-03-03 | 웨어울프 세라퓨틱스, 인크. | 분리 모이어티 및 이의 사용 방법 |
| BR112022009110A2 (pt) | 2019-11-14 | 2022-07-26 | Werewolf Therapeutics Inc | Polipeptídeos de citocina ativáveis e métodos de uso destes |
| PH12022551426A1 (en) * | 2020-01-06 | 2023-11-20 | Cytomx Therapeutics Inc | Auristatin-related compounds, conjugated auristatin-related compounds, and methods of use thereof |
| CA3174665A1 (en) | 2020-04-09 | 2021-10-14 | Cytomx Therapeutics, Inc. | Compositions containing activatable antibodies |
| CN112285361B (zh) * | 2020-09-27 | 2023-12-05 | 中国人民解放军空军军医大学 | 排除抗-cd38单克隆抗体药物对抗人球蛋白检测干扰的试剂 |
| WO2022081541A1 (en) * | 2020-10-13 | 2022-04-21 | Chan Zuckerberg Biohub, Inc. | Compositions and methods involving antibody constructs |
| WO2023070353A1 (en) * | 2021-10-27 | 2023-05-04 | Adagene Pte. Ltd. | Anti-cd47 antibodies and methods of use thereof |
| JP2025524628A (ja) | 2022-07-12 | 2025-07-30 | シートムエックス セラピューティクス,インコーポレイテッド | Epcamイムノコンジュゲート及びその使用 |
| CN120058950A (zh) * | 2023-11-28 | 2025-05-30 | 昆山新蕴达生物科技有限公司 | 抗adam9的抗体及其用途 |
| WO2025240659A2 (en) | 2024-05-14 | 2025-11-20 | Cytomx Therapeutics, Inc. | Activatable constructs, compositions and methods |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| DE3788058T2 (de) | 1986-08-28 | 1994-04-21 | Teijin Ltd | Zelltoxischer antikörperkomplex und verfahren zu seiner herstellung. |
| US5151510A (en) | 1990-04-20 | 1992-09-29 | Applied Biosystems, Inc. | Method of synethesizing sulfurized oligonucleotide analogs |
| DE69303494T2 (de) | 1992-11-13 | 1997-01-16 | Idec Pharma Corp | Therapeutische verwendung von chimerischen und markierten antikörper gegen menschlichen b lymphozyt beschränkter differenzierung antigen für die behandlung von b-zell-lymphoma |
| US5635483A (en) | 1992-12-03 | 1997-06-03 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Tumor inhibiting tetrapeptide bearing modified phenethyl amides |
| US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
| US6130237A (en) | 1996-09-12 | 2000-10-10 | Cancer Research Campaign Technology Limited | Condensed N-aclyindoles as antitumor agents |
| EP1286700A2 (en) * | 2000-06-01 | 2003-03-05 | Universite Catholique De Louvain | Tumor activated prodrug compounds |
| US7465790B2 (en) | 2000-10-09 | 2008-12-16 | Isis Innovation, Inc. | Therapeutic antibodies |
| US6884869B2 (en) | 2001-04-30 | 2005-04-26 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
| US20040109855A1 (en) | 2002-07-23 | 2004-06-10 | Herman Waldmann | Therapeutic antibodies with reduced side effect |
| ES2544527T3 (es) | 2002-07-31 | 2015-09-01 | Seattle Genetics, Inc. | Conjugados de fármacos y su uso para tratar el cáncer, una enfermedad autoinmune o una enfermedad infecciosa |
| US8809504B2 (en) | 2002-09-03 | 2014-08-19 | Vit Lauermann | Inhibitor which is deactivatable by a reagent produced by a target cell |
| US8088387B2 (en) * | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| EP3434275A1 (en) | 2003-11-06 | 2019-01-30 | Seattle Genetics, Inc. | Assay for cancer cells based on the use of auristatin conjugates with antibodies |
| CA2558399C (en) * | 2004-03-02 | 2015-05-19 | Seattle Genetics, Inc. | Partially loaded antibodies and methods of their conjugation |
| WO2006071441A2 (en) * | 2004-11-30 | 2006-07-06 | Curagen Corporation | Antibodies directed to gpnmb and uses thereof |
| CN103127523A (zh) * | 2005-06-20 | 2013-06-05 | Psma开发有限公司 | Psma抗体-药物缀合物 |
| EP2535346B1 (en) | 2005-08-31 | 2017-08-02 | The Regents of The University of California | Cellular libraries of peptide sequences (CLiPS) and methods of using the same |
| CA2645347A1 (en) | 2006-03-10 | 2007-09-20 | Diatos | Anticancer drugs conjugated to antibody via an enzyme cleavable linker |
| WO2009014726A1 (en) | 2007-07-26 | 2009-01-29 | The Regents Of The University Of California | Methods for enhancing bacterial cell display of proteins and peptides |
| US20090304719A1 (en) * | 2007-08-22 | 2009-12-10 | Patrick Daugherty | Activatable binding polypeptides and methods of identification and use thereof |
| US20100189727A1 (en) * | 2008-12-08 | 2010-07-29 | Tegopharm Corporation | Masking Ligands For Reversible Inhibition Of Multivalent Compounds |
| WO2010081173A2 (en) | 2009-01-12 | 2010-07-15 | Cytomx Therapeutics, Llc | Modified antibody compositions, methods of making and using thereof |
| EP2427479B1 (en) | 2009-05-07 | 2018-11-21 | The Regents of The University of California | Antibodies and methods of use thereof |
| CA2930801C (en) * | 2010-11-05 | 2019-05-28 | Rinat Neuroscience Corporation | Engineered polypeptide conjugates and methods for making thereof using transglutaminase |
| SG10201605401WA (en) | 2011-04-01 | 2016-08-30 | Wyeth Llc | Antibody-drug conjugates |
| EP3501546A3 (de) | 2011-04-21 | 2019-09-18 | Seattle Genetics, Inc. | Cystein-wirkstoff konjugate und ihre verwendung |
| WO2013068874A1 (en) | 2011-11-11 | 2013-05-16 | Pfizer Inc. | Antibody-drug conjugates |
| US8871908B2 (en) * | 2011-11-11 | 2014-10-28 | Rinat Neuroscience Corp. | Antibodies specific for Trop-2 and their uses |
| TWI589592B (zh) | 2011-11-17 | 2017-07-01 | 輝瑞股份有限公司 | 胞毒性肽類以及其抗體藥物共軛體 |
| BR112014020697B1 (pt) * | 2012-02-24 | 2024-01-09 | Alteogen Inc | Anticorpo modificado compreendendo um motivo contendo cisteína na terminação do anticorpo, conjugado anticorpo-droga modificado compreendendo uma droga ligada ao anticorpo modificado e método de produção do mesmo |
| US9856314B2 (en) * | 2012-06-22 | 2018-01-02 | Cytomx Therapeutics, Inc. | Activatable antibodies having non-binding steric moieties and methods of using the same |
| SG11201408554QA (en) * | 2012-06-22 | 2015-02-27 | Cytomx Therapeutics Inc | Anti-jagged 1/jagged 2 cross-reactive antibodies, activatable anti-jagged antibodies and methods of use thereof |
| WO2014004694A1 (en) | 2012-06-26 | 2014-01-03 | Massachusetts Institute Of Technology | Reversible masking of pore-forming proteins for macromolecular delivery |
| US9487590B2 (en) | 2012-09-25 | 2016-11-08 | Cytomx Therapeutics, Inc. | Activatable antibodies that bind interleukin-6 receptor and methods of use thereof |
| US20150290342A1 (en) * | 2012-10-24 | 2015-10-15 | Polytherics Limited | Drug-protein conjugates |
| CA2896282C (en) * | 2013-01-04 | 2021-07-20 | Cytomx Therapeutics, Inc. | Compositions and methods for detecting protease activity in biological systems |
| BR112015030514A2 (pt) * | 2013-06-04 | 2017-08-29 | Cytomx Therapeutics Inc | Composições e métodos para conjugação de anticorpos ativáveis |
-
2014
- 2014-06-04 BR BR112015030514A patent/BR112015030514A2/pt not_active IP Right Cessation
- 2014-06-04 KR KR1020157036292A patent/KR20160018579A/ko not_active Ceased
- 2014-06-04 RU RU2015156888A patent/RU2015156888A/ru not_active Application Discontinuation
- 2014-06-04 JP JP2016517967A patent/JP6660294B2/ja active Active
- 2014-06-04 CN CN201480043966.1A patent/CN105658240A/zh active Pending
- 2014-06-04 US US14/296,207 patent/US9517276B2/en active Active
- 2014-06-04 EP EP14733931.1A patent/EP3003387A1/en active Pending
- 2014-06-04 CA CA2913732A patent/CA2913732A1/en not_active Abandoned
- 2014-06-04 CN CN202210873109.0A patent/CN116063479A/zh active Pending
- 2014-06-04 WO PCT/US2014/040931 patent/WO2014197612A1/en not_active Ceased
- 2014-06-04 AU AU2014274982A patent/AU2014274982B2/en not_active Ceased
-
2016
- 2016-11-22 US US15/359,100 patent/US20170072067A1/en not_active Abandoned
-
2020
- 2020-02-07 JP JP2020019517A patent/JP2020079292A/ja active Pending
- 2020-02-26 AU AU2020201405A patent/AU2020201405A1/en not_active Abandoned
-
2021
- 2021-04-09 US US17/227,004 patent/US11992528B2/en active Active
-
2024
- 2024-04-26 US US18/648,088 patent/US20250099606A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2015156888A (ru) | Композиции и методы конъюгирования активируемых антител | |
| JP2022512124A5 (enExample) | ||
| JP7481852B2 (ja) | 免疫リガンド/ペイロード複合体の生産方法 | |
| JP2026004397A5 (enExample) | ||
| RU2016135239A (ru) | Субстраты матриптазы и u-активатора плазминогена и другие расщепляемые остатки и способы их применения | |
| JP2018504925A5 (enExample) | ||
| JP2016525551A5 (enExample) | ||
| JP2017509594A5 (enExample) | ||
| JP2018520092A5 (enExample) | ||
| RU2016106115A (ru) | Мультспецифические антитела, мультспецифические активируемые антитела и способы их применения | |
| JP2016538240A5 (enExample) | ||
| HRP20220631T1 (hr) | Supstrati koje mogu cijepati matrične metaloproteaze i serinske proteaze, te postupci njihove uporabe | |
| JP2015516813A5 (enExample) | ||
| JP2017523176A5 (enExample) | ||
| RU2015100656A (ru) | Способ получения конъюгатов fc-фрагмента антитела, включающих по меньшей мере одну связывающую группировку, которая специфически связывается с мишенью, и их применения | |
| HRP20200721T1 (hr) | Aktivirajuća anti-cd166 antitijela i postupci njihove uporabe | |
| RU2015101803A (ru) | Перекрестно реактивные антитела к jagged 1/k jagged 2, активируемые антитела к jagged и способы их применения | |
| HRP20220172T1 (hr) | Protutijela protiv cd71 koja se mogu aktivirati, te postupci njihove uporabe | |
| JP2020500016A5 (enExample) | ||
| CO6180466A2 (es) | Composiciones y metodos para diagnosticar y tratar cancer | |
| JP2018520991A5 (enExample) | ||
| PE20071055A1 (es) | Anticuerpos anti mn | |
| CN102665768B (zh) | 肽清除剂 | |
| IN2012DN02535A (enExample) | ||
| CA2648109A1 (en) | Combination of an anti-ed-b fibronectin domain antibody-il-2 fusion protein and gemcitabine |