MX353608B - Anticuerpo modificado en el que el tema que comprende residuos de cisteina esta ligado, conjugado de farmaco de anticuerpo modificado que comprende el anticuerpo modificado y metodo de produccion para el mismo. - Google Patents

Anticuerpo modificado en el que el tema que comprende residuos de cisteina esta ligado, conjugado de farmaco de anticuerpo modificado que comprende el anticuerpo modificado y metodo de produccion para el mismo.

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Publication number
MX353608B
MX353608B MX2014010054A MX2014010054A MX353608B MX 353608 B MX353608 B MX 353608B MX 2014010054 A MX2014010054 A MX 2014010054A MX 2014010054 A MX2014010054 A MX 2014010054A MX 353608 B MX353608 B MX 353608B
Authority
MX
Mexico
Prior art keywords
antibody
modified antibody
drug conjugate
bound
drug
Prior art date
Application number
MX2014010054A
Other languages
English (en)
Other versions
MX2014010054A (es
Inventor
Soon Jae Park
Hye-Shin Chung
Seonhun Kwon
Sunbae Lee
Sun-Ah You
Yong Mo Kim
Original Assignee
Alteogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alteogen Inc filed Critical Alteogen Inc
Publication of MX2014010054A publication Critical patent/MX2014010054A/es
Publication of MX353608B publication Critical patent/MX353608B/es

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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
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Abstract

La presente invención se refiere a un anticuerpo en el que un motivo compuesto de una secuencia de amino ácido que incluye uno o más residuos de cisteína se une al termino de anticuerpo parental, particularmente al termino de cadena pesada del anticuerpo parental. También, la presente invención se refiere a un conjugado anticuerpo-fármaco (mADC) que comprende un fármaco unido al anticuerpo, y un método para producir el anticuerpo o el conjugado anticuerpo-fármaco. El conjugado anticuerpo-fármaco modificado de acuerdo a la invención puede entregarse de manera segura el fármaco a una célula diana debido a su alta especificidad antígeno, y de este modo puede aumentar el efecto terapéutico del fármaco. También puede aumentar la usabilidad de los fármacos, particularmente fármacos anticancerígenos, el uso de los cuales esta restringido debido a su toxicidad, a pesar de su alta eficacia. Además, la invención se refiere a una composición para el tratamiento de enfermedades, particularmente canceres, que comprende el conjugado anticuerpo-fármaco modificado.
MX2014010054A 2012-02-24 2013-02-22 Anticuerpo modificado en el que el tema que comprende residuos de cisteina esta ligado, conjugado de farmaco de anticuerpo modificado que comprende el anticuerpo modificado y metodo de produccion para el mismo. MX353608B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20120019221 2012-02-24
PCT/KR2013/001417 WO2013125891A1 (ko) 2012-02-24 2013-02-22 시스테인 잔기를 포함하는 모티프가 결합된 변형항체, 상기 변형항체를 포함하는 변형항체-약물 접합체 및 그 제조방법

Publications (2)

Publication Number Publication Date
MX2014010054A MX2014010054A (es) 2015-05-11
MX353608B true MX353608B (es) 2018-01-19

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US (2) US9814782B2 (es)
EP (1) EP2818480B1 (es)
JP (1) JP6067754B2 (es)
KR (2) KR101541764B1 (es)
CN (1) CN104220458B (es)
AU (1) AU2013222935B2 (es)
BR (1) BR112014020697B1 (es)
CA (1) CA2864872C (es)
MX (1) MX353608B (es)
RU (1) RU2582259C2 (es)
WO (1) WO2013125891A1 (es)

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WO2013125891A1 (ko) * 2012-02-24 2013-08-29 (주)알테오젠 시스테인 잔기를 포함하는 모티프가 결합된 변형항체, 상기 변형항체를 포함하는 변형항체-약물 접합체 및 그 제조방법
BR112015030514A2 (pt) * 2013-06-04 2017-08-29 Cytomx Therapeutics Inc Composições e métodos para conjugação de anticorpos ativáveis
CN107075473B (zh) * 2014-11-07 2021-07-13 国立大学法人大阪大学 其中未分化细胞被去除的分化诱导的细胞群、其用途及其制备方法
CN104569373B (zh) * 2015-01-27 2016-08-17 苏州博源医疗科技有限公司 一种甲氨蝶呤均相酶免疫检测试剂及其制备和检测方法
CN106146627B (zh) * 2015-03-31 2019-11-12 上海业力生物科技有限公司 Fc特异结合蛋白、IgG亲和层析介质及其制备方法与应用
DK3334760T3 (da) * 2015-08-12 2021-04-19 Pfizer Antistofcysteiner med kappe og uden kappe, og deres anvendelse i antistof-lægemiddel-konjugering
KR101704379B1 (ko) * 2015-10-27 2017-02-08 (주)알테오젠 항체-약물 접합체 및 그 제조방법
CA3015054A1 (en) * 2016-02-18 2017-08-24 Kyoto University Complex capable of inhibiting genetic function in exosome, and cancer proliferation and/or metastasis suppressor
MA45328A (fr) 2016-04-01 2019-02-06 Avidity Biosciences Llc Compositions acide nucléique-polypeptide et utilisations de celles-ci
WO2017176007A1 (ko) 2016-04-06 2017-10-12 (주)알테오젠 변형항체를 포함하는 항체-약물 접합체
ES2929010T3 (es) * 2016-04-06 2022-11-24 Alteogen Inc Conjugado de anticuerpo-fármaco que comprende anticuerpo modificado
IL294146B2 (en) * 2016-05-17 2024-01-01 Abbvie Biotherapeutics Inc Antibody conjugates against cMet with a drug and methods of using them
SG11201900699QA (en) * 2016-08-09 2019-02-27 Seattle Genetics Inc Drug conjugates with self-stabilizing linkers having improved physiochemical properties
WO2018065501A1 (en) * 2016-10-05 2018-04-12 F. Hoffmann-La Roche Ag Methods for preparing antibody drug conjugates
JP7066714B2 (ja) * 2016-12-21 2022-05-13 バイエル・ファルマ・アクティエンゲゼルシャフト 酵素的に切断可能な基を有する抗体薬物コンジュゲート（ａｄｃ）
CA3060225A1 (en) * 2017-05-09 2018-11-15 Cyano Biotech Gmbh Modified microcystins and nodularins
GB201710620D0 (en) 2017-07-03 2017-08-16 Glaxosmithkline Intellectual Property Ltd Targeted protein degradation
MA51103A (fr) 2017-12-06 2020-10-14 Avidity Biosciences Inc Compositions et procédés de traitement de l'atrophie musculaire et de la dystrophie myotonique
CN108218985B (zh) * 2017-12-12 2021-04-30 山西农业大学 一种利用特征多肽制备fst蛋白特异性抗体的方法及其应用
WO2020089811A1 (en) 2018-10-31 2020-05-07 Novartis Ag Dc-sign antibody drug conjugates
JP2020080784A (ja) * 2018-11-29 2020-06-04 シスメックス株式会社 融合ポリペプチド、融合ポリペプチドの製造方法、及び融合ポリペプチドをコードするｄｎａ
JP2022519120A (ja) * 2019-02-04 2022-03-18 ミネルヴァ バイオテクノロジーズ コーポレーション 抗ｎｍｅ抗体および癌または癌転移の治療方法
CN117843795A (zh) * 2019-03-11 2024-04-09 凯惠科技发展(上海)有限公司 一种含半胱氨酸的抗体、药物偶联物及其应用
EP3947474A4 (en) * 2019-03-25 2023-07-05 Immunwork Inc. COMPOSITE POLYPEPTIDE WITH A METAL BOND MOTIFS AND MOLECULAR CONSTRUCT THEREOF
US20230151342A1 (en) * 2020-02-28 2023-05-18 The Broad Institute, Inc Zinc finger degradation domains
TW202144572A (zh) 2020-03-19 2021-12-01 美商亞維代堤生物科學公司 治療臉肩胛肱骨肌肉失養症之組合物及方法
KR20230028796A (ko) * 2020-06-26 2023-03-02 미네르바 바이오테크놀로지 코포레이션 항-nme 항체 및 암 또는 암 전이의 치료 방법
AU2022345098A1 (en) 2021-09-16 2024-04-04 Avidity Biosciences, Inc. Compositions and methods of treating facioscapulohumeral muscular dystrophy

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0590058B1 (en) * 1991-06-14 2003-11-26 Genentech, Inc. HUMANIZED Heregulin ANTIBODy
US6214345B1 (en) 1993-05-14 2001-04-10 Bristol-Myers Squibb Co. Lysosomal enzyme-cleavable antitumor drug conjugates
US5464934A (en) * 1993-05-14 1995-11-07 Mallinckrodt Medical, Inc. Metal chelates as spacer compounds in biologically active peptides
AU2887195A (en) * 1994-06-24 1996-01-19 Akzo Nobel N.V. Kit for pretargeting and novel pretargeting conjugates
US20040018194A1 (en) 2000-11-28 2004-01-29 Francisco Joseph A. Recombinant anti-CD30 antibodies and uses thereof
GB0124317D0 (en) 2001-10-10 2001-11-28 Celltech R&D Ltd Biological products
WO2005117986A2 (en) * 2004-06-01 2005-12-15 Genentech, Inc. Antibody drug conjugates and methods
US20050180972A1 (en) 2002-07-31 2005-08-18 Wahl Alan F. Anti-CD20 antibody-drug conjugates for the treatment of cancer and immune disorders
EP1391213A1 (en) 2002-08-21 2004-02-25 Boehringer Ingelheim International GmbH Compositions and methods for treating cancer using maytansinoid CD44 antibody immunoconjugates and chemotherapeutic agents
CA2508631A1 (en) * 2002-12-09 2004-06-24 Toolgen, Inc. Regulatory zinc finger proteins
PT2489364E (pt) 2003-11-06 2015-04-16 Seattle Genetics Inc Compostos de monometilvalina conjugados com anticorpos
ITMI20040928A1 (it) 2004-05-07 2004-08-07 Uni Di Bologna Dipartiment O D Procedura per la preparazione di coniugati della doxorubicina con l'albumina umana lattosaminata
DK1791565T3 (en) 2004-09-23 2016-08-01 Genentech Inc Cysteingensplejsede antibodies and conjugates
PA8660701A1 (es) 2005-02-04 2006-09-22 Pfizer Prod Inc Agonistas de pyy y sus usos
KR20140085544A (ko) * 2006-05-30 2014-07-07 제넨테크, 인크. 항체 및 면역접합체 및 이들의 용도
WO2008140538A1 (en) * 2006-10-04 2008-11-20 Verenium Corporation Dna display screen for expression product with desired binding properties
CA2671457C (en) * 2006-12-01 2017-09-26 Medarex, Inc. Human antibodies that bind cd22 and uses thereof
EP2144628B1 (en) * 2007-05-08 2012-10-17 Genentech, Inc. Cysteine engineered anti-muc16 antibodies and antibody drug conjugates
WO2009026274A1 (en) * 2007-08-22 2009-02-26 Medarex, Inc. Site-specific attachment of drugs or other agents to engineered antibodies with c-terminal extensions
MY188455A (en) * 2007-10-19 2021-12-09 Genentech Inc Cysteine engineered anti-tenb2 antibodies and antibody drug conjugates
TW201120210A (en) * 2009-11-05 2011-06-16 Hoffmann La Roche Glycosylated repeat-motif-molecule conjugates
EP2579897A1 (en) * 2010-06-08 2013-04-17 Genentech, Inc. Cysteine engineered antibodies and conjugates
WO2013125891A1 (ko) * 2012-02-24 2013-08-29 (주)알테오젠 시스테인 잔기를 포함하는 모티프가 결합된 변형항체, 상기 변형항체를 포함하는 변형항체-약물 접합체 및 그 제조방법

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