JP2018504925A5 - - Google Patents
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- JP2018504925A5 JP2018504925A5 JP2017556794A JP2017556794A JP2018504925A5 JP 2018504925 A5 JP2018504925 A5 JP 2018504925A5 JP 2017556794 A JP2017556794 A JP 2017556794A JP 2017556794 A JP2017556794 A JP 2017556794A JP 2018504925 A5 JP2018504925 A5 JP 2018504925A5
- Authority
- JP
- Japan
- Prior art keywords
- isolated polypeptide
- optionally
- agent
- linking peptide
- isolated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 62
- 229920001184 polypeptide Polymers 0.000 claims 46
- 102000004196 processed proteins & peptides Human genes 0.000 claims 46
- 239000003795 chemical substances by application Substances 0.000 claims 16
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- 108010022999 Serine Proteases Proteins 0.000 claims 5
- 102000012479 Serine Proteases Human genes 0.000 claims 5
- 210000004899 c-terminal region Anatomy 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical group 0.000 claims 5
- 239000000758 substrate Substances 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- BLUGYPPOFIHFJS-UUFHNPECSA-N (2s)-n-[(2s)-1-[[(3r,4s,5s)-3-methoxy-1-[(2s)-2-[(1r,2r)-1-methoxy-2-methyl-3-oxo-3-[[(1s)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino]propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]-3-methyl-2-(methylamino)butanamid Chemical group CN[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C=1SC=CN=1)CC1=CC=CC=C1 BLUGYPPOFIHFJS-UUFHNPECSA-N 0.000 claims 2
- IEDXPSOJFSVCKU-HOKPPMCLSA-N [4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrolidin-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-[(2S)-1-[[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-N-methylcarbamate Chemical group CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)c1ccccc1)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C(=O)OCc1ccc(NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@@H](NC(=O)CCCCCN2C(=O)CCC2=O)C(C)C)cc1)C(C)C IEDXPSOJFSVCKU-HOKPPMCLSA-N 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 238000010494 dissociation reaction Methods 0.000 claims 2
- 230000005593 dissociations Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 108010093470 monomethyl auristatin E Proteins 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- WOWDZACBATWTAU-FEFUEGSOSA-N (2s)-2-[[(2s)-2-(dimethylamino)-3-methylbutanoyl]amino]-n-[(3r,4s,5s)-1-[(2s)-2-[(1r,2r)-3-[[(1s,2r)-1-hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-n,3-dimethylbutanamide Chemical group CC(C)[C@H](N(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C)[C@@H](O)C1=CC=CC=C1 WOWDZACBATWTAU-FEFUEGSOSA-N 0.000 claims 1
- 102100026802 72 kDa type IV collagenase Human genes 0.000 claims 1
- 108010075254 C-Peptide Proteins 0.000 claims 1
- 101000627872 Homo sapiens 72 kDa type IV collagenase Proteins 0.000 claims 1
- 101001011906 Homo sapiens Matrix metalloproteinase-14 Proteins 0.000 claims 1
- 101000990902 Homo sapiens Matrix metalloproteinase-9 Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 108010091175 Matriptase Proteins 0.000 claims 1
- 102100030216 Matrix metalloproteinase-14 Human genes 0.000 claims 1
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 claims 1
- 108010006035 Metalloproteases Proteins 0.000 claims 1
- 102000005741 Metalloproteases Human genes 0.000 claims 1
- 229940122255 Microtubule inhibitor Drugs 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010039509 Scab Diseases 0.000 claims 1
- 102100037942 Suppressor of tumorigenicity 14 protein Human genes 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 108010044540 auristatin Proteins 0.000 claims 1
- HXCHCVDVKSCDHU-LULTVBGHSA-N calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 claims 1
- 229930195731 calicheamicin Natural products 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 229940039227 diagnostic agent Drugs 0.000 claims 1
- AMRJKAQTDDKMCE-UHFFFAOYSA-N dolastatin Chemical compound CC(C)C(N(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(C(C)C)C(OC)CC(=O)N1CCCC1C(OC)C(C)C(=O)NC(C=1SC=CN=1)CC1=CC=CC=C1 AMRJKAQTDDKMCE-UHFFFAOYSA-N 0.000 claims 1
- 229930188854 dolastatin Natural products 0.000 claims 1
- VQNATVDKACXKTF-XELLLNAOSA-N duocarmycin Chemical compound COC1=C(OC)C(OC)=C2NC(C(=O)N3C4=CC(=O)C5=C([C@@]64C[C@@H]6C3)C=C(N5)C(=O)OC)=CC2=C1 VQNATVDKACXKTF-XELLLNAOSA-N 0.000 claims 1
- 229960005501 duocarmycin Drugs 0.000 claims 1
- 229930184221 duocarmycin Natural products 0.000 claims 1
- 230000000873 masking effect Effects 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 231100000782 microtubule inhibitor Toxicity 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021204362A JP7540990B2 (ja) | 2015-01-20 | 2021-12-16 | マトリックスメタロプロテアーゼ切断可能及びセリンプロテアーゼ切断可能な基質並びにそれらの使用方法 |
| JP2024135724A JP2024170436A (ja) | 2015-01-20 | 2024-08-15 | マトリックスメタロプロテアーゼ切断可能及びセリンプロテアーゼ切断可能な基質並びにそれらの使用方法 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562105490P | 2015-01-20 | 2015-01-20 | |
| US62/105,490 | 2015-01-20 | ||
| US201562258015P | 2015-11-20 | 2015-11-20 | |
| US62/258,015 | 2015-11-20 | ||
| US201662278713P | 2016-01-14 | 2016-01-14 | |
| US62/278,713 | 2016-01-14 | ||
| PCT/US2016/014132 WO2016118629A1 (en) | 2015-01-20 | 2016-01-20 | Matrix metalloprotease-cleavable and serine protease cleavable substrates and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021204362A Division JP7540990B2 (ja) | 2015-01-20 | 2021-12-16 | マトリックスメタロプロテアーゼ切断可能及びセリンプロテアーゼ切断可能な基質並びにそれらの使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018504925A JP2018504925A (ja) | 2018-02-22 |
| JP2018504925A5 true JP2018504925A5 (enExample) | 2019-02-28 |
| JP6996981B2 JP6996981B2 (ja) | 2022-03-03 |
Family
ID=55358121
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017556794A Active JP6996981B2 (ja) | 2015-01-20 | 2016-01-20 | マトリックスメタロプロテアーゼ切断可能及びセリンプロテアーゼ切断可能な基質並びにそれらの使用方法 |
| JP2021204362A Active JP7540990B2 (ja) | 2015-01-20 | 2021-12-16 | マトリックスメタロプロテアーゼ切断可能及びセリンプロテアーゼ切断可能な基質並びにそれらの使用方法 |
| JP2024135724A Pending JP2024170436A (ja) | 2015-01-20 | 2024-08-15 | マトリックスメタロプロテアーゼ切断可能及びセリンプロテアーゼ切断可能な基質並びにそれらの使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021204362A Active JP7540990B2 (ja) | 2015-01-20 | 2021-12-16 | マトリックスメタロプロテアーゼ切断可能及びセリンプロテアーゼ切断可能な基質並びにそれらの使用方法 |
| JP2024135724A Pending JP2024170436A (ja) | 2015-01-20 | 2024-08-15 | マトリックスメタロプロテアーゼ切断可能及びセリンプロテアーゼ切断可能な基質並びにそれらの使用方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (5) | US11046759B2 (enExample) |
| EP (2) | EP3247393B1 (enExample) |
| JP (3) | JP6996981B2 (enExample) |
| KR (1) | KR102784383B1 (enExample) |
| CN (7) | CN114478704B (enExample) |
| AU (2) | AU2016209403A1 (enExample) |
| CA (1) | CA2974087A1 (enExample) |
| DK (1) | DK3247393T3 (enExample) |
| EA (1) | EA201791647A1 (enExample) |
| ES (1) | ES2919879T3 (enExample) |
| HR (1) | HRP20220631T8 (enExample) |
| HU (1) | HUE058974T2 (enExample) |
| IL (2) | IL300408B2 (enExample) |
| MA (1) | MA41374A (enExample) |
| PL (1) | PL3247393T3 (enExample) |
| PT (1) | PT3247393T (enExample) |
| RS (1) | RS63276B1 (enExample) |
| SG (2) | SG10201913901QA (enExample) |
| WO (1) | WO2016118629A1 (enExample) |
| ZA (1) | ZA202208160B (enExample) |
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| CN105722859B (zh) | 2013-07-25 | 2021-05-07 | 西托姆克斯治疗公司 | 多特异性抗体、多特异性可活化抗体及其使用方法 |
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