|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US4485045A
(en)
|
1981-07-06 |
1984-11-27 |
Research Corporation |
Synthetic phosphatidyl cholines useful in forming liposomes
|
|
US4522811A
(en)
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
|
US4544545A
(en)
|
1983-06-20 |
1985-10-01 |
Trustees University Of Massachusetts |
Liposomes containing modified cholesterol for organ targeting
|
|
EP0279862B1
(en)
|
1986-08-28 |
1993-11-03 |
Teijin Limited |
Cytocidal antibody complex and process for its preparation
|
|
US5013556A
(en)
|
1989-10-20 |
1991-05-07 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5151510A
(en)
|
1990-04-20 |
1992-09-29 |
Applied Biosystems, Inc. |
Method of synethesizing sulfurized oligonucleotide analogs
|
|
DK0752248T3
(da)
|
1992-11-13 |
2000-11-13 |
Idec Pharma Corp |
Terapeutisk anvendelse af kimæriske og radioaktivt mærkede antistoffer mod humant B-lymfocytbegrænset differentieringsantig
|
|
AR007087A1
(es)
|
1996-05-10 |
1999-10-13 |
Danisco |
Una codificacion de fragmento de adn aislado para una enzima que posee actividad de alfa-glucuronidasa, fragmento de adn correspondiente, vectorrecombinante que tiene insertada dicha codificacion de fragmento de adn, celula huesped transformada con dicho vector recombinante, metodo para producir alfa-
|
|
WO2001034769A2
(en)
*
|
1999-11-05 |
2001-05-17 |
Human Genome Sciences, Inc. |
24 human secreted proteins
|
|
AUPO930697A0
(en)
|
1997-09-19 |
1997-10-09 |
Walter And Eliza Hall Institute Of Medical Research, The |
Catalytic antibodies and a method of producing same
|
|
US6551795B1
(en)
|
1998-02-18 |
2003-04-22 |
Genome Therapeutics Corporation |
Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics
|
|
ES2299244T3
(es)
|
1998-05-13 |
2008-05-16 |
Domantis Limited |
Sistema de exposicion de fagos para la seleccion de proteinas correctamente plegadas.
|
|
US20030236190A1
(en)
*
|
1998-09-02 |
2003-12-25 |
Renuka Pillutla |
Isulin and IGF-1 receptor agonists and antagonists
|
|
US6875741B2
(en)
*
|
1998-09-02 |
2005-04-05 |
Renuka Pillutla |
Insulin and IGF-1 receptor agonists and antagonists
|
|
US7504490B1
(en)
*
|
1998-10-16 |
2009-03-17 |
Oscient Pharmaceuticals Corporation |
Nucleic acid and amino acid sequences relating to Apergillus fumigatus for diagnostics and therapeutics
|
|
WO2000024756A1
(en)
|
1998-10-23 |
2000-05-04 |
Human Genome Sciences, Inc. |
Fibroblast growth factor receptor-5
|
|
US20090087878A9
(en)
*
|
1999-05-06 |
2009-04-02 |
La Rosa Thomas J |
Nucleic acid molecules associated with plants
|
|
AU7833000A
(en)
*
|
1999-09-27 |
2001-04-30 |
Human Genome Sciences, Inc. |
38 human secreted proteins
|
|
WO2001055301A2
(en)
|
2000-01-31 |
2001-08-02 |
Human Genome Sciences, Inc. |
Nucleic acids, proteins, and antibodies
|
|
US6436703B1
(en)
*
|
2000-03-31 |
2002-08-20 |
Hyseq, Inc. |
Nucleic acids and polypeptides
|
|
US20110131679A2
(en)
*
|
2000-04-19 |
2011-06-02 |
Thomas La Rosa |
Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
|
|
WO2001092523A2
(en)
|
2000-05-30 |
2001-12-06 |
Curagen Corporation |
Human polynucleotides and polypeptides encoded thereby
|
|
EP1286700A2
(en)
|
2000-06-01 |
2003-03-05 |
Universite Catholique De Louvain |
Tumor activated prodrug compounds
|
|
US7097977B1
(en)
*
|
2000-07-14 |
2006-08-29 |
Japan Science And Technology Corporation |
Target of anticancer agent
|
|
AU2001280464A1
(en)
|
2000-08-04 |
2002-02-18 |
Eli Lilly And Company |
C1q-related factor, homologous polypeptides and therapeutic uses thereof
|
|
US7465790B2
(en)
|
2000-10-09 |
2008-12-16 |
Isis Innovation, Inc. |
Therapeutic antibodies
|
|
WO2002030460A2
(en)
|
2000-10-09 |
2002-04-18 |
Isis Innovation Ltd. |
Therapeutic antibodies
|
|
AU2002230630A1
(en)
|
2000-11-08 |
2002-05-21 |
Beth Israel Deaconess Medical Center, Inc. |
Methods for determining protease cleavage site motifs
|
|
US7214786B2
(en)
|
2000-12-14 |
2007-05-08 |
Kovalic David K |
Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
|
|
AU2002306849A1
(en)
|
2001-03-21 |
2002-10-08 |
Elitra Pharmaceuticals, Inc. |
Identification of essential genes in microorganisms
|
|
US7630836B2
(en)
*
|
2001-05-30 |
2009-12-08 |
The Kitasato Institute |
Polynucleotides
|
|
AU2002315525A1
(en)
|
2001-07-03 |
2003-01-21 |
Dendreon San Diego Llc |
Nucleic acid molecules encoding a transmembrane serine protease 20, the encoded polypeptides and methods based thereon
|
|
US20050208602A1
(en)
|
2001-08-10 |
2005-09-22 |
Rosen Craig A |
89 human secreted proteins
|
|
US7439319B2
(en)
|
2001-09-14 |
2008-10-21 |
Burnham Institute For Medical Research |
Selective substrates for matrix metalloproteinases
|
|
WO2003038083A1
(en)
|
2001-10-29 |
2003-05-08 |
Bayer Healthcare Ag |
Regulation of human type i adenylate cyclase
|
|
CN101044154A
(zh)
|
2002-02-14 |
2007-09-26 |
威廉·J·鲁特 |
治疗宿主中切割的嵌合分子
|
|
US20060009840A1
(en)
*
|
2002-03-15 |
2006-01-12 |
Hossainy Syed F |
Carrier for releasing a therapeutic substance in response to the presence of an enzyme
|
|
US20030194704A1
(en)
*
|
2002-04-03 |
2003-10-16 |
Penn Sharron Gaynor |
Human genome-derived single exon nucleic acid probes useful for gene expression analysis two
|
|
JP2003339385A
(ja)
*
|
2002-05-29 |
2003-12-02 |
Toyobo Co Ltd |
新規3−ヒドロキシ酪酸脱水素酵素遺伝子、新規3−ヒドロキシ酪酸脱水素酵素の製造法、ならびに、新規3−ヒドロキシ酪酸脱水素酵素を用いたケトン体の測定方法および測定用組成物
|
|
US20040109855A1
(en)
|
2002-07-23 |
2004-06-10 |
Herman Waldmann |
Therapeutic antibodies with reduced side effect
|
|
US8809504B2
(en)
|
2002-09-03 |
2014-08-19 |
Vit Lauermann |
Inhibitor which is deactivatable by a reagent produced by a target cell
|
|
US20040216190A1
(en)
*
|
2003-04-28 |
2004-10-28 |
Kovalic David K. |
Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement
|
|
WO2004099254A2
(en)
|
2003-05-06 |
2004-11-18 |
The Government Of The United States, As Represented By The Secretary Of Health And Human Services |
Activation of recombinant diphtheria toxin fusion proteins by specific proteases highly expressed on the surface of tumor cells
|
|
US7276497B2
(en)
|
2003-05-20 |
2007-10-02 |
Immunogen Inc. |
Cytotoxic agents comprising new maytansinoids
|
|
US9079936B2
(en)
|
2003-07-01 |
2015-07-14 |
University Of Maryland, Baltimore |
Derivatives of APF and methods of use
|
|
WO2005090393A2
(en)
|
2004-02-09 |
2005-09-29 |
The Government Of The United States, As Represented By The Secretary Of Health And Human Services |
Multimeric protein toxins to target cells having multiple identifying characteristics
|
|
GB0417430D0
(en)
|
2004-08-05 |
2004-09-08 |
Uc3 |
A novel HPV vaccine comprising peptides from host cell proteins
|
|
CA2592249C
(en)
|
2004-12-20 |
2014-07-29 |
Amgen Fremont Inc. |
Binding proteins specific for human matriptase
|
|
CA2601400A1
(en)
*
|
2005-03-19 |
2006-09-28 |
Medical Research Council |
Improvements in or relating to treatment and prevention of viral infections
|
|
EP1865981A2
(en)
|
2005-04-07 |
2007-12-19 |
Chiron Corporation |
Cacna1e in cancer diagnosis, detection and treatment
|
|
AU2006284651C1
(en)
|
2005-08-31 |
2013-09-12 |
The Regents Of The University Of California |
Cellular libraries of peptide sequences (CLiPS) and methods of using the same
|
|
JP5219819B2
(ja)
|
2005-10-21 |
2013-06-26 |
カタリスト・バイオサイエンシーズ・インコーポレイテッド |
補体活性化を阻害する修飾プロテアーゼ
|
|
JP2009529522A
(ja)
|
2006-03-10 |
2009-08-20 |
ディアト |
酵素で切断可能なリンカーを介して抗体に複合された抗癌剤
|
|
US20130332133A1
(en)
*
|
2006-05-11 |
2013-12-12 |
Ramot At Tel Aviv University Ltd. |
Classification of Protein Sequences and Uses of Classified Proteins
|
|
BRPI0717638A2
(pt)
|
2006-10-27 |
2013-11-12 |
Genentech Inc |
Anticorpors e imunoconjugados e usos para os mesmos
|
|
TWI412367B
(zh)
|
2006-12-28 |
2013-10-21 |
梅達雷克斯有限責任公司 |
化學鏈接劑與可裂解基質以及其之綴合物
|
|
JP2010528647A
(ja)
|
2007-06-06 |
2010-08-26 |
ドマンティス リミテッド |
ポリペプチド、抗体可変ドメインおよびアンタゴニスト
|
|
GB0724331D0
(en)
|
2007-12-13 |
2008-01-23 |
Domantis Ltd |
Compositions for pulmonary delivery
|
|
CA2688433A1
(en)
|
2007-06-06 |
2008-12-11 |
Domantis Limited |
Methods for selecting protease resistant polypeptides
|
|
US20090304719A1
(en)
|
2007-08-22 |
2009-12-10 |
Patrick Daugherty |
Activatable binding polypeptides and methods of identification and use thereof
|
|
GB0816447D0
(en)
*
|
2008-09-08 |
2008-10-15 |
Glaxosmithkline Biolog Sa |
Vaccine
|
|
GB0819287D0
(en)
|
2008-10-22 |
2008-11-26 |
Univ Bradford |
Compounds
|
|
US8895702B2
(en)
|
2008-12-08 |
2014-11-25 |
City Of Hope |
Development of masked therapeutic antibodies to limit off-target effects; application to anti-EGFR antibodies
|
|
RU2636046C2
(ru)
|
2009-01-12 |
2017-11-17 |
Сайтомкс Терапьютикс, Инк |
Композиции модифицированных антител, способы их получения и применения
|
|
WO2010088691A2
(en)
|
2009-02-02 |
2010-08-05 |
Washington State University |
Compositions and methods for treating or preventing conditions and diseases associated with mannheimia haemolytica
|
|
ES2610356T3
(es)
|
2009-02-03 |
2017-04-27 |
Amunix Operating Inc. |
Polipéptidos recombinantes extendidos y composiciones que comprenden los mismos
|
|
AU2010215761B2
(en)
|
2009-02-23 |
2017-04-06 |
Cytomx Therapeutics, Inc |
Proproteins and methods of use thereof
|
|
CA2761310C
(en)
|
2009-05-07 |
2017-02-28 |
Charles S. Craik |
Antibodies and methods of use thereof
|
|
US20120157824A1
(en)
|
2009-09-02 |
2012-06-21 |
Nanoscale Corporation |
Mri and optical assays for proteases
|
|
EP2504024A2
(de)
*
|
2009-09-27 |
2012-10-03 |
Ruhr-Universität Bochum |
Verfahren zur therapie und diagnose von morbus alzheimer
|
|
US8524220B1
(en)
|
2010-02-09 |
2013-09-03 |
David Gordon Bermudes |
Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria
|
|
US20110214205A1
(en)
|
2010-02-26 |
2011-09-01 |
Monsanto Technology Llc. |
Isolated Novel Nucleic Acid and Protein Molecules from Foxtail Millet and Methods of Using Those Molecules to Generate Transgenic Plants with Enhanced Agronomic Traits
|
|
EP2650003B1
(en)
|
2010-05-20 |
2016-07-27 |
Allergan, Inc. |
Degradable clostridial toxins
|
|
GB201009271D0
(en)
*
|
2010-06-02 |
2010-07-21 |
Promar As |
Compositions
|
|
PL391627A1
(pl)
|
2010-06-25 |
2012-01-02 |
Adamed Spółka Z Ograniczoną Odpowiedzialnością |
Przeciwnowotworowe białko fuzyjne
|
|
CN103068847B
(zh)
|
2010-08-24 |
2019-05-07 |
罗切格利卡特公司 |
可活化的双特异性抗体
|
|
US20120107894A1
(en)
*
|
2010-10-28 |
2012-05-03 |
Joule Unlimited Technologies, Inc. |
Methods and Compositions for the Recombinant Biosynthesis of Terminal Olefins
|
|
EP4112727A3
(de)
*
|
2010-11-17 |
2023-03-15 |
Basf Se |
Verfahren zur biokatalytischen cyclisierung von terpenen und darin einsetzbare cyclase-mutanten
|
|
WO2012158818A2
(en)
|
2011-05-16 |
2012-11-22 |
Fabion Pharmaceuticals, Inc. |
Multi-specific fab fusion proteins and methods of use
|
|
CA2836338C
(en)
|
2011-05-16 |
2022-05-03 |
Koninklijke Philips N.V. |
Tetrazine derivatives used in bio-orthogonal drug activation
|
|
US20140193342A1
(en)
*
|
2011-06-10 |
2014-07-10 |
The Regents Of The University Of California |
Enzyme directed assembly of particle theranostics
|
|
AU2012275295B2
(en)
|
2011-06-28 |
2016-11-10 |
Inhibrx, Lp |
WAP domain fusion polypeptides and methods of use thereof
|
|
US20140087362A1
(en)
*
|
2012-03-16 |
2014-03-27 |
Aladar A. Szalay |
Methods for assessing effectiveness and monitoring oncolytic virus treatment
|
|
CN110078827A
(zh)
|
2012-04-27 |
2019-08-02 |
西托姆克斯治疗公司 |
结合表皮生长因子受体的可活化的抗体其使用方法
|
|
WO2013185113A1
(en)
|
2012-06-08 |
2013-12-12 |
Biogen Idec Ma Inc. |
Procoagulant compounds
|
|
EP2863948B1
(en)
|
2012-06-22 |
2018-10-24 |
Cytomx Therapeutics Inc. |
Anti-jagged 1/jagged 2 cross-reactive antibodies, activatable anti-jagged antibodies and methods of use thereof
|
|
US9856314B2
(en)
|
2012-06-22 |
2018-01-02 |
Cytomx Therapeutics, Inc. |
Activatable antibodies having non-binding steric moieties and methods of using the same
|
|
EP2882844B1
(en)
|
2012-08-10 |
2018-10-03 |
Cytomx Therapeutics Inc. |
Protease-resistant systems for polypeptide display and methods of making and using thereof
|
|
US9487590B2
(en)
|
2012-09-25 |
2016-11-08 |
Cytomx Therapeutics, Inc. |
Activatable antibodies that bind interleukin-6 receptor and methods of use thereof
|
|
CN105008918A
(zh)
|
2013-01-04 |
2015-10-28 |
西托姆克斯治疗公司 |
用于检测生物系统中的蛋白酶活性的组合物和方法
|
|
US20140273089A1
(en)
*
|
2013-03-14 |
2014-09-18 |
Amgen, Inc. |
Fibroblast Growth Factor Receptor-Like Molecules and Uses Thereof
|
|
HK1215592A1
(zh)
*
|
2013-04-16 |
2016-09-02 |
Commonwealth Scientific And Industrial Research Organisation |
G蛋白偶联受体库
|
|
EP2988786A4
(en)
|
2013-04-22 |
2016-12-21 |
Avelas Biosciences Inc |
COMPOSITIONS FOR SELECTIVE DRUG ADMINISTRATION AND METHOD OF USE
|
|
WO2014193973A2
(en)
|
2013-05-28 |
2014-12-04 |
Dcb-Usa Llc |
Antibody locker for the inactivation of protein drug
|
|
KR20160018579A
(ko)
|
2013-06-04 |
2016-02-17 |
싸이톰스 테라퓨틱스, 인크. |
활성화가능 항체를 접합하기 위한 조성물 및 방법
|
|
WO2014200910A2
(en)
*
|
2013-06-10 |
2014-12-18 |
Iogenetics, Llc |
Bioinformatic processes for determination of peptide binding
|
|
WO2014202616A2
(en)
|
2013-06-19 |
2014-12-24 |
Dsm Ip Assets B.V. |
Rasamsonia gene and use thereof
|
|
NZ718283A
(en)
*
|
2013-09-25 |
2022-05-27 |
Cytomx Therapeutics Inc |
Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof
|
|
US9562073B2
(en)
*
|
2014-01-31 |
2017-02-07 |
Cytomx Therapeutics, Inc. |
Matriptase and u-plasminogen activator substrates and other cleavable moieties and methods of use thereof
|
|
KR102208963B1
(ko)
*
|
2014-05-14 |
2021-01-28 |
삼성전자주식회사 |
신규한 아크릴산 생성 경로를 갖는 미생물 및 이를 이용한 아크릴산 생산 방법
|
|
CA2955947A1
(en)
|
2014-07-25 |
2016-01-28 |
Cytomx Therapeutics, Inc. |
Anti-cd3 antibodies, activatable anti-cd3 antibodies, multispecific anti-cd3 antibodies, multispecific activatable anti-cd3 antibodies, and methods of using the same
|
|
CN114805532A
(zh)
|
2014-10-24 |
2022-07-29 |
百时美施贵宝公司 |
修饰的fgf-21多肽及其用途
|
|
MA41374A
(fr)
*
|
2015-01-20 |
2017-11-28 |
Cytomx Therapeutics Inc |
Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci
|
|
KR20160107038A
(ko)
*
|
2015-03-03 |
2016-09-13 |
경남대학교 산학협력단 |
마이오신 아형을 분석하는 방법
|
|
CN108112254B
(zh)
|
2015-03-13 |
2022-01-28 |
西托姆克斯治疗公司 |
抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法
|
|
CA2984892A1
(en)
|
2015-05-04 |
2016-11-10 |
Cytomx Therapeutics, Inc. |
Anti-itga3 antibodies, activatable anti-itga3 antibodies, and methods of use thereof
|
|
IL292798A
(en)
|
2015-05-04 |
2022-07-01 |
Cytomx Therapeutics Inc |
Anti-cd166 antibodies, activatable anti-cd166 antibodies, preparations containing them and their uses
|
|
BR112017023862A2
(pt)
|
2015-05-04 |
2018-07-17 |
Cytomx Therapeutics Inc |
anticorpos anti-cd71, anticorpos anti-cd71 ativáveis, e métodos de uso destes
|
|
CN107709356A
(zh)
|
2015-06-26 |
2018-02-16 |
南加利福尼亚大学 |
用于肿瘤特异性活化的掩蔽嵌合抗原受体t细胞
|
|
MX383464B
(es)
|
2015-07-13 |
2025-03-14 |
Cytomx Therapeutics Inc |
Anticuerpos anti-pd-1, anticuerpos anti-pd-1 activables, y métodos de uso de los mismos.
|
|
WO2017117425A1
(en)
*
|
2015-12-31 |
2017-07-06 |
Synthetic Genomics, Inc. |
Expression of type i fatty acid synthase genes in eukaryotic algae
|
|
WO2017191274A2
(en)
|
2016-05-04 |
2017-11-09 |
Curevac Ag |
Rna encoding a therapeutic protein
|
|
US10337051B2
(en)
*
|
2016-06-16 |
2019-07-02 |
The Regents Of The University Of California |
Methods and compositions for detecting a target RNA
|
|
WO2018071672A1
(en)
|
2016-10-12 |
2018-04-19 |
The Regents Of The University Of Colorado |
Novel engineered and chimeric nucleases
|
|
SG11201907504PA
(en)
*
|
2017-02-17 |
2019-09-27 |
Hyasynth Biologicals Inc |
Method and cell line for production of phytocannabinoids and phytocannabinoid analogues in yeast
|
|
CN107723311A
(zh)
*
|
2017-11-28 |
2018-02-23 |
中国科学院遗传与发育生物学研究所 |
一种与植物种子粒重相关的TaCKX2‑3D蛋白及其编码基因与应用
|
|
US12060586B2
(en)
*
|
2018-02-15 |
2024-08-13 |
The Broad Institute, Inc. |
Cell data recorders and uses thereof
|
|
WO2020077267A1
(en)
|
2018-10-11 |
2020-04-16 |
Northwestern University |
Biomarker of chronic kidney disease in liver transplant recipients
|
|
CA3120327A1
(en)
|
2018-12-06 |
2020-06-11 |
Cytomx Therapeutics, Inc. |
Matrix metalloprotease-cleavable and serine or cysteine protease-cleavable substrates and methods of use thereof
|