|
US7157555B1
(en)
*
|
1997-08-08 |
2007-01-02 |
Amylin Pharmaceuticals, Inc. |
Exendin agonist compounds
|
|
US7829084B2
(en)
*
|
2001-01-17 |
2010-11-09 |
Trubion Pharmaceuticals, Inc. |
Binding constructs and methods for use thereof
|
|
US7754208B2
(en)
|
2001-01-17 |
2010-07-13 |
Trubion Pharmaceuticals, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
KR20110086881A
(ko)
|
2002-12-20 |
2011-08-01 |
암겐 인코포레이티드 |
미오스타틴을 저해하는 결합제
|
|
ES2333598T5
(es)
|
2003-05-06 |
2013-09-04 |
Biogen Idec Hemophilia Inc |
Proteinas quimericas del factor de coagulacion fc para tratar la hemofilia.
|
|
TWI353991B
(en)
|
2003-05-06 |
2011-12-11 |
Syntonix Pharmaceuticals Inc |
Immunoglobulin chimeric monomer-dimer hybrids
|
|
PL2520654T3
(pl)
|
2003-08-26 |
2017-08-31 |
The Regents Of The University Of Colorado, A Body Corporate |
Inhibitory aktywności proteazy serynowej i ich zastosowanie w sposobach i kompozycjach do leczenia zakażeń bakteryjnych
|
|
WO2005047337A1
(en)
*
|
2003-11-13 |
2005-05-26 |
Hanmi Pharmaceutical Co., Ltd. |
A pharmaceutical composition comprising an immunoglobulin fc region as a carrier
|
|
US8263084B2
(en)
*
|
2003-11-13 |
2012-09-11 |
Hanmi Science Co., Ltd |
Pharmaceutical composition for treating obesity-related disease comprising insulinotropic peptide conjugate
|
|
KR101135244B1
(ko)
*
|
2007-11-29 |
2012-04-24 |
한미사이언스 주식회사 |
인슐린 분비 펩타이드 결합체를 포함하는 비만 관련질환 치료용 조성물
|
|
US8110665B2
(en)
*
|
2003-11-13 |
2012-02-07 |
Hanmi Holdings Co., Ltd. |
Pharmaceutical composition comprising an immunoglobulin FC region as a carrier
|
|
PL2348114T3
(pl)
|
2004-04-21 |
2019-08-30 |
Alexion Pharmaceuticals, Inc. |
Koniugaty do dostarczania do kości i sposób ich wykorzystania do nakierowywania białek na kość
|
|
US20070081984A1
(en)
|
2005-10-11 |
2007-04-12 |
Shunji Tomatsu |
Compositions and methods for treating hypophosphatasia
|
|
CA2572765C
(en)
*
|
2004-07-08 |
2013-05-21 |
Amgen Inc. |
Compound having improved bioefficiency when administered in a multidose regimen
|
|
US7442778B2
(en)
|
2004-09-24 |
2008-10-28 |
Amgen Inc. |
Modified Fc molecules
|
|
KR100594607B1
(ko)
*
|
2004-11-03 |
2006-06-30 |
재단법인서울대학교산학협력재단 |
신규한 경구투여용 재조합 인간 성장호르몬 분비미생물제제 및 그 제조방법
|
|
EP1833510A4
(en)
*
|
2004-12-27 |
2010-02-10 |
Progenics Pharmaceuticals Neva |
ORAL ADMINISTRATION ANTITOXIN ANTIBODIES AND METHODS OF MAKING AND USING THE SAME
|
|
WO2006084337A1
(en)
*
|
2005-02-14 |
2006-08-17 |
Apollo Life Sciences Limited |
A molecule and chimeric molecules thereof
|
|
KR100754667B1
(ko)
|
2005-04-08 |
2007-09-03 |
한미약품 주식회사 |
비펩타이드성 중합체로 개질된 면역글로불린 Ｆｃ 단편 및이를 포함하는 약제학적 조성물
|
|
US7833979B2
(en)
|
2005-04-22 |
2010-11-16 |
Amgen Inc. |
Toxin peptide therapeutic agents
|
|
EP2295080A3
(en)
|
2005-07-25 |
2011-06-22 |
Emergent Product Development Seattle, LLC |
B-cell reduction using CD37-specific and CD20-specific binding molecules
|
|
US8008453B2
(en)
*
|
2005-08-12 |
2011-08-30 |
Amgen Inc. |
Modified Fc molecules
|
|
KR100824505B1
(ko)
*
|
2005-08-16 |
2008-04-22 |
한미약품 주식회사 |
개시 메티오닌 잔기가 제거된 면역글로불린 Ｆｃ 영역의대량 생산방법
|
|
PT1928910E
(pt)
*
|
2005-08-16 |
2014-03-06 |
Hanmi Science Co Ltd |
Um método para produção em massa de uma região fc da imunoglobulina com deleção dos resíduos de metionina inicial
|
|
CN101534865A
(zh)
*
|
2005-10-19 |
2009-09-16 |
Ibc药品公司 |
生物活性装配体的制备方法及其用途
|
|
WO2007048127A2
(en)
*
|
2005-10-20 |
2007-04-26 |
The Scripps Research Institute |
Fc labeling for immunostaining and immunotargeting
|
|
TW200732350A
(en)
*
|
2005-10-21 |
2007-09-01 |
Amgen Inc |
Methods for generating monovalent IgG
|
|
US8067562B2
(en)
|
2005-11-01 |
2011-11-29 |
Amgen Inc. |
Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1
|
|
US10155816B2
(en)
*
|
2005-11-28 |
2018-12-18 |
Genmab A/S |
Recombinant monovalent antibodies and methods for production thereof
|
|
EP1968621A2
(en)
*
|
2005-12-06 |
2008-09-17 |
Amgen Inc. |
Uses of myostatin antagonists
|
|
CN100475270C
(zh)
|
2006-01-20 |
2009-04-08 |
清华大学 |
一种治疗肿瘤的药物及其应用
|
|
CN101002945B
(zh)
|
2006-01-20 |
2012-09-05 |
清华大学 |
一种用于肿瘤治疗的新型复合物
|
|
CN105837690A
(zh)
*
|
2006-06-12 |
2016-08-10 |
新兴产品开发西雅图有限公司 |
具有效应功能的单链多价结合蛋白
|
|
US8513393B2
(en)
*
|
2006-08-28 |
2013-08-20 |
Ares Trading S.A. |
Process for the purification of Fc-containing proteins
|
|
US20140147441A1
(en)
*
|
2006-09-12 |
2014-05-29 |
The General Hospital Corporation |
Compositions containing alpha-1-antitrypsin and methods for use
|
|
AR063384A1
(es)
|
2006-10-25 |
2009-01-28 |
Amgen Inc |
Agentes terapeuticos a base de peptidos derivados de toxinas
|
|
US20080181903A1
(en)
*
|
2006-12-21 |
2008-07-31 |
Pdl Biopharma, Inc. |
Conjugate of natriuretic peptide and antibody constant region
|
|
JP2008169195A
(ja)
*
|
2007-01-05 |
2008-07-24 |
Hanmi Pharmaceutical Co Ltd |
キャリア物質を用いたインスリン分泌ペプチド薬物結合体
|
|
CN101219219B
(zh)
|
2007-01-10 |
2013-02-13 |
北京普罗吉生物科技发展有限公司 |
包含血管抑素或其片段的复合物、其制备方法及应用
|
|
WO2008127780A2
(en)
*
|
2007-02-21 |
2008-10-23 |
Nantero, Inc. |
Symmetric touch screen system with carbon nanotube-based transparent conductive electrode pairs
|
|
US7947646B2
(en)
|
2007-03-06 |
2011-05-24 |
Amgen Inc. |
Variant activin receptor polypeptides
|
|
US8501678B2
(en)
|
2007-03-06 |
2013-08-06 |
Atara Biotherapeutics, Inc. |
Variant activin receptor polypeptides and uses thereof
|
|
EP2738257A1
(en)
|
2007-05-22 |
2014-06-04 |
Amgen Inc. |
Compositions and methods for producing bioactive fusion proteins
|
|
KR100897938B1
(ko)
*
|
2007-05-30 |
2009-05-18 |
주식회사 제넥신 |
면역글로불린 융합 단백질
|
|
WO2008145140A2
(en)
|
2007-05-31 |
2008-12-04 |
Genmab A/S |
Transgenic animals producing monovalent human antibodies and antibodies obtainable from these animals
|
|
CN103897063B
(zh)
*
|
2007-06-01 |
2017-04-12 |
马里兰大学巴尔的摩分校 |
免疫球蛋白恒定区Fc受体结合剂
|
|
US20100310561A1
(en)
*
|
2007-06-06 |
2010-12-09 |
Boehringer Ingelheim International Gmbh |
Natriuretic fusion proteins
|
|
CN101842389A
(zh)
*
|
2007-06-12 |
2010-09-22 |
惠氏有限责任公司 |
抗cd20治疗组合物和方法
|
|
CN101990439A
(zh)
*
|
2007-07-06 |
2011-03-23 |
特鲁比昂药品公司 |
具有置于c末端的特异性结合结构域的结合肽
|
|
WO2009052415A1
(en)
*
|
2007-10-17 |
2009-04-23 |
The Regents Of The University Of California |
Peptide for the induction of immune tolerance as treatment for systemic lupus erythematosus
|
|
JP2011503000A
(ja)
*
|
2007-11-02 |
2011-01-27 |
セントコア・オーソ・バイオテツク・インコーポレーテツド |
半合成ＧＬＰ−１ペプチド−Ｆｃ融合コンストラクト、その方法及び使用
|
|
PT2132228E
(pt)
*
|
2008-04-11 |
2011-10-11 |
Emergent Product Dev Seattle |
Imunoterapia de cd37 e sua combinação com um quimioterápico bifuncional
|
|
TWI388570B
(zh)
*
|
2008-07-23 |
2013-03-11 |
韓美科學有限公司 |
包含具有三個官能端的非肽醯聚合物的多肽複合物
|
|
RU2457856C2
(ru)
*
|
2008-08-05 |
2012-08-10 |
Виктор Владимирович Чалов |
Композиция, обладающая противовирусным и антимикробным действием, для перорального применения
|
|
MX2011001031A
(es)
*
|
2008-08-07 |
2011-04-26 |
Ipsen Pharma Sas |
Analogos de polipeptidos insulinotropicos dependientes de glucosa.
|
|
CA2733006A1
(en)
*
|
2008-08-07 |
2010-02-11 |
Ipsen Pharma S.A.S. |
Analogues of glucose-dependent insulinotropic polypeptide (gip) modified at n-terminal
|
|
KR20110043688A
(ko)
|
2008-08-07 |
2011-04-27 |
입센 파마 에스.에이.에스 |
포도당 의존적인 인슐린 분비 자극성 폴리펩타이드 유사체
|
|
WO2010033216A1
(en)
*
|
2008-09-19 |
2010-03-25 |
Nektar Therapeutics |
Polymer conjugates of nesiritide peptides
|
|
EP2898900B1
(en)
|
2008-09-19 |
2017-11-15 |
Nektar Therapeutics |
Polymer conjugates of ziconotide
|
|
WO2010051335A1
(en)
*
|
2008-10-31 |
2010-05-06 |
Amgen Inc. |
Materials and methods relating to stem cell mobilization by multi-pegylated granulocyte colony stimulating factor
|
|
NZ627111A
(en)
|
2008-11-26 |
2015-10-30 |
Amgen Inc |
Variants of activin iib receptor polypeptides and uses thereof
|
|
WO2010065578A2
(en)
*
|
2008-12-04 |
2010-06-10 |
Leukosight Inc. |
POLYPEPTIDES COMPRISING Fc FRAGMENTS OF IMMUNOGLOBULIN G (IgG) AND METHODS OF USING THE SAME
|
|
US20100158893A1
(en)
*
|
2008-12-19 |
2010-06-24 |
Baxter International Inc. |
Systems and methods for obtaining immunoglobulin from blood
|
|
KR20100084996A
(ko)
*
|
2009-01-19 |
2010-07-28 |
한미홀딩스 주식회사 |
면역글로불린 단편을 이용한 생리활성 단백질 또는 펩타이드의 생산 방법
|
|
US9238878B2
(en)
|
2009-02-17 |
2016-01-19 |
Redwood Bioscience, Inc. |
Aldehyde-tagged protein-based drug carriers and methods of use
|
|
EP2401378B1
(en)
|
2009-02-25 |
2013-08-14 |
Merck Sharp & Dohme Corp. |
Metabolic engineering of a galactose assimilation pathway in the glycoengineered yeast pichia pastoris
|
|
CN102427823A
(zh)
*
|
2009-03-24 |
2012-04-25 |
拜耳医药保健有限公司 |
因子viii变体及使用方法
|
|
EP2423233B1
(en)
|
2009-04-22 |
2015-03-11 |
Alteogen, Inc |
In vivo half life increased fusion protein or peptide maintained by sustained in vivo release, and method for increasing in vivo half-life using same
|
|
CA2779577A1
(en)
*
|
2009-11-02 |
2011-05-05 |
Therapeomic Ag |
Stabilized protein formulations and use thereof
|
|
WO2011075185A1
(en)
|
2009-12-18 |
2011-06-23 |
Oligasis |
Targeted drug phosphorylcholine polymer conjugates
|
|
CA2784826A1
(en)
*
|
2009-12-18 |
2011-06-23 |
Exodos Life Sciences Limited Partnership |
Methods and compositions for stable liquid drug formulations
|
|
US8829163B2
(en)
*
|
2010-01-19 |
2014-09-09 |
Hanmi Science Co., Ltd |
Liquid formulations for long-acting erythropoietin conjugate
|
|
US9867777B2
(en)
*
|
2010-01-19 |
2018-01-16 |
Hanmi Science Co., Ltd. |
Liquid formulations for long-acting G-CSF conjugate
|
|
WO2011093470A1
(ja)
*
|
2010-01-28 |
2011-08-04 |
協和発酵キリン株式会社 |
Bone morphogenetic protein receptor 1B(BMPR1B)細胞外ドメイン又はその変異体を含む蛋白質を含有する骨疾患治療用医薬組成物
|
|
KR101930961B1
(ko)
|
2010-02-24 |
2018-12-19 |
머크 샤프 앤드 돔 코포레이션 |
피키아 파스토리스에서 생산된 치료 당단백질 상의 ｎ-글리코실화 부위 점유를 증가시키는 방법
|
|
CN102811782A
(zh)
*
|
2010-03-08 |
2012-12-05 |
通用电气健康护理生物科学股份公司 |
免疫球蛋白G Fc区结合多肽
|
|
AR080993A1
(es)
*
|
2010-04-02 |
2012-05-30 |
Hanmi Holdings Co Ltd |
Formulacion de accion prolongada de interferon beta donde se usa un fragmento de inmunoglobulina
|
|
AR081066A1
(es)
*
|
2010-04-02 |
2012-06-06 |
Hanmi Holdings Co Ltd |
Conjugado de insulina donde se usa un fragmento de inmunoglobulina
|
|
AR081755A1
(es)
*
|
2010-04-02 |
2012-10-17 |
Hanmi Holdings Co Ltd |
Formulacion de accion prolongada de la hormona estimuladora de los foliculos donde se usa un fragmento de inmunoglobulina, metodo de preparacion y metodo para tratar a un sujeto que sufre un trastorno reproductivo
|
|
US9981017B2
(en)
|
2010-04-02 |
2018-05-29 |
Hanmi Science Co., Ltd. |
Insulin conjugate using an immunoglobulin fragment
|
|
EP2563406A4
(en)
|
2010-04-30 |
2013-11-13 |
Alexion Pharma Internat Sarl |
METHOD, COMPOSITIONS AND KITS FOR TREATING MATRIX MINERALIZATION DISORDERS
|
|
ES2674567T3
(es)
|
2010-05-21 |
2018-07-02 |
Merrimack Pharmaceuticals, Inc. |
Proteínas de fusión biespecíficas
|
|
KR101330868B1
(ko)
*
|
2010-06-08 |
2013-11-18 |
한미사이언스 주식회사 |
면역글로불린 단편을 이용한 인슐린 유도체 약물 결합체
|
|
KR20120002129A
(ko)
*
|
2010-06-30 |
2012-01-05 |
한미홀딩스 주식회사 |
면역글로불린 단편을 이용한 제７인자（Ｆａｃｔｏｒ Ⅶａ）약물 결합체
|
|
KR101337797B1
(ko)
|
2010-07-14 |
2013-12-06 |
한미사이언스 주식회사 |
지속형 인간 성장 호르몬 결합체 액상 제제
|
|
KR101382593B1
(ko)
*
|
2010-07-21 |
2014-04-10 |
한미사이언스 주식회사 |
신규한 지속형 글루카곤 결합체 및 이를 포함하는 비만 예방 및 치료용 약학적 조성물
|
|
EP3543257A1
(en)
|
2010-07-28 |
2019-09-25 |
Gliknik Inc. |
Fusion proteins of natural human protein fragments to create orderly multimerized immunoglobulin fc compositions
|
|
KR101333958B1
(ko)
*
|
2010-10-20 |
2013-11-27 |
주식회사 한독 |
인간 인터루킨-1 수용체 길항제-하이브리드 Ｆｃ 융합단백질
|
|
WO2012053828A2
(ko)
*
|
2010-10-20 |
2012-04-26 |
주식회사 한독약품 |
인간 인터루킨-1 수용체 길항제-하이브리드 Ｆｃ 융합단백질
|
|
KR101303388B1
(ko)
|
2010-10-26 |
2013-09-03 |
한미사이언스 주식회사 |
지속형 인터페론 알파 결합체의 액상 제제
|
|
EP2465536A1
(en)
*
|
2010-12-14 |
2012-06-20 |
CSL Behring AG |
CD89 activation in therapy
|
|
JP5766296B2
(ja)
|
2010-12-23 |
2015-08-19 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
ポリペプチド−ポリヌクレオチド複合体、およびエフェクター成分の標的化された送達におけるその使用
|
|
EP2658979B1
(en)
|
2010-12-27 |
2018-02-14 |
Alexion Pharmaceuticals, Inc. |
Compositions comprising natriuretic peptides and methods of use thereof
|
|
JP6162606B2
(ja)
|
2011-01-14 |
2017-07-12 |
レッドウッド バイオサイエンス， インコーポレイテッド |
アルデヒド−タグ付き免疫グロブリンポリペプチド及びその使用方法
|
|
CN102309765B
(zh)
*
|
2011-02-28 |
2013-10-16 |
北京韩美药品有限公司 |
包含免疫球蛋白Fc片段作为载体的长效抗凝多肽及其制备方法
|
|
JP5977814B2
(ja)
|
2011-04-08 |
2016-08-24 |
アムジエン・インコーポレーテツド |
増殖分化因子１５（ｇｄｆ−１５）を使用して代謝障害を治療または改善する方法
|
|
UA113626C2
(xx)
|
2011-06-02 |
2017-02-27 |
|
Композиція для лікування діабету, що містить кон'югат інсуліну тривалої дії та кон'югат інсулінотропного пептиду тривалої дії
|
|
CN102807619B
(zh)
*
|
2011-06-03 |
2016-08-03 |
北京韩美药品有限公司 |
含有免疫球蛋白Fc片段和粒细胞-巨噬细胞集落刺激因子的复合物及其药物组合物
|
|
UA126465C2
(uk)
|
2011-06-10 |
2022-10-12 |
Ханмі Сайенс Ко., Лтд. |
Пептид, що має активність оксинтомодуліну, та фармацевтична композиція для лікування ожиріння, яка його містить
|
|
PL2721062T3
(pl)
*
|
2011-06-17 |
2019-05-31 |
Hanmi Science Co Ltd |
Koniugat zawierający oksyntomodulinę oraz fragment immunoglobuliny i jego zastosowanie
|
|
KR20200044138A
(ko)
*
|
2011-06-24 |
2020-04-28 |
더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 |
알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도
|
|
CN103946388A
(zh)
*
|
2011-06-28 |
2014-07-23 |
英伊布里克斯有限责任公司 |
Wap结构域融合多肽及其使用方法
|
|
SG10201601621PA
(en)
*
|
2011-06-28 |
2016-04-28 |
Inhibrx Llc |
Serpin fusion polypeptides and methods of use thereof
|
|
US10400029B2
(en)
|
2011-06-28 |
2019-09-03 |
Inhibrx, Lp |
Serpin fusion polypeptides and methods of use thereof
|
|
CN111053918A
(zh)
*
|
2011-09-05 |
2020-04-24 |
韩美科学株式会社 |
一种包含干扰素α-缀合物的抗癌用药物组合物
|
|
UY34347A
(es)
|
2011-09-26 |
2013-04-30 |
Novartis Ag |
Proteínas de función dual para tratar trastornos metabólicos
|
|
JP6108630B2
(ja)
*
|
2011-10-06 |
2017-04-05 |
ハンミ サイエンス カンパニー リミテッドＨａｎｍｉ Ｓｃｉｅｎｃｅ Ｃｏ．，Ｌｔｄ． |
血液凝固因子ＶＩＩ及びＶＩＩａ誘導体、それらを含む結合体及び複合体、並びにそれらの使用
|
|
WO2013065343A1
(ja)
*
|
2011-10-31 |
2013-05-10 |
株式会社 島津製作所 |
非ペプチドヒンジ部含有フレキシブル抗体様分子
|
|
KR20130049671A
(ko)
*
|
2011-11-04 |
2013-05-14 |
한미사이언스 주식회사 |
생리활성 폴리펩타이드 결합체 제조 방법
|
|
BR112014015003A2
(pt)
|
2011-12-19 |
2019-09-24 |
Amgen Inc |
composição farmacêutica, método para tratar um cancer e método para reduzir o tamanho de uma massa tumoral
|
|
CN103172745A
(zh)
*
|
2011-12-21 |
2013-06-26 |
北京韩美药品有限公司 |
包含免疫球蛋白Fc片段的长效人内皮抑素
|
|
KR102041412B1
(ko)
*
|
2011-12-30 |
2019-11-11 |
한미사이언스 주식회사 |
면역글로불린 Ｆｃ 단편 유도체
|
|
KR101895047B1
(ko)
|
2011-12-30 |
2018-09-06 |
한미사이언스 주식회사 |
면역글로불린 단편을 이용한 위치 특이적 글루카곤 유사 펩타이드-2 약물 결합체
|
|
US10774132B2
(en)
|
2012-01-09 |
2020-09-15 |
The Scripps Research Instittue |
Ultralong complementarity determining regions and uses thereof
|
|
WO2013106489A1
(en)
|
2012-01-09 |
2013-07-18 |
The Scripps Research Institute |
Humanized antibodies with ultralong cdr3s
|
|
JP2015504675A
(ja)
|
2012-01-10 |
2015-02-16 |
ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイトＴＨＥ ＲＥＧＥＮＴＳ ＯＦ ＴＨＥ ＵＮＩＶＥＲＳＩＴＹ ＯＦ ＣＯＬＯＲＡＤＯ，ａ ｂｏｄｙ ｃｏｒｐｏｒａｔｅ |
アルファ−１アンチトリプシン融合分子の組成物、方法、及び使用
|
|
WO2013113008A1
(en)
|
2012-01-26 |
2013-08-01 |
Amgen Inc. |
Growth differentiation factor 15 (gdf-15) polypeptides
|
|
AR090281A1
(es)
|
2012-03-08 |
2014-10-29 |
Hanmi Science Co Ltd |
Proceso mejorado para la preparacion de un complejo polipeptidico fisiologicamente activo
|
|
EP2636684A1
(en)
|
2012-03-09 |
2013-09-11 |
CSL Behring AG |
Prevention of infection
|
|
MX360245B
(es)
|
2012-03-09 |
2018-10-26 |
Csl Behring Ag |
Composiciones que comprenden inmunoglobulinas de tipo secretor.
|
|
EP2636681A1
(en)
|
2012-03-09 |
2013-09-11 |
CSL Behring AG |
Process for enriching IgA
|
|
US10064951B2
(en)
*
|
2012-03-30 |
2018-09-04 |
Hanmi Science Co., Ltd. |
Liquid formulation of highly concentrated long-acting human growth hormone conjugate
|
|
WO2013162050A1
(ja)
*
|
2012-04-23 |
2013-10-31 |
株式会社Ｎｒｌファーマ |
ラクトフェリン融合タンパク質及びその製造方法
|
|
US10052366B2
(en)
|
2012-05-21 |
2018-08-21 |
Alexion Pharmaceuticsl, Inc. |
Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof
|
|
JP6498600B2
(ja)
|
2012-06-08 |
2019-04-10 |
ストロ バイオファーマ インコーポレーテッド |
部位特異的な非天然アミノ酸残基を含む抗体、その調製方法、及びその使用方法
|
|
EP2863955B1
(en)
|
2012-06-26 |
2016-11-23 |
Sutro Biopharma, Inc. |
Modified fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use
|
|
EP2867253B1
(en)
|
2012-06-27 |
2016-09-14 |
F. Hoffmann-La Roche AG |
Method for selection and production of tailor-made highly selective and multi-specific targeting entities containing at least two different binding entities and uses thereof
|
|
MX2014014804A
(es)
*
|
2012-06-27 |
2015-02-12 |
Hoffmann La Roche |
Metodo para la elaboracion de conjugados de la region fc de anticuerpos que comprenden por lo menos una entidad de union que se une especificamente a un objetivo y usos del mismo.
|
|
AR094821A1
(es)
*
|
2012-07-25 |
2015-09-02 |
Hanmi Pharm Ind Co Ltd |
Formulación líquida de un conjugado de péptido insulinotrópico de acción prolongada
|
|
AR092862A1
(es)
|
2012-07-25 |
2015-05-06 |
Hanmi Pharm Ind Co Ltd |
Formulacion liquida de insulina de accion prolongada y un peptido insulinotropico y metodo de preparacion
|
|
US10441665B2
(en)
|
2012-07-25 |
2019-10-15 |
Hanmi Pharm. Co., Ltd. |
Liquid formulation of long acting insulinotropic peptide conjugate
|
|
KR101968344B1
(ko)
|
2012-07-25 |
2019-04-12 |
한미약품 주식회사 |
옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물
|
|
AR091902A1
(es)
|
2012-07-25 |
2015-03-11 |
Hanmi Pharm Ind Co Ltd |
Formulacion liquida de un conjugado de insulina de accion prolongada
|
|
KR20150058236A
(ko)
|
2012-08-20 |
2015-05-28 |
글리크닉 인코포레이티드 |
항원 결합 및 다가 fc 감마 수용체 결합 활성을 가진 분자
|
|
DK2890402T3
(da)
|
2012-08-31 |
2019-07-15 |
Sutro Biopharma Inc |
Modificerede aminosyrer omfattende en azidogruppe
|
|
WO2014043523A1
(en)
|
2012-09-14 |
2014-03-20 |
The Johns Hopkins University |
Compositions and methods for rendering tumor cells susceptible to cd8+ t cell-mediated killing
|
|
BR112015003938A2
(pt)
|
2012-09-14 |
2018-09-04 |
Hoffmann La Roche |
métodos de produção de polipeptídeos, de produção de aglutinantes multiespecíficos, de seleção de aglutinantes multiespecíficos, de seleção de anticorpos biespecíficos e de determinação de combinação, anticorpo biespecífico, formulação farmcêutica e uso de anticorpo biespecífico
|
|
KR101993393B1
(ko)
|
2012-11-06 |
2019-10-01 |
한미약품 주식회사 |
옥신토모듈린 유도체를 포함하는 당뇨병 또는 비만성 당뇨병 치료용 조성물
|
|
PT2916819T
(pt)
|
2012-11-06 |
2019-10-28 |
Hanmi Pharm Ind Co Ltd |
Formulação líquida de conjugado proteico que compreende a oxintomodulina e um fragmento de imunoglobulina.
|
|
CN105073781A
(zh)
|
2013-01-11 |
2015-11-18 |
加州生物医学研究所 |
牛融合抗体
|
|
CN103217489B
(zh)
*
|
2013-01-15 |
2016-03-09 |
珠海市丽珠单抗生物技术有限公司 |
一种测定蛋白纯化工艺过程中样品的糖基化和末端修饰情况的方法
|
|
KR102073748B1
(ko)
|
2013-01-31 |
2020-02-05 |
한미약품 주식회사 |
재조합 효모 형질전환체 및 이를 이용하여 면역글로불린 단편을 생산하는 방법
|
|
SG11201505960VA
(en)
|
2013-02-01 |
2015-08-28 |
Santa Maria Biotherapeutics Inc |
Administration of an anti-activin-a compound to a subject
|
|
AU2014219037A1
(en)
*
|
2013-02-22 |
2015-08-13 |
Zoetis Services Llc |
In ovo administration of growth factors for improving poultry performance
|
|
JP6374412B2
(ja)
*
|
2013-03-05 |
2018-08-15 |
ハンミ ファーム．カンパニー リミテッドＨａｎｍｉ Ｐｈａｒｍ．Ｃｏ．，Ｌｔｄ． |
生理活性ポリペプチド結合体の高収率生産のための改善された製造方法
|
|
US20160017017A1
(en)
|
2013-03-11 |
2016-01-21 |
Novo Nordisk Healthcare Ag |
Growth Hormone Compounds
|
|
US20140271641A1
(en)
*
|
2013-03-14 |
2014-09-18 |
University Of Guelph |
Thrombospondin-1 polypeptides and methods of using same
|
|
TWI828269B
(zh)
|
2013-03-15 |
2024-01-01 |
美商百歐維拉提夫治療公司 |
因子ix多肽調配物
|
|
US9587235B2
(en)
|
2013-03-15 |
2017-03-07 |
Atyr Pharma, Inc. |
Histidyl-tRNA synthetase-Fc conjugates
|
|
KR101895634B1
(ko)
*
|
2013-05-31 |
2018-09-05 |
한미약품 주식회사 |
변이된 힌지 영역을 포함하는 IgG4 Fc 단편
|
|
WO2015006555A2
(en)
|
2013-07-10 |
2015-01-15 |
Sutro Biopharma, Inc. |
Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use
|
|
AR096890A1
(es)
*
|
2013-07-12 |
2016-02-03 |
Hanmi Pharm Ind Co Ltd |
Conjugando fc de inmunoglobulina, que mantiene la afinidad de unión del fragmento fc de la inmunoglobulina a fcrn
|
|
AR096891A1
(es)
*
|
2013-07-12 |
2016-02-03 |
Hanmi Pharm Ind Co Ltd |
Conjugado de monómero polipéptido biológicamente activo y conjugado de fragmento fc de inmunoglobulina, que muestra aclaramiento mediado por receptor reducido, y el método para la preparación del mismo
|
|
US10640574B2
(en)
|
2013-07-18 |
2020-05-05 |
Taurus Biosciences, Llc |
Humanized antibodies with ultralong complementary determining regions
|
|
UA116665C2
(uk)
|
2013-07-31 |
2018-04-25 |
Емджен Інк. |
Гібридний білок, що містить область фактора диференціації та росту 15 (gdf-15)
|
|
EP3038657A2
(en)
|
2013-08-28 |
2016-07-06 |
Bioasis Technologies Inc. |
Cns-targeted conjugates having modified fc regions and methods of use thereof
|
|
WO2015035342A2
(en)
|
2013-09-08 |
2015-03-12 |
Oligasis Llc |
Factor viii zwitterionic polymer conjugates
|
|
EP3043810B1
(en)
|
2013-09-09 |
2019-10-23 |
CanImGuide Therapeutics AB |
Immune system modulators
|
|
BR112016006455A2
(pt)
|
2013-09-27 |
2017-08-01 |
Hanmi Pharm Ind Co Ltd |
?formulação de conjugado de hormônio de crescimento humano de ação prolongada?
|
|
BR112016006054B1
(pt)
*
|
2013-09-30 |
2021-11-30 |
3M Innovative Properties Company |
Fibra, lenço umedecido e processo para melhorar a estabilidade hidrolítica de uma manta fibrosa
|
|
US9975942B2
(en)
|
2013-11-11 |
2018-05-22 |
Wake Forest University Health Services |
EPHA3 And multi-valent targeting of tumors
|
|
AU2015206890B2
(en)
|
2014-01-20 |
2019-05-23 |
Hanmi Pharm. Co., Ltd. |
Long-acting insulin and use thereof
|
|
US10421796B2
(en)
*
|
2014-01-21 |
2019-09-24 |
Gray D Shaw |
Variants of IgG Fc with limited amine groups
|
|
UA130573C2
(uk)
*
|
2014-03-31 |
2026-03-25 |
Ханмі Фарм. Ко., Лтд. |
Спосіб покращення розчинності білка та пептиду із застосуванням зв'язування з fc-фрагментом імуноглобуліну
|
|
SMT201900160T1
(it)
*
|
2014-04-11 |
2019-05-10 |
Medimmune Llc |
Composti coniugati comprendenti anticorpi ingegnerizzati con cisteina
|
|
CA2947255A1
(en)
*
|
2014-04-28 |
2015-11-05 |
The National Institute for Biotechnology in the Negev Ltd. |
Variants of dr3 and use thereof
|
|
KR20150133576A
(ko)
*
|
2014-05-20 |
2015-11-30 |
삼성전자주식회사 |
화학적 개질된 표적화 단백질 및 그의 이용
|
|
AR100639A1
(es)
|
2014-05-29 |
2016-10-19 |
Hanmi Pharm Ind Co Ltd |
Composición para tratar diabetes que comprende conjugados de análogos de insulina de acción prolongada y conjugados de péptidos insulinotrópicos de acción prolongada
|
|
AR100695A1
(es)
|
2014-05-30 |
2016-10-26 |
Hanmi Pharm Ind Co Ltd |
Composición para el tratamiento de diabetes mellitus que comprende insulina y un agonista dual glp-1 / glucagón
|
|
DK3160994T3
(da)
*
|
2014-06-27 |
2025-05-05 |
Innate Pharma |
Multispecifikke antigenbindende proteiner
|
|
WO2015197593A1
(en)
|
2014-06-27 |
2015-12-30 |
Innate Pharma |
MULTISPECIFIC NKp46 BINDING PROTEINS
|
|
US9840553B2
(en)
|
2014-06-28 |
2017-12-12 |
Kodiak Sciences Inc. |
Dual PDGF/VEGF antagonists
|
|
US10822596B2
(en)
|
2014-07-11 |
2020-11-03 |
Alexion Pharmaceuticals, Inc. |
Compositions and methods for treating craniosynostosis
|
|
KR102463267B1
(ko)
|
2014-07-24 |
2022-11-03 |
제넨테크, 인크. |
적어도 하나의 트리설파이드 결합을 함유하는 단백질에서 티올 모이어티에 제제의 접합 방법
|
|
TWI802396B
(zh)
|
2014-09-16 |
2023-05-11 |
南韓商韓美藥品股份有限公司 |
長效glp-1/高血糖素受體雙促效劑治療非酒精性脂肝疾病之用途
|
|
US9616114B1
(en)
|
2014-09-18 |
2017-04-11 |
David Gordon Bermudes |
Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
|
|
KR20210013299A
(ko)
|
2014-10-17 |
2021-02-03 |
코디악 사이언시스 인코포레이티드 |
부티릴콜린에스테라제 양성이온성 중합체 컨쥬게이트
|
|
WO2016090251A1
(en)
|
2014-12-05 |
2016-06-09 |
Alexion Pharmaceuticals, Inc. |
Treating seizure with recombinant alkaline phosphatase
|
|
KR102418477B1
(ko)
|
2014-12-30 |
2022-07-08 |
한미약품 주식회사 |
글루카곤 유도체
|
|
CR20170293A
(es)
|
2014-12-30 |
2017-11-03 |
Hanmi Pharm Ind Co Ltd |
Derivados de glucagón con estabilidad mejorada
|
|
US10603361B2
(en)
|
2015-01-28 |
2020-03-31 |
Alexion Pharmaceuticals, Inc. |
Methods of treating a subject with an alkaline phosphatase deficiency
|
|
EP3265117B1
(en)
|
2015-03-06 |
2020-11-11 |
CanImGuide Therapeutics AB |
Immune system modulators and compositions
|
|
KR20170141215A
(ko)
|
2015-04-06 |
2017-12-22 |
악셀레론 파마 인코포레이티드 |
싱글-암 유형 i과 유형 ii 수용체 융합 단백질들 및 이들의 용도
|
|
SI3286206T1
(sl)
*
|
2015-04-22 |
2021-07-30 |
Biogen Ma Inc. |
Novi hibridni proteini ligandske pasti actriib za zdravljenje bolezni zaradi izgube mišične mase
|
|
PL3288965T3
(pl)
*
|
2015-04-29 |
2019-11-29 |
Mediolanum Farm S P A |
Rozpuszczalny chimeryczny receptor interleukiny-10 i jego zastosowanie terapeutyczne
|
|
US10676723B2
(en)
|
2015-05-11 |
2020-06-09 |
David Gordon Bermudes |
Chimeric protein toxins for expression by therapeutic bacteria
|
|
CN107743494B
(zh)
|
2015-06-02 |
2022-04-29 |
诺和诺德股份有限公司 |
具有极性重组延伸体的胰岛素
|
|
ES2983120T3
(es)
*
|
2015-06-12 |
2024-10-21 |
Ubi Pharma Inc |
Proteínas de fusión de inmunoglobulinas y usos de las mismas
|
|
US11820807B2
(en)
*
|
2015-06-12 |
2023-11-21 |
Ubi Pharma Inc |
Immunoglobulin fusion proteins and uses thereof
|
|
WO2016207278A1
(en)
|
2015-06-23 |
2016-12-29 |
Innate Pharma |
Multispecific nk engager proteins
|
|
TN2017000555A1
(en)
|
2015-06-30 |
2019-04-12 |
Hanmi Pharm Ind Co Ltd |
Glucagon derivative and a composition comprising a long acting conjugate of the same
|
|
SI3325011T1
(sl)
|
2015-07-24 |
2021-02-26 |
Gliknik Inc. |
Fuzijski proteini humanih proteinskih fragmentov za tvorbo pravilnih multimeriziranih imunoglobulin FC sestavkov s povečanim vezanjem komplementa
|
|
ES2978112T3
(es)
|
2015-07-24 |
2024-09-05 |
Hanmi Pharmaceutical Co Ltd |
Método de preparación de un conjugado polipeptídico fisiológicamente activo
|
|
AU2016308624B2
(en)
|
2015-08-17 |
2022-06-23 |
Alexion Pharmaceuticals, Inc. |
Manufacturing of alkaline phosphatases
|
|
UY36870A
(es)
|
2015-08-28 |
2017-03-31 |
Hanmi Pharm Ind Co Ltd |
Análogos de insulina novedosos
|
|
KR102784293B1
(ko)
|
2015-09-21 |
2025-03-20 |
압테보 리서치 앤드 디벨롭먼트 엘엘씨 |
Cd3 결합 폴리펩타이드
|
|
EP3341025A4
(en)
|
2015-09-24 |
2019-05-01 |
Hanmi Pharm. Co., Ltd. |
PROTEIN COMPLEX BY USING A SPECIFIC ROLE OF AN IMMUNOMOBILIN FRAGMENT FOR LINKING
|
|
TW201718629A
(zh)
*
|
2015-09-25 |
2017-06-01 |
韓美藥品股份有限公司 |
包含多個生理多肽及免疫球蛋白Ｆｃ區之蛋白質接合物
|
|
EP3355904A4
(en)
|
2015-09-28 |
2019-06-12 |
Alexion Pharmaceuticals, Inc. |
IDENTIFICATION OF EFFECTIVE DOSE SHEETS FOR TISSUE-SPECIFIC ALKALINE PHOSPHATASE ENZYMERSAT THERAPY OF HYPOPHOSPHATASIA
|
|
EP3355931B1
(en)
|
2015-10-01 |
2024-06-26 |
Novo Nordisk A/S |
Protein conjugates
|
|
BR112018006578A2
(pt)
*
|
2015-10-01 |
2018-12-26 |
Heat Biologics, Inc. |
composições e métodos para juntar domínios extracelulares tipo i e tipo ii como proteínas quiméricas heterólogas
|
|
CA3000742A1
(en)
|
2015-10-02 |
2017-04-06 |
Silver Creek Pharmaceuticals, Inc. |
Bi-specific therapeutic proteins for tissue repair
|
|
US20170095577A1
(en)
*
|
2015-10-06 |
2017-04-06 |
Washington University |
Noninvasive imaging of focal atherosclerotic lesions using fluorescence molecular tomography
|
|
JP2018533571A
(ja)
|
2015-10-30 |
2018-11-15 |
アレクシオン ファーマシューティカルズ， インコーポレイテッド |
患者の頭蓋縫合早期癒合症を治療するための方法
|
|
EP3395366B1
(en)
*
|
2015-12-21 |
2023-11-22 |
Hefei Lifeon Pharmaceutical Co., Ltd. |
Drug design method, obtained drug and application thereof
|
|
KR20170079409A
(ko)
*
|
2015-12-30 |
2017-07-10 |
한미약품 주식회사 |
지속형 인간 성장 호르몬 결합체의 신규 액상 제제
|
|
KR20250057128A
(ko)
|
2015-12-30 |
2025-04-28 |
코디악 사이언시스 인코포레이티드 |
항체 및 이의 접합체
|
|
JP6712323B2
(ja)
|
2015-12-31 |
2020-06-17 |
ハンミ ファーマシューティカル カンパニー リミテッド |
グルカゴン、ｇｌｐ−１及びｇｉｐ受容体のすべてに活性を有する三重活性体
|
|
MX2018009085A
(es)
|
2016-01-27 |
2019-05-09 |
Sutro Biopharma Inc |
Conjugados de anticuerpos anti-cd74, composiciones que comprenden conjugados de anticuerpos anti-cd74 y metodos de uso de congujados de anticuerpos anti-cd74.
|
|
AR107483A1
(es)
*
|
2016-01-29 |
2018-05-02 |
Hanmi Pharm Ind Co Ltd |
Conjugado de enzimas terapéuticas
|
|
EP3426286A4
(en)
|
2016-03-08 |
2019-12-04 |
Alexion Pharmaceuticals, Inc. |
PROCESS FOR TREATING HYPOPHOSPHATASIA IN CHILDREN
|
|
KR20180125979A
(ko)
|
2016-04-01 |
2018-11-26 |
알렉시온 파마슈티칼스, 인코포레이티드 |
알칼리성 포스파타아제로 근육 약화의 치료
|
|
WO2017173395A1
(en)
|
2016-04-01 |
2017-10-05 |
Alexion Pharmaceuticals, Inc. |
Methods for treating hypophosphatasia in adolescents and adults
|
|
CN109071634A
(zh)
|
2016-04-26 |
2018-12-21 |
R.P.谢勒技术有限责任公司 |
抗体偶联物及其制备和使用方法
|
|
WO2017191817A1
(ja)
|
2016-05-02 |
2017-11-09 |
味の素株式会社 |
アジド基含有Ｆｃタンパク質
|
|
CN106008722B
(zh)
*
|
2016-05-13 |
2019-10-15 |
未名生物医药有限公司 |
一种重组β-hNGF-Fc融合蛋白、制备方法及用途
|
|
US10988744B2
(en)
|
2016-06-06 |
2021-04-27 |
Alexion Pharmaceuticals, Inc. |
Method of producing alkaline phosphatase
|
|
CA3026420A1
(en)
|
2016-06-07 |
2017-12-14 |
Gliknik Inc. |
Cysteine-optimized stradomers
|
|
SG11201811697SA
(en)
|
2016-06-29 |
2019-01-30 |
Hanmi Pharmaceutical Co Ltd |
Glucagon derivative, conjugate thereof, composition comprising same and therapeutic use thereof
|
|
JP7018933B2
(ja)
|
2016-08-18 |
2022-02-14 |
アレクシオン ファーマシューティカルズ， インコーポレイテッド |
気管気管支軟化症の治療方法
|
|
CA3034240C
(en)
*
|
2016-08-30 |
2024-04-23 |
Genexine,Inc. |
Pharmaceutical composition for treating growth hormone deficiency containing hgh fusion protein
|
|
BR112019005637A2
(pt)
|
2016-09-23 |
2019-07-30 |
Hanmi Pharm Ind Co Ltd |
análogos da insulina com afinidade reduzida para o receptor de insulina e seu uso
|
|
JOP20190085A1
(ar)
|
2016-10-20 |
2019-04-17 |
Biogen Ma Inc |
طرق علاج الضمور العضلي ومرض العظام باستخدام بروتينات احتجاز مركب ترابطي actriib هجين حديثة
|
|
EP3549950A4
(en)
*
|
2016-12-05 |
2020-08-19 |
Hanmi Pharm. Co., Ltd. |
CONJUGATE WITH MITIGATED IMMUNE RESPONSE
|
|
US11129906B1
(en)
|
2016-12-07 |
2021-09-28 |
David Gordon Bermudes |
Chimeric protein toxins for expression by therapeutic bacteria
|
|
US11180535B1
(en)
|
2016-12-07 |
2021-11-23 |
David Gordon Bermudes |
Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
|
|
EP3551647A4
(en)
|
2016-12-09 |
2021-01-13 |
Gliknik Inc. |
MANUFACTURING OPTIMIZATION OF GL-2045, A MULTIMERIZING STRADOMER
|
|
IL266988B2
(en)
|
2016-12-09 |
2024-11-01 |
Gliknik Inc |
Methods of treating inflammatory disorders with multivalent fc compounds
|
|
AU2018215840A1
(en)
*
|
2017-02-03 |
2019-08-01 |
Hanmi Pharm. Co., Ltd. |
Long-Acting Conjugate Of A Physiologically Active Material And Use Thereof
|
|
CN118994414A
(zh)
|
2017-02-27 |
2024-11-22 |
沙塔克实验室有限公司 |
基于tigit和light的嵌合蛋白
|
|
BR112019017713A2
(pt)
|
2017-02-27 |
2020-04-07 |
Shattuck Labs Inc |
proteínas quiméricas à base de csf1r
|
|
WO2018174668A2
(ko)
|
2017-03-23 |
2018-09-27 |
한미약품 주식회사 |
인슐린 수용체와의 결합력이 감소된 인슐린 아날로그의 결합체 및 이의 용도
|
|
MX2019011508A
(es)
|
2017-03-31 |
2019-11-01 |
Alexion Pharma Inc |
Metodos para tratar la hipofosfatasia (hpp) en adultos y adolescentes.
|
|
MA49339A
(fr)
*
|
2017-04-05 |
2020-02-12 |
Novo Nordisk As |
Conjugués insuline-fc à extension oligomère
|
|
MA50141A
(fr)
*
|
2017-04-20 |
2020-07-29 |
Novo Nordisk As |
Procédés de purification de protéines de fusion d'albumine
|
|
CN110536694A
(zh)
|
2017-04-20 |
2019-12-03 |
Atyr 医药公司 |
用于治疗肺部炎症的组合物和方法
|
|
CN109206522B
(zh)
*
|
2017-07-07 |
2021-11-09 |
北京三有利和泽生物科技有限公司 |
一种长效抗凝血融合蛋白及其应用
|
|
JP6566324B2
(ja)
*
|
2017-09-29 |
2019-08-28 |
サイデン化学株式会社 |
粘着シート
|
|
JP2020535199A
(ja)
*
|
2017-09-29 |
2020-12-03 |
ハンミ ファーマシューティカル カンパニー リミテッド |
効力が向上した持続性タンパク質結合体
|
|
MX2020002918A
(es)
|
2017-10-02 |
2020-07-22 |
Denali Therapeutics Inc |
Proteinas de fusion que comprenden enzimas de terapia de reemplazo de enzimas.
|
|
KR20190045081A
(ko)
*
|
2017-10-23 |
2019-05-02 |
주식회사 프로젠 |
변형된 egf 단백질 및 이를 유효성분으로 포함하는 피부 상태 개선용 화장료 조성물
|
|
KR102167827B1
(ko)
*
|
2017-12-20 |
2020-10-20 |
주식회사 알테오젠 |
신규한 성장 호르몬 수용체 길항제 및 이의 융합 단백질
|
|
CN108218998A
(zh)
*
|
2017-12-31 |
2018-06-29 |
武汉班科生物技术股份有限公司 |
一种突变型人源IgG的Fc片段及其制备方法与应用
|
|
KR101974305B1
(ko)
*
|
2018-02-14 |
2019-04-30 |
한미사이언스 주식회사 |
생리활성 폴리펩타이드 결합체 제조 방법
|
|
US12071476B2
(en)
|
2018-03-02 |
2024-08-27 |
Kodiak Sciences Inc. |
IL-6 antibodies and fusion constructs and conjugates thereof
|
|
WO2019190990A1
(en)
*
|
2018-03-26 |
2019-10-03 |
Regeneron Pharmaceuticals, Inc. |
Humanized rodents for testing therapeutic agents
|
|
KR102209108B1
(ko)
|
2018-03-27 |
2021-01-28 |
국립암센터 |
Oct4 기능 저해용 펩티드를 포함하는 줄기세포성 억제용 조성물
|
|
US11913039B2
(en)
|
2018-03-30 |
2024-02-27 |
Alexion Pharmaceuticals, Inc. |
Method for producing recombinant alkaline phosphatase
|
|
US11505610B2
(en)
|
2018-04-06 |
2022-11-22 |
Atyr Pharma, Inc. |
Compositions and methods comprising anti-NRP2 antibodies
|
|
PE20201350A1
(es)
|
2018-04-09 |
2020-11-30 |
Amgen Inc |
Proteinas de fusion del factor de diferenciacion de crecimiento 15
|
|
JP7490925B2
(ja)
|
2018-07-26 |
2024-05-28 |
エータイアー ファーマ， インコーポレイテッド |
Ｎｒｐ２関連疾患を治療するための組成物および方法
|
|
JP7820148B2
(ja)
|
2018-08-10 |
2026-02-25 |
アレクシオン ファーマシューティカルズ， インコーポレイテッド |
アルカリホスファターゼを用いて神経線維腫症１型および関連状態を治療する方法
|
|
US10780121B2
(en)
|
2018-08-29 |
2020-09-22 |
Shattuck Labs, Inc. |
FLT3L-based chimeric proteins
|
|
AU2020260931B2
(en)
*
|
2019-04-23 |
2023-08-24 |
Lg Chem, Ltd. |
Fusion polypeptide comprising Fc region of immunoglobulin and GDF15
|
|
US11267858B2
(en)
*
|
2019-05-31 |
2022-03-08 |
Spectrum Pharmaceuticals, Inc. |
Methods of treatment using G-CSF protein complex
|
|
CN112142850A
(zh)
*
|
2019-06-27 |
2020-12-29 |
深圳市卫光生物制品股份有限公司 |
人神经生长因子-乳铁蛋白重组蛋白及用途
|
|
WO2021067655A1
(en)
|
2019-10-04 |
2021-04-08 |
Amgen Inc. |
Use of gdf15 for treating cardiometabolic syndrome and other conditions
|
|
AU2020364071A1
(en)
|
2019-10-10 |
2022-05-26 |
Kodiak Sciences Inc. |
Methods of treating an eye disorder
|
|
CN110669134A
(zh)
*
|
2019-10-15 |
2020-01-10 |
广东菲鹏生物有限公司 |
IgM-FC片段、IgM-FC抗体及制备方法和应用
|
|
MX2022007114A
(es)
|
2019-12-09 |
2022-07-11 |
Alexion Pharma Inc |
Polipeptidos de fosfatasa alcalina y metodos de uso de los mismos.
|
|
CA3159979A1
(en)
*
|
2019-12-11 |
2021-06-17 |
Yeonchul Kim |
Fusion polypeptide comprising gdf15 and polypeptide region capable of o-glycosylation
|
|
CN111153996B
(zh)
*
|
2020-01-10 |
2021-12-14 |
苏州睿瀛生物技术有限公司 |
G蛋白偶联受体的抗体及其制备方法和g蛋白偶联受体试剂盒
|
|
CN111505291B
(zh)
*
|
2020-04-14 |
2023-04-25 |
山东省千佛山医院 |
一种排除巨酶分子对血清酶浓度检测带来干扰的方法
|
|
EP4154867A4
(en)
|
2020-05-22 |
2025-01-29 |
Hanmi Pharm. Co., Ltd. |
LIQUID FORMULATION
|
|
MX2023002673A
(es)
|
2020-09-04 |
2023-05-12 |
Alexion Pharma Inc |
Métodos para el tratamiento de trastornos de mineralización ósea.
|
|
CN112098639B
(zh)
*
|
2020-09-21 |
2024-01-02 |
天津医科大学 |
以氧化石墨烯为载体的二抗的合成及应用
|
|
CN117098559A
(zh)
*
|
2020-11-03 |
2023-11-21 |
波塔力克斯有限公司 |
修饰的尿酸酶及其用途
|
|
EP4291224A4
(en)
|
2021-02-12 |
2025-01-01 |
Alexion Pharmaceuticals, Inc. |
Alkaline phosphatase polypeptides and methods of use thereof
|
|
WO2023034809A1
(en)
|
2021-08-30 |
2023-03-09 |
Lassen Therapeutics 1, Inc. |
Anti-il-11rα antibodies
|
|
IL314551A
(en)
*
|
2022-01-28 |
2024-09-01 |
argenx BV |
Use of anti-MUSK antibodies to treat neuromuscular disorders
|
|
JP2025508988A
(ja)
*
|
2022-03-03 |
2025-04-10 |
ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア |
副甲状腺ホルモン融合物をコードするウイルスベクター及び副甲状腺機能低下症の治療におけるその使用
|
|
CN114588315A
(zh)
*
|
2022-03-14 |
2022-06-07 |
东莞市人民医院 |
抗炎蛋白涂层的制备方法、生物工程功能材料及其应用
|
|
CN120435493A
(zh)
*
|
2022-12-05 |
2025-08-05 |
阿雷克森制药公司 |
用于多功能抑制baff、april和新生儿fc受体的taci-fc融合蛋白
|
|
JP2026503273A
(ja)
|
2023-01-06 |
2026-01-28 |
ラッセン・セラピューティクス・インコーポレイテッド |
抗ｉｌ－１８ｂｐ抗体
|
|
TW202430560A
(zh)
|
2023-01-06 |
2024-08-01 |
美商拉森醫療公司 |
抗ｉｌ－１８ｂｐ抗體
|
|
CN120787238A
(zh)
|
2023-01-06 |
2025-10-14 |
拉森医疗公司 |
用于治疗甲状腺眼病的抗IL-11Rα抗体
|