JP2020506693A5 - - Google Patents

Download PDF

Info

Publication number
JP2020506693A5
JP2020506693A5 JP2019540076A JP2019540076A JP2020506693A5 JP 2020506693 A5 JP2020506693 A5 JP 2020506693A5 JP 2019540076 A JP2019540076 A JP 2019540076A JP 2019540076 A JP2019540076 A JP 2019540076A JP 2020506693 A5 JP2020506693 A5 JP 2020506693A5
Authority
JP
Japan
Prior art keywords
ace2
variant
amino acid
acid sequence
fusion protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019540076A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020506693A (ja
JP7332157B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/014991 external-priority patent/WO2018140456A1/en
Publication of JP2020506693A publication Critical patent/JP2020506693A/ja
Publication of JP2020506693A5 publication Critical patent/JP2020506693A5/ja
Priority to JP2023127196A priority Critical patent/JP2023133564A/ja
Application granted granted Critical
Publication of JP7332157B2 publication Critical patent/JP7332157B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019540076A 2017-01-24 2018-01-24 アンジオテンシン変換酵素2(ace2)の活性な低分子量変異体 Active JP7332157B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023127196A JP2023133564A (ja) 2017-01-24 2023-08-03 アンジオテンシン変換酵素2(ace2)の活性な低分子量変異体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762449857P 2017-01-24 2017-01-24
US62/449,857 2017-01-24
PCT/US2018/014991 WO2018140456A1 (en) 2017-01-24 2018-01-24 Active low molecular weight variants of angiotensin converting enzyme 2 (ace2)

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023127196A Division JP2023133564A (ja) 2017-01-24 2023-08-03 アンジオテンシン変換酵素2(ace2)の活性な低分子量変異体

Publications (3)

Publication Number Publication Date
JP2020506693A JP2020506693A (ja) 2020-03-05
JP2020506693A5 true JP2020506693A5 (enExample) 2021-03-11
JP7332157B2 JP7332157B2 (ja) 2023-08-23

Family

ID=62979214

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019540076A Active JP7332157B2 (ja) 2017-01-24 2018-01-24 アンジオテンシン変換酵素2(ace2)の活性な低分子量変異体
JP2023127196A Pending JP2023133564A (ja) 2017-01-24 2023-08-03 アンジオテンシン変換酵素2(ace2)の活性な低分子量変異体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023127196A Pending JP2023133564A (ja) 2017-01-24 2023-08-03 アンジオテンシン変換酵素2(ace2)の活性な低分子量変異体

Country Status (4)

Country Link
US (4) US10443049B2 (enExample)
EP (1) EP3574094A4 (enExample)
JP (2) JP7332157B2 (enExample)
WO (1) WO2018140456A1 (enExample)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7332157B2 (ja) 2017-01-24 2023-08-23 ノースウェスタン ユニバーシティ アンジオテンシン変換酵素2(ace2)の活性な低分子量変異体
CA3082610A1 (en) 2017-11-29 2019-06-06 Max-Delbruck-Centrum Fur Molekulare Medizin In Der Helmholtz-Gemeinschaft Methods for modulating pigmentation by angiotensin-converting enzyme 2 modulation
JP7340372B2 (ja) * 2019-07-11 2023-09-07 浜松ホトニクス株式会社 光活性化アデニル酸シクラーゼ
BR112022014552A2 (pt) * 2020-01-23 2022-10-25 Avirus Inc Polipeptídeo recombinante, composição farmacêutica, método de prevenção ou tratamento de uma infecção viral em um indivíduo que necessita do mesmo, molécula de rna, composição terapêutica, sistema de expressão, polipeptídeo recombinante para tratar infecção por sars-cov-2 e polinucleotídeo que codifica o polipeptídeo recombinante
US11518788B2 (en) * 2020-07-10 2022-12-06 Avirus, Inc. Methods and compositions for treating and preventing viral infection
US20210236583A1 (en) * 2020-02-03 2021-08-05 Yuntao Wu Targeting the renin-angiotensin system for treatment of environment-and pathogen-induced lung injury
TWI886211B (zh) * 2020-02-13 2025-06-11 美商西雅圖免疫公司 重組ace2-fc融合分子以及製造及使用彼等之方法
EP4073243A4 (en) * 2020-02-13 2024-08-07 Sichuan Baili Pharmaceutical Co. Ltd. RECOMBINANT ECA2-FC FUSION MOLECULES, METHODS OF PREPARATION AND USE THEREOF
WO2022173424A1 (en) * 2021-02-10 2022-08-18 Systimmune, Inc. Recombinant ace2-fc fusion molecules and methods of making and using thereof
CN115297867A (zh) * 2020-02-20 2022-11-04 理筱龙 人参皂甙m1作为血管收缩素调节酶的调节剂及其在治疗包括冠状病毒引起的症状的疾病或病征的用途
CN111474363A (zh) * 2020-02-22 2020-07-31 安徽华培生物科技有限公司 一种新型冠状病毒检测方法
WO2021174107A2 (en) * 2020-02-26 2021-09-02 Northwestern University Soluble ace2 variants and uses therefor
JP7554837B2 (ja) 2020-02-27 2024-09-20 華輝安健(北京)生物科技有限公司 可溶性ace2及び融合タンパク質、並びにその適用
WO2021170113A1 (zh) * 2020-02-29 2021-09-02 南京金斯瑞生物科技有限公司 ACE-2-Fc融合蛋白治疗冠状病毒的方法
US20210284716A1 (en) 2020-03-11 2021-09-16 Immunitybio, Inc. ACE2-Fc Trap
US12285480B2 (en) 2020-03-11 2025-04-29 Nantcell, Inc. Method of inducing immunity against SARS-CoV-2 using spike and nucleocapsid-ETSD immunogens delivered by RNA and replication-defective adenoviruses
US11857620B2 (en) 2020-03-11 2024-01-02 Immunitybio, Inc. Method of inducing immunity against SARS-CoV-2 using spike (s) and nucleocapsid (N)-ETSD immunogens delivered by a replication-defective adenovirus
CN115244077B (zh) * 2020-03-11 2025-04-29 南特细胞公司 蛋白质治疗剂
CN116057176A (zh) * 2020-03-21 2023-05-02 赖瑞克斯生物科技公司 Ace2和补体途径的双特异性和三特异性功能分子及其用途
WO2021195009A1 (en) * 2020-03-23 2021-09-30 Sapience Therapeutics, Inc. Peptide antagonists of ace2-binding proteins
CN113444710A (zh) * 2020-03-25 2021-09-28 上海英脉德医疗科技有限公司 ACE2-Fc融合蛋白及其用途
WO2021202456A1 (en) * 2020-03-30 2021-10-07 The Wistar Institute Of Anatomy And Biology Synthetic soluble receptor mimics and methods of use for treatment of covid-19
WO2021197501A1 (zh) * 2020-04-02 2021-10-07 创观(苏州)生物科技有限公司 病毒不易感动物
US20230203466A1 (en) * 2020-04-03 2023-06-29 Medgenome Inc. Ace2 receptor polymorphisms and varying susceptibility to sars-cov-2, methods for diagnosis and treatment
EP4126009A4 (en) * 2020-04-03 2024-04-17 The University of North Carolina at Chapel Hill BINDING PROTEINS FOR USE AGAINST ACE2-TARGETED VIRUSES
WO2021216547A1 (en) * 2020-04-20 2021-10-28 Sorrento Therapeutics, Inc. Pulmonary administration of ace2 polypeptides
WO2021237239A1 (en) * 2020-05-18 2021-11-25 Northwestern University Active low molecular weight variant of angiotensin converting enzyme 2 (ace2) for the treatment of diseases and conditions of the eye
US11773385B2 (en) * 2020-05-19 2023-10-03 Children's Medical Center Corporation High-affinity human ACE2 construct for use in diagnosing and treating coronaviruses
WO2021247675A1 (en) * 2020-06-02 2021-12-09 Ngm Biopharmaceuticals, Inc. Coronavirus-binding agents and uses thereof
DE102020207224A1 (de) 2020-06-09 2021-12-09 Christoph Karle Protein oder Peptid, insbesondere zur Prophylaxe und/oder Behandlung einer durch Coronaviren, insbesondere SARS-CoV-2-Viren, hervorgerufenen Infektion oder Infektionskrankheit und/oder einer Folgekrankheit davon
CA3179834A1 (en) * 2020-06-25 2021-12-30 David S. Block Ace2-fc fusion proteins and methods of use
WO2022008642A1 (en) 2020-07-08 2022-01-13 Apeiron Biologics Ag Treatment of sars-cov-2 infection with a combination of targets
WO2022012688A1 (en) * 2020-07-17 2022-01-20 Shenzhen Bay Laboratory Ace2-ig fusion variants
KR102492081B1 (ko) 2020-07-28 2023-01-26 재단법인대구경북과학기술원 코로나바이러스 감염증 covid-19 치료용 펩타이드 및 이의 용도
US20220041660A1 (en) * 2020-08-06 2022-02-10 University Of Delaware Compositions and methods for sequestering viral particles in respiratory tract
WO2022029011A1 (en) * 2020-08-06 2022-02-10 BioNTech SE Binding agents for coronavirus s protein
WO2022035998A1 (en) * 2020-08-11 2022-02-17 City Of Hope Compositions and uses of sars-cov-2 targeted chimeric antigen receptor modified nk cells
JP7635370B2 (ja) * 2020-10-01 2025-02-25 システィミューン, インク. 組換えace2-fc融合分子、その製造方法及びその使用
WO2022075667A1 (ko) * 2020-10-05 2022-04-14 한양대학교 산학협력단 안정화된 ace2 변이체, 이를 이용한 ace2-fc 융합단백질 및 covid-19 예방 또는 치료용 약학 조성물
WO2022082217A1 (en) * 2020-10-16 2022-04-21 Eureka Therapeutics, Inc. Compositions for preventing or treating viral and other microbial infections
WO2022108013A1 (ko) * 2020-11-20 2022-05-27 재단법인대구경북과학기술원 코로나바이러스 감염증 covid-19 치료제 단백질 ctp 알파, ctp 베타, ctp 감마, ctp 델타 및 이의 용도
CA3200885A1 (en) 2020-11-23 2022-05-27 Genentech, Inc. Methods for modulating host cell surface interactions with sars-cov-2
WO2022119380A1 (ko) * 2020-12-03 2022-06-09 주식회사 유틸렉스 신규한 ace2 변이체 및 그의 이용
EP4011387A1 (en) * 2020-12-11 2022-06-15 IMBA-Institut für Molekulare Biotechnologie GmbH Superior neutralization of sars-cov-2 by deglycosylated human angiotensin converting enzyme 2
WO2022159433A1 (en) 2021-01-20 2022-07-28 Singh Biotechnology, Llc Therapeutics directed against coronavirus
CA3206022A1 (en) * 2021-01-26 2022-08-04 Traian Sulea Ace2-receptor ectodomain fusion molecules and uses thereof
WO2022165246A1 (en) * 2021-01-29 2022-08-04 The Trustees Of The University Of Pennsylvania Compositions and method of use of mutant ace2 decoy variants
WO2022207918A1 (en) 2021-04-02 2022-10-06 Apeiron Biologics Ag COVID-19 Therapy
WO2022246041A2 (en) * 2021-05-20 2022-11-24 Achelois Biopharma, Inc. Compositions and methods for multivalent surface display on enveloped particles
CN113324933B (zh) * 2021-06-01 2022-07-26 浙江大学 一种检测血管紧张素转换酶的方法及其应用
WO2022271863A1 (en) * 2021-06-23 2022-12-29 Chan Zuckerberg Biohub, Inc. Coronavirus neutralizing compositions and associated methods
WO2023108040A2 (en) * 2021-12-09 2023-06-15 Gliknik Inc. Ace2-fc fusion proteins and methods of use
EP4508077A4 (en) 2022-04-14 2026-03-25 Invisishield Tech Ltd COMPOSITIONS FOR PREVENTING OR TREATMENT OF INFLUENZA INFECTIONS
CA3256035A1 (en) 2022-04-14 2023-10-19 Invisishield Technologies Ltd. COMPOSITIONS FOR PREVENTING OR TREATMENT OF CORONAVIRUS INFECTIONS
EP4335870A1 (en) 2022-09-06 2024-03-13 NantCell, Inc. Peptide therapeutics against sars-cov-2 spike protein
CN116023509A (zh) * 2022-11-18 2023-04-28 中国药科大学 一种融合蛋白及其应用
DE202023100085U1 (de) 2023-01-09 2023-02-03 Sundararajan Gothandam Eine doppelte Blockade des Renin-Angiotensin-Systems zur Verringerung der frühen Veränderungen der diabetischen Retinopathie und Nephropathie
CN118085110A (zh) * 2024-04-02 2024-05-28 中国药科大学 一种靶向肿瘤的融合蛋白及其应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4540930A (en) 1983-09-12 1985-09-10 Wisconsin Alumni Research Foundation Plywheel-powered mobile X-ray apparatus
US5124154A (en) 1990-06-12 1992-06-23 Insite Vision Incorporated Aminosteroids for ophthalmic use
US6610497B1 (en) 1997-12-11 2003-08-26 Millennium Pharmaceuticals, Inc. Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therefor
US7396664B2 (en) 1999-06-08 2008-07-08 Regeneron Pharmaceuticals, Inc. VEGF-binding fusion proteins and nucleic acids encoding the same
US20030113726A1 (en) 2000-12-04 2003-06-19 Zenta Tsuchihashi Human single nucleotide polymorphisms
AT506258A1 (de) 2007-12-18 2009-07-15 Apeiron Biolog Forschungs Und Behandlung inflammatorischer krankheiten
KR20120092611A (ko) * 2009-09-30 2012-08-21 글락소 그룹 리미티드 연장된 반감기를 갖는 약물 융합체 및 컨쥬게이트
US20130210726A1 (en) * 2012-02-10 2013-08-15 Tarix Pharmaceuticals Ltd. Compositions and methods for treatment of peripheral vascular disease
JP2015519345A (ja) 2012-05-25 2015-07-09 ヤンセン バイオテツク,インコーポレーテツド 非天然コンセンサスアルブミン結合ドメイン
US9757433B2 (en) 2013-01-14 2017-09-12 Apeiron Biologicals AG Modified ACE2 polypeptides
EP3058074B1 (en) 2013-10-18 2019-02-20 Trustees Of The University Of Pennsylvania Oral delivery of angiotensin converting enzyme 2 (ace2) or angiotensin-(1-7) bioencapsulated in plant cells
JP7332157B2 (ja) 2017-01-24 2023-08-23 ノースウェスタン ユニバーシティ アンジオテンシン変換酵素2(ace2)の活性な低分子量変異体
WO2021174107A2 (en) 2020-02-26 2021-09-02 Northwestern University Soluble ace2 variants and uses therefor
WO2021237239A1 (en) 2020-05-18 2021-11-25 Northwestern University Active low molecular weight variant of angiotensin converting enzyme 2 (ace2) for the treatment of diseases and conditions of the eye

Similar Documents

Publication Publication Date Title
US20230115655A1 (en) Engineered polypeptides having enhanced duration of action
JP4659068B2 (ja) Ob融合タンパク質組成物および方法
TWI853223B (zh) Gdf15融合蛋白及其用途
US7112659B2 (en) OB fusion protein compositions and methods
US8420098B2 (en) Fibronectin based scaffold domain proteins that bind to PCSK9
JP2018070625A5 (enExample)
JP2016511752A5 (enExample)
JP7834637B2 (ja) 治療用融合タンパク質
US20180305430A1 (en) Engineered Polypeptides Having Enhanced Duration of Action and Reduced Immunogenicity
JP6325585B2 (ja) インターロイキン−22のウイルス性肝炎の治療における応用
JP2017531613A5 (enExample)
EP3574094A1 (en) Active low molecular weight variants of angiotensin converting enzyme 2 (ace2)
JP2009534392A (ja) 凍結乾燥された治療用ペプチボディ製剤
JP2011526303A (ja) エラスチン様ペプチドを含む治療剤
JP2016512213A5 (enExample)
JP2008535800A5 (enExample)
JP6825181B2 (ja) 膵炎を治療するための薬剤の製造におけるil−22二量体の使用
US20250295737A1 (en) Treatment Using Heterodimeric Relaxin Fusions
JP2021523214A5 (enExample)
RU2021136703A (ru) Новый модифицированный слитый белок fc-фрагмента иммуноглобулина и его применение