JP2010530220A5 - - Google Patents
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- JP2010530220A5 JP2010530220A5 JP2010510887A JP2010510887A JP2010530220A5 JP 2010530220 A5 JP2010530220 A5 JP 2010530220A5 JP 2010510887 A JP2010510887 A JP 2010510887A JP 2010510887 A JP2010510887 A JP 2010510887A JP 2010530220 A5 JP2010530220 A5 JP 2010530220A5
- Authority
- JP
- Japan
- Prior art keywords
- variable domain
- antagonist
- sequence
- dom4
- interleukin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102000010932 Interleukin-1 receptor type 1 Human genes 0.000 claims 21
- 108050001109 Interleukin-1 receptor type 1 Proteins 0.000 claims 21
- 239000005557 antagonist Substances 0.000 claims 16
- 108060003951 Immunoglobulin Proteins 0.000 claims 14
- 102000018358 immunoglobulin Human genes 0.000 claims 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 102000005962 receptors Human genes 0.000 claims 4
- 108020003175 receptors Proteins 0.000 claims 4
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 3
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 3
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 3
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 3
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 3
- 102000000589 Interleukin-1 Human genes 0.000 claims 3
- 108010002352 Interleukin-1 Proteins 0.000 claims 3
- 108091005804 Peptidases Proteins 0.000 claims 3
- 239000004365 Protease Substances 0.000 claims 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 3
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 102000004889 Interleukin-6 Human genes 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 102000004890 Interleukin-8 Human genes 0.000 claims 1
- 108090001007 Interleukin-8 Proteins 0.000 claims 1
- 102000016387 Pancreatic elastase Human genes 0.000 claims 1
- 108010067372 Pancreatic elastase Proteins 0.000 claims 1
- 108010019160 Pancreatin Proteins 0.000 claims 1
- 102000004142 Trypsin Human genes 0.000 claims 1
- 108090000631 Trypsin Proteins 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000009977 dual effect Effects 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 239000000710 homodimer Substances 0.000 claims 1
- 238000000099 in vitro assay Methods 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 229940100601 interleukin-6 Drugs 0.000 claims 1
- 229940096397 interleukin-8 Drugs 0.000 claims 1
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 229940055695 pancreatin Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000012588 trypsin Substances 0.000 claims 1
- 238000013389 whole blood assay Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93363207P | 2007-06-06 | 2007-06-06 | |
| US60/933,632 | 2007-06-06 | ||
| GB0724331.4 | 2007-12-13 | ||
| GBGB0724331.4A GB0724331D0 (en) | 2007-12-13 | 2007-12-13 | Compositions for pulmonary delivery |
| PCT/GB2008/050406 WO2008149149A2 (en) | 2007-06-06 | 2008-06-04 | Polypeptides, antibody variable domains and antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010530220A JP2010530220A (ja) | 2010-09-09 |
| JP2010530220A5 true JP2010530220A5 (cg-RX-API-DMAC7.html) | 2011-07-14 |
| JP5444215B2 JP5444215B2 (ja) | 2014-03-19 |
Family
ID=39791116
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010510886A Expired - Fee Related JP5325211B2 (ja) | 2007-06-06 | 2008-06-04 | ポリペプチド、抗体可変ドメインおよびアンタゴニスト |
| JP2010510888A Pending JP2010530364A (ja) | 2007-06-06 | 2008-06-04 | ポリペプチド、抗体可変ドメインおよびアンタゴニスト |
| JP2010510887A Active JP5444215B2 (ja) | 2007-06-06 | 2008-06-04 | ポリペプチド、抗体可変ドメインおよびアンタゴニスト |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010510886A Expired - Fee Related JP5325211B2 (ja) | 2007-06-06 | 2008-06-04 | ポリペプチド、抗体可変ドメインおよびアンタゴニスト |
| JP2010510888A Pending JP2010530364A (ja) | 2007-06-06 | 2008-06-04 | ポリペプチド、抗体可変ドメインおよびアンタゴニスト |
Country Status (31)
Families Citing this family (66)
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| DE102005023617A1 (de) | 2005-05-21 | 2006-11-23 | Aspre Ag | Verfahren zum Mischen von Farben in einem Display |
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| BRPI0819932A2 (pt) * | 2007-12-13 | 2019-07-30 | Glaxo Group Ltd | composição, uso de uma composição, dispositivo nebulizador, inalador ou intranasal, processos para produzir uma composição farmacêutica e uma composição polipeptídica, e, uso de um tampão fisiologicamente aceitável. |
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