ATE479760T1 - Universelles signalpeptid gas1 - Google Patents
Universelles signalpeptid gas1Info
- Publication number
- ATE479760T1 ATE479760T1 AT05729650T AT05729650T ATE479760T1 AT E479760 T1 ATE479760 T1 AT E479760T1 AT 05729650 T AT05729650 T AT 05729650T AT 05729650 T AT05729650 T AT 05729650T AT E479760 T1 ATE479760 T1 AT E479760T1
- Authority
- AT
- Austria
- Prior art keywords
- heavy chain
- chain variable
- variable domain
- immunoglobulin heavy
- domain polypeptide
- Prior art date
Links
- 102100036683 Growth arrest-specific protein 1 Human genes 0.000 title abstract 2
- 101001072723 Homo sapiens Growth arrest-specific protein 1 Proteins 0.000 title abstract 2
- 108010076504 Protein Sorting Signals Proteins 0.000 title abstract 2
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 abstract 4
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 abstract 4
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 238000012258 culturing Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
- C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/055—Fusion polypeptide containing a localisation/targetting motif containing a signal for localisation to secretory granules (for exocytosis)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Crystallography & Structural Chemistry (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Gas Separation By Absorption (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55576404P | 2004-03-24 | 2004-03-24 | |
| PCT/GB2005/001180 WO2005093074A1 (en) | 2004-03-24 | 2005-03-24 | Gas1 universal leader |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE479760T1 true ATE479760T1 (de) | 2010-09-15 |
Family
ID=34963448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05729650T ATE479760T1 (de) | 2004-03-24 | 2005-03-24 | Universelles signalpeptid gas1 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7846721B2 (de) |
| EP (2) | EP2172553A1 (de) |
| AT (1) | ATE479760T1 (de) |
| CY (1) | CY1111063T1 (de) |
| DE (1) | DE602005023291D1 (de) |
| DK (1) | DK1737962T3 (de) |
| ES (1) | ES2351509T3 (de) |
| PL (1) | PL1737962T3 (de) |
| PT (1) | PT1737962E (de) |
| SI (1) | SI1737962T1 (de) |
| WO (1) | WO2005093074A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1841796A2 (de) | 2004-12-02 | 2007-10-10 | Domantis Limited | Bispezifische domänen-antikörper gegen serum albumin und glp-1 oder pyy |
| CA2688434A1 (en) | 2007-06-06 | 2008-12-11 | Domantis Limited | Polypeptides, antibody variable domains and antagonists |
| CN102307897B (zh) | 2008-12-05 | 2016-01-20 | 葛兰素集团有限公司 | 选出蛋白酶抗性多肽的方法 |
| US9534043B2 (en) | 2009-02-19 | 2017-01-03 | Glaxo Group Limited | Anti-serum albumin binding variants |
| PE20120170A1 (es) | 2009-02-19 | 2012-03-21 | Glaxo Group Ltd | Variantes de union a anti-albumina de suero mejoradas |
| EA022925B1 (ru) | 2009-02-19 | 2016-03-31 | Глаксо Груп Лимитед | Улучшенные полипептиды, вариабельные домены антител и антагонисты против tnfr1 |
| EP2453920A2 (de) | 2009-07-16 | 2012-05-23 | Glaxo Group Limited | Antagonisten, verwendung und verfahren zur teilweisen tnfr1-hemmung |
| SG177601A1 (en) | 2009-07-16 | 2012-02-28 | Glaxo Group Ltd | Improved anti-serum albumin binding single variable domains |
| EP2459593A2 (de) | 2009-07-29 | 2012-06-06 | Glaxo Group Limited | Einzeldomänenantikörper gegen tgf-beta-rezeptor typ ii |
| WO2011086143A2 (en) | 2010-01-14 | 2011-07-21 | Glaxo Group Limited | Liver targeting molecules |
| CA2796932A1 (en) | 2010-04-21 | 2011-10-27 | Glaxo Group Limited | Binding domains |
| EP2571900A1 (de) | 2010-05-20 | 2013-03-27 | Glaxo Group Limited | Verbesserte antiserumalbuminbindende varianten |
| EP2603607B1 (de) * | 2010-08-11 | 2016-04-06 | Celula, Inc. | Dns genotypisierung |
| WO2012020143A1 (en) | 2010-08-13 | 2012-02-16 | Glaxo Group Limited | Improved anti-serum albumin binding variants |
| EA201390116A1 (ru) | 2010-08-20 | 2013-09-30 | Глаксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Улучшенные связывающие варианты против сывороточного альбумина |
| CA2823104A1 (en) | 2011-01-06 | 2012-07-12 | Glaxo Group Limited | Ligands that bind tgf-beta receptor ii |
| EP2670778A1 (de) | 2011-02-02 | 2013-12-11 | Glaxo Group Limited | Neuartige antigenbindende proteine |
| PL2699601T3 (pl) | 2011-04-21 | 2018-05-30 | Bristol-Myers Squibb Company | Polipeptydy przeciwciała, które antagonizują CD40 |
| ES2743401T3 (es) * | 2012-07-05 | 2020-02-19 | Hoffmann La Roche | Sistema de expresión y secreción |
| EP3113796A1 (de) | 2014-03-07 | 2017-01-11 | Bristol-Myers Squibb Company | Verfahren zur verwendung von antikörperpolypeptiden mit cd40-antagonisierung zur behandlung von entzündlichen darmerkrankungen |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9400600A (pt) * | 1994-02-17 | 1995-10-24 | Finep Financiadora De Estudos | Processos para produção de uma protéina recombinante e/ou de glicosilfosfatidilinositol (GPI) em células de microorganismos eucariontes e para a obtenção de leveduras de S. cerevisae; célula de levedura sequência de nucleotídios; meio de cultura; medicamento ou vacina; e produto dos ditos processos |
| US6555310B1 (en) * | 1997-04-04 | 2003-04-29 | Biosite Diagnostics, Inc. | Polyclonal libraries |
| US7094579B2 (en) * | 2002-02-13 | 2006-08-22 | Xoma Technology Ltd. | Eukaryotic signal sequences for prokaryotic expression |
-
2005
- 2005-03-24 SI SI200531167T patent/SI1737962T1/sl unknown
- 2005-03-24 DK DK05729650.1T patent/DK1737962T3/da active
- 2005-03-24 WO PCT/GB2005/001180 patent/WO2005093074A1/en not_active Ceased
- 2005-03-24 PT PT05729650T patent/PT1737962E/pt unknown
- 2005-03-24 PL PL05729650T patent/PL1737962T3/pl unknown
- 2005-03-24 AT AT05729650T patent/ATE479760T1/de active
- 2005-03-24 DE DE602005023291T patent/DE602005023291D1/de not_active Expired - Lifetime
- 2005-03-24 EP EP09155173A patent/EP2172553A1/de not_active Withdrawn
- 2005-03-24 ES ES05729650T patent/ES2351509T3/es not_active Expired - Lifetime
- 2005-03-24 EP EP05729650A patent/EP1737962B1/de not_active Expired - Lifetime
-
2006
- 2006-07-27 US US11/494,965 patent/US7846721B2/en not_active Expired - Fee Related
-
2010
- 2010-11-29 CY CY20101101090T patent/CY1111063T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2172553A1 (de) | 2010-04-07 |
| DK1737962T3 (da) | 2010-12-13 |
| DE602005023291D1 (de) | 2010-10-14 |
| US7846721B2 (en) | 2010-12-07 |
| EP1737962A1 (de) | 2007-01-03 |
| CY1111063T1 (el) | 2015-06-11 |
| WO2005093074A1 (en) | 2005-10-06 |
| PT1737962E (pt) | 2010-12-03 |
| SI1737962T1 (sl) | 2011-01-31 |
| ES2351509T3 (es) | 2011-02-07 |
| PL1737962T3 (pl) | 2011-02-28 |
| US20070026462A1 (en) | 2007-02-01 |
| EP1737962B1 (de) | 2010-09-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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