JP2009513136A5 - - Google Patents

Info

Publication number

JP2009513136A5

JP2009513136A5 JP2008537902A JP2008537902A JP2009513136A5 JP 2009513136 A5 JP2009513136 A5 JP 2009513136A5 JP 2008537902 A JP2008537902 A JP 2008537902A JP 2008537902 A JP2008537902 A JP 2008537902A JP 2009513136 A5 JP2009513136 A5 JP 2009513136A5

Authority

JP

Japan

Prior art keywords

seq

host cell

substrate

group

cell according

Prior art date

2006-10-25

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims 22
• AMIMRNSIRUDHCM-UHFFFAOYSA-N Isopropylaldehyde Chemical compound CC(C)C=O AMIMRNSIRUDHCM-UHFFFAOYSA-N 0.000 claims 20
• 239000000758 substrate Substances 0.000 claims 20
• 238000006243 chemical reaction Methods 0.000 claims 13
• 230000000813 microbial effect Effects 0.000 claims 13
• 229920001184 polypeptide Polymers 0.000 claims 13
• 102000004196 processed proteins & peptides Human genes 0.000 claims 13
• 108090000765 processed proteins & peptides Proteins 0.000 claims 13
• 125000003275 alpha amino acid group Chemical group 0.000 claims 11
• QHKABHOOEWYVLI-UHFFFAOYSA-N 3-methyl-2-oxobutanoic acid Chemical compound CC(C)C(=O)C(O)=O QHKABHOOEWYVLI-UHFFFAOYSA-N 0.000 claims 10
• JTEYKUFKXGDTEU-UHFFFAOYSA-N 2,3-dihydroxy-3-methylbutanoic acid Chemical compound CC(C)(O)C(O)C(O)=O JTEYKUFKXGDTEU-UHFFFAOYSA-N 0.000 claims 8
• WTLNOANVTIKPEE-UHFFFAOYSA-N 2-acetyloxypropanoic acid Chemical compound OC(=O)C(C)OC(C)=O WTLNOANVTIKPEE-UHFFFAOYSA-N 0.000 claims 8
• KDSNLYIMUZNERS-UHFFFAOYSA-N 2-methylpropanamine Chemical compound CC(C)CN KDSNLYIMUZNERS-UHFFFAOYSA-N 0.000 claims 8
• 108020004414 DNA Proteins 0.000 claims 6
• 102000053602 DNA Human genes 0.000 claims 6
• 238000000034 method Methods 0.000 claims 6
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 4
• LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims 4
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 4
• 229910052799 carbon Inorganic materials 0.000 claims 4
• AEWHYWSPVRZHCT-NDZSKPAWSA-N isobutyryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C(C)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 AEWHYWSPVRZHCT-NDZSKPAWSA-N 0.000 claims 4
• 239000004474 valine Substances 0.000 claims 4
• 240000004808 Saccharomyces cerevisiae Species 0.000 claims 3
• 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 3
• 108010000700 Acetolactate synthase Proteins 0.000 claims 2
• 108010021809 Alcohol dehydrogenase Proteins 0.000 claims 2
• 102000007698 Alcohol dehydrogenase Human genes 0.000 claims 2
• 102000005369 Aldehyde Dehydrogenase Human genes 0.000 claims 2
• 108020002663 Aldehyde Dehydrogenase Proteins 0.000 claims 2
• 101710118140 Alpha-keto-acid decarboxylase Proteins 0.000 claims 2
• 241000194108 Bacillus licheniformis Species 0.000 claims 2
• 241000252867 Cupriavidus metallidurans Species 0.000 claims 2
• 101710088194 Dehydrogenase Proteins 0.000 claims 2
• 241000194032 Enterococcus faecalis Species 0.000 claims 2
• 241000588724 Escherichia coli Species 0.000 claims 2
• 102000004867 Hydro-Lyases Human genes 0.000 claims 2
• 108090001042 Hydro-Lyases Proteins 0.000 claims 2
• 108010000200 Ketol-acid reductoisomerase Proteins 0.000 claims 2
• 101710164401 Omega-aminotransferase Proteins 0.000 claims 2
• 241000235648 Pichia Species 0.000 claims 2
• 241000589776 Pseudomonas putida Species 0.000 claims 2
• 241000187561 Rhodococcus erythropolis Species 0.000 claims 2
• 102000003929 Transaminases Human genes 0.000 claims 2
• 108090000340 Transaminases Proteins 0.000 claims 2
• 108030003572 Valine decarboxylases Proteins 0.000 claims 2
• 229940032049 enterococcus faecalis Drugs 0.000 claims 2
• 238000000855 fermentation Methods 0.000 claims 2
• 230000004151 fermentation Effects 0.000 claims 2
• 150000004715 keto acids Chemical class 0.000 claims 2
• GNFTZDOKVXKIBK-UHFFFAOYSA-N 3-(2-methoxyethoxy)benzohydrazide Chemical compound COCCOC1=CC=CC(C(=O)NN)=C1 GNFTZDOKVXKIBK-UHFFFAOYSA-N 0.000 claims 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 241000588986 Alcaligenes Species 0.000 claims 1
• 241000186063 Arthrobacter Species 0.000 claims 1
• 244000063299 Bacillus subtilis Species 0.000 claims 1
• 241000894006 Bacteria Species 0.000 claims 1
• 241000186146 Brevibacterium Species 0.000 claims 1
• FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 claims 1
• 241000222120 Candida <Saccharomycetales> Species 0.000 claims 1
• 241000193403 Clostridium Species 0.000 claims 1
• 241000192700 Cyanobacteria Species 0.000 claims 1
• 241000194031 Enterococcus faecium Species 0.000 claims 1
• 241000194030 Enterococcus gallinarum Species 0.000 claims 1
• 241000588722 Escherichia Species 0.000 claims 1
• 229930091371 Fructose Natural products 0.000 claims 1
• 239000005715 Fructose Substances 0.000 claims 1
• RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims 1
• 241000233866 Fungi Species 0.000 claims 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
• 241000588748 Klebsiella Species 0.000 claims 1
• 241000186660 Lactobacillus Species 0.000 claims 1
• 240000006024 Lactobacillus plantarum Species 0.000 claims 1
• 235000013965 Lactobacillus plantarum Nutrition 0.000 claims 1
• 241000179039 Paenibacillus Species 0.000 claims 1
• 241000178960 Paenibacillus macerans Species 0.000 claims 1
• 241000316848 Rhodococcus <scale insect> Species 0.000 claims 1
• 241000235070 Saccharomyces Species 0.000 claims 1
• 241000607142 Salmonella Species 0.000 claims 1
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
• 229930006000 Sucrose Natural products 0.000 claims 1
• 101710100604 Valine dehydrogenase Proteins 0.000 claims 1
• 241000588901 Zymomonas Species 0.000 claims 1
• YTAHJIFKAKIKAV-XNMGPUDCSA-N [(1R)-3-morpholin-4-yl-1-phenylpropyl] N-[(3S)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]carbamate Chemical compound O=C1[C@H](N=C(C2=C(N1)C=CC=C2)C1=CC=CC=C1)NC(O[C@H](CCN1CCOCC1)C1=CC=CC=C1)=O YTAHJIFKAKIKAV-XNMGPUDCSA-N 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
• 239000008103 glucose Substances 0.000 claims 1
• 150000004676 glycans Chemical class 0.000 claims 1
• 229940039696 lactobacillus Drugs 0.000 claims 1
• 229940072205 lactobacillus plantarum Drugs 0.000 claims 1
• 150000002772 monosaccharides Chemical class 0.000 claims 1
• 229920001542 oligosaccharide Polymers 0.000 claims 1
• 150000002482 oligosaccharides Chemical class 0.000 claims 1
• 229920001282 polysaccharide Polymers 0.000 claims 1
• 239000005017 polysaccharide Substances 0.000 claims 1
• 239000005720 sucrose Substances 0.000 claims 1