JP2009509541A5 - - Google Patents

Info

Publication number

JP2009509541A5

JP2009509541A5 JP2008533648A JP2008533648A JP2009509541A5 JP 2009509541 A5 JP2009509541 A5 JP 2009509541A5 JP 2008533648 A JP2008533648 A JP 2008533648A JP 2008533648 A JP2008533648 A JP 2008533648A JP 2009509541 A5 JP2009509541 A5 JP 2009509541A5

Authority

JP

Japan

Prior art keywords

seq

coa

host cell

group

butanol

Prior art date

2006-09-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 21
• ZTQSAGDEMFDKMZ-UHFFFAOYSA-N Butyraldehyde Chemical compound CCCC=O ZTQSAGDEMFDKMZ-UHFFFAOYSA-N 0.000 claims 12
• 239000000758 substrate Substances 0.000 claims 11
• 238000006243 chemical reaction Methods 0.000 claims 7
• 229920001184 polypeptide Polymers 0.000 claims 7
• 102000004196 processed proteins & peptides Human genes 0.000 claims 7
• 108090000765 processed proteins & peptides Proteins 0.000 claims 7
• 125000003275 alpha amino acid group Chemical group 0.000 claims 6
• HGBOYTHUEUWSSQ-UHFFFAOYSA-N valeric aldehyde Natural products CCCCC=O HGBOYTHUEUWSSQ-UHFFFAOYSA-N 0.000 claims 6
• 238000000034 method Methods 0.000 claims 5
• 230000000813 microbial effect Effects 0.000 claims 5
• 229920001791 ((R)-3-Hydroxybutanoyl)(n-2) Polymers 0.000 claims 4
• QHHKKMYHDBRONY-RMNRSTNRSA-N 3-hydroxybutanoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 QHHKKMYHDBRONY-RMNRSTNRSA-N 0.000 claims 4
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
• 241000235648 Pichia Species 0.000 claims 4
• OJFDKHTZOUZBOS-CITAKDKDSA-N acetoacetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 OJFDKHTZOUZBOS-CITAKDKDSA-N 0.000 claims 4
• ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 claims 4
• CRFNGMNYKDXRTN-CITAKDKDSA-N butyryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCC)O[C@H]1N1C2=NC=NC(N)=C2N=C1 CRFNGMNYKDXRTN-CITAKDKDSA-N 0.000 claims 4
• 229910052799 carbon Inorganic materials 0.000 claims 4
• KFWWCMJSYSSPSK-PAXLJYGASA-N crotonoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)/C=C/C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 KFWWCMJSYSSPSK-PAXLJYGASA-N 0.000 claims 4
• 240000004808 Saccharomyces cerevisiae Species 0.000 claims 3
• 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 3
• 108010055682 3-hydroxybutyryl-CoA dehydrogenase Proteins 0.000 claims 2
• 102000005345 Acetyl-CoA C-acetyltransferase Human genes 0.000 claims 2
• 108010006229 Acetyl-CoA C-acetyltransferase Proteins 0.000 claims 2
• 241000194108 Bacillus licheniformis Species 0.000 claims 2
• 108010068197 Butyryl-CoA Dehydrogenase Proteins 0.000 claims 2
• 241000252867 Cupriavidus metallidurans Species 0.000 claims 2
• 108020004414 DNA Proteins 0.000 claims 2
• 102000053602 DNA Human genes 0.000 claims 2
• 101710088194 Dehydrogenase Proteins 0.000 claims 2
• 108010023922 Enoyl-CoA hydratase Proteins 0.000 claims 2
• 102000011426 Enoyl-CoA hydratase Human genes 0.000 claims 2
• 241000194032 Enterococcus faecalis Species 0.000 claims 2
• 241000588724 Escherichia coli Species 0.000 claims 2
• 102100039894 Hemoglobin subunit delta Human genes 0.000 claims 2
• 241000194036 Lactococcus Species 0.000 claims 2
• 241000178960 Paenibacillus macerans Species 0.000 claims 2
• 241000589776 Pseudomonas putida Species 0.000 claims 2
• 241000187561 Rhodococcus erythropolis Species 0.000 claims 2
• 241000235070 Saccharomyces Species 0.000 claims 2
• 102100024639 Short-chain specific acyl-CoA dehydrogenase, mitochondrial Human genes 0.000 claims 2
• 108010057307 butanol dehydrogenase Proteins 0.000 claims 2
• 229940032049 enterococcus faecalis Drugs 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 241000588986 Alcaligenes Species 0.000 claims 1
• 241000186063 Arthrobacter Species 0.000 claims 1
• 244000063299 Bacillus subtilis Species 0.000 claims 1
• 241000894006 Bacteria Species 0.000 claims 1
• 241000186146 Brevibacterium Species 0.000 claims 1
• 241000193403 Clostridium Species 0.000 claims 1
• 241000186216 Corynebacterium Species 0.000 claims 1
• 241000192700 Cyanobacteria Species 0.000 claims 1
• 241000194031 Enterococcus faecium Species 0.000 claims 1
• 241000194030 Enterococcus gallinarum Species 0.000 claims 1
• 241000588722 Escherichia Species 0.000 claims 1
• 229930091371 Fructose Natural products 0.000 claims 1
• 239000005715 Fructose Substances 0.000 claims 1
• RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims 1
• 241000233866 Fungi Species 0.000 claims 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
• 241000588748 Klebsiella Species 0.000 claims 1
• 240000006024 Lactobacillus plantarum Species 0.000 claims 1
• 235000013965 Lactobacillus plantarum Nutrition 0.000 claims 1
• 241000179039 Paenibacillus Species 0.000 claims 1
• 241000316848 Rhodococcus <scale insect> Species 0.000 claims 1
• 241000607142 Salmonella Species 0.000 claims 1
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
• 229930006000 Sucrose Natural products 0.000 claims 1
• 241000588901 Zymomonas Species 0.000 claims 1
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
• 239000008103 glucose Substances 0.000 claims 1
• 150000004676 glycans Chemical class 0.000 claims 1
• 229940072205 lactobacillus plantarum Drugs 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 150000002772 monosaccharides Chemical class 0.000 claims 1
• 229920001542 oligosaccharide Polymers 0.000 claims 1
• 150000002482 oligosaccharides Chemical class 0.000 claims 1
• 229920001282 polysaccharide Polymers 0.000 claims 1
• 239000005017 polysaccharide Substances 0.000 claims 1
• 239000005720 sucrose Substances 0.000 claims 1