JP2009005695A5 - - Google Patents
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- Publication number
- JP2009005695A5 JP2009005695A5 JP2008149091A JP2008149091A JP2009005695A5 JP 2009005695 A5 JP2009005695 A5 JP 2009005695A5 JP 2008149091 A JP2008149091 A JP 2008149091A JP 2008149091 A JP2008149091 A JP 2008149091A JP 2009005695 A5 JP2009005695 A5 JP 2009005695A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- binding portion
- monoclonal antibody
- antibody
- madcam
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000427 antigen Substances 0.000 claims 36
- 108091007433 antigens Proteins 0.000 claims 36
- 102000036639 antigens Human genes 0.000 claims 36
- 239000000203 mixture Substances 0.000 claims 15
- 125000003275 alpha amino acid group Chemical group 0.000 claims 13
- 208000027866 inflammatory disease Diseases 0.000 claims 12
- 108020004707 nucleic acids Proteins 0.000 claims 9
- 150000007523 nucleic acids Chemical class 0.000 claims 9
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 230000002401 inhibitory effect Effects 0.000 claims 8
- 210000000265 leukocyte Anatomy 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 7
- 230000009261 transgenic effect Effects 0.000 claims 6
- 206010009900 Colitis ulcerative Diseases 0.000 claims 4
- 208000011231 Crohn disease Diseases 0.000 claims 4
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 4
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 241001465754 Metazoa Species 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 210000004408 hybridoma Anatomy 0.000 claims 3
- 210000004698 lymphocyte Anatomy 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 206010008609 Cholangitis sclerosing Diseases 0.000 claims 2
- 208000012258 Diverticular disease Diseases 0.000 claims 2
- 206010013554 Diverticulum Diseases 0.000 claims 2
- 238000012413 Fluorescence activated cell sorting analysis Methods 0.000 claims 2
- 208000007882 Gastritis Diseases 0.000 claims 2
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 208000034189 Sclerosis Diseases 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 238000007792 addition Methods 0.000 claims 2
- 210000000941 bile Anatomy 0.000 claims 2
- 239000012472 biological sample Substances 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 208000024908 graft versus host disease Diseases 0.000 claims 2
- 229940027941 immunoglobulin g Drugs 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 208000019423 liver disease Diseases 0.000 claims 2
- 208000010157 sclerosing cholangitis Diseases 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- WUBBRNOQWQTFEX-UHFFFAOYSA-N 4-aminosalicylic acid Chemical compound NC1=CC=C(C(O)=O)C(O)=C1 WUBBRNOQWQTFEX-UHFFFAOYSA-N 0.000 claims 1
- 101150109698 A2 gene Proteins 0.000 claims 1
- 108010067225 Cell Adhesion Molecules Proteins 0.000 claims 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- 238000009007 Diagnostic Kit Methods 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 1
- 229940113720 aminosalicylate Drugs 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 claims 1
- 229960002170 azathioprine Drugs 0.000 claims 1
- 230000021164 cell adhesion Effects 0.000 claims 1
- 102000008395 cell adhesion mediator activity proteins Human genes 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229960001265 ciclosporin Drugs 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 229960001334 corticosteroids Drugs 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229930182912 cyclosporin Natural products 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000002889 endothelial cell Anatomy 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 230000002519 immonomodulatory effect Effects 0.000 claims 1
- 239000002955 immunomodulating agent Substances 0.000 claims 1
- 229940121354 immunomodulator Drugs 0.000 claims 1
- 230000009545 invasion Effects 0.000 claims 1
- 210000003563 lymphoid tissue Anatomy 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 238000013508 migration Methods 0.000 claims 1
- 230000005012 migration Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 1
- 230000007115 recruitment Effects 0.000 claims 1
- 229960002930 sirolimus Drugs 0.000 claims 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 229940046728 tumor necrosis factor alpha inhibitor Drugs 0.000 claims 1
- 239000002452 tumor necrosis factor alpha inhibitor Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53549004P | 2004-01-09 | 2004-01-09 | |
| US60/535,490 | 2004-01-09 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006549399A Division JP4315982B2 (ja) | 2004-01-09 | 2005-01-07 | ＭＡｄＣＡＭに対する抗体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009260786A Division JP5094818B2 (ja) | 2004-01-09 | 2009-11-16 | ＭＡｄＣＡＭに対する抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009005695A JP2009005695A (ja) | 2009-01-15 |
| JP2009005695A5 true JP2009005695A5 (enExample) | 2009-04-23 |
| JP4729076B2 JP4729076B2 (ja) | 2011-07-20 |
Family
ID=34794356
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006549399A Expired - Lifetime JP4315982B2 (ja) | 2004-01-09 | 2005-01-07 | ＭＡｄＣＡＭに対する抗体 |
| JP2008149091A Expired - Lifetime JP4729076B2 (ja) | 2004-01-09 | 2008-06-06 | ＭＡｄＣＡＭに対する抗体 |
| JP2009260786A Expired - Lifetime JP5094818B2 (ja) | 2004-01-09 | 2009-11-16 | ＭＡｄＣＡＭに対する抗体 |
| JP2012154794A Expired - Lifetime JP5836896B2 (ja) | 2004-01-09 | 2012-07-10 | ＭＡｄＣＡＭに対する抗体 |
| JP2015138764A Expired - Lifetime JP6215875B2 (ja) | 2004-01-09 | 2015-07-10 | ＭＡｄＣＡＭに対する抗体 |
| JP2017004899A Expired - Lifetime JP6423024B2 (ja) | 2004-01-09 | 2017-01-16 | ＭＡｄＣＡＭに対する抗体 |
| JP2018087973A Expired - Lifetime JP6637104B2 (ja) | 2004-01-09 | 2018-05-01 | ＭＡｄＣＡＭに対する抗体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006549399A Expired - Lifetime JP4315982B2 (ja) | 2004-01-09 | 2005-01-07 | ＭＡｄＣＡＭに対する抗体 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009260786A Expired - Lifetime JP5094818B2 (ja) | 2004-01-09 | 2009-11-16 | ＭＡｄＣＡＭに対する抗体 |
| JP2012154794A Expired - Lifetime JP5836896B2 (ja) | 2004-01-09 | 2012-07-10 | ＭＡｄＣＡＭに対する抗体 |
| JP2015138764A Expired - Lifetime JP6215875B2 (ja) | 2004-01-09 | 2015-07-10 | ＭＡｄＣＡＭに対する抗体 |
| JP2017004899A Expired - Lifetime JP6423024B2 (ja) | 2004-01-09 | 2017-01-16 | ＭＡｄＣＡＭに対する抗体 |
| JP2018087973A Expired - Lifetime JP6637104B2 (ja) | 2004-01-09 | 2018-05-01 | ＭＡｄＣＡＭに対する抗体 |
Country Status (37)
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| SI1784426T1 (sl) | 2004-09-03 | 2012-03-30 | Genentech Inc | Humanizirani antagonisti proti beta in njihove uporabe |
| DK1865986T3 (en) * | 2005-03-08 | 2016-04-11 | Pfizer Prod Inc | The anti-CTLA-4 antibody compositions |
| JP5620626B2 (ja) | 2005-03-31 | 2014-11-05 | 中外製薬株式会社 | 会合制御によるポリペプチド製造方法 |
| ATE483732T1 (de) * | 2005-07-08 | 2010-10-15 | Pfizer Ltd | Madcam-antikörper |
| WO2007007151A2 (en) * | 2005-07-11 | 2007-01-18 | Pfizer Limited | Use of anti-mad-cam antibody for the treatment of emphysema |
| WO2007007160A2 (en) * | 2005-07-11 | 2007-01-18 | Pfizer Limited | Anti-madcam antibodies to treat fever |
| BRPI0613459A2 (pt) * | 2005-07-11 | 2011-01-11 | Pfizer Ltd | combinação de anticorpo anti-madcam e inibidor de caspase antifibrótica para tratar fibrose hepática |
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