JP2014534218A5 - - Google Patents
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- Publication number
- JP2014534218A5 JP2014534218A5 JP2014538927A JP2014538927A JP2014534218A5 JP 2014534218 A5 JP2014534218 A5 JP 2014534218A5 JP 2014538927 A JP2014538927 A JP 2014538927A JP 2014538927 A JP2014538927 A JP 2014538927A JP 2014534218 A5 JP2014534218 A5 JP 2014534218A5
- Authority
- JP
- Japan
- Prior art keywords
- binding protein
- tnf
- fragment
- seq
- region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161550587P | 2011-10-24 | 2011-10-24 | |
| US61/550,587 | 2011-10-24 | ||
| PCT/US2012/061690 WO2013063114A1 (en) | 2011-10-24 | 2012-10-24 | Immunobinders directed against tnf |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014534218A JP2014534218A (ja) | 2014-12-18 |
| JP2014534218A5 true JP2014534218A5 (enExample) | 2015-12-17 |
Family
ID=47144149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014538927A Pending JP2014534218A (ja) | 2011-10-24 | 2012-10-24 | Tnfを標的とする免疫結合剤 |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US9803009B2 (enExample) |
| EP (1) | EP2771362A1 (enExample) |
| JP (1) | JP2014534218A (enExample) |
| KR (1) | KR20140084253A (enExample) |
| CN (1) | CN104093739A (enExample) |
| AR (1) | AR088512A1 (enExample) |
| AU (1) | AU2012328921B2 (enExample) |
| BR (1) | BR112014009799A2 (enExample) |
| CA (1) | CA2853357A1 (enExample) |
| CL (1) | CL2014001054A1 (enExample) |
| CO (1) | CO7020873A2 (enExample) |
| CR (1) | CR20140225A (enExample) |
| DO (1) | DOP2014000083A (enExample) |
| EC (1) | ECSP14001249A (enExample) |
| HK (1) | HK1200464A1 (enExample) |
| IL (1) | IL232129A0 (enExample) |
| IN (1) | IN2014CN03936A (enExample) |
| MX (1) | MX2014004981A (enExample) |
| PE (1) | PE20141545A1 (enExample) |
| PH (1) | PH12014500866A1 (enExample) |
| RS (1) | RS20140203A1 (enExample) |
| RU (1) | RU2014120755A (enExample) |
| SG (1) | SG11201401774VA (enExample) |
| TW (1) | TW201326207A (enExample) |
| UY (1) | UY34409A (enExample) |
| WO (1) | WO2013063114A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2771575A1 (en) | 2009-08-29 | 2011-03-03 | Abbott Laboratories | Therapeutic dll4 binding proteins |
| WO2011109298A2 (en) | 2010-03-02 | 2011-09-09 | Abbott Laboratories | Therapeutic dll4 binding proteins |
| KR20130100118A (ko) | 2010-08-03 | 2013-09-09 | 아비에 인코포레이티드 | 이원 가변 도메인 면역글로불린 및 이의 용도 |
| UY33679A (es) | 2010-10-22 | 2012-03-30 | Esbatech | Anticuerpos estables y solubles |
| AR084210A1 (es) * | 2010-12-08 | 2013-05-02 | Abbott Lab | PROTEINAS DE UNION AL TNF-a |
| UY34410A (es) | 2011-10-24 | 2013-05-31 | Abbvie Inc | Inmunoligantes biespecificos dirigidos contra tnf |
| AU2012328921B2 (en) | 2011-10-24 | 2017-05-11 | Abbvie Inc. | Immunobinders directed against TNF |
| AR088513A1 (es) | 2011-10-24 | 2014-06-18 | Abbvie Inc | Inmunoenlazantes dirigidos contra esclerostina |
| PE20151179A1 (es) | 2012-11-01 | 2015-09-12 | Abbvie Inc | Inmunoglobulinas de dominio variable dual anti-vegf/dll4 y usos de las mismas |
| EP2938637A2 (en) * | 2012-12-28 | 2015-11-04 | AbbVie Inc. | Multivalent binding protein compositions |
| US9458244B2 (en) | 2012-12-28 | 2016-10-04 | Abbvie Inc. | Single chain multivalent binding protein compositions and methods |
| AU2014337263B2 (en) | 2013-10-16 | 2019-12-12 | Outlook Therapeutics, Inc. | Buffer formulations for enhanced antibody stability |
| US20160002326A1 (en) | 2014-06-10 | 2016-01-07 | Abbvie Inc. | Compositions and methods for treating rheumatoid arthritis |
| US10093733B2 (en) | 2014-12-11 | 2018-10-09 | Abbvie Inc. | LRP-8 binding dual variable domain immunoglobulin proteins |
| EP3247718B1 (en) | 2015-01-21 | 2021-09-01 | Outlook Therapeutics, Inc. | Modulation of charge variants in a monoclonal antibody composition |
| TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗vegf、pdgf及/或其受體之結合蛋白 |
| AR104847A1 (es) | 2015-06-17 | 2017-08-16 | Lilly Co Eli | Formulación de anticuerpo anti-cgrp |
| CN108350063A (zh) * | 2015-09-14 | 2018-07-31 | 星系生物科技责任有限公司 | 针对血管生成因子的高度有效的单克隆抗体 |
| CA3004830A1 (en) | 2015-11-11 | 2017-05-18 | Opi Vi- Ip Holdco Llc | Composition and methods for anti-tnfr2 antibodies |
| GB201522394D0 (en) | 2015-12-18 | 2016-02-03 | Ucb Biopharma Sprl | Antibodies |
| EP3411401A1 (en) | 2016-02-03 | 2018-12-12 | Oncobiologics, Inc. | Buffer formulations for enhanced antibody stability |
| RS62040B1 (sr) | 2016-06-02 | 2021-07-30 | Abbvie Inc | Agonist receptora glukokortikoida i njegovi imunokonjugati |
| WO2018085407A1 (en) * | 2016-11-02 | 2018-05-11 | Nanoproteagen | Polymeric nanoparticles |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| CN107903323B (zh) * | 2017-11-15 | 2020-04-17 | 中国药科大学 | 抗hTNF-α全人源抗体及其用途 |
| EP3658192B1 (en) | 2017-12-01 | 2021-04-28 | AbbVie Inc. | Glucocorticoid receptor agonist and immunoconjugates thereof |
| WO2023205739A2 (en) * | 2022-04-20 | 2023-10-26 | Senti Biosciences, Inc. | Antigen-binding domains and methods of use thereof |
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| US4980286A (en) | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| DE3631229A1 (de) * | 1986-09-13 | 1988-03-24 | Basf Ag | Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung |
| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・2・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
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| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
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| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
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| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| DE69129154T2 (de) | 1990-12-03 | 1998-08-20 | Genentech, Inc., South San Francisco, Calif. | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
| DE69233697T2 (de) | 1991-03-01 | 2008-01-24 | Dyax Corp., Cambridge | Verfahren zur Entwicklung von bindenden Mikroproteinen |
| PT100379B (pt) | 1991-04-10 | 1999-01-29 | Scripps Research Inst | Bibliotecas de receptores heterodimericos usando fagomideos |
| JPH07503124A (ja) | 1991-06-14 | 1995-04-06 | ゾーマ・コーポレーション | 微生物によって生産される抗体断片とそれらの複合体 |
| DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
| ES2301158T3 (es) | 1992-07-24 | 2008-06-16 | Amgen Fremont Inc. | Produccion de anticuerpos xenogenicos. |
| DE69433279T2 (de) | 1993-02-10 | 2004-07-15 | Unilever N.V. | Isolierungsverfahren verwendend immobilisierte proteine mit spezifischen bindungskapazitäten |
| US6091001A (en) | 1995-03-29 | 2000-07-18 | Abgenix, Inc. | Production of antibodies using Cre-mediated site-specific recombination |
| US6130364A (en) | 1995-03-29 | 2000-10-10 | Abgenix, Inc. | Production of antibodies using Cre-mediated site-specific recombination |
| AU705616B2 (en) | 1995-04-21 | 1999-05-27 | Cell Genesys, Inc. | Generation of large genomic DNA deletions |
| CA2219361C (en) | 1995-04-27 | 2012-02-28 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| WO1996034096A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| ATE239041T1 (de) * | 1996-02-09 | 2003-05-15 | Basf Ag | Humane antikörper welche an humanen tnfalpha binden |
| US5714352A (en) | 1996-03-20 | 1998-02-03 | Xenotech Incorporated | Directed switch-mediated DNA recombination |
| US6699658B1 (en) | 1996-05-31 | 2004-03-02 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
| US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
| EP1972194A1 (en) | 1996-12-03 | 2008-09-24 | Amgen Fremont Inc. | Transgenic mammals having human ig loci including plural vh and vk regions and antibodies produced therefrom |
| IL131016A (en) | 1997-01-21 | 2004-12-15 | Gen Hospital Corp | Selection of proteins using RNA-protein blends |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| KR20010034554A (ko) | 1998-03-03 | 2001-04-25 | 레이몬드, 엠. 위티 | 치료제로서의 cd147 결합 분자 |
| US20020029391A1 (en) | 1998-04-15 | 2002-03-07 | Claude Geoffrey Davis | Epitope-driven human antibody production and gene expression profiling |
| JP2002522063A (ja) | 1998-08-17 | 2002-07-23 | アブジェニックス インコーポレイテッド | 増加した血清半減期を有する改変された分子の生成 |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| ES2706547T3 (es) | 1998-12-23 | 2019-03-29 | Pfizer | Anticuerpos monoclonales humanos para CTLA-4 |
| US7029872B2 (en) | 2000-06-28 | 2006-04-18 | Glycofi, Inc | Methods for producing modified glycoproteins |
| US7449308B2 (en) | 2000-06-28 | 2008-11-11 | Glycofi, Inc. | Combinatorial DNA library for producing modified N-glycans in lower eukaryotes |
| EP1345968A2 (en) | 2000-12-28 | 2003-09-24 | Altus Biologics Inc. | Crystals of whole antibodies and fragments thereof and methods for making and using them |
| US20030186374A1 (en) | 2001-10-01 | 2003-10-02 | Hufton Simon E. | Multi-chain eukaryotic display vectors and uses thereof |
| JP4754219B2 (ja) * | 2002-12-02 | 2011-08-24 | アムジエン・フレモント・インコーポレイテツド | 腫瘍壊死因子を対象とする抗体、およびそれらの使用 |
| WO2004063335A2 (en) | 2003-01-08 | 2004-07-29 | Applied Molecular Evolution | TNF-α BINDING MOLECULES |
| CN1835974A (zh) | 2003-06-16 | 2006-09-20 | 细胞技术研究与发展公司 | 对硬化素特异的抗体和用于增加骨矿化的方法 |
| WO2006014477A1 (en) | 2004-07-06 | 2006-02-09 | Bioren, Inc. | HIGH AFFINITY ANTI-TNF-α ANTIBODIES AND METHOD |
| US7592429B2 (en) | 2005-05-03 | 2009-09-22 | Ucb Sa | Sclerostin-binding antibody |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| WO2008133722A2 (en) | 2006-11-10 | 2008-11-06 | Ucb Pharma S.A. | Anti human sclerostin antibodies |
| US20100036091A1 (en) | 2006-11-10 | 2010-02-11 | Amgen Inc. | Antibody-based diagnostics and therapeutics |
| EP2131860B1 (en) | 2007-03-20 | 2013-12-18 | Eli Lilly & Company | Anti-sclerostin antibodies |
| AR068767A1 (es) | 2007-10-12 | 2009-12-02 | Novartis Ag | Anticuerpos contra esclerostina, composiciones y metodos de uso de estos anticuerpos para tratar un trastorno patologico mediado por esclerostina |
| ES2579231T3 (es) | 2008-01-15 | 2016-08-08 | Abbvie Inc | Vectores de expresión de mamíferos mejorados y usos de los mismos |
| EP2297209A4 (en) | 2008-06-03 | 2012-08-01 | Abbott Lab | IMMUNOGLOBULINS WITH TWO VARIABLE DOMAINS AND USES THEREOF |
| NZ594514A (en) | 2009-03-05 | 2013-06-28 | Abbott Lab | Interleukin-17 BINDING PROTEINS |
| UY32979A (es) | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| MX2012011629A (es) | 2010-04-07 | 2013-03-05 | Abbvie Inc | Proteinas de union a tnf-alfa. |
| KR20130100118A (ko) | 2010-08-03 | 2013-09-09 | 아비에 인코포레이티드 | 이원 가변 도메인 면역글로불린 및 이의 용도 |
| AR084210A1 (es) * | 2010-12-08 | 2013-05-02 | Abbott Lab | PROTEINAS DE UNION AL TNF-a |
| AU2012328921B2 (en) | 2011-10-24 | 2017-05-11 | Abbvie Inc. | Immunobinders directed against TNF |
| UY34410A (es) | 2011-10-24 | 2013-05-31 | Abbvie Inc | Inmunoligantes biespecificos dirigidos contra tnf |
| AR088513A1 (es) | 2011-10-24 | 2014-06-18 | Abbvie Inc | Inmunoenlazantes dirigidos contra esclerostina |
| CA2904407A1 (en) | 2013-03-15 | 2014-09-18 | Abbvie Inc. | Dual specific binding proteins directed against tnf.alpha. |
-
2012
- 2012-10-24 AU AU2012328921A patent/AU2012328921B2/en not_active Ceased
- 2012-10-24 RS RS20140203A patent/RS20140203A1/sr unknown
- 2012-10-24 TW TW101139327A patent/TW201326207A/zh unknown
- 2012-10-24 PH PH1/2014/500866A patent/PH12014500866A1/en unknown
- 2012-10-24 AR ARP120103977A patent/AR088512A1/es unknown
- 2012-10-24 PE PE2014000587A patent/PE20141545A1/es not_active Application Discontinuation
- 2012-10-24 US US13/659,658 patent/US9803009B2/en not_active Expired - Fee Related
- 2012-10-24 EP EP12783475.2A patent/EP2771362A1/en not_active Withdrawn
- 2012-10-24 SG SG11201401774VA patent/SG11201401774VA/en unknown
- 2012-10-24 RU RU2014120755/10A patent/RU2014120755A/ru not_active Application Discontinuation
- 2012-10-24 BR BR112014009799A patent/BR112014009799A2/pt unknown
- 2012-10-24 HK HK15100709.5A patent/HK1200464A1/xx unknown
- 2012-10-24 UY UY0001034409A patent/UY34409A/es not_active Application Discontinuation
- 2012-10-24 IN IN3936CHN2014 patent/IN2014CN03936A/en unknown
- 2012-10-24 MX MX2014004981A patent/MX2014004981A/es unknown
- 2012-10-24 CA CA2853357A patent/CA2853357A1/en not_active Abandoned
- 2012-10-24 JP JP2014538927A patent/JP2014534218A/ja active Pending
- 2012-10-24 KR KR1020147013794A patent/KR20140084253A/ko not_active Withdrawn
- 2012-10-24 CN CN201280064311.3A patent/CN104093739A/zh active Pending
- 2012-10-24 WO PCT/US2012/061690 patent/WO2013063114A1/en not_active Ceased
-
2013
- 2013-11-06 US US14/073,479 patent/US20140170152A1/en not_active Abandoned
-
2014
- 2014-04-13 IL IL232129A patent/IL232129A0/en unknown
- 2014-04-24 CL CL2014001054A patent/CL2014001054A1/es unknown
- 2014-04-24 DO DO2014000083A patent/DOP2014000083A/es unknown
- 2014-05-14 CR CR20140225A patent/CR20140225A/es unknown
- 2014-05-19 EC ECIEPI20141249A patent/ECSP14001249A/es unknown
- 2014-05-22 CO CO14110749A patent/CO7020873A2/es unknown
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