JP2016501877A5 - - Google Patents

Info

Publication number

JP2016501877A5

JP2016501877A5 JP2015545481A JP2015545481A JP2016501877A5 JP 2016501877 A5 JP2016501877 A5 JP 2016501877A5 JP 2015545481 A JP2015545481 A JP 2015545481A JP 2015545481 A JP2015545481 A JP 2015545481A JP 2016501877 A5 JP2016501877 A5 JP 2016501877A5

Authority

JP

Japan

Prior art keywords

antibody

antigen

binding portion

chain variable

variable region

Prior art date

2013-11-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000427 antigen Substances 0.000 claims 27
• 102000036639 antigens Human genes 0.000 claims 27
• 108091007433 antigens Proteins 0.000 claims 27
• 125000003275 alpha amino acid group Chemical group 0.000 claims 19
• 239000003053 toxin Substances 0.000 claims 13
• 231100000765 toxin Toxicity 0.000 claims 13
• 239000008194 pharmaceutical composition Substances 0.000 claims 6
• 239000012634 fragment Substances 0.000 claims 4
• 238000000034 method Methods 0.000 claims 4
• 241000193163 Clostridioides difficile Species 0.000 claims 3
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 239000003242 anti bacterial agent Substances 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 229940079593 drug Drugs 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• RBORURQQJIQWBS-QVRNUERCSA-N (4ar,6r,7r,7as)-6-(6-amino-8-bromopurin-9-yl)-2-hydroxy-2-sulfanylidene-4a,6,7,7a-tetrahydro-4h-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol Chemical compound C([C@H]1O2)OP(O)(=S)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1Br RBORURQQJIQWBS-QVRNUERCSA-N 0.000 claims 1
• 241000261561 Bembidion difficile Species 0.000 claims 1
• 101001055311 Equus asinus Immunoglobulin heavy constant alpha Proteins 0.000 claims 1
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
• 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
• 108010059993 Vancomycin Proteins 0.000 claims 1
• 239000007822 coupling agent Substances 0.000 claims 1
• 229940127089 cytotoxic agent Drugs 0.000 claims 1
• 239000002254 cytotoxic agent Substances 0.000 claims 1
• 231100000599 cytotoxic agent Toxicity 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 238000010494 dissociation reaction Methods 0.000 claims 1
• 230000005593 dissociations Effects 0.000 claims 1
• 230000002163 immunogen Effects 0.000 claims 1
• VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims 1
• 229960000282 metronidazole Drugs 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1
• MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 claims 1
• 229960003165 vancomycin Drugs 0.000 claims 1
• MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims 1