CA2892973A1 - Antibodies against clostridium difficile - Google Patents
Antibodies against clostridium difficile Download PDFInfo
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- CA2892973A1 CA2892973A1 CA2892973A CA2892973A CA2892973A1 CA 2892973 A1 CA2892973 A1 CA 2892973A1 CA 2892973 A CA2892973 A CA 2892973A CA 2892973 A CA2892973 A CA 2892973A CA 2892973 A1 CA2892973 A1 CA 2892973A1
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Classifications
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
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- Medicinal Chemistry (AREA)
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- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Immunology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Microbiology (AREA)
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- Oncology (AREA)
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- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261730790P | 2012-11-28 | 2012-11-28 | |
| US61/730,790 | 2012-11-28 | ||
| PCT/US2013/072467 WO2014085749A2 (en) | 2012-11-28 | 2013-11-29 | Antibodies against clostridium difficile |
Publications (1)
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|---|---|
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| IL (1) | IL239063A0 (enExample) |
| WO (1) | WO2014085749A2 (enExample) |
Families Citing this family (9)
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| EP2699587B1 (en) | 2011-04-22 | 2019-07-03 | Wyeth LLC | Compositions relating to a mutant clostridium difficile toxin and methods thereof |
| BR122016023101B1 (pt) * | 2012-10-21 | 2022-03-22 | Pfizer Inc | Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile |
| CA2892973A1 (en) * | 2012-11-28 | 2014-06-05 | Cnj Holdings, Inc. | Antibodies against clostridium difficile |
| TW201718627A (zh) * | 2015-06-11 | 2017-06-01 | 梅茲製藥有限兩合公司 | 重組梭菌神經毒素及其使用與形成方法、包括其之醫藥組合物及對應其之前驅物、編碼前驅物之核酸序列及其獲得方法與前驅物之形成方法、載體與包括核酸序列之重組宿主細胞 |
| USD952157S1 (en) | 2020-06-19 | 2022-05-17 | Qualigen Inc. | Whole blood treatment cartridge |
| WO2022087021A1 (en) * | 2020-10-20 | 2022-04-28 | Fzata, Inc. | Neutralized antibody and method of use thereof |
| CN114853895B (zh) * | 2020-11-30 | 2023-05-09 | 四川大学华西医院 | 一种抗糖基转移酶a亚单位的纳米抗体及其应用 |
| WO2022241297A2 (en) * | 2021-05-14 | 2022-11-17 | Phenomic Ai | Combination therapy for treatment of tumors comprising cancer-associated fibroblasts |
| CN116239683B (zh) * | 2023-02-15 | 2024-12-27 | 兰州生物制品研究所有限责任公司 | 一种抗艰难梭菌毒素b的单克隆抗体及其制备方法和应用 |
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| US5358868A (en) | 1987-11-24 | 1994-10-25 | Connaught Laboratories Limited | Genetic detoxification of pertussis toxin |
| US5221618A (en) | 1987-11-24 | 1993-06-22 | Connaught Laboratories Limited | Genetic detoxification of pertussis toxin |
| GB8727489D0 (en) | 1987-11-24 | 1987-12-23 | Connaught Lab | Detoxification of pertussis toxin |
| US5244657A (en) | 1987-11-24 | 1993-09-14 | Connaught Laboratories Limited | Genetic detoxification of pertussis toxin |
| US5332583A (en) | 1987-11-24 | 1994-07-26 | Connaught Laboratories Limited | Vaccine containing genetically-detoxified pertussis holotoxin |
| US5435945A (en) | 1992-05-29 | 1995-07-25 | Procor Sulphur Services, Inc. | Method and apparatus for generating sulphur seed particles for sulphur granule production |
| DE19739685A1 (de) * | 1997-09-10 | 1999-03-11 | Eichel Streiber Christoph Von | Monoklonale Antikörper zur Therapie und Prophylaxe von Erkrankungen durch Clostridium difficile |
| PT1265928E (pt) * | 2000-01-27 | 2010-09-30 | Medimmune Llc | Anticorpos neutralizantes com afinidade ultra-elevada |
| KR100708398B1 (ko) | 2002-03-22 | 2007-04-18 | (주) 에이프로젠 | 인간화 항체 및 이의 제조방법 |
| AU2003299527A1 (en) * | 2002-06-17 | 2004-06-07 | Jimmy D. Ballard | Mutant of clostridium difficile toxin b and methods of use |
| GB0309126D0 (en) * | 2003-04-17 | 2003-05-28 | Neutec Pharma Plc | Clostridium difficile focussed antibodies |
| WO2005035575A2 (en) * | 2003-08-22 | 2005-04-21 | Medimmune, Inc. | Humanization of antibodies |
| KR101332927B1 (ko) * | 2004-02-06 | 2013-11-26 | 메다렉스, 인코포레이티드 | 클로스트리듐 디피실리 독소에 대한 항체 및 이의 용도 |
| CN102875681A (zh) | 2005-07-08 | 2013-01-16 | 拜奥根Idec马萨诸塞公司 | 抗-αvβ6抗体及其用途 |
| WO2007065037A2 (en) | 2005-12-02 | 2007-06-07 | Curagen Corporation | Antibodies against mmp-13 (collagenase-3) and uses thereof |
| CN103709249B (zh) | 2006-12-20 | 2016-02-24 | Mmr全球公司 | 抗体及其制备和使用方法 |
| AU2009219358A1 (en) * | 2008-02-28 | 2009-09-03 | 3M Innovative Properties Company | Antibodies to Clostridium difficile spores and uses thereof |
| EP2405940B1 (en) * | 2009-02-20 | 2021-08-04 | Secretary of State for Health and Social Care | Antibodies to clostridium difficile toxins |
| WO2011063346A1 (en) * | 2009-11-20 | 2011-05-26 | Northshore University Health System Research Institute | Targeting of the c-terminal segment of c. difficile toxin b for improved clinical diagnosis, prevention, and treatment |
| EP2558493B1 (en) * | 2010-04-15 | 2019-09-18 | Progenics Pharmaceuticals, Inc. | Antibodies for the treatment of clostridium difficile-associated infection and disease |
| GB201016742D0 (en) * | 2010-10-05 | 2010-11-17 | Health Prot Agency | Clostridium difficile antigens |
| EP2632949B1 (en) * | 2010-10-25 | 2017-09-13 | National Research Council of Canada | Clostridium difficile-specific antibodies and uses thereof |
| EP2661500A2 (en) * | 2010-12-29 | 2013-11-13 | Cangene Corporation | Clostridium difficile antigens |
| US9815889B2 (en) * | 2011-08-02 | 2017-11-14 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. | Antibodies for prevention and treatment of diseases caused by clostridium difficile |
| SG11201400916XA (en) * | 2011-08-22 | 2014-06-27 | Cangene Corp | Clostridium difficile antibodies |
| PT2758432T (pt) * | 2011-09-16 | 2019-06-14 | Ucb Biopharma Sprl | Anticorpos neutralizantes contra as exotoxinas principais tcda e tcdb de clostridium difficile |
| DE102011121238A1 (de) * | 2011-12-14 | 2013-06-20 | Universitätsklinikum Hamburg-Eppendorf | Einzeldomänen-antikörper gegen clostridium difficile toxine |
| EP2921502A4 (en) * | 2012-10-19 | 2016-09-28 | Evec Inc | AGAINST TOXIN FROM CLOSTRIDIUM DIFFICILE OR ANTIGENBINDING FRAGMENT SPECIFIC HUMAN ANTIBODY |
| CA2892973A1 (en) * | 2012-11-28 | 2014-06-05 | Cnj Holdings, Inc. | Antibodies against clostridium difficile |
| US10160797B2 (en) * | 2013-03-15 | 2018-12-25 | Sanofi Pasteur Biologics, Llc | Antibodies against Clostridium difficile toxins and methods of using the same |
| EP2957570B1 (en) * | 2014-06-20 | 2019-04-17 | Immunimed Inc. | Polyclonal antibodies against clostridium difficile and uses thereof |
| US11434264B2 (en) * | 2015-02-13 | 2022-09-06 | Quanterix Corporation | Immunoassays for differential detection of clostridium difficile |
| CA2976976C (en) * | 2015-02-19 | 2023-02-28 | Immune Biosolutions Inc. | Clostridium difficile toxins a and/or b antigen and epitope antibody, and pharmaceutical uses thereof |
-
2013
- 2013-11-29 CA CA2892973A patent/CA2892973A1/en not_active Abandoned
- 2013-11-29 EP EP13857740.8A patent/EP2925362A4/en not_active Withdrawn
- 2013-11-29 HK HK16105037.6A patent/HK1216999A1/zh unknown
- 2013-11-29 CN CN201811406032.6A patent/CN109776676A/zh active Pending
- 2013-11-29 AU AU2013352034A patent/AU2013352034B2/en not_active Ceased
- 2013-11-29 JP JP2015545481A patent/JP2016501877A/ja not_active Ceased
- 2013-11-29 US US14/648,234 patent/US10117933B2/en active Active
- 2013-11-29 CN CN201380071593.4A patent/CN105025926B/zh not_active Expired - Fee Related
- 2013-11-29 WO PCT/US2013/072467 patent/WO2014085749A2/en not_active Ceased
-
2015
- 2015-05-28 IL IL239063A patent/IL239063A0/en unknown
-
2018
- 2018-10-29 AU AU2018256482A patent/AU2018256482A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20150290319A1 (en) | 2015-10-15 |
| AU2013352034A1 (en) | 2015-07-02 |
| EP2925362A4 (en) | 2016-07-20 |
| CN105025926B (zh) | 2018-12-14 |
| HK1216999A1 (zh) | 2016-12-16 |
| WO2014085749A3 (en) | 2015-07-16 |
| IL239063A0 (en) | 2015-07-30 |
| AU2018256482A1 (en) | 2018-11-22 |
| AU2013352034B2 (en) | 2018-08-02 |
| CN109776676A (zh) | 2019-05-21 |
| WO2014085749A2 (en) | 2014-06-05 |
| EP2925362A2 (en) | 2015-10-07 |
| US10117933B2 (en) | 2018-11-06 |
| JP2016501877A (ja) | 2016-01-21 |
| CN105025926A (zh) | 2015-11-04 |
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| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20181123 |
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| FZDE | Discontinued |
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| FZDE | Discontinued |
Effective date: 20210831 |