CN109776676A - 针对艰难梭菌的抗体 - Google Patents

针对艰难梭菌的抗体 Download PDF

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Publication number
CN109776676A
CN109776676A CN201811406032.6A CN201811406032A CN109776676A CN 109776676 A CN109776676 A CN 109776676A CN 201811406032 A CN201811406032 A CN 201811406032A CN 109776676 A CN109776676 A CN 109776676A
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CN
China
Prior art keywords
antibody
ser
seq
antigen
toxin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201811406032.6A
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English (en)
Chinese (zh)
Inventor
R·卡桑
D·约翰斯通
L·萨沃德
J·A·乔治
J·贝里
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CNJ Holdings Inc
Original Assignee
CNJ Holdings Inc
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Filing date
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Publication of CN109776676A publication Critical patent/CN109776676A/zh
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1282Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201811406032.6A 2012-11-28 2013-11-29 针对艰难梭菌的抗体 Pending CN109776676A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261730790P 2012-11-28 2012-11-28
US61/730,790 2012-11-28
CN201380071593.4A CN105025926B (zh) 2012-11-28 2013-11-29 针对艰难梭菌的抗体

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201380071593.4A Division CN105025926B (zh) 2012-11-28 2013-11-29 针对艰难梭菌的抗体

Publications (1)

Publication Number Publication Date
CN109776676A true CN109776676A (zh) 2019-05-21

Family

ID=50828602

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201811406032.6A Pending CN109776676A (zh) 2012-11-28 2013-11-29 针对艰难梭菌的抗体
CN201380071593.4A Expired - Fee Related CN105025926B (zh) 2012-11-28 2013-11-29 针对艰难梭菌的抗体

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201380071593.4A Expired - Fee Related CN105025926B (zh) 2012-11-28 2013-11-29 针对艰难梭菌的抗体

Country Status (9)

Country Link
US (1) US10117933B2 (enExample)
EP (1) EP2925362A4 (enExample)
JP (1) JP2016501877A (enExample)
CN (2) CN109776676A (enExample)
AU (2) AU2013352034B2 (enExample)
CA (1) CA2892973A1 (enExample)
HK (1) HK1216999A1 (enExample)
IL (1) IL239063A0 (enExample)
WO (1) WO2014085749A2 (enExample)

Cited By (1)

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CN114853896A (zh) * 2020-11-30 2022-08-05 四川大学华西医院 一种抗糖基转移酶a亚单位的纳米抗体及其应用

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EP2699587B1 (en) 2011-04-22 2019-07-03 Wyeth LLC Compositions relating to a mutant clostridium difficile toxin and methods thereof
BR122016023101B1 (pt) * 2012-10-21 2022-03-22 Pfizer Inc Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile
CA2892973A1 (en) * 2012-11-28 2014-06-05 Cnj Holdings, Inc. Antibodies against clostridium difficile
TW201718627A (zh) * 2015-06-11 2017-06-01 梅茲製藥有限兩合公司 重組梭菌神經毒素及其使用與形成方法、包括其之醫藥組合物及對應其之前驅物、編碼前驅物之核酸序列及其獲得方法與前驅物之形成方法、載體與包括核酸序列之重組宿主細胞
USD952157S1 (en) 2020-06-19 2022-05-17 Qualigen Inc. Whole blood treatment cartridge
WO2022087021A1 (en) * 2020-10-20 2022-04-28 Fzata, Inc. Neutralized antibody and method of use thereof
WO2022241297A2 (en) * 2021-05-14 2022-11-17 Phenomic Ai Combination therapy for treatment of tumors comprising cancer-associated fibroblasts
CN116239683B (zh) * 2023-02-15 2024-12-27 兰州生物制品研究所有限责任公司 一种抗艰难梭菌毒素b的单克隆抗体及其制备方法和应用

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Cited By (2)

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Publication number Priority date Publication date Assignee Title
CN114853896A (zh) * 2020-11-30 2022-08-05 四川大学华西医院 一种抗糖基转移酶a亚单位的纳米抗体及其应用
CN114853896B (zh) * 2020-11-30 2023-05-09 四川大学华西医院 一种抗糖基转移酶a亚单位的纳米抗体及其应用

Also Published As

Publication number Publication date
US20150290319A1 (en) 2015-10-15
AU2013352034A1 (en) 2015-07-02
EP2925362A4 (en) 2016-07-20
CN105025926B (zh) 2018-12-14
CA2892973A1 (en) 2014-06-05
HK1216999A1 (zh) 2016-12-16
WO2014085749A3 (en) 2015-07-16
IL239063A0 (en) 2015-07-30
AU2018256482A1 (en) 2018-11-22
AU2013352034B2 (en) 2018-08-02
WO2014085749A2 (en) 2014-06-05
EP2925362A2 (en) 2015-10-07
US10117933B2 (en) 2018-11-06
JP2016501877A (ja) 2016-01-21
CN105025926A (zh) 2015-11-04

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