AU2013352034B2 - Antibodies against Clostridium difficile - Google Patents

Antibodies against Clostridium difficile Download PDF

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Publication number
AU2013352034B2
AU2013352034B2 AU2013352034A AU2013352034A AU2013352034B2 AU 2013352034 B2 AU2013352034 B2 AU 2013352034B2 AU 2013352034 A AU2013352034 A AU 2013352034A AU 2013352034 A AU2013352034 A AU 2013352034A AU 2013352034 B2 AU2013352034 B2 AU 2013352034B2
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AU
Australia
Prior art keywords
ser
thr
leu
tyr
gly
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2013352034A
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English (en)
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AU2013352034A1 (en
Inventor
Jody Berry
Joyee Antony George
Darrell JOHNSTONE
Cory Nykiforuk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emergent Biosolutions Canada Inc
Original Assignee
Emergent Biosolutions Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emergent Biosolutions Canada Inc filed Critical Emergent Biosolutions Canada Inc
Publication of AU2013352034A1 publication Critical patent/AU2013352034A1/en
Assigned to EMERGENT BIOSOLUTIONS CANADA INC. reassignment EMERGENT BIOSOLUTIONS CANADA INC. Alteration of Name(s) of Applicant(s) under S113 Assignors: CNJ HOLDINGS, INC.
Application granted granted Critical
Publication of AU2013352034B2 publication Critical patent/AU2013352034B2/en
Priority to AU2018256482A priority Critical patent/AU2018256482A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1282Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2013352034A 2012-11-28 2013-11-29 Antibodies against Clostridium difficile Ceased AU2013352034B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2018256482A AU2018256482A1 (en) 2012-11-28 2018-10-29 Antibodies Against Clostridium Difficile

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261730790P 2012-11-28 2012-11-28
US61/730,790 2012-11-28
PCT/US2013/072467 WO2014085749A2 (en) 2012-11-28 2013-11-29 Antibodies against clostridium difficile

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2018256482A Division AU2018256482A1 (en) 2012-11-28 2018-10-29 Antibodies Against Clostridium Difficile

Publications (2)

Publication Number Publication Date
AU2013352034A1 AU2013352034A1 (en) 2015-07-02
AU2013352034B2 true AU2013352034B2 (en) 2018-08-02

Family

ID=50828602

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2013352034A Ceased AU2013352034B2 (en) 2012-11-28 2013-11-29 Antibodies against Clostridium difficile
AU2018256482A Abandoned AU2018256482A1 (en) 2012-11-28 2018-10-29 Antibodies Against Clostridium Difficile

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2018256482A Abandoned AU2018256482A1 (en) 2012-11-28 2018-10-29 Antibodies Against Clostridium Difficile

Country Status (9)

Country Link
US (1) US10117933B2 (enExample)
EP (1) EP2925362A4 (enExample)
JP (1) JP2016501877A (enExample)
CN (2) CN105025926B (enExample)
AU (2) AU2013352034B2 (enExample)
CA (1) CA2892973A1 (enExample)
HK (1) HK1216999A1 (enExample)
IL (1) IL239063A0 (enExample)
WO (1) WO2014085749A2 (enExample)

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HUE047085T2 (hu) 2011-04-22 2020-04-28 Wyeth Llc Clostridium difficile mutáns toxinjához kapcsolódó készítmények és eljárásai
BR122016023101B1 (pt) 2012-10-21 2022-03-22 Pfizer Inc Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile
US10117933B2 (en) * 2012-11-28 2018-11-06 Emergent Biosolutions Canada Inc. Antibodies against Clostridium difficile
TW201718627A (zh) * 2015-06-11 2017-06-01 梅茲製藥有限兩合公司 重組梭菌神經毒素及其使用與形成方法、包括其之醫藥組合物及對應其之前驅物、編碼前驅物之核酸序列及其獲得方法與前驅物之形成方法、載體與包括核酸序列之重組宿主細胞
USD952157S1 (en) 2020-06-19 2022-05-17 Qualigen Inc. Whole blood treatment cartridge
EP4232818A1 (en) * 2020-10-20 2023-08-30 Fzata, Inc. Neutralized antibody and method of use thereof
CN114853896B (zh) * 2020-11-30 2023-05-09 四川大学华西医院 一种抗糖基转移酶a亚单位的纳米抗体及其应用
WO2022241297A2 (en) * 2021-05-14 2022-11-17 Phenomic Ai Combination therapy for treatment of tumors comprising cancer-associated fibroblasts
CN116239683B (zh) * 2023-02-15 2024-12-27 兰州生物制品研究所有限责任公司 一种抗艰难梭菌毒素b的单克隆抗体及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011130650A2 (en) * 2010-04-15 2011-10-20 Progenics Pharmaceuticals, Inc. Antibodies for the treatment of clostridium difficile-associated infection and disease

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US5221618A (en) 1987-11-24 1993-06-22 Connaught Laboratories Limited Genetic detoxification of pertussis toxin
US5332583A (en) 1987-11-24 1994-07-26 Connaught Laboratories Limited Vaccine containing genetically-detoxified pertussis holotoxin
US5358868A (en) 1987-11-24 1994-10-25 Connaught Laboratories Limited Genetic detoxification of pertussis toxin
US5244657A (en) 1987-11-24 1993-09-14 Connaught Laboratories Limited Genetic detoxification of pertussis toxin
US5435945A (en) 1992-05-29 1995-07-25 Procor Sulphur Services, Inc. Method and apparatus for generating sulphur seed particles for sulphur granule production
DE19739685A1 (de) * 1997-09-10 1999-03-11 Eichel Streiber Christoph Von Monoklonale Antikörper zur Therapie und Prophylaxe von Erkrankungen durch Clostridium difficile
DK1265928T3 (da) 2000-01-27 2010-11-15 Medimmune Llc RSV-neutraliserende antistoffer med ultra høj affinitet
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GB0309126D0 (en) * 2003-04-17 2003-05-28 Neutec Pharma Plc Clostridium difficile focussed antibodies
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JP4588763B2 (ja) * 2004-02-06 2010-12-01 ユニバーシティー オブ マサチューセッツ クロストリジウム・ディフィシル(Clostridiumdifficile)毒素に対する抗体およびその使用
CN102875681A (zh) * 2005-07-08 2013-01-16 拜奥根Idec马萨诸塞公司 抗-αvβ6抗体及其用途
WO2007065037A2 (en) 2005-12-02 2007-06-07 Curagen Corporation Antibodies against mmp-13 (collagenase-3) and uses thereof
BRPI0720565A2 (pt) 2006-12-20 2013-09-17 Mmr Information Systems Inc anticorpos e mÉtodos para a sua preparaÇço e seu uso
US8697374B2 (en) * 2008-02-28 2014-04-15 3M Innovative Properties Company Antibodies to Clostridium difficile spores and uses thereof
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SG11201400916XA (en) * 2011-08-22 2014-06-27 Cangene Corp Clostridium difficile antibodies
PT2758432T (pt) * 2011-09-16 2019-06-14 Ucb Biopharma Sprl Anticorpos neutralizantes contra as exotoxinas principais tcda e tcdb de clostridium difficile
DE102011121238A1 (de) * 2011-12-14 2013-06-20 Universitätsklinikum Hamburg-Eppendorf Einzeldomänen-antikörper gegen clostridium difficile toxine
US20150259402A1 (en) * 2012-10-19 2015-09-17 Evec Inc. Human antibody specific to toxin produced from clostridium difficile, or antigen-binding fragment thereof
US10117933B2 (en) * 2012-11-28 2018-11-06 Emergent Biosolutions Canada Inc. Antibodies against Clostridium difficile
WO2014144292A2 (en) * 2013-03-15 2014-09-18 Sanofi Pasteur Biologics , Llc Antibodies against clostridium difficile toxins and methods of using the same
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Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2011130650A2 (en) * 2010-04-15 2011-10-20 Progenics Pharmaceuticals, Inc. Antibodies for the treatment of clostridium difficile-associated infection and disease

Also Published As

Publication number Publication date
IL239063A0 (en) 2015-07-30
WO2014085749A3 (en) 2015-07-16
CN105025926A (zh) 2015-11-04
US20150290319A1 (en) 2015-10-15
AU2013352034A1 (en) 2015-07-02
AU2018256482A1 (en) 2018-11-22
CN109776676A (zh) 2019-05-21
WO2014085749A2 (en) 2014-06-05
JP2016501877A (ja) 2016-01-21
EP2925362A2 (en) 2015-10-07
US10117933B2 (en) 2018-11-06
CN105025926B (zh) 2018-12-14
HK1216999A1 (zh) 2016-12-16
EP2925362A4 (en) 2016-07-20
CA2892973A1 (en) 2014-06-05

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Legal Events

Date Code Title Description
HB Alteration of name in register

Owner name: EMERGENT BIOSOLUTIONS CANADA INC.

Free format text: FORMER NAME(S): CNJ HOLDINGS, INC.

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ JOHNSTONE, DARRELL; GEORGE, JOYEE ANTONY; BERRY, JODY AND NYKIFORUK, CORY

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired