JP2008515992A5 - - Google Patents
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- JP2008515992A5 JP2008515992A5 JP2007536867A JP2007536867A JP2008515992A5 JP 2008515992 A5 JP2008515992 A5 JP 2008515992A5 JP 2007536867 A JP2007536867 A JP 2007536867A JP 2007536867 A JP2007536867 A JP 2007536867A JP 2008515992 A5 JP2008515992 A5 JP 2008515992A5
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- Prior art keywords
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- cancer
- disease
- alkyl
- leukemia
- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims 14
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 11
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 8
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 125000003277 amino group Chemical group 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 150000002367 halogens Chemical group 0.000 claims 6
- 230000001154 acute effect Effects 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 206010039491 Sarcoma Diseases 0.000 claims 3
- -1 benzo [1,4] dioxin-yl group Chemical group 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
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- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 claims 1
- FTNJQNQLEGKTGD-UHFFFAOYSA-N 1,3-benzodioxole Chemical compound C1=CC=C2OCOC2=C1 FTNJQNQLEGKTGD-UHFFFAOYSA-N 0.000 claims 1
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 1
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- 208000037550 Primary familial polycythemia Diseases 0.000 claims 1
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- 208000007014 Retinitis pigmentosa Diseases 0.000 claims 1
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- 208000021841 acute erythroid leukemia Diseases 0.000 claims 1
- 208000011912 acute myelomonocytic leukemia M4 Diseases 0.000 claims 1
- 208000036676 acute undifferentiated leukemia Diseases 0.000 claims 1
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- 208000005980 beta thalassemia Diseases 0.000 claims 1
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- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
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- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
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- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000003238 esophagus Anatomy 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
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- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
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- 210000003757 neuroblast Anatomy 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
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- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61763404P | 2004-10-13 | 2004-10-13 | |
| US61765304P | 2004-10-13 | 2004-10-13 | |
| US61767004P | 2004-10-13 | 2004-10-13 | |
| US61763304P | 2004-10-13 | 2004-10-13 | |
| US61765504P | 2004-10-13 | 2004-10-13 | |
| US62417004P | 2004-11-03 | 2004-11-03 | |
| PCT/US2005/036764 WO2006044505A2 (en) | 2004-10-13 | 2005-10-13 | Compounds for nonsense suppression, and methods for their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008515992A JP2008515992A (ja) | 2008-05-15 |
| JP2008515992A5 true JP2008515992A5 (https=) | 2008-11-27 |
Family
ID=35517967
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007536837A Pending JP2008515985A (ja) | 2004-10-13 | 2005-10-13 | ナンセンス抑制の化合物とその使用方法 |
| JP2007536867A Pending JP2008515992A (ja) | 2004-10-13 | 2005-10-13 | 体細胞変異に起因する疾患の阻止／治療用医薬を製造するための規定化合物の使用 |
| JP2007536865A Pending JP2008515990A (ja) | 2004-10-13 | 2005-10-13 | ナンセンス抑制のための化合物およびその使用方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007536837A Pending JP2008515985A (ja) | 2004-10-13 | 2005-10-13 | ナンセンス抑制の化合物とその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007536865A Pending JP2008515990A (ja) | 2004-10-13 | 2005-10-13 | ナンセンス抑制のための化合物およびその使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (10) | US9611230B2 (https=) |
| EP (13) | EP2402323A3 (https=) |
| JP (3) | JP2008515985A (https=) |
| KR (3) | KR20070067201A (https=) |
| AU (3) | AU2005295730A1 (https=) |
| BR (2) | BRPI0516110A (https=) |
| CA (5) | CA2582885A1 (https=) |
| IL (3) | IL182461A0 (https=) |
| MX (3) | MX2007004484A (https=) |
| SG (2) | SG156640A1 (https=) |
| WO (5) | WO2006044505A2 (https=) |
Families Citing this family (122)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003252136A1 (en) | 2002-07-24 | 2004-02-09 | Ptc Therapeutics, Inc. | METHODS FOR IDENTIFYING SMALL MOLEDULES THAT MODULATE PREMATURE TRANSLATION TERMINATION AND NONSENSE MEDIATED mRNA DECAY |
| HUE047569T2 (hu) | 2003-04-11 | 2020-04-28 | Ptc Therapeutics Inc | 1,2,4-oxadiazol-benzoesav vegyület és nonszensz szupresszióra történõ alkalmazása |
| EP2402323A3 (en) * | 2004-10-13 | 2012-05-30 | PTC Therapeutics, Inc. | Pyrazole or triazole compounds and their use for the manufacture of a medicament for treating somatic mutation-related diseases |
| EP1940801A2 (en) * | 2005-10-14 | 2008-07-09 | NeuroSearch A/S | Imidazole derivatives and their use for modulating the gaba-a receptor complex |
| US20090304641A1 (en) | 2005-10-17 | 2009-12-10 | Children's Hospital Boston | Methods and Compositions for Regulating Gene Expression |
| CA2641880C (en) | 2006-02-10 | 2014-09-09 | Summit Corporation Plc | Treatment of duchenne muscular dystrophy |
| RU2462246C2 (ru) * | 2006-03-30 | 2012-09-27 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Способы получения функционального белка из днк, имеющей нонсенс-мутацию, и лечения нарушений, ассоциированных с ней |
| US10022352B2 (en) | 2006-04-07 | 2018-07-17 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| US7645789B2 (en) | 2006-04-07 | 2010-01-12 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
| NZ571803A (en) | 2006-04-07 | 2011-12-22 | Vertex Pharma | Amide indole derivatives as modulators of ATP-binding cassette transporters |
| USRE50453E1 (en) | 2006-04-07 | 2025-06-10 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
| PL2076501T3 (pl) * | 2006-09-25 | 2016-06-30 | Ptc Therapeutics Inc | Postacie krystaliczne kwasu 3-[5-(2-fluorofenylo)[1,2,4]oksadiazol-3-ilo]-benzoesowego |
| KR100858357B1 (ko) * | 2006-10-02 | 2008-09-11 | (주) 디지탈바이오텍 | 벤조퓨란계 유도체 화합물을 유효성분으로 함유하는인지기능 장애의 예방 및 치료용 조성물 |
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| WO2008157407A2 (en) * | 2007-06-13 | 2008-12-24 | University Of Virginia Patent Foundation | Thiadiazole, oxadiazole and triazole derivatives for treating leukemia |
| CA2685540C (en) | 2007-08-03 | 2018-10-16 | Graham Michael Wynne | Drug combinations for the treatment of duchenne muscular dystrophy |
| US8551534B2 (en) | 2007-10-10 | 2013-10-08 | Parion Sciences, Inc. | Inhaled hypertonic saline delivered by a heated nasal cannula |
| SI2217572T1 (sl) | 2007-11-16 | 2014-05-30 | Vertex Pharmaceuticals Incorporated | Izokinolinski modulatorji prenaĺ alcev z atp-vezavno kaseto |
| SI2225230T1 (sl) | 2007-12-07 | 2017-03-31 | Vertex Pharmaceuticals Incorporated | Trdne oblike 3-(6-(1-2,2-difluorobenzo(d)(1,3)dioxol-5-il)ciklopropan- karboksamido)-3-metilpiridin-2-il) benzojske kisline |
| EP2271621B1 (en) | 2008-03-31 | 2013-11-20 | Vertex Pharmaceuticals Incorporated | Pyridyl derivatives as cftr modulators |
| JP5369854B2 (ja) | 2008-04-21 | 2013-12-18 | 住友化学株式会社 | 有害節足動物防除組成物および縮合複素環化合物 |
| AU2009260519A1 (en) | 2008-05-30 | 2009-12-23 | Merck Sharp & Dohme Corp. | Novel substituted azabenzoxazoles |
| TW201000099A (en) | 2008-06-20 | 2010-01-01 | Amgen Inc | S1P1 receptor agonists and use thereof |
| CN102076670B (zh) * | 2008-06-24 | 2013-05-22 | Irm责任有限公司 | 调节g蛋白偶联受体的化合物和方法 |
| MY159575A (en) * | 2009-04-02 | 2017-01-13 | Merck Serono Sa | Dihydroorotate dehydrogenase inhibitors |
| US9126938B2 (en) | 2009-08-17 | 2015-09-08 | The Brigham And Women's Hospital, Inc. | Phosphatidylcholine transfer protein inhibitors |
| BR112012006956A2 (pt) | 2009-10-12 | 2015-09-15 | Bayer Cropscience Ag | 1- (pirida-3-il) -pirazóisol e 1- (pirimida-5-il) - pirazóisol como pesticidas |
| WO2011085269A1 (en) * | 2010-01-08 | 2011-07-14 | Selexagen Therapeutics, Inc. | Raf kinase inhibitors |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| US20110251253A1 (en) | 2010-03-25 | 2011-10-13 | Vertex Pharmaceuticals Incorporated | Solid forms of (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide |
| HRP20211752T1 (hr) | 2010-04-07 | 2022-02-18 | Vertex Pharmaceuticals Incorporated | Farmaceutski pripravci 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il)ciklopropankarboksamido)-3-metilpiridin-2-il)benzojeve kiseline i njihova primjena |
| HRP20160682T1 (hr) | 2010-04-07 | 2016-07-29 | Vertex Pharmaceuticals Incorporated | Čvrsti oblici 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il)ciklopropankarboksiamido)-3-metilpiridin-2-il)benzojeve kiseline |
| ES2608474T3 (es) | 2010-04-22 | 2017-04-11 | Vertex Pharmaceuticals Incorporated | Proceso de producción de compuestos indol cycloalkylcarboxamido |
| KR101799429B1 (ko) * | 2010-05-03 | 2017-11-21 | 에스케이바이오팜 주식회사 | 신경 세포 사멸 또는 신경 퇴화를 억제하기 위한 약학적 조성물 |
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2005
- 2005-10-13 EP EP10185139A patent/EP2402323A3/en not_active Withdrawn
- 2005-10-13 US US11/577,191 patent/US9611230B2/en not_active Expired - Fee Related
- 2005-10-13 WO PCT/US2005/036764 patent/WO2006044505A2/en not_active Ceased
- 2005-10-13 JP JP2007536837A patent/JP2008515985A/ja active Pending
- 2005-10-13 EP EP15168072.5A patent/EP2939674A1/en not_active Withdrawn
- 2005-10-13 KR KR1020077010767A patent/KR20070067201A/ko not_active Withdrawn
- 2005-10-13 EP EP10185130.1A patent/EP2311455B1/en not_active Expired - Lifetime
- 2005-10-13 WO PCT/US2005/036762 patent/WO2006044503A2/en not_active Ceased
- 2005-10-13 AU AU2005295730A patent/AU2005295730A1/en not_active Abandoned
- 2005-10-13 CA CA002582885A patent/CA2582885A1/en not_active Abandoned
- 2005-10-13 CA CA002583971A patent/CA2583971A1/en not_active Abandoned
- 2005-10-13 EP EP16163831.7A patent/EP3067053A1/en not_active Withdrawn
- 2005-10-13 US US11/577,189 patent/US9315467B2/en active Active
- 2005-10-13 BR BRPI0516110-0A patent/BRPI0516110A/pt not_active IP Right Cessation
- 2005-10-13 KR KR1020077009154A patent/KR20070067165A/ko not_active Withdrawn
- 2005-10-13 EP EP05815159.8A patent/EP1815206B1/en not_active Expired - Lifetime
- 2005-10-13 EP EP05807667A patent/EP1799659A1/en not_active Withdrawn
- 2005-10-13 US US11/577,177 patent/US9051342B2/en not_active Expired - Fee Related
- 2005-10-13 EP EP10185137A patent/EP2316452A1/en not_active Withdrawn
- 2005-10-13 WO PCT/US2005/037052 patent/WO2006044682A1/en not_active Ceased
- 2005-10-13 EP EP05804194A patent/EP1799207A2/en not_active Withdrawn
- 2005-10-13 KR KR1020077010794A patent/KR20070065429A/ko not_active Withdrawn
- 2005-10-13 SG SG200906828-9A patent/SG156640A1/en unknown
- 2005-10-13 AU AU2005295727A patent/AU2005295727A1/en not_active Abandoned
- 2005-10-13 EP EP10185133A patent/EP2363129A1/en not_active Withdrawn
- 2005-10-13 US US11/577,176 patent/US20080269191A1/en not_active Abandoned
- 2005-10-13 EP EP10185126.9A patent/EP2301538B1/en not_active Expired - Lifetime
- 2005-10-13 MX MX2007004484A patent/MX2007004484A/es unknown
- 2005-10-13 BR BRPI0515995-4A patent/BRPI0515995A/pt not_active IP Right Cessation
- 2005-10-13 EP EP05807462A patent/EP1799212A2/en not_active Withdrawn
- 2005-10-13 WO PCT/US2005/036673 patent/WO2006044456A1/en not_active Ceased
- 2005-10-13 EP EP05804171A patent/EP1812071A2/en not_active Withdrawn
- 2005-10-13 CA CA002583177A patent/CA2583177A1/en not_active Abandoned
- 2005-10-13 US US11/577,192 patent/US7902235B2/en not_active Expired - Fee Related
- 2005-10-13 WO PCT/US2005/036761 patent/WO2006044502A2/en not_active Ceased
- 2005-10-13 CA CA002583159A patent/CA2583159A1/en not_active Abandoned
- 2005-10-13 MX MX2007004487A patent/MX2007004487A/es unknown
- 2005-10-13 MX MX2007004479A patent/MX2007004479A/es unknown
- 2005-10-13 EP EP10185128.5A patent/EP2301536B1/en not_active Expired - Lifetime
- 2005-10-13 JP JP2007536867A patent/JP2008515992A/ja active Pending
- 2005-10-13 CA CA002583976A patent/CA2583976A1/en not_active Abandoned
- 2005-10-13 SG SG200906829-7A patent/SG156641A1/en unknown
- 2005-10-13 AU AU2005295778A patent/AU2005295778A1/en not_active Abandoned
- 2005-10-13 JP JP2007536865A patent/JP2008515990A/ja active Pending
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2007
- 2007-04-11 IL IL182461A patent/IL182461A0/en unknown
- 2007-04-11 IL IL182464A patent/IL182464A0/en unknown
- 2007-04-11 IL IL182459A patent/IL182459A0/en unknown
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2011
- 2011-03-07 US US13/042,456 patent/US8710031B2/en not_active Expired - Fee Related
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2014
- 2014-04-28 US US14/263,478 patent/US9273076B2/en not_active Expired - Lifetime
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2015
- 2015-06-08 US US14/733,615 patent/US20150274674A1/en not_active Abandoned
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2016
- 2016-04-15 US US15/130,318 patent/US20160229818A1/en not_active Abandoned
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2017
- 2017-03-31 US US15/475,240 patent/US20170204073A1/en not_active Abandoned
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